Jarvis, CO
Eric Jarvis, Boulder, CO US
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20100093838 | REGULATION OF ANGIOGENESIS WITH ZINC FINGER PROTEINS - Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided. | 04-15-2010 |
20100144041 | L-Arabinose Fermenting Yeast - An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the only carbon source, and to produce ethanol. Methods of producing ethanol include utilizing these modified yeast strains. | 06-10-2010 |
20120129241 | AN L-ARABINOSE FERMENTING YEAST - An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the only carbon source, and to produce ethanol. A yeast strain engineered to metabolize arabinose through a novel pathway is also disclosed. Methods of producing ethanol include utilizing these modified yeast strains. | 05-24-2012 |
20130189788 | L-ARABINOSE FERMENTING YEAST - An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the only carbon source, and to produce ethanol. A yeast strain engineered to metabolize arabinose through a novel pathway is also disclosed. Methods of producing ethanol include utilizing these modified yeast strains. | 07-25-2013 |
20140322765 | Enhanced Processive Cellulases - Nucleic acid sequences encoding chimeric polypeptides that exhibit enhanced cellulase activities are disclosed herein. These nucleic acids may be expressed in hosts such as fungi, which in turn may be cultured to produce chimeric polypeptides. Also disclosed are chimeric polypeptides and their use in the degradation of cellulosic materials. | 10-30-2014 |
Eric Edward Jarvis, Boulder, CO US
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20100186438 | SUB-WET BULB EVAPORATIVE CHILLER WITH PRE-COOLING OF INCOMING AIR FLOW - An evaporative chiller cooling water to below ambient wet bulb temperature. Sub-wet bulb chilling is achieved by pre-cooling incoming air upstream of the saturator. The incoming air is ambient air at ambient air temperature that is cooled using the coolness of the lower temperature outgoing air exiting the saturator. The pre-cooling lowers the temperature of the incoming air and lowers its wet bulb temperature below that of ambient air. The saturator water is chilled to below the ambient wet bulb temperature. The air in the saturator flows across the water as it gravity drips or flows from the top to the bottom of the saturator. The pre-cooled air flows across the saturator with the coolest air directed across the bottom of the saturator where the coldest water is flowing and with the hottest air directed across the top where the hottest water is flowing to provide gradient chilling. | 07-29-2010 |
20100261271 | Regulation of endogenous gene expression in cells using zinc finger proteins - The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins. | 10-14-2010 |
20100279406 | Alteration of tumor growth using zinc finger proteins - The present invention provides methods for altering tumor growth using zinc finger proteins. | 11-04-2010 |
20110247087 | Regulation of endogenous gene expression in cells using zinc finger proteins - The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins. | 10-06-2011 |
20120204591 | SUB-WET BULB EVAPORATIVE WATER CHILLER WITH GRADIENT CHILLING AND AIR-TO-AIR HEAT EXCHANGE - An evaporative chiller cooling water to below ambient wet bulb temperature. Sub-wet bulb chilling is achieved by pre-cooling incoming air upstream of the saturator. The incoming air is ambient air at ambient air temperature that is cooled using the coolness of the lower temperature outgoing air exiting the saturator. The pre-cooling lowers the temperature of the incoming air and lowers its wet bulb temperature below that of ambient air. The saturator water is chilled to below the ambient wet bulb temperature. The air in the saturator flows across the water as it gravity drips or flows from the top to the bottom of the saturator. The pre-cooled air flows across the saturator with the coolest air directed across the bottom of the saturator where the coldest water is flowing and with the hottest air directed across the top where the hottest water is flowing to provide gradient chilling. | 08-16-2012 |
20120294838 | Regulation of endogenous gene expression in cells using zinc finger proteins - The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins. | 11-22-2012 |
20130333407 | SUB-WET BULB EVAPORATIVE CHILLER SYSTEM WITH MULTIPLE INTEGRATED SUBUNITS OR CHILLERS - A cooling system integrating a plurality of evaporative chillers, which each cool water to below ambient wet bulb temperature. In an air-to-air heat exchanger of each chiller, the incoming airstream used to evaporate water from the water stream is first cooled indirectly using the cooled air that is exhausted from a saturator of an adjacent chiller or subunit. By pre-chilling the air without adding moisture, each of the chillers of the cooling system is able to achieve water temperatures below the ambient wet bulb temperature. The system integrates or “daisy chains” multiple sub-wet bulb evaporative chillers or subunits such that the cool air output from one subunit is used to pre-cool the incoming air of another neighboring unit. To this end, adjacent units have their heat exchangers fluidically connected together (e.g., air flow output from each saturator is passed as cool return air through channels of an adjacent heat exchanger). | 12-19-2013 |
Thale Jarvis, Boulder, CO US
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20080207703 | Antibacterial heterocyclic ureas - The present invention provides novel heterocyclic urea compounds having useful antibacterial activity, pharmaceutical compositions comprising one or more of these compounds, methods of making the same, and methods of using the same. | 08-28-2008 |
20100286169 | Antibacterial Sulfone and Sulfoxide Substituted Heterocyclic Urea Compounds - The present invention provides novel sulfone and sulfoxide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and methods of production are provided. | 11-11-2010 |
20120015941 | Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds - The present invention provides novel amide and sulfonamide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided. | 01-19-2012 |
20130116150 | Lung Cancer Biomarkers and Uses Thereof - The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 18, Table 20, or Table 21, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value. | 05-09-2013 |
Thale C. Jarvis, Boulder, CO US
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20120115752 | Method for Generating Aptamers with Improved Off-Rates - The present disclosure describes the identification and use of aptamers and photoaptamers having slower dissociation rate constants than those obtained using previously described methods. Specifically, the present disclosure describes methods for the identification and use of aptamers to one or more targets within a histological or cytological sample, which have slow rates of dissociation. The aptamers may be used to assess localization, relative density, and presence or absence of one or more targets in cytological and histological samples. Targets may be selected that are specific and diagnostic of a given disease state for which the sample was collected. The aptamers may also be used to introduce target specific signal moieties. In addition to target identification, the aptamers may be used to amplify signal generation through a variety of methods. | 05-10-2012 |
20140315986 | APTAMERS THAT BIND TO IL-6 AND THEIR USE IN TREATING OR DIAGNOSING IL-6 MEDIATED CONDITIONS - Aptamers that bind IL-6 are provided. Pharmaceutical compositions comprising IL-6 aptamers are provided, as well as methods of treating conditions using the aptamers are also provided. | 10-23-2014 |
Thale Cross Jarvis, Boulder, CO US
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20100028862 | BACTERIAL REPLICATION SYSTEMS AND METHODS - Reconstituted bacterial replication assemblies and methods for their use are provided. | 02-04-2010 |