Heifetz
Alexander Heifetz, Abingdon GB
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20150203486 | Imidazopyridine Derivatives as Modulators of TNF Activity - A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. | 07-23-2015 |
Alexander Heifetz, Buffalo Grove, IL US
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20110001081 | HEAT TRANSFER FLUIDS CONTAINING NANOPARTICLES - A nanofluid of a base heat transfer fluid and a plurality of ceramic nanoparticles suspended throughout the base heat transfer fluid applicable to commercial and industrial heat transfer applications. The nanofluid is stable, non-reactive and exhibits enhanced heat transfer properties relative to the base heat transfer fluid, with only minimal increases in pumping power required relative to the base heat transfer fluid. In a particular embodiment, the plurality of ceramic nanoparticles comprise silicon carbide and the base heat transfer fluid comprises water and water and ethylene glycol mixtures. | 01-06-2011 |
20130257646 | COMPRESSIVE PASSIVE MILLIMETER WAVE IMAGER - A compressive scanning approach for millimeter wave imaging and sensing. A Hadamard mask is position to receive millimeter waves from an object to be imaged. A subset of the full set of Hadamard acquisitions is sampled. The subset is used to reconstruct an image representing the object. | 10-03-2013 |
20150177030 | TRANSIENT MULTIVARIABLE SENSOR EVALUATION - A method and system for performing transient multivariable sensor evaluation. The method and system includes a computer system for identifying a model form, providing training measurement data, generating a basis vector, monitoring system data from sensor, loading the system data in a non-transient memory, performing an estimation to provide desired data and comparing the system data to the desired data and outputting an alarm for a defective sensor. | 06-25-2015 |
Alexander Heifetz, Didcot GB
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20120165304 | 6,7,8,9-Tetrahydro-5H-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them - The present invention relates to compounds defined by formula (I), wherein the groups X, Y, W and R | 06-28-2012 |
20140066428 | 6,7,8,9-Tetrahydro-5H-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them - The present invention relates to compounds defined by formula I | 03-06-2014 |
Alexander Heifetz, Buffalo, IL US
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20120242544 | RADAR DETECTION OF RADIATION-INDUCED IONIZATION IN AIR - A millimeter wave measurement system has been developed for remote detection of airborne nuclear radiation, based on electromagnetic scattering from radiation-induced ionization in air. Specifically, methods of monitoring radiation-induced ionization of air have been investigated, and the ionized air has been identified as a source of millimeter wave radar reflection, which can be utilized to determine the size and strength of a radiation source. | 09-27-2012 |
Alexander Heifetz, Oxon GB
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20140051676 | Triazine-oxadiazoles - The invention relates to new derivatives of formula (I), | 02-20-2014 |
20150025057 | Triazine-oxadiazoles - The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of chronic pain. | 01-22-2015 |
Alexander Heifetz, Abingdon, Oxfordshire GB
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20150191482 | Imidazopyrazine Derivatives as Modulators of TNF Activity - A series of imidazo[1,2-α]pyrazine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorder; and oncological disorders. | 07-09-2015 |
Alexander Heifetz, Bnei-Brak IL
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20090163537 | Thienopyridinone Compounds and Methods of Treatment - The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included. | 06-25-2009 |
20100113485 | Piperidinylamino-thieno[2,3-D] Pyrimidine Compounds - The invention relates to 5-HT receptor modulators, particularly 5-HT | 05-06-2010 |
20110082157 | Piperidinylamino-Thieno [2,3-D] Pyrimidine Compounds - The invention relates to 5-HT receptor antagonists. Novel piperidinylamino-thieno [2,3-d] pyrimidine compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as pulmonary arterial hypertension, migraine, hypertension, disorders of the gastrointestinal tract, restenosis, asthma, obstructive airway disease, prostatic hyperplasia and priapism, anxiety, depression, schizophrenia, neural injury and stroke. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also provided. | 04-07-2011 |
20110195953 | COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS - The invention generally relates to thienopyridinone 5-HT | 08-11-2011 |
Daniel Heifetz, Ellicott City, MD US
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20080290097 | Bowl to maintain a crispy dry cereal - The present invention is a uniquely shaped divided bowl that has two separated sections: 1) a cereal section, and 2) a milk and fruit section. These sections are approximately the same size. The consumer places the dry cereal into the cereal section and then places milk and fruit into the milk and fruit section. It should be understood that the consumer might chose to have only milk in the milk and fruit section. An important feature of the design of the milk and fruit section is a groove at its bottom surface into which the last of the milk and fruit goes so that the last bites can be consumed without titling the bowl. | 11-27-2008 |
Gennadi Heifetz, Rishon Le Zion IL
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20140199159 | WELL PUMP SYSTEM - Provided is a well pump system that includes a pressure pipe, a rotatable shaft surrounded by a plurality of bearings, a pumping mechanism mounted to the pressure pipe and having a plurality of pump impellers mounted to a second end of the shaft, a rotating mechanism mounted to a first end of the shaft and configured for rotating it within the bearings, thereby causing the pump impellers to move the fluid in the pressure pipe, and at least one non-return valve configured for assuming at least two states including a first, opened state, in which the second pipe chamber is in fluid communication with the first pipe chamber, and a second, closed state, in which the non-return valve obstructs the fluid communication between the first and the second pipe chambers, thereby lubricating them. | 07-17-2014 |
Israel Heifetz, Tel Aviv IL
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20080202996 | WATER DISPENSER AND FILTER CARTRIDGE FOR USE THEREIN - A water dispenser including a water inlet adapted to receive water from a water supply, a water filter operative to filter water received from the water supply via the water inlet, a water outlet operative to provide filtered water received from the water filter, a water spill collector and a pivotably mounted drainage-equipped water container support having a first operative orientation underlying the water outlet and defining a downwardly inclined water spill drainage pathway communicating with the water spill collector and a second, non-operative, orientation not underlying the water outlet. | 08-28-2008 |
20090071890 | WATER DISPENSER AND FILTER CARTRIDGE FOR USE THEREIN - A water dispenser including a water inlet adapted to receive water from a water supply, a water filter operative to filter water received from the water supply via the water inlet, a water outlet operative to provide filtered water received from the water filter, a water spill collector and a pivotably mounted drainage-equipped water container support having a first operative orientation underlying the water outlet and defining a downwardly inclined water spill drainage pathway communicating with the water spill collector and a second, non-operative, orientation not underlying the water outlet. | 03-19-2009 |
20100163470 | WATER DISPENSER AND FILTER CARTRIDGE FOR USE THEREIN - A water dispenser including a water inlet adapted to receive water from a water supply, a water filter operative to filter water received from the water supply via the water inlet, a water outlet operative to provide filtered water received from the water filter, a water spill collector and a pivotably mounted drainage-equipped water container support having a first operative orientation underlying the water outlet and defining a downwardly inclined water spill drainage pathway communicating with the water spill collector and a second, non-operative, orientation not underlying the water outlet. | 07-01-2010 |
Laurence Heifetz, Truckee, CA US
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20140270458 | Portable Blood Count Monitor - Devices, systems, and methods are disclosed for determining the number and type of blood cells in a blood sample. The blood sample is collected and held in a slide. In the slide, the blood sample is separated and channeled into at least two sampling chambers, one for red blood cells, another for white blood cells, and optionally yet another for platelets. The sampling chambers have wetting agents, lysing agents, staining agents, or the like therein to mix with the blood and facilitate cell count. The slide is placed in a portable slide analyzer where the sampling chambers are illuminated and images of the sampling chambers are taken. These images are converted into electronic form and sent by a communications module of the slide analyzer to a remote external location where the images are analyzed to determine the number and type of blood cells in the blood sample. | 09-18-2014 |
20140273064 | Portable Blood Count Monitor - This disclosure describes the development of a sample preparation, measurement, and analysis method that permits accurate characterization of red blood cells, platelets, and white blood cells, including a 3-part differential of the white blood cells count, to be performed on small volumes of a biological sample. This method is compatible with compact and portable instrumentation that permits the sample collection to be performed in a subject's home and analysis to be performed elsewhere by transmission of the data to a laboratory or doctor's office. | 09-18-2014 |
Peter Heifetz, San Diego, CA US
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20110151515 | PRODUCTION OF FC-FUSION POLYPEPTIDES IN EUKARYOTIC ALGAE - Methods and compositions are disclosed to engineer plastids comprising heterologous genes encoding immuno-activating domains fused to an extracellular domain (ECD) of a receptor or surface glycoprotein, a growth factor or an enzyme and produced within a subcellular organelle, such as a chloroplast. The immuno-activating domains may include those regions of a protein capable of modulating the interaction between immune effector cells via proteins containing stereoselective binding domains and specific ligands, such as the Fc regions of antibodies. The present disclosure also demonstrates the utility of plants, including green algae, for the production of complex multi-domain fusion proteins as soluble bioactive therapeutic agents. | 06-23-2011 |
Peter B. Heifetz, San Diego, CA US
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20140271599 | PRODUCT AND PROCESS FOR MUCUS VISCOSITY NORMALIZATION - Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The composition contains a protein or peptide containing a thioredoxin monocysteinic active site in a reduced state and optionally further contains a reducing system. | 09-18-2014 |
Peter Bernard Heifetz, San Diego, CA US
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20090197337 | Methods for the production of multimeric proteins and related compositions - Improved methods for the production of multimeric-protein-complexes, such as redox proteins and immunoglobins, in association with oil bodies are described. The redox protein is enzymatically active when prepared in association with the oil bodies. Also provided are related nucleic acids, proteins, cells, plants, and compositions. | 08-06-2009 |
20120020992 | Production of Biologically Active Proteins - A fusion protein that is expressed in a recombinant protein body-like assembly (RPBLA) in host eukaryotic cells and organisms is disclosed. More particularly, a biologically active polypeptide fused to a protein sequence that mediates the induction of RPBLA formation is expressed and accumulated in host cells after transformation with an appropriate vector. The eukaryotic host cell does not produce protein bodies in the absence of the fusion protein. Methods for preparing and using the RPBLAs and the fusion protein are also disclosed, as are nucleic acid molecules that encode the fusion proteins. | 01-26-2012 |
Yael Heifetz, Rehovot IL
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20110283945 | SEX-PEPTIDES RESISTANT TO PROTEOLYTIC DEGRADATION AND THEIR USE IN BIOLOGICAL CONTROL OF INSECTS - An isolated nucleic acid molecule comprising, or consisting of, a polynucleotide sequence encoding an oligopeptide capable of inducing post-mating depression of receptivity to mating in female insects, wherein said oligopeptide is resistant to proteolytic degradation, is provided for expression in sterile transgenic male insects useful in the control of insect populations. | 11-24-2011 |