Patent application number | Description | Published |
20110087220 | SURGICAL INSTRUMENT COMPRISING AN ENERGY TRIGGER LOCKOUT - A surgical instrument can comprise a lock movable between a locked position and an unlocked position, wherein the lock can be engaged with a drive shaft in order to prevent the drive shaft from being advanced when the lock is in its locked position. The surgical instrument can further comprise an electrical input and, in addition, a switch movable between an unactuated position and an actuated position, wherein the electrical input is electrically disconnected from an electrode when the switch is in its unactuated position, wherein the switch is configured to electrically couple the electrical input and the electrode when the switch is in its actuated position, and wherein the switch and the lock are operably coupled such that the movement of the switch from its unactuated position to its actuated position moves the lock from its locked position to its unlocked position. | 04-14-2011 |
20110144530 | Pressure Sensing Adapter for Gastric Band System Injector - The body of a pressure sensing component includes a pressure sensor, a first opening, and a first pair of electrical contacts. A cap of the pressure sensing component comprises a second opening, a wiper seal, and a second pair of electrical contacts. The cap is rotatable relative to the body. When the cap is in a first rotational position, the first and second openings are in fluid communication with each other; and the first pair of contacts are not coupled with the second pair of contacts. When the cap is in a second rotational position, the seal isolates the first opening from the second opening; and the first pair of contacts are coupled with the second pair of contacts. The pressure sensing component may be coupled with a syringe and needle to externally adjust and monitor the pressure of fluid in an implanted gastric band system. | 06-16-2011 |
20120083783 | SURGICAL INSTRUMENT WITH JAW MEMBER - A surgical instrument for supplying energy to tissue may comprise a handle, a trigger, an electrical input, and a shaft extending from the handle. The surgical instrument may comprise an end effector. The end effector may comprise a cammed compression surface. The end effector may comprise an electrode comprising a tapered tissue contacting surface. Some surgical instruments may comprise an overload member. | 04-05-2012 |
20120110810 | Medical Device With Feature For Sterile Acceptance Of Non-Sterile Reusable Component - An apparatus maintains the sterility of a medical device while providing for the insertion of an insertable component into the medical device. The apparatus includes a medical device having a housing sized to contain the insertable component, an active feature, a cap, and a hinge member. A container encases the medical device within a device recess, a cap recess, and a container cover. The insertable component may be inserted into the housing while limiting potential contact with the exterior of the medical device. An alternative assembly comprises an insertion assembly having a handle and the insertable component detachably attached thereto. The medical device comprises a housing, an active feature, and a flexible member. An insertion tube is insertable within the flexible member to limit contact when the insertable component is inserted into the housing. Yet another configuration includes a resiliently hinged door assembly releasable by a release button. | 05-10-2012 |
20120110824 | Medical Device Packaging With Window For Insertion Of Reusable Component - A system for inserting components into a medical device includes a container and an attachment member. The attachment member is coupled to a sidewall having an opening and is configured to be coupled to a medical device. Utilizing the attachment member and opening, an insertable component may be inserted into a medical device within the container while limiting the risk of contamination to the interior of the container. Alternatively, a cutting knob and an alignment member mounted to a container may be used. Cutting knob and alignment member are coupled and a knife on cutting knob is rotated about alignment member to create an opening in the container to access the interior of the medical device. Another alternative includes sandwiching an insertable component between an attachable member and the medical device while the attachable member and medical device are contained within flexible packaging that may be torn away. | 05-10-2012 |
20120111591 | Packaging For Reclaimable Component Of A Medical Device - An apparatus for reclaiming insertable electrical components includes a lid, a container base, and a seal. The container base includes a container bottom and sidewalls. The container bottom further includes a recess that is defined by a recess bottom and recess sidewalls and is sized and configured to receive an insertable electrical component. The lid includes at least one boss to restrain the movement of a portion of the insertable electrical component when the insertable electrical component is inserted into the recess of the container base and the lid is attached to the container base. The boss may include a boss contact attached to the boss, and the boss contact may be electrically coupled to a discharge device or to an exterior contact. | 05-10-2012 |
20120115007 | Sterile Housing For Non-Sterile Medical Device Component - An apparatus for powering a medical device includes a battery pack, a connection feature on the battery pack, and a protective layer. In some versions the protective layer covers the battery pack and the connection feature to provide a fluid tight seal. In some versions, the connection feature comprises at least one electrode, which may pierce the protective layer to establish electrical communication with the medical device from within the protective layer such that a non-sterile battery pack could be used to deliver power to a sterile medical device without compromising sterility of the medical device. The protective layer may form a compartment. The at least one electrode may have a conical shape to facilitate piercing the protective layer. | 05-10-2012 |
20120116380 | Sterile Medical Instrument Charging Device - A system includes a medical device and a charging device. A sterile barrier may be interposed between the medical device and the charging device. The medical device includes an integral power source and an active element. The charging device is configured to charge the integral power source. The charging device may charge the integral power source through direct contact between features of the charging device and features the medical device. The charging device may alternatively charge the integral power source wirelessly, such as through inductive coupling. The medical device may include conductive prongs that are retained by the charging device. The charging device may physically couple with the medical device via magnets. The medical device and the charging device may be provided together in a sterile package as a kit. The kit may also include a reclamation bag to facilitate reclamation of electrical components. | 05-10-2012 |
20120305427 | Sterile Package System For Medical Device - An apparatus for aseptic insertion includes a container, a first cover, and a second cover. The container includes a first compartment, a second compartment, and a detachable wall disposed between the first compartment and the second compartment. The first cover is sized and configured to attach to the first compartment and the second cover is sized and configured to attach to the container. The detachable wall may defined by a top portion, a portion of a first distal wall of the first compartment, and a portion of a second proximal wall of the second compartment. The detachable wall may be removably attached to the first cover by the top portion of the detachable wall. | 12-06-2012 |
20130030350 | Devices and Methods for Anchoring an Endoluminal Sleeve in the GI Tract - An endoluminal sleeve device for internally lining a section of the GI tract, comprises a sleeve configured for deployment inside a duodenum, the sleeve having walls of a flexible material defining a sleeve lumen, a proximal end defining a proximal lumen opening, and a distal end defining a distal lumen opening, an anchoring component having a slender transport configuration and a bulky deployed configuration, wherein the anchoring component is locatable at a distance from the proximal sleeve end and connected thereto by an elongated tether. | 01-31-2013 |
20130116218 | METHODS AND COMPOSITIONS OF BILE ACIDS - Methods and compositions are provided for treating metabolic disorders by modulating bile acid levels. Generally, the methods and compositions can modulate bile acid levels, such as serum bile acid levels, to treat a metabolic disorder. In one embodiment, a method of modulating a bile acid level includes measuring a bile acid level and delivering a composition effective to modulate the bile acid level. A method for modulating a bile acid profile includes comparing a bile acid profile to a target profile and delivering a bile acid cocktail to increase bile acid levels. In another embodiment, a pharmaceutical composition for increasing bile acid levels includes a bile acid cocktail effective to increase bile acid levels. The composition is further useful as part of an implantable system. | 05-09-2013 |
20130153622 | DEVICES AND METHODS FOR ENDOLUMINAL PLICATION - Devices and methods are provided for forming and securing a tissue plication. More particularly, the devices and methods of the present invention can be used to create multiple tissue folds on an anterior and posterior wall of a stomach cavity to reduce the volume thereof. In one aspect, a method of acquiring and fixating tissue is disclosed that includes inserting a surgical device having first and second jaws and a tissue acquisition member into a body lumen, positioning the device in a first position in which the jaws extend substantially parallel to a tissue surface, drawing tissue through the jaws by moving the tissue acquisition member away from the jaws, and driving at least one fastener through the tissue disposed between the jaws. | 06-20-2013 |
20130153623 | DEVICES AND METHODS FOR ENDOLUMINAL PLICATION - Devices and methods are provided for forming and securing a tissue plication. More particularly, the devices and methods of the present invention can be used to create tissue folds on an anterior and posterior wall of a stomach cavity to reduce the volume thereof. In one aspect, a tissue acquisition and fixation system is disclosed that includes an elongate shaft, an end effector coupled to the elongate shaft and having first and second jaws, and a tissue acquisition member coupled to the end effector by a linkage assembly. At least a portion of the linkage assembly and tissue acquisition member are slidably movable in a direction parallel to a longitudinal axis of the jaws. Further, the tissue acquisition member is vertically movable relative to the end effector such that a distance between a longitudinal axis of the tissue acquisition member and the jaws can be adjusted. | 06-20-2013 |
20130153624 | DEVICES AND METHODS FOR ENDOLUMINAL PLICATION - Devices and methods are provided for forming and securing a tissue plication. More particularly, the devices and methods of the present invention can be used to create multiple tissue folds on an anterior and posterior wall of a stomach cavity to reduce the volume thereof. In one aspect, a tissue acquisition and fixation system is disclosed including a stapling member having first and second jaws that are effective to apply at least one staple to tissue engaged between the jaws, a tissue acquisition member coupled to at least one of the first and second jaws, and a secondary tissue acquirer coupled to the tissue acquisition member. The secondary tissue acquirer is configured to engage tissue and maintain the tissue in position relative to the tissue acquisition member. | 06-20-2013 |
20130153625 | DEVICES AND METHODS FOR ENDOLUMINAL PLICATION - Devices and methods are provided for forming and securing a tissue plication. More particularly, the devices and methods of the present invention can be used to create multiple tissue folds on an anterior and posterior wall of a stomach cavity to reduce the volume thereof. In one aspect, a tissue acquisition and fixation system is disclosed that includes an elongate shaft, a staple applying assembly having a proximal end coupled to the distal end of the elongate shaft and having first and second jaws, and a tissue acquisition member coupled to the staple applying assembly by a linkage mechanism. The linkage mechanism is configured to move the tissue acquisition member between a first position that is longitudinally offset and proximal to the staple applying assembly, and a second position that is longitudinally adjacent to the staple applying assembly. | 06-20-2013 |
20130153626 | DEVICES AND METHODS FOR ENDOLUMINAL PLICATION - Devices and methods are provided for forming and securing a tissue plication. More particularly, the devices and methods of the present invention can be used to create multiple tissue folds on an anterior and posterior wall of a stomach cavity to reduce the volume thereof. In one aspect, a method of gastric volume reduction is disclosed that includes advancing a tissue acquisition and fixation device endoscopically into a stomach, manipulating the device to form a first fold of tissue on an interior surface of an anterior wall of the stomach, and manipulating the device to form a second fold of tissue on an interior surface of a posterior wall of the stomach, where the second fold is not attached to the first fold. | 06-20-2013 |
20130153631 | FEATURE TO LOCK KNOB OF TISSUE STAPLER - A surgical stapling instrument for performing a circular anastomosis comprises a stapling head assembly, an actuator handle assembly, a shaft assembly, a safety latch, and a locking member. The stapling head assembly includes an anvil that moves relative to a staple holder and a staple driver to drive staples from the staple holder into tissue and against the anvil. The actuator handle assembly has a first actuator that controls motion of the anvil and a second actuator that controls motion of the staple driver. The shaft assembly couples the stapling head assembly to the actuator handle assembly. The safety latch prevents operation of the second actuator when the gap between the anvil and staple holder is outside a predetermined range. The locking member is configured to prevent adjustment of the anvil gap after the desired staple height has been set inside the predetermined range. | 06-20-2013 |
20130153642 | DEVICES AND METHODS FOR ENDOLUMINAL PLICATION - Devices and methods are provided for forming and securing a tissue plication. More particularly, the devices and methods of the present invention can be used to create multiple tissue folds on an anterior and posterior wall of a stomach cavity to reduce the volume thereof. In one aspect, a tissue acquisition and fixation system is described that includes a staple applying assembly having first and second jaws, and a tissue acquisition member that extends substantially parallel to a plane running through the first and second jaws. The tissue acquisition member is effective to engage and position tissue between the first and second jaws, and the jaws are effective to apply at least one staple to the tissue engaged therebetween. | 06-20-2013 |
20130175318 | TISSUE STAPLER ANVIL FEATURE TO PREVENT PREMATURE JAW OPENING - A surgical instrument includes a handle assembly having a trigger operable to fire a staple driver to staple tissue. The instrument includes a pointed rod to which an anvil may be coupled. An anvil detection feature is included to determine when the anvil is coupled to the rod. In some versions, the anvil detection feature comprises a translatable rod that inhibits a lockout feature from disengaging. In other versions, an anvil sensing tube is disposed about the pointed rod and interferes with actuation of the trigger in a first position. A recess in the tube permits trigger to actuate when the anvil sensing tube is in the second position. Alternatively, a resilient tab is coupled to the pointed rod and resists actuation of the staple driver. A trigger lockout assembly may include a spring-loaded button that “pops” out when a push rod is actuated, thereby freeing a pivotable lockout feature. | 07-11-2013 |
20130175319 | TISSUE STAPLER SAFETY SWITCH FEATURE TO PREVENT PREMATURE JAW OPENING - A surgical stapler comprises an anvil assembly, an anvil shaft, a driver, an actuating arm, a safety switch, and a safety feature. The anvil assembly couples with the anvil shaft. The driver drives a plurality of staples into tissue. The actuating arm is in communication with the surgical stapler and is configured to actuate the driver to drive the plurality of staples into tissue. The safety switch is moveable between a locked and an unlocked position. The safety switch prevents operation of the actuating arm when the safety switch is in the locked position. The safety switch enables operation of the actuating arm when the safety switch is in the unlocked position. The safety feature may prevent operation of the driver even when the safety switch is in the unlocked position or prevent operation of the safety switch. | 07-11-2013 |
20130175320 | RATCHETING FEATURE ON TISSUE STAPLE TRIGGER TO PREVENT PREMATURE JAW OPENING - A surgical instrument includes a body, a pivotable trigger, and a ratcheting assembly. The ratcheting assembly may include a rotary ratchet coupled to the trigger and a pawl coupled to the body. The rotary ratchet may further include a ramp that disengages the ratchet from the pawl. A release feature may be included to selectively disengage a second member of the ratcheting assembly from a first member. In some versions, the release feature may include a rotation knob or a slidable handle. In another configuration, the ratcheting assembly may have a first member coupled to an actuator and a second member coupled to the body. The assembly may include a lock member coupled to the body that selectively engages a plurality of teeth disposed on the actuator. Alternatively, the assembly may include a pivotable pawl coupled to the actuator that engages one or more notches formed in the body. | 07-11-2013 |
20130253536 | METHODS AND DEVICES FOR CREATING TISSUE PLICATIONS - Devices and methods for forming and securing a tissue plication are disclosed herein. In one aspect, a tissue manipulation device is described that includes a first jaw member pivotally coupled to a distal end of an elongate shaft and having an articulating portion located distal to the proximal end of the first jaw member. The device also includes a second jaw member pivotally coupled to the first jaw member such that the jaws move in a first plane, and a fastener delivery member attached to the second jaw member. The articulating portion of the first jaw member is configured to move the first and second jaw members between a straight configuration in which a longitudinal axis of the elongate shaft is contained within the first plane and an articulated configuration in which the longitudinal axis of the elongate shaft is transverse to the first plane. | 09-26-2013 |
20140135804 | ULTRASONIC AND ELECTROSURGICAL DEVICES - Disclosed are ultrasonic and electrosurgical devices. The disclosed embodiments include ultrasonic blades comprising various grasping features, devices configured to prevent ingress of surgical matter, e.g., fluid and tissue, in the space between an ultrasonic blade and an inner or outer tube distal of the distal seal, alternate closure mechanisms for ultrasonic devices, ultrasonic transducer rotation limiters to limit the rotation of an ultrasonic transducer, ultrasonic transducer rotation systems to provide unlimited continuous rotation of an ultrasonic device, integrated ultrasonic instrument electrically connected to provide RF spot coagulation with an ultrasonic (RF) generator, and coated ultrasonic/RF blades. | 05-15-2014 |
20140276738 | SURGICAL INSTRUMENT WITH MULTIPLE CLAMPING MECHANISMS - A nested trigger assembly for a surgical instrument may generally comprise a first trigger and a second trigger, wherein the first trigger and the second trigger are movable together on a first stroke of the nested trigger assembly, wherein the second trigger is configured to be biased away from the first trigger after the first stroke and before a second stroke, and wherein the second trigger is configured to be moved toward to the first trigger during the second stroke. A surgical instrument may generally comprise a shaft comprising a proximal end and a distal end, a handle extending from the proximal end, wherein the handle comprises a gripping portion, and a nested trigger assembly extending from the handle. The nested trigger assemble may comprise one of a separable trigger assembly and a divisible trigger assembly. | 09-18-2014 |
20140330298 | CLAMP ARM FEATURES FOR ULTRASONIC SURGICAL INSTRUMENT - A surgical apparatus comprises a body, an ultrasonic transducer, a shaft, an acoustic waveguide, an articulation section, and an end effector. The ultrasonic transducer is operable to convert electrical power into ultrasonic vibrations. The shaft couples the end effector and the body together. The acoustic waveguide is coupled with the transducer. The end effector comprises a clamp arm and an ultrasonic blade in acoustic communication with the ultrasonic transducer. The clamp arm is configured to pivot toward and away from the ultrasonic blade. The shaft assembly comprises an inner tube configured to longitudinally translate to thereby pivot the clamp arm toward and away from the ultrasonic blade. A distal portion of the inner tube is operable to flex to thereby accommodate pivoting of the clamp arm. | 11-06-2014 |
Patent application number | Description | Published |
20080265991 | Gain control module and applications thereof - A gain control module includes an amplifier, a least significant bit (LSB) gain stage, and a most significant bit (MSB) gain stage. The amplifier includes a first input, a second input, and an output. The LSB gain stage produces a LSB gain based on an LSB portion of a gain control signal, wherein the LSB gain stage receives an input signal. The MSB gain stage produces an MSB gain based on an MSB portion of the gain control signal, wherein the MSB gain stage is coupled to the LSB gain stage, the first input of the amplifier, and the output of the amplifier, wherein the gain control module amplifies the input signal in accordance with the gain control signal. | 10-30-2008 |
20090085782 | ADJUSTABLE DAC AND APPLICATIONS THEREOF - A digital to analog converter (DAC) includes at least one digital to analog conversion module and a gated termination. The at least one digital to analog conversion module is coupled to convert at least one bit of a digital signal into an analog signal. The gated termination is coupled to an analog output of the at least one digital to analog conversion module to provide a first termination when a termination selection signal is in a first state and to provide a second termination when the termination selection signal is in a second state. | 04-02-2009 |
20090086104 | MULTIMEDIA SOC WITH ADVANCED JACK SENSE APPLICATIONS - In a multimedia SOC that includes a plurality of jack sense modules coupled to the plurality of video output pins, a processing module functions to: enable one or more of the plurality of jack sense modules to determine a video connection to the SOC, enable a video decoder in a first mode when the video connection is of a first type, and enable the video decoder in a second mode when the video connection is of a second type | 04-02-2009 |
20090109191 | Touch Screen Driver for Resolving Plural Contemporaneous Touches and Methods for Use Therewith - A touch screen driver that can be used with a resistive touch screen includes an input/output module that supplies at least one input signal to at least one of a plurality of input/output ports of the touch screen and that generates at least one output signal, in response to the at least one input signal, and in accordance with at least one control signal. A controller module generates the at least one control signal and that generates a position signal representing a resolved position in accordance with a plurality of contemporaneous touches of the resistive touch screen. | 04-30-2009 |
20100156390 | Comparative Signal Strength Detection - A method for signal strength detection begins by comparing a signal strength representation of a signal with a signal strength representation of a reference signal. The method continues by adjusting, when the signal strength representation of the signal compares unfavorably with the signal strength representation of the reference signal, at least one of the signal strength representation of the signal and the signal strength representation of the reference signal until the signal strength representation of the signal compares favorably with the signal strength representation of the reference signal. The method continues by determining signal strength of the signal based on the adjusting of the signal strength representation of the signal and signal strength of the reference signal. | 06-24-2010 |
20110222712 | AUDIO OUTPUT DRIVER FOR REDUCING ELECTROMAGNETIC INTERFERENCE AND IMPROVING AUDIO CHANNEL PERFORMANCE - An audio output circuit includes an on-chip left channel amplifier module, an on-chip center channel amplifier module, and an on-chip right channel amplifier module. A left channel IC pin is operably coupled to an output of the on-chip left channel amplifier module. A right channel IC pin is operably coupled to an output of the on-chip right channel amplifier module. A center channel IC pin is operably coupled to an output of the on-chip center channel amplifier module. A center channel feedback IC pin is operably coupled to an input of the on-chip center channel amplifier module to provide a feedback loop. A left jack connection is operably coupled to the left channel IC pin. A right jack connection is operably coupled to the right channel IC pin. A jack return connection coupled to the center feedback IC pin. An inductor has a first node coupled to the jack return connection and a second node coupled to the center channel IC pin. | 09-15-2011 |
20140341230 | Method and Apparatus for Controlling a Multichannel TDM device - A method for developing TDM data with embedded control data includes obtaining signal data and control data, formatting the signal data and the control data into a plurality of channels of a DIN signal, and transmitting the DIN signal on one line of a 3-bit TDM bus. A multichannel input device includes a control extractor receptive to the three-bit TDM bus and operative to extract CNTL data from the DIN data, a DAI receptive to the 3-bit TDM bus and the channel select input and operative to develop a SIGNAL data output, and a DAC block including a DAC, the DAC block being receptive to the SIGNAL data and the CNTL data. | 11-20-2014 |
20140341398 | MULTICHANNEL DIGITAL AUDIO INTERFACE - A multichannel input device with automatic number-of-channels detection includes an automatic channel and bit depth detector, a digital audio interface (DAI), an analog device, and a digital-to-analog converter (DAC) coupling the DAI to the analog device. The automatic number-of-channels and bit depth detector has a BCLK input, a LRCLK input, a number of channels NCHAN output, and a bit depth B output. The DAI has a data DIN input, the BCLK input, the LRCLK input, an NCHAN input and a B input and has an output including data associated with an assigned channel. | 11-20-2014 |
Patent application number | Description | Published |
20110217278 | Medication and Treatment for Disease - A treatment is described for diseases with symptoms that can include fatigue, muscle aches and spasms, weakness, demylenation, and nerve pain. Diseases can include fibromyalgia, depression, and auto-immune and immuno-suppressive diseases, such as MS. The treatment comprises about 1-10 mg naltrexone, at least about 20 μg vitamin B12, at least about 5 mg vitamin B6, at least about 2 mg coenzyme Q, and preferably at least one ancillary medication selected from the group consisting of diazepam, cyclcobenzaprine, clonazepam, alprazolam, 9-tetrahydrocannibinol, fumarate, caffeine, and combinations thereof. The treatment can be administered orally, and can decrease mental and physical symptoms such as, for example, fatigue, gait problems, visual dysfunction, and pain while improving cognitive skills. | 09-08-2011 |
20110251544 | Utilization of Stents for the Treatment of Blood Borne Carcinomas - A filter and a method treat blood borne carcinomas by inducing apoptosis in carcinoma cells. The filter includes comprises a stent having an interior wall defining a channel containing a packing material and at least one antineoplastic agent. The method includes placing a patient's blood in apposition of the antineoplastic agent by pumping the blood through the stent. The blood remains in apposition to the antineoplastic agent for a sufficient time period to induce an apoptotic cascade. | 10-13-2011 |
20110295175 | Sequential Extracoporeal Treatment of Bodily Fluids - An article and method to treat extracorporeally a patient's bodily fluid. The bodily fluid can include blood, cerebral spinal fluid and lymph. A first stage of the method includes applying a treatment. The treatment can comprise dosing with a medication, thermal treatment, or irradiation. The treatment can occur at levels that could otherwise compromise the patient's health. A second stage of the method substantially removes the treatment from the bodily fluid. The bodily fluid can then be returned to the patient. The article includes a treatment chamber that applies the treatment and a removal module for removing the treatment. The method can be a continuous process such as, for example, a dialysis process. | 12-01-2011 |
20120000838 | Sequential Extracorporeal Treatment of Bodily Fluids - An article and method to treat extracorporeally a patient's bodily fluid. The bodily fluid can include blood, cerebral spinal fluid and lymph. A first stage of the method includes applying a treatment. The treatment can comprise dosing with a medication, thermal treatment, or irradiation. The treatment can occur at levels that could otherwise compromise the patient's health. A second stage of the method substantially removes the treatment from the bodily fluid. The bodily fluid can then be returned to the patient. The article includes a treatment chamber that applies the treatment and a removal module for removing the treatment. The method can be a continuous process such as, for example, a dialysis process. | 01-05-2012 |
20140037656 | Treatment for Tauopathies - A method is described to treat tauopathies by extracorporeally treating a patient's cerebrospinal fluid (CSF). The method includes introducing an antibody into the CSF that is targeted to an antigen associated with tauopathies. The antibody can include an albumin moiety, and targets the removal of antigens such as tau protein, phosphorylated tau (pTau) protein, Ubiquitin and PKN. The antibody-antigen complex can be removed from the CSF and the CSF can be returned to the patient. | 02-06-2014 |
20140193514 | Method for the Treatment of Cancer - The invention describes a method to treat an extracorporeally body fluid. The body fluid can include, for example, blood, cerebral spinal fluid and lymph. A first stage of the method applies a treatment to the extracorporeal body fluid. The treatment comprises combining at least one antibody with a CA antigen to produce an antibody-CA antigen moiety. A second stage of the method substantially removes the antibody-CA antigen moiety from the extracorporeal body fluid. | 07-10-2014 |
20150071935 | Treatment for the rapid amelioration of clinical depression - The present invention relates to an article and method of extracorporeal treating a patient's body fluid, for example, CSF (cerebrospinal fluid), lymph, or blood. The treatment includes a plurality of stages comprising removing the body fluid from a patient, applying an extracorporeal treatment to the body fluid, and returning the body fluid to the patient. In the first stage of the treatment, the body fluid is removed from the patient. A convenient method for removing blood is utilizing standard venipuncture technique. A convenient method for removing CSF is using a standard lumbar puncture. In the second stage, a treatment is applied to the body fluid. The treatment can include an antibody directed against targeted antigen(s)/TA(s). The third stage comprises returning the body fluid to the patient, and can also include removing the treatment from the body fluid. | 03-12-2015 |
20150079192 | Treatment of cancer by manipulating the immune system - The present invention relates to the treatment of cancers. Specifically, the invention pertains to a method for the extracorporeal treatment of one or more body fluids (e.g., blood or cerebrospinal fluid, CSF) in two stages characterized by removing a body fluid (e.g., blood or CSF) from a living body diseased with a type of cancer, passing the body fluid through a first stage of applying a treatment to at least one antigen in the body fluid. More specifically, the treatment comprises creating an antibody-antigen moiety during passage thereof through said first stage, passing the treated body fluid through a second stage, removing antibody-antigen moiety from the body fluid during passage through the second stage, and returning the purified body fluid to the body. | 03-19-2015 |
Patent application number | Description | Published |
20140241944 | Utilization of stents for the treatment of blood borne carcinomas - A filter and a method to treat blood borne carcinomas by inducing apoptosis in carcinoma cells. The filter includes a stent having an interior wall defining a channel containing a packing material and at least one antineoplastic agent. The method includes placing a patient's blood in apposition of the antineoplastic agent by pumping the blood through the stent. The blood remains in apposition to the antineoplastic agent for a sufficient time period to induce an apoptotic cascade. | 08-28-2014 |
20140251917 | Method for the treatment of multiple sclerosis - The present invention relates to a treatment of multiple sclerosis, and includes the extracorporeal treatment of one or more body fluids, such as, for example blood, cerebral-spinal fluid, or lymphatic fluid. A treatment is applied to the extracorporeal body fluid where the treatment targets at least one target multiple sclerosis antigen in the body fluid. The treatment can include creating an antibody-antigen moiety and then removing antibody-antigen moiety from the body fluid before returning the body fluid to a patient. | 09-11-2014 |
20140356341 | Medication and treatment for disease - A treatment is described for diseases with symptoms that can include fatigue, muscle aches and spasms, weakness, demylenation, and nerve pain. Diseases can include fibromyalgia, depression, and auto-immune and immuno-suppressive diseases, such as MS. The treatment comprises about 1-10 mg naltrexone, at least about 20 μg vitamin B12, at least about 5 mg vitamin B6, at least about 2 mg coenzyme Q, and preferably at least one ancillary medication selected from the group consisting of diazepam, cyclcobenzaprine, clonazepam, alprazolam, 9-tetrahydrocannibinol, fumarate, caffeine, and combinations thereof. The treatment can be administered orally, and can decrease mental and physical symptoms such as, for example, fatigue, gait problems, visual dysfunction, and pain while improving cognitive skills. | 12-04-2014 |
20150027950 | Treatment for atherosclerosis - A method is described to treat atherosclerosis by extracorporeally treating a patient's blood. A patient's blood is treated extracorporeally using a moiety that targets an antigen in the blood. The moiety facilitates removal of the blood antigen. The cleansed blood is then returned to the patient. | 01-29-2015 |
20150030692 | Treatment for chronic pain syndromes - A method is described to treat chronic pain syndromes by treating extracorporeally a patient's cerebrospinal fluid (CSF). A patient's CSF is treated extracorporeally using a moiety that targets an antigen in the CSF. This moiety facilitates removal of the CSF antigen. The cleansed CSF is then returned to the patient. | 01-29-2015 |
20150056608 | Method for Treating Infectious Diseases Using Emissive Energy - The present invention relates to the treatment of infectious diseases, specifically by extracorporeally eradicating the pathogen. This invention comprises methods for the extracorporeal treatment of infectious diseases that will remove infectious pathogens (leukemia cells, bacteria, viruses, or fungi causing a septicemia, metastatic cancer cells, target protein, viruses, parasites, fungi and prions) in humans by targeting such pathogens with a laser or other high-energy source of emissive radiation. More specifically, the method involves removing a bodily fluid from a patient, attaching an antibody to pathogens in the bodily fluid, sensing the antibody-pathogen moiety, using a high-powered, focused laser to destroy the antibody-pathogen moiety, removing the remains of the antibody-pathogen by filtering or other suitable mechanism(s), and returning the bodily fluid to the patient. | 02-26-2015 |
20150079098 | Method of treating cancer - A method is described to treat cancer by extracorporeally treating a bodily fluid of a patient. A patient's body fluid is treated extracorporeally using a moiety that targets an antigen in the bodily fluid. The treatment can include applying an anti-angiogenesis, anti-tumorigenesis, anti-metastasis, or chemotherapeutic treatment to at least one antigen in the bodily fluid. The moiety facilitates removal of the antigen. The cleansed body fluid is then returned to the patient. | 03-19-2015 |
Patent application number | Description | Published |
20100313286 | G protein-related kinase mutants in essential hypertension - Disclosed are methods for identifying individuals predisposed to essential hypertension and related conditions such as salt sensitivity by detecting the presence of polymorphic or mutant forms of the GRK4 gene, or its expression product. Also disclosed are methods for identifying polymorphic or mutant GRK4s in individuals known to be suffering from such conditions, as well as methods and compositions for conducting drug discovery and therapeutic intervention. | 12-09-2010 |
20110190667 | Method and System for the Derivation of Human Gait Characteristics and Detecting Falls Passively from Floor Vibrations - The gait monitor system and method provides various basic gait parameters including step count, cadence, and step duration, in addition to its ability to distinguish between normal, limping and shuffling gait modes, as well as determine falls. Moreover, this gait monitor may be provided with additional sensors, e.g. beam break at the beginning and end of a corridor to estimate average walking velocity (with the distance between the beams known or determined); this enables the calculation of additional gait characteristics such as average step length and average stride length. These parameters can additionally be used to detect various gait anomalies and other diagnostic information. | 08-04-2011 |
20110282171 | MICROELECTRONIC BIOSENSOR PLUG - A plug capable of providing information relating to a physical or chemical property of a body fluid, or the presence or amount of a molecular component therein in a living organism is disclosed. Specifically, one embodiment plug is capable of being inserted into a portion of a human eyelid in order to provide information relating to tear fluid is disclosed. This embodiment plug includes a body having a passage which allows for the natural flow of tear fluid therethrough. In addition, a sensing mechanism is provided which is capable of measuring, for example, glucose levels in the body of a patient through the analysis of the tear fluid. Such plug may further be designed so as to double as a punctal plug useful in preventing dry eye. Methods of utilizing and implanting such plugs are also disclosed. | 11-17-2011 |
20120009559 | AUTOMATED CELL CULTURE SYSTEM AND PROCESS - The present invention relates generally to the field of cell culture, which is a laboratory process used primarily for the growth, propagation, and production of cells for analysis and the production and harvesting of cell products. The present invention comprises functionalized and/or engineered hydrogel microcarriers that exhibit any or all of the following properties: controllable buoyancy, ferro- or paramagnetism, molecular or fabricated reporting elements, and optical clarity. The microcarriers are used in a bioreactor that employs external forces to control said microcarrier kinetic energy and translational or positional orientation in order to facilitate cell growth and/or cellular analysis. The bioreactor can be part of an automated system that employs any or all of the following; a microcarrier manufacturing method, a monitoring method, a cell culture method, and an analytical method. Either a single bioreactor or a plurality of bioreactors are used in the automated system to enable cell culture and analysis with a minimum of human intervention. | 01-12-2012 |
20130189723 | AUTOMATED CELL CULTURE SYSTEM AND PROCESS - The present invention relates generally to the field of cell culture, which is a laboratory process used primarily for the growth, propagation, and production of cells for analysis and the production and harvesting of cell products. The present invention comprises functionalized and/or engineered hydrogel microcarriers that exhibit any or all of the following properties: controllable buoyancy, ferro- or paramagnetism, molecular or fabricated reporting elements, and optical clarity. The microcarriers are used in a bioreactor that employs external forces to control said microcarrier kinetic energy and translational or positional orientation in order to facilitate cell growth and/or cellular analysis. The bioreactor can be part of an automated system that employs any or all of the following; a microcarrier manufacturing method, a monitoring method, a cell culture method, and an analytical method. Either a single bioreactor or a plurality of bioreactors are used in the automated system to enable cell culture and analysis with a minimum of human intervention. | 07-25-2013 |
20150080767 | System and Method for the Inference of Activities of Daily Living and Instrumental Activities of Daily Living Automatically - A method and related system to, among other things, automatically infer answers to all of the ADL questions and the first four questions of the IADL in the home. The inference methods detect the relevant activities unobtrusively, continuously, accurately, objectively, quantifiably and without relying on the patient's own memory (which may be fading due to aging or an existing health condition, such as Traumatic Brain Injury (TBI)) or on a caregiver's subjective report. The methods rely on the judicious placement of a number of sensors in the subject's place of residence, including motion detection sensors in every room, the decomposition of each relevant activity into the sub-tasks involved, identification of additional sensors required to detect the relevant sub-tasks and spatial-temporal conditions between the signals of sensors to formulate the rules that will detect the occurrence of the specific activities of interest. | 03-19-2015 |
Patent application number | Description | Published |
20090047596 | Donor element with release-modifier for thermal transfer - A donor element useful in an assemblage for imaging by exposure to light comprises a support layer, a light-to-heat conversion layer disposed adjacent the support layer containing a light absorber, and a transfer layer disposed adjacent the light-to-heat conversion layer opposite the support layer. The donor element also includes a release-modifier disposed between the support layer and the transfer layer. | 02-19-2009 |
20090047597 | Donor element for radiation-induced thermal transfer - A donor element useful in an assemblage for imaging by exposure to radiation comprises a substrate, a transfer-assist layer disposed adjacent the substrate comprising one or more water-soluble or water-dispersible radiation-absorbing compound(s), and a transfer layer disposed adjacent the transfer-assist layer opposite the substrate. | 02-19-2009 |
20090297739 | METAL COMPOSITIONS, THERMAL IMAGING DONORS AND PATTERNED MULTILAYER COMPOSITIONS DERIVED THEREFROM - The invention provides metal compositions, including silver compositions, and thermal imaging donors prepared with the compositions. The donors are useful for thermal transfer patterning of a metal layers and optionally, a corresponding proximate portion of an additional transfer layer onto a thermal imaging receiver. The compositions are useful for dry fabrication of electronic devices. Also provided are patterned multilayer compositions comprising one or more base film(s), and one or more patterned metal layers, including EMI shields and touchpad sensors. | 12-03-2009 |
20100239794 | Donor elements and processes for thermal transfer of nanoparticle layers - The invention discloses processes for thermal transfer patterning of a nanoparticle layer and a corresponding proximate portion of a carrier layer, and optionally additional transfer layers, together onto a thermal imaging receiver. The invention is useful for dry fabrication of electronic devices. Additional embodiments of the invention include multilayer thermal imaging donors comprising in layered sequence: a base film, a carrier layer and a nanoparticle layer. The carrier layer can be a dielectric or conducting layer. When the carrier layer is a dielectric layer, the base film includes a light attenuating agent in the form of a dye or pigment. | 09-23-2010 |
20110151153 | POLYMERIC CONDUCTIVE DONOR - Provided are donor articles comprising a donor substrate and a conductive layer, wherein the conductive layer comprises (a) at least one electrically conductive polymer; (b) a binder comprising a polymer selected from the group consisting of poly(2-alkyl-2-oxazoline), poly(vinylpyrrolidone-co-vinyl acetate), polyvinyl acetal, poly(3-morpholinylethylene), poly(2,4-dimethyl-6-triazinylethylene), poly(N-1,2,4-triazolylethylene), poly(vinylsulfate), poly(vinylformamide), and poly[N-(p-sulfophenyl)imino-3-hydroxymethyl-1,4-phenyleneimino-1,4-phenylene] or a combination thereof; and (c) a polyanion. Also provided are methods of transferring at least a portion of an electrically conductive layer from such a donor article to a receiver, the patterned receivers and patterned donor articles made by such methods, electronic devices comprising the patterned receivers, and electronic devices comprising the patterned donor articles. | 06-23-2011 |
20110244390 | DONOR ELEMENT WITH MALEIC ANHYDRIDE BASED POLYMERS FOR THERMAL TRANSFER - This invention pertains to a donor element for use with a receiver element in an imagable assemblage for light-induced transfer of material from the donor element to the receiver element. Specifically, this invention relates to such a donor element comprising a copolymer based on styrene and maleic anhydride. | 10-06-2011 |