Patent application number | Description | Published |
20120238730 | INTEGRATED APPROACH TO THE ISOLATION AND PURIFICATION OF ANTIBODIES - Disclosed herein is an integrated approach to purification process development and execution, including processes comprising particular capture and fine purification steps; processes that employ of a minimal number of buffer systems, and processes that make use of minimally-corrosive buffer systems, as well as combinations thereof. | 09-20-2012 |
20130344084 | CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES - The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations. | 12-26-2013 |
20140161815 | CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES - The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations. | 06-12-2014 |
20150110799 | LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME - The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 04-23-2015 |
20150132801 | LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME - The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 05-14-2015 |
20150140006 | LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME - The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 05-21-2015 |
20150259410 | LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME - The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 09-17-2015 |
Patent application number | Description | Published |
20110075166 | PREVIEW OF A DOCUMENT WITH PRINTABLE COMPONENTS AT A PRINTING DEVICE BASED ON ITS PRINTING CAPABILITY - An apparatus, method, system and medium are described that support functionality to receive document(s) to be printed at a printing device, and enable editing the document(s) prior to printing. Modifications to the document(s) may be generated based on the user edits, and a print preview of the modified documents may be displayed and may enable further edits. In some embodiments, the print preview may be provided to the user on a display that is part of the printing device. In some embodiments, the print preview may be provided to the user through a UI presented on a client device. Display of the modified document(s) may be a rasterized image of the modified document(s), generated based on capabilities of a selected printing device. In some embodiments, modifications may be made to an intermediate version of the document(s), and that intermediate version may be cached. | 03-31-2011 |
20110075200 | PREVIEW AND MODIFICATION OF PRINTABLE COMPONENTS OF A DOCUMENT AT A PRINTING DEVICE - An apparatus, method, system and medium are described that support functionality to receive document(s) to be printed at a printing device, and enable editing the document(s) prior to printing. Modifications to the document(s) may be generated based on the user edits, and a print preview of the modified documents may be displayed and may enable further edits. In some embodiments, the print preview may be provided to the user on a display that is part of the printing device. In some embodiments, the print preview may be provided to the user through a UI presented on a client device. Display of the modified document(s) may be a rasterized image of the modified document(s), generated based on capabilities of a selected printing device. In some embodiments, modifications may be made to an intermediate version of the document(s), and that intermediate version may be cached. | 03-31-2011 |
20120307266 | THREE COLOR NEUTRAL AXIS CONTROL IN A PRINTING DEVICE - A color printing method includes converting source color data to intermediate color data represented in a device independent color space using a first multidimensional gamut mapping of the first device dependent color space to the device independent color space. The device independent color space has a neutral color component. The method further includes converting the intermediate color data to destination color data represented in a second device dependent color space using a second multidimensional gamut mapping of the device independent color space to the second device dependent color space. The second device dependent color space has three primary color components and a virtual black color component defined by substantially equal tonal values of the three primary color components. The second multidimensional gamut mapping includes a mapping from the neutral color component of the device independent color space to the virtual black color component of the second device dependent color space. | 12-06-2012 |
Patent application number | Description | Published |
20100106476 | Fast Simulation Method For Integrated Circuits With Power Management Circuitry - In a fast simulation technique, the output node of a power supply module of the integrated circuit can be designated as an ideal power node. At this point, the power supply module can be designated a fan-in block and any blocks connected to the power node can be designated fan-out blocks. Then, DC initialization and transient simulation for each time step can be performed for the circuit. During the transient simulation, any inter-relationship of the fan-out blocks can be determined and a sensitivity model can be calculated for each fan-out block. Because the power node is designated as an ideal power node, the results of the sensitivity model for each fan-out block can be added asynchronously to a total loadings of the power node. The total loadings can be loaded into a matrix, which is computed for the fan-in block, and a simulation waveform point can be output. | 04-29-2010 |
20120292256 | Hydrophobic Materials Made By Vapor Deposition Coating and Applications Thereof - Methods are provided for vapor deposition coating of hydrophobic materials and applications thereof. The method for making a hydrophobic material includes providing a natural mineral, providing a silicone-based material, heating the silicone-based material to release vaporous molecules of the silicone-based material, and depositing the vaporous molecules of the silicone-based material to form a layer of the silicone-based material on surfaces of the natural mineral. | 11-22-2012 |
20130246015 | Electronic Circuit Simulation Method With Adaptive Iteration - In accordance with an exemplary simulation technique, an improved selective application of Newton-Raphson iterations can improve accuracy while ensuring good performance. In this method, selectively applying Newton-Raphson iteration in a simulation of a unit of the integrated circuit design can include determining second order effects to define a linearity value. Newton-Raphson iteration is performed when the linearity value is less than a linearity threshold and convergence of the simulation is not achieved. | 09-19-2013 |
20140147655 | Hydrophobic Materials Made By Vapor Deposition Coating and Applications Thereof - Methods are provided for vapor deposition coating of hydrophobic materials and applications thereof. The method for making a hydrophobic material includes providing a natural mineral, providing a silicone-based material, heating the silicone-based material to release vaporous molecules of the silicone-based material, and depositing the vaporous molecules of the silicone-based material to form a layer of the silicone-based material on surfaces of the natural mineral. | 05-29-2014 |
Patent application number | Description | Published |
20100104560 | BOTULINUM NEUROTOXIN E RECEPTORS AND USES THEREOF - An isolated polypeptide comprising an amino acid sequence selected from amino acids 506-582 of SV2A, wherein position 573 is N and is glycosylated, or amino acids 449-525 of SV2B, wherein position 516 is N and is glycosylated. The present invention also provides an antibody that binds specifically to the polypeptide, an isolated nucleic acid comprising a polynucleotide that encodes the polypeptide; a method for reducing BoNT/E toxicity in an animal; a method for identifying an agent that blocks or inhibits binding between BoNT/E and an SV2A or SV2B protein; a method for monitoring synaptic vesicle endo- or exocytosis, a method for specifically delivering a chemical entity to a cell which has a specific receptor to a BoNT toxin. Also provided are a chimeric toxin for targeting a proteolytic domain of a toxin to a cell, the chimeric toxin comprising a catalytic or proteolytic domain of the BoNT toxin, and a ligand or a fragment thereof for a non-BoNT receptor on the cell; a method for targeting a proteolytic domain of a BoNT toxin to a cell, an isolated non-neuronal cell comprising a BoNT toxin receptor; and a method for screening for an inhibitor of a BoNT toxin. | 04-29-2010 |
20140322730 | Botulinum Neurotoxin E Receptors and Uses Thereof - An isolated polypeptide comprising an amino acid sequence selected from amino acids 506-582 of SV2A, wherein position 573 is N and is glycosylated, or amino acids 449-525 of SV2B, wherein position 516 is N and is glycosylated. The present invention also provides an antibody that binds specifically to the polypeptide, an isolated nucleic acid comprising a polynucleotide that encodes the polypeptide; a method for reducing BoNT/E toxicity in an animal; a method for identifying an agent that blocks or inhibits binding between BoNT/E and an SV2A or SV2B protein; a method for monitoring synaptic vesicle endo- or exocytosis, a method for specifically delivering a chemical entity to a cell which has a specific receptor to a BoNT toxin. Also provided are a chimeric toxin for targeting a proteolytic domain of a toxin to a cell, the chimeric toxin comprising a catalytic or proteolytic domain of the BoNT toxin, and a ligand or a fragment thereof for a non-BoNT receptor on the cell; a method for targeting a proteolytic domain of a BoNT toxin to a cell, an isolated non-neuronal cell comprising a BoNT toxin receptor; and a method for screening for an inhibitor of a BoNT toxin. | 10-30-2014 |
Patent application number | Description | Published |
20120175546 | ORGANICALLY MODIFIED HYBRID AEROGELS - Disclosed and claimed herein are hybrid aerogels which are compositions of tetraalkoxysilanes and bis-(trialkoxysilyl)imides that exhibit low thermal conductivities and high compressive strengths. Methods for their preparation are also provided. | 07-12-2012 |
20120189782 | ELECTRONIC DEVICE MANUFACTURE USING LOW-k DIELECTRIC MATERIALS - Materials and methods for manufacturing electronic devices and semiconductor components using low dielectric materials comprising polyimide based aerogels are described. Additional methods for manipulating the properties of the dielectric materials and affecting the overall dielectric property of the system are also provided. | 07-26-2012 |
20130005842 | SULFUR-CONTAINING ORGANIC-INORGANIC HYBRID GEL COMPOSITIONS AND AEROGELS - Methods and materials are described for preparing organic-inorganic hybrid gel compositions where a sulfur-containing cross-linking agent covalently links the organic and inorganic components. The gel compositions are further dried to provide porous gel compositions and aerogels. The mechanical and thermal properties of the dried gel compositions are also disclosed. | 01-03-2013 |
20130287661 | AEROGEL SORBENTS - The current invention describes methods and compositions of various sorbents based on aerogels of various silanes and their use as sorbent for carbon dioxide. Methods further provide for optimizing the compositions to increase the stability of the sorbents for prolonged use as carbon dioxide capture matrices. | 10-31-2013 |
20150021509 | ORGANICALLY MODIFIED HYBRID AEROGELS - Disclosed and claimed herein are hybrid aerogels which are compositions of tetraalkoxysilanes and bis-(trialkoxysilyl) imides that exhibit low thermal conductivities and high compressive strengths. Methods for their preparation are also provided. | 01-22-2015 |
20150145106 | ELECTRONIC DEVICE MANUFACTURE USING LOW-k DIELECTRIC MATERIALS - Materials and methods for manufacturing electronic devices and semiconductor components using low dielectric materials comprising polyimide based aerogels are described. Additional methods for manipulating the properties of the dielectric materials and affecting the overall dielectric property of the system are also provided. | 05-28-2015 |
20150259476 | ORGANICALLY MODIFIED HYBRID AEROGELS - Disclosed and claimed herein are hybrid aerogels which are compositions of tetraalkoxysilanes and bis-(trialkoxysilyl) imides that exhibit low thermal conductivities and high compressive strengths. Methods for their preparation are also provided. | 09-17-2015 |
20150344663 | SULFUR-CONTAINING ORGANIC-INORGANIC HYBRID GEL COMPOSITIONS AND AEROGELS - Methods and materials are described for preparing organic-inorganic hybrid gel compositions where a sulfur-containing cross-linking agent covalently links the organic and inorganic components. The gel compositions are further dried to provide porous gel compositions and aerogels. The mechanical and thermal properties of the dried gel compositions are also disclosed. | 12-03-2015 |
Patent application number | Description | Published |
20100203200 | METHODS FOR PRESERVING FRESH PRODUCE - The present invention pertains to methods of preserving fresh produce with a produce preservative which extends the shelf life of fresh produce, particularly cut fresh produce. The produce preservative preserves the texture, flavor, appearance, crispness, and color of the fresh produce, particularly the exposed surface of the fresh produce. The method comprises the following steps: providing a solution of produce preservative comprising: water, magnesium ions or zinc ions or tin ions; and ascorbate ions, or erythorbate ions; wherein the magnesium ion or zinc ions or tin ions and ascorbate ions are present in a mole ratio of preferably from 0.2:1 to 8:1, more preferably from 0.75:1 to 8:1, more preferably from 1:1 to 4:1, most preferably 1.5:1 to 3:1, applying said produce preservative to the produce; applying said produce preservative to the produce. | 08-12-2010 |
20120201939 | Methods for Preserving Fresh Produce - Methods of preserving fresh produce with a produce preservative which extends the shelf life of fresh produce, particularly cut fresh produce, and preserves the texture, flavor, appearance, crispness, and color of the fresh produce, particularly the exposed surface of the fresh produce, are provided. The method comprises: providing a solution of produce preservative comprising: water; a preservative cation which is selected from the group consisting of a strontium ion, lithium ion, barium ion, aluminum ion, copper ion, ammonium ion, iron ion, manganese ion, potassium ion, or mixtures thereof; and ascorbate ions, or erythorbate ions; wherein the ascorbate ions or erythorbate ions and the preservative cation are present in an ion ratio of preferably from 0.2:1 to 8:1, more preferably 0.75:1 to 8:1, even more preferably from 1:1 to 4:1, yet more preferably 1.5:1 to 3:1; most preferably 1.1:1 to 2.5:1; and, applying said produce preservative to the produce. The invention also relates to fresh produce preserved with the produce preservatives. | 08-09-2012 |
20130309380 | METHODS FOR PRESERVING FRESH PRODUCE - Methods of preserving fresh produce with a produce preservative which extends the shelf life of fresh produce, particularly cut fresh produce, and preserves the texture, flavor, appearance, crispness, and color of the fresh produce, particularly the exposed surface of the fresh produce, are provided. The method comprises: providing a solution of produce preservative comprising: water; a preservative cation which is selected from the group consisting of a strontium ion, lithium ion, barium ion, aluminum ion, copper ion, ammonium ion, iron ion, manganese ion, potassium ion, or mixtures thereof; and ascorbate ions, or erythorbate ions; wherein the ascorbate ions or erythorbate ions and the preservative cation are present in an ion ratio of preferably from 0.2:1 to 8:1, more preferably 0.75:1 to 8:1, even more preferably from 1:1 to 4:1, yet more preferably 1.5:1 to 3:1; most preferably 1.1:1 to 2.5:1; and, applying said produce preservative to the produce. The invention also relates to fresh produce preserved with the produce preservatives. | 11-21-2013 |
20140348945 | ANTIMICROBIAL WASH - A new antimicrobial wash for treating fresh fruits and vegetables to reduce microorganisms, especially human pathogens, comprises an aqueous solution of hydrogen peroxide and one or more fruit acids. | 11-27-2014 |
Patent application number | Description | Published |
20110001117 | NANOSCALE WIRE-BASED MEMORY DEVICES - The present invention generally relates to nanotechnology and sub-microelectronic devices that can be used in circuitry, and, in particular, to nanoscale wires and other nanostructures able to encode data. One aspect of the present invention is directed to a device comprising an electrical crossbar array comprising at least two crossed wires at a cross point. In some cases, at least one of the crossed wires is a nanoscale wire, and in certain instances, at least one of the crossed wires is a nanoscale wire comprising a core and at least one shell surrounding the core. For instance, the core may comprise a crystal (e.g., crystalline silicon) and the shell may be at least partially amorphous (e.g., amorphous silicon). In certain embodiments, the cross point may exhibit intrinsic current rectification, or other electrical behaviors, and the cross point can be used as a memory device. For example, in one embodiment, the cross point may exhibit a first conductance at a positive voltage, and the cross point may exhibit a second conductance at a negative voltage. Accordingly, by applying suitable voltages to the cross point, data may be stored at the cross point. Other aspects of the present invention are directed to systems and methods for making or using such devices, kits involving such devices, or the like. | 01-06-2011 |
Patent application number | Description | Published |
20130158021 | AMINO ACID-, PEPTIDE-AND POLYPEPTIDE-LIPIDS, ISOMERS, COMPOSITIONS, AND USES THEREOF - Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: | 06-20-2013 |
20150140070 | LIPID FORMULATIONS FOR DELIVERY OF MESSENGER RNA - The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c: | 05-21-2015 |
Patent application number | Description | Published |
20140329884 | 1,3,5-TRIAZINANE-2,4,6-TRIONE DERIVATIVES AND USES THEREOF - The present invention provides novel 1,3,5-triazinane-2,4,6-trione derivatives, such as compounds of any one of Formulae (I) and (II), and salts thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, or plasmid DNA). The present invention also provides methods and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, and lung diseases. | 11-06-2014 |
Patent application number | Description | Published |
20090131485 | Deuterated pirfenidone - This invention relates to novel substituted pyridinones, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a TNF (tumor necrosis factor)-alpha production inhibitor/TGF (transforming growth factor)-beta inhibitor. | 05-21-2009 |
20090149651 | PROCESSES AND INTERMEDIATES FOR PRODUCING AMINOBENZIMIDAZOLE UREAS - The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of bacterial gyrase and Topoisomerase IV (Topo IV). | 06-11-2009 |
20130018193 | DEUTERATED PIRFENIDONE - This invention relates to novel substituted pyridinones, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a TNF (tumor necrosis factor)-alpha production inhibitor/TGF (transforming growth factor)-beta inhibitor. | 01-17-2013 |