Giuliano, US
Armando E. Giuliano, Los Angeles, CA US
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20100068743 | Method for predicting response of cancer patient to anticancer drug treatment - A method predicts a response of a cancer patient to anticancer drug based on a cell cycle profile score obtained by analyzing a malignant tumor of the cancer patient, wherein the method can predict a disease outcome including a complete response, a partial response, stable disease, no response, and time to progression of disease as patient's response to anticancer drug therapy. | 03-18-2010 |
Concetta Giuliano, Winter Springs, FL US
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20080199403 | Composition and Method for Direct Visualization of the Human Appendix - A positive contrast agent composition containing meglumine diatrizoate, sodium diatrizoate, simethicone, famotidine and aspartame in predetermined amounts that is orally administered to a patient for clinical evaluations of appendicitis wherein a positive contrast effect is achieved. Methods of use include orally administering individual doses of the composition approximately 50 minutes prior to appendix visualization using computerized axial tomography. | 08-21-2008 |
David Giuliano, Rochester, NY US
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20130094157 | POWER CONVERTERS WITH INTEGRATED CAPACITORS - An apparatus having a power converter circuit having a first active layer having a first set of active devices disposed on a face thereof, a first passive layer having first set of passive devices disposed on a face thereof, and interconnection to enable the active devices disposed on the face of the first active layer to be interconnected with the non-active devices disposed on the face of the first passive layer, wherein the face on which the first set of active devices on the first active layer is disposed faces the face on which the first set of passive devices on the first passive layer is disposed. | 04-18-2013 |
David Giuliano, Brookline, MA US
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20140301057 | POWER CONVERTERS WITH INTEGRATED CAPACITORS - An apparatus having a power converter circuit having a first active layer having a first set of active devices disposed on a face thereof, a first passive layer having first set of passive devices disposed on a face thereof, and interconnection to enable the active devices disposed on the face of the first active layer to be interconnected with the non-active devices disposed on the face of the first passive layer, wherein the face on which the first set of active devices on the first active layer is disposed faces the face on which the first set of passive devices on the first passive layer is disposed. | 10-09-2014 |
20140327479 | EFFICIENT GATE DRIVERS FOR SWITCHED CAPACITOR CONVERTERS - An apparatus for converting voltage includes terminals coupled to external circuits at corresponding voltages and a switching network having driving circuits and semiconductor switches that interconnect capacitors in successive states to one another and to the terminals. The switches interconnect some capacitors to one another through a series of switches when an activation pattern causes them to be activated. Each driving circuit has power connections, a control input, and a drive output coupled to and controlling at least one switch. A drive output of one of them couples to and drives each switch. Some of the driving circuits are powered via corresponding power connections from at least one of the capacitors such that a voltage across the corresponding power connections is less than a highest of the corresponding voltages. The terminals and the switching network are constituents of a switched capacitor converter. | 11-06-2014 |
David M. Giuliano, Rochester, NY US
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20090278520 | Power Converter with Capacitive Energy Transfer and Fast Dynamic Response - A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or regulation) stage. The circuits and techniques achieve high performance over a wide input voltage range or a wide output voltage range. The converter can be used, for example, to power logic devices in portable battery operated devices. | 11-12-2009 |
20130154600 | CONTROL OF POWER CONVERTERS WITH CAPACITIVE ENERGY TRANSFER - An apparatus for power conversion comprises a voltage transformation element, a regulating element, and a controller; wherein, a period of the voltage transformation element is equal to a product of a coefficient and a period of the regulating circuit, and wherein the coefficient is selected from a group consisting of a positive integer and a reciprocal of said integer. | 06-20-2013 |
David M. Giuliano, Cambridge, MA US
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20120313602 | Power Converter With Capacitive Energy Transfer And Fast Dynamic Response - A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or regulation) stage. The circuits and techniques achieve high performance over a wide input voltage range or a wide output voltage range. The converter can be used, for example, to power logic devices in portable battery operated devices. | 12-13-2012 |
20120326684 | Power Converter With Capacitive Energy Transfer And Fast Dynamic Response - A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or regulation) stage. The circuits and techniques achieve high performance over a wide input voltage range or a wide output voltage range. The converter can be used, for example, to power logic devices in portable battery operated devices. | 12-27-2012 |
David M. Giuliano, Brookline, MA US
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20130229841 | DC-DC CONVERTER WITH MODULAR STAGES - An apparatus for electric power conversion includes a converter having a regulating circuit and switching network. The regulating circuit has magnetic storage elements, and switches connected to the magnetic storage elements and controllable to switch between switching configurations. The regulating circuit maintains an average DC current through a magnetic storage element. The switching network includes charge storage elements connected to switches that are controllable to switch between plural switch configurations. In one configuration, the switches forms an arrangement of charge storage elements in which at least one charge storage element is charged using the magnetic storage element through the network input or output port. In another, the switches form an arrangement of charge storage elements in which an element discharges using the magnetic storage element through one of the input port and output port of the switching network. | 09-05-2013 |
20140266132 | RECONFIGURABLE SWITCHED CAPACITOR POWER CONVERTER TECHNIQUES - An apparatus for converting a first voltage into a second voltage includes a reconfigurable switched capacitor power converter having a selectable conversion gain. converter includes a cascade multiplier switched capacitor network having capacitors, each of which electrically connects to a stack node and to a phase node. A controller causes the network to transition between first and second operation modes. In the first mode, at least one capacitor is isolated from a charge transfer path of the reconfigurable switched capacitor power converter. Consequently, in the first mode of operation, the power converter operates with a first gain. In the second mode, the power converter operates with a second conversion gain. Meanwhile, a third voltage across the at least one capacitor is free to assume any value. | 09-18-2014 |
20140268945 | RECONFIGURABLE SWITCHED CAPACITOR POWER CONVERTER TECHNIQUES - An apparatus for converting a first voltage into a second voltage includes a reconfigurable switched capacitor power converter having a selectable conversion gain. converter includes a cascade multiplier switched capacitor network having capacitors, each of which electrically connects to a stack node and to a phase node. A controller causes the network to transition between first and second operation modes. In the first mode, at least one capacitor is isolated from a charge transfer path of the reconfigurable switched capacitor power converter. Consequently, in the first mode of operation, the power converter operates with a first gain. In the second mode, the power converter operates with a second conversion gain. Meanwhile, a third voltage across the at least one capacitor is free to assume any value. | 09-18-2014 |
20140300328 | CONTROL OF POWER CONVERTERS WITH CAPACITIVE ENERGY TRANSFER - An apparatus for power conversion comprises a voltage transformation element, a regulating element, and a controller; wherein, a period of the voltage transformation element is equal to a product of a coefficient and a period of the regulating circuit, and wherein the coefficient is selected from a group consisting of a positive integer and a reciprocal of said integer. | 10-09-2014 |
20150077175 | CHARGE PUMP TIMING CONTROL - Cycle timing of a charge pump is adapted according to monitoring of operating characteristics of a charge pump and/or peripheral elements coupled to the charge pump. In some examples, this adaptation provides maximum or near maximum cycle times while avoiding violation of predefine constraints (e.g., operating limits) in the charge pump and/or peripheral elements. | 03-19-2015 |
20150102798 | DC-DC CONVERTER WITH MODULAR STAGES - An apparatus for electric power conversion includes a converter having a regulating circuit and switching network. The regulating circuit has magnetic storage elements, and switches connected to the magnetic storage elements and controllable to switch between switching configurations. The regulating circuit maintains an average DC current through a magnetic storage element. The switching network includes charge storage elements connected to switches that are controllable to switch between plural switch configurations. In one configuration, the switches forms an arrangement of charge storage elements in which at least one charge storage element is charged using the magnetic storage element through the network input or output port. In another, the switches form an arrangement of charge storage elements in which an element discharges using the magnetic storage element through one of the input port and output port of the switching network. | 04-16-2015 |
David Michael Giuliano, Rochester, NY US
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20140369018 | POWER CONVERTERS HAVING CAPACITIVE ENERGY TRANSFER ELEMENTS AND ARRANGEMENTS OF ENERGY STORAGE ELEMENTS FOR POWER CONVERTERS - A power converter includes a PCB and a semiconductor die coupled to the PCB. The semiconductor die includes first through fourth switching devices. The power converter further includes a first energy storage element electrically connected to the first and second switching devices and a second energy storage element electrically connected to the third and fourth switching devices. The first energy storage element is mounted over the first and second switching devices and the second energy storage element is mounted over the third and fourth switching devices. | 12-18-2014 |
John P. Giuliano, Ledgewood, NJ US
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20110073017 | THREE-DIMENSIONAL TELESCOPING ADJUSTABLE EQUIPMENT MOUNTING FIXTURE - An adjustable equipment curb has upper and lower frames, each having opposed first and second length-adjustable sides and opposed length-adjustable first and second ends interconnectable to form a rigid frame and height-adjustable mounting legs. The lower frame may be used alone, or may support the upper frame through a shock mount system having mounts affixed to both the upper and lower frames and shock absorbing springs between the mounts. The frames may be formed of interconnecting channel members, and the lower frame channel members may be of a perforated construction that, in conjunction with applied sheathing, provides acoustic damping. Seismic brackets may be affixed to the either of the frames to provide resist seismic shock and developed moment resistance. | 03-31-2011 |
20130341485 | THREE-DIMENSIONAL TELESCOPING ADJUSTABLE EQUIPMENT MOUNTING FIXTURE - An adjustable equipment curb has a lower frame having opposed first and second length-adjustable sides and opposed length-adjustable first and second ends interconnectable to form a rigid frame and height-adjustable mounting legs. The lower frame may be used alone, or may support an upper frame through a shock mount system having mounts affixed to both the upper and lower frames and shock absorbing springs between the mounts. The frames may be formed of interconnecting channel members, and the lower frame channel members may be of a perforated construction that, in conjunction with applied sheathing, provides acoustic damping. Seismic brackets may be affixed to the frame to provide increased resistance to seismic shock. | 12-26-2013 |
Kenneth Giuliano, Pittsburgh, PA US
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20090170091 | Method For Predicting Biological Systems Responses - The inventive method employs a “systems biology” approach to predicting biological responses resulting from exposure to the test substance. In one embodiment, the invention provides an automated method for predicting the biological systems effects of a test substance. In another embodiment, the invention provides a method for constructing a knowledgebase (or database) of response profiles for reference substances with known biological systems effects. In another embodiment, the invention provides a set of protocols and software tools used to carry out the profiling. Another embodiment of the invention is a panel of reagents and protocols required for generating response profiles, either to create an knowledgebase, or to use with an existing knowledgebase and informatics software to profile substance physiological effects. Another embodiment of the invention is a database of physiological profiles. | 07-02-2009 |
Kenneth A. Giuliano, Pittsburgh, PA US
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20090131270 | METHODS FOR THE DETECTION OF MOLECULAR INTERACTIONS WITHIN CELLS - The invention provides a method of detecting the effect of an agent of interest on the interaction between two or more polypeptides introduced into a cell. The invention also provides a method for quantifying the interaction between at least two molecules of interest, which are introduced into a cell. A method for quantifying the effects of an agent of interest or the interaction between two molecules of interest on cellular constituents or functions in the same cells is also provided. The above inventive methods can be automatically quantified by a device, such as a HCS device, and utilized in the construction of a database. | 05-21-2009 |
20100009352 | Method for Modeling a Disease - The invention described herein provides for methods of profiling cellular models of disease. Cellular systems biology is the investigation of the integrated and interacting networks of genes, proteins, and metabolites that are responsible for normal and abnormal cell functions. Methods and reagents for the profiling a disease state, the treatment of a disease state and assaying of treatments of a disease state are provided. | 01-14-2010 |
20100112602 | Protein-Protein Interaction Biosensors and Methods of Use Thereof - The invention provides methods and reagents for identifying an agent, such as by screening a library of agents, that modulates the interaction of two or more polypeptides, the method comprising: introducing into a cell at least a first polypeptide, each comprising a binding domain, wherein the first polypeptide comprises a localization domain of the second polypeptide; and detecting the cellular location of the first polypeptide, the second polypeptide or a combination thereof, wherein a change in the cellular location of the first polypeptide, the second polypeptide or a combination thereof indicates that the agent modulates the interaction of the two or more polypeptides. The invention also provides methods and reagents for identifying the binding domains of one or more polypeptides. | 05-06-2010 |
20130190198 | METHOD FOR AUTOMATED TISSUE ANALYSIS - The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a diversity of cellular states or biomarkers in a tissue specimen representing the ‘systems” nature of biology. This cellular profile is interpreted using informatics tools, to identify similarities between specimens, in vivo medical conditions, and suggest options for treating medical conditions. | 07-25-2013 |
20140212892 | Method For Automated Tissue Analysis - The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a diversity of cellular states or biomarkers in a tissue specimen representing the ‘systems” nature of biology. This cellular profile is interpreted using informatics tools, to identify similarities between specimens, in vivo medical conditions, and suggest options for treating medical conditions. | 07-31-2014 |
Michael Giuliano, Derby, CT US
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20150148523 | GAMMA AMINO ACID BUILDING BLOCKS - The invention provides compounds and methods, for example, to carry out organocatalytic Michael additions of aldehydes to cyclically constrained nitroethylene compounds catalyzed by a proline derivative to provide cyclically constrained α-substituted-γ-nitro-aldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96 to >99% e.e.). | 05-28-2015 |
Michael Giuliano, Madison, WI US
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20110118440 | GAMMA AMINO ACID BUILDING BLOCKS - The invention provides compounds and methods, for example, to carry out organocatalytic Michael additions of aldehydes to cyclically constrained nitroethylene compounds catalyzed by a proline derivative to provide cyclically constrained α-substituted-γ-nitro-aldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96 to >99% e.e.). | 05-19-2011 |
Vincent Giuliano, Winter Park, FL US
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20130156872 | Integrated Neuromodulation System for Mood Enhancement of a Living Human Subject - The present invention is an ingestable blended formulation which will cause a series of distinct biochemical changes in-vivo; initiate desirable psychological consequences in that person; and induce an observable increase in cognitive functions for that living human subject. In particular, the initiated psychological events will generate a positive change in one's personal perceptions, evoke optimism as the subjective state of mind, and elicit a more sociable attitude and favorable mood as the observable behavior of the affected human person. Moreover, in addition to the initiation of a more positive state of mind, another major result and effect of ingesting the blended formulation is an observable amplification of human brain functions and a substantive increase of human concentration, focus and memory. | 06-20-2013 |
Vincent Giuliano, Winter Springs, FL US
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20090214680 | Weight Loss Composition - The present invention comprises a purposefully formulated weight loss composition and a method for causing a meaningful weight loss in a living human subject. The formulated weight loss composition, in its most preferred embodiments comprises: at least one amino acid that is a pharmacologically active precursor in the catecholamine biosynthesis pathway; one or more sympathomimetic agents; a lipolytic agent; a high-Dalton macromolecular protein, and a plurality of micronutrients. The preferred composition is formulated as a dry particulate admixture initially; and then is made into a fluid beverage, which is able to achieve multiple physiologic functions in-vivo. These in-vivo functions include: causing a meaningful weight loss, with a preference for lipolysis and fat metabolism; providing for a low glycemic index; offering lean muscle maintenance and replenishment; and concomitantly initiating dopaminergic (D2-receptor) brain stimulation, resulting in improved cognitive function and affective augmentation. | 08-27-2009 |
20140106014 | Integrated Neuromodulation System for Mood Enhancement of a Living Human Subject - The present invention is an ingestable blended formulation which will cause a series of distinct biochemical changes in-vivo; initiate desirable psychological consequences in that person; and induce an observable increase in cognitive functions for that living human subject. In particular, the initiated psychological events will generate a positive change in one's personal perceptions, evoke optimism as the subjective state of mind, and elicit a more sociable attitude and favorable mood as the observable behavior of the affected human person. Moreover, in addition to the initiation of a more positive state of mind, another major result and effect of ingesting the blended formulation is an observable amplification of human brain functions and a substantive increase of human concentration, focus and memory. | 04-17-2014 |