Patent application number | Description | Published |
20080287650 | High purity peptides - The invention relates to methods for the preparation of highly purified peptides. The peptides are prepared in high optical purity of at least about 98.5%, and preferably at least about 99%. Specifically, Nesiritide (SEQ. ID NO. 1) having a purity of at least 99% as measured by HPLC and containing about 0.05% to about 0.5% [D-His]-Nesiritide (SEQ. ID NO. 1) as measured by chiral GC/MS. | 11-20-2008 |
20100029916 | PROCESS FOR PRODUCTION OF BIVALIRUDIN - The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp | 02-04-2010 |
20100273982 | PROCESS FOR PRODUCTION OF BIVALIRUDIN - The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp | 10-28-2010 |
20110160431 | PRODUCTION OF PEPTIDES CONTAINING POLY-GLY SEQUENCES USING FMOC CHEMISTRY - A peptide containing a poly-Gly sequence, such as bivalirudin, can be prepared in a purified form in which low amounts of GIy deletion or GIy addition byproducts are present. A protected poly-Gly-containing peptide is attached to a resin using Fmoc-Gly-GIy-OH units for assembly of the poly-Gly segment. The protected peptide is then cleaved from the resin with an acidic composition to produce an unprotected or semi-protected crude peptide, which can then be isolated from acidic composition. | 06-30-2011 |
20130196916 | PROCESS FOR PRODUCTION OF BIVALIRUDIN - The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp | 08-01-2013 |
20130196917 | PROCESS FOR PRODUCTION OF BIVALIRUDIN - The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp | 08-01-2013 |
20130196918 | PROCESS FOR PRODUCTION OF BIVALIRUDIN - The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp | 08-01-2013 |
20130196919 | PROCESS FOR PRODUCTION OF BIVALIRUDIN - The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp | 08-01-2013 |
20130196920 | PROCESS FOR PRODUCTION OF BIVALIRUDIN - The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp | 08-01-2013 |
20130203674 | PROCESS FOR PRODUCTION OF BIVALIRUDIN - The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp | 08-08-2013 |
Patent application number | Description | Published |
20090319245 | POSITION AND ANGLE DIGITAL DETECTION AND SIMULATION - A position detection and simulation platform includes software configurable logic and programmable inputs and outputs to support software configuration only changes for use with a variety of position feedback devices including synchros, resolvers, linear variable differential transformers, and rotary variable differential transformers. The platform provides support for all of these devices without making hardware changes to the platform; all changes are accomplished through software programming of configurable registers and logic devices. In this way the platform can universally be applied to applications that require interfacing to any of the supported devices. Additionally, the platform can be reconfigured through software to provide complete simulation of any of the supported devices. | 12-24-2009 |
20110227556 | DYNAMICALLY POWERING A POSITION AND ANGLE DIGITAL DETECTION AND SIMULATION OUTPUT - A position detection and simulation platform includes software configurable logic and programmable inputs and outputs to support software configuration only changes for use with a variety of position feedback devices including synchros, resolvers, linear variable differential transformers, and rotary variable differential transformers. Power to the software configurable outputs is dynamically controlled so that the power supply voltage presented to the outputs satisfies a minimum threshold above the amplitude of the output signal. Dynamic control is based on at least one of a digital representation of a signal to be output, an analog version of the signal to be output, or the signal being output. | 09-22-2011 |
20140114631 | DYNAMICALLY POWERING A POSITION AND ANGLE DIGITAL DETECTION AND SIMULATION OUTPUT - A position detection and simulation platform includes software configurable logic and programmable inputs and outputs to support software configuration only changes for use with a variety of position feedback devices including synchros, resolvers, linear variable differential transformers, and rotary variable differential transformers. Power to the software configurable outputs is dynamically controlled so that the power supply voltage presented to the outputs satisfies a minimum threshold above the amplitude of the output signal. Dynamic control is based on at least one of a digital representation of a signal to be output, an analog version of the signal to be output, or the signal being output. | 04-24-2014 |
Patent application number | Description | Published |
20080287692 | Synthesis of cyclopentadiene derivatives - A compound of formula (X): | 11-20-2008 |
20090062491 | Metallocene Compounds - A bridged metallocene compound of formula (I) wherein: M is an atom of a transition metal; X, is a hydrogen atom, a halogen atom, or a hydrocarbon-based group; R1 is a C1-C40 hydrocarbon radical; R2 and R3, form together a condensed 3-7 membered ring; R4 is a hydrogen atom or a C1-C40 hydrocarbon radical; W is an aromatic 5 or 6 membered ring. | 03-05-2009 |
20090171047 | Metallocene Compounds - A bridged metallocene compound of formula (I) | 07-02-2009 |
20090221772 | Metallocene Compounds - A bridged metallocene compound of formula (I) wherein: M is a transition metal; X, is a hydrogen atom, a halogen atom, or a hydrocarbon group optionally containing hetematoms; L is a divalent bridging group; R | 09-03-2009 |
20090275712 | Metallocene Compounds - A bridged metallocene compound of formula (I) | 11-05-2009 |
20110021344 | Method for preparing non-metallocene ligands - A method of preparing supported catalysts useful for olefin polymerization is described. The catalysts comprise a Group 4 metal complex that incorporates a tridentate dianionic ligand. An activator mixture is first made from a boron compound having Lewis acidity and an excess of an alumoxane. The activator mixture is then combined with a support and the Group 4 metal complex to give a supported catalyst. The method provides an active, supported catalyst capable of making high-molecular-weight polyolefins. | 01-27-2011 |
20110021727 | Catalysts based on 2-(2-aryloxy)quinoline or 2-(2-aryloxy)dihydroquinoline ligands - Catalysts useful for polymerizing olefins are disclosed. The catalysts comprise an activator and a Group 4 metal complex that incorporates a dianionic, tridentate 2-(2-aryloxy)quinoline or 2-(2-aryloxy)dihydroquinoline ligand. In one aspect, supported catalysts are prepared by first combining a boron compound having Lewis acidity with excess alumoxane to produce an activator mixture, followed by combining the activator mixture with a support and the tridentate, dianionic Group 4 metal complex. The catalysts are easy to synthesize, support, and activate, and they enable facile production of high-molecular-weight polyolefins. | 01-27-2011 |
20120016092 | Catalysts based on quinoline precursors - Catalysts useful for polymerizing olefins are disclosed. The catalysts comprise a transition metal complex, an optional activator, and an optional support. The complex is the reaction product of a Group 3-6 transition metal source, an optional alkylating agent, and a ligand precursor comprising a 2-imino-8-anilinoquinoline or a 2-aminoalkyl-8-anilinoquinoline. The catalysts, which are easy to synthesize by in-situ metallation of the ligand precursor, offer polyolefin manufacturers good activity and the ability to make high-molecular-weight ethylene copolymers that have little or no long-chain branching. | 01-19-2012 |
20130023635 | CATALYSTS BASED ON HETEROCYCLIC-8-ANILINOQUINOLINE LIGANDS - A catalyst system useful for polymerizing olefins is disclosed. The catalyst system comprises an activator and a Group 4 metal complex. The complex incorporates a dianionic, tridentate heterocyclic-8-anilinoquinoline ligand. In one aspect, a supported catalyst system is prepared by first combining a boron compound having Lewis acidity with excess alumoxane to produce an activator mixture, followed by combining the activator mixture with a support and the dianionic, tridentate Group 4 metal complex. The Group 4 metal complexes are easy to synthesize, support, and activate, and they enable facile production of high-molecular-weight polyolefins. | 01-24-2013 |