Patent application number | Description | Published |
20080208790 | Document Processing Device, and Document Processing Method - A technique is provided for adding an annotation to a document described in a markup language. Upon acquisition of a document described in a markup language, a document processing apparatus | 08-28-2008 |
20090083617 | INPUT FORM DESIGN DEVICE AND INPUT FORM DESIGN METHOD - A structured document file can be created effectively. The screen display unit | 03-26-2009 |
20090094509 | DOCUMENT PROCESSING DEVICE, AND DOCUMENT PROCESSING METHOD - A technology is provided in which a document described in a markup language is appropriately processed. In the document processing apparatus, when the definition file creating unit creates a new definition file, the definition file name creating unit creates a name of the definition file. When the document acquisition unit acquires a document, the namespace URI reference acquisition unit acquires a namespace URI reference of a vocabulary which is a tag set to which an element included in an XML document belongs. The definition file name creating unit creates a name of a definition file by computing a hash value of the namespace URI reference. The definition file acquisition unit acquires a definition file of which name is created by the definition file name creating unit. When the definition file is acquired, an element included in the document is mapped to an element of an XHTML vocabulary, for example, by the mapping unit, thereby the element being displayed and edited by the HTML unit or the like. | 04-09-2009 |
Patent application number | Description | Published |
20140234340 | ANTIGEN-BINDING MOLECULE CAPABLE OF BINDING TO PLURALITY OF ANTIGEN MOLECULES REPEATEDLY - An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction. | 08-21-2014 |
20140271617 | ION CONCENTRATION-DEPENDENT BINDING MOLECULE LIBRARY - Disclosed is a library consisting essentially of a plurality of antigen-binding molecules differing in sequence from each other, wherein an antigen-binding domain in each of the antigen-binding molecules comprises at least one amino acid residue that changes the antigen-binding activity of the antigen-binding molecule depending on ion concentration conditions. Also disclosed are a composition comprising a plurality of polynucleotide molecules each encoding the antigen-binding molecules, a composition comprising a plurality of vectors each comprising the polynucleotide molecules, a method for selecting the antigen-binding molecules, a method for isolating the polynucleotide molecules, a method for producing the antigen-binding molecules, and a pharmaceutical composition comprising any of the antigen-binding molecules. | 09-18-2014 |
20140370020 | ANTIGEN-BINDING MOLECULE HAVING REGULATED CONJUGATION BETWEEN HEAVY-CHAIN AND LIGHT-CHAIN - It was found that association between CH1 and CL can be suppressed by substituting amino acids that exist on the interface between CH 1 and CL with electrically-charged amino acids, and that formation of heterogeneous molecules is enabled more efficiently than by introducing knobs into holes mutations into CH3 domain. | 12-18-2014 |
20150056182 | DRUG CONTAINING CARRIER INTO CELL FOR FORMING IMMUNE COMPLEX - The present inventors discovered that by forming a large immune complex comprising antigens containing two or more antigenic binding units (epitopes) and two or more antigen-binding molecules (for example, antibodies), elimination from the plasma of the antigens containing two or more antigenic binding units can be accelerated. Moreover, they found that by using this characteristic and by further using antigen-binding molecules having an ion-dependent antigen-binding activity, elimination of the antigens can further be accelerated and the above problem can be solved. | 02-26-2015 |