Patent application number | Description | Published |
20080235814 | Transgenic mammals having human Ig loci including plural VH and VK regions and antibodies produced therefrom - The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (V | 09-25-2008 |
20090149637 | Human antibodies derived from immunized xenomice - Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof. | 06-11-2009 |
20100010202 | Human antibodies derived from immunized xenomice - Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof. | 01-14-2010 |
20100305307 | HUMAN MONOCLONAL ANTIBODIES TO EPIDERMAL GROWTH FACTOR RECEPTOR - In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided. Also provided in accordance with the invention are antibodies that possess one or more of the following functional characteristics: (i) inhibit tyrosine phosphorylation of EGF-r, (ii) do not inhibit EGF-r internalization, (ii) inhibit EGF-r degradation, (iii) inhibition of EGF induced EGF-r degradation, (iv) protect threonine phosphorylation of EGF-r, (v) protect threonine phosphorylation of other molecules, particularly a 62 KD molecule identified by immunoprecipitation, and (vi) inhibit vascular endothelial cell growth factor signal by tumor cells by greater than 50% and endothelial cells by greater than 40% relative to control. | 12-02-2010 |
20120117669 | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENOMICE - Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof. | 05-10-2012 |
20130117871 | Human Antibodies Derived from Immunized Xenomice - Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof. | 05-09-2013 |
Patent application number | Description | Published |
20090059082 | METHODS AND SYSTEMS TO TRANSMIT, VIEW, AND MANIPULATE MEDICAL IMAGES IN A GENERAL PURPOSE VIEWING AGENT - An apparatus may include a processor configured to determine a first value for a center of brightness and a second value for a window width for contrast. The processor may further be configured to process a first image to generate a second image having a reduced bit-depth based at least in part upon the determined first and second values. The processor may additionally be configured to provide the second image to a remote device to facilitate viewing and manipulation of the second image in a general purpose viewing agent. Corresponding methods, computer program products, and systems are also provided. | 03-05-2009 |
20090132285 | METHODS, COMPUTER PROGRAM PRODUCTS, APPARATUSES, AND SYSTEMS FOR INTERACTING WITH MEDICAL DATA OBJECTS - A method, apparatus, and computer program product are provided for interacting with medical data objects. An apparatus may include a processor configured to map a DICOM object comprising medical data content to a hierarchy of one or more containers. The processor may be further configured to provide a user interface allowing a user to view a representation of the hierarchy and access the medical data content of the one or more containers. The processor may additionally be configured to receive data that a user has added to a container. The processor may also be configured to associate the received data with the DICOM object based at least in part upon the container to which the received data was added. Corresponding methods and computer program products are also provided. | 05-21-2009 |
20090274384 | METHODS, COMPUTER PROGRAM PRODUCTS, APPARATUSES, AND SYSTEMS TO ACCOMMODATE DECISION SUPPORT AND REFERENCE CASE MANAGEMENT FOR DIAGNOSTIC IMAGING - A method, apparatus, and computer program product are provided to accommodate decision support and reference case management for diagnostic imaging. An apparatus may include a processor configured to receive a request for an image from a client device. The processor may be further configured to retrieve a source image corresponding to the requested image from a memory. The processor may additionally be configured to process the source image to generate a second image having a greater resolution than the source image. The processor may also be configured to provide the second image to the client device to facilitate viewing and manipulation of the second image at the client device. Corresponding methods and computer program products are also provided. | 11-05-2009 |
20120191793 | METHODS, COMPUTER PROGRAM PRODUCTS, APPARATUSES, AND SYSTEMS TO ACCOMMODATE DECISION SUPPORT AND REFERENCE CASE MANAGEMENT FOR DIAGNOSTIC IMAGING - A method, apparatus, and computer program product are provided to accommodate decision support and reference case management for diagnostic imaging. An apparatus may include a processor configured to receive a request for an image from a client device. The processor may be further configured to retrieve a source image corresponding to the requested image from a memory. The processor may additionally be configured to process the source image to generate a second image having a greater resolution than the source image. The processor may also be configured to provide the second image to the client device to facilitate viewing and manipulation of the second image at the client device. Corresponding methods and computer program products are also provided. | 07-26-2012 |