Patent application number | Description | Published |
20080210306 | Integrated surface-machined micro flow controller method and apparatus - A surface-micromachined mass flow controller (MFC) comprises an electrostatically actuated microvalve integrated with a thermal flow sensor. The microvalve comprises a normally-open diaphragm defining an aperture allowing fluid communication between first and second flow channels. The diaphragm includes a second electrode actuable toward a valve seat including a first electrode. Fabricated utilizing a multilayer Parylene process, the active microvalve and the flow sensor are integrated onto a single chip to perform closed-loop flow control. For flow control, both Pulse Width Modulation (PWM) and actuation voltage adjustment are demonstrated. | 09-04-2008 |
20090306585 | IMPLANTABLE PUMPS AND CANNULAS THEREFOR - In various embodiments, an implantable pump includes a cannula. The pump (e.g., the cannula thereof) may include, for example, flow sensors, pressure sensors, filters, and/or other components. | 12-10-2009 |
20090306594 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of an implantable electrolytic pump include a drug reservoir, a cannula fluidly coupled to the reservoir, a pumping mechanism for forcing liquid from the reservoir through the cannula, control circuitry for operating the pumping mechanism, and a power source comprising primary and auxiliary batteries in a stacked configuration, only the main battery being operatively coupled to the control circuitry during normal operation, the control circuitry operatively coupling the back-up battery upon detection of an electrical fault. The pump may further include a hermetic enclosure containing the control circuitry and the power source. | 12-10-2009 |
20090306595 | IMPLANTABLE DRUG-DELIVERY DEVICES, AND APPARATUS AND METHODS FOR FILLING THE DEVICES - In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device. | 12-10-2009 |
20090311133 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump. | 12-17-2009 |
20090312742 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of an implantable electrolytic pump include a first expandable diaphragm and a second flexible diaphragm, and first and second chambers each for containing a fluid, wherein the first expandable diaphragm separates the first and second chambers and provides a fluid barrier therebetween, and the second chamber is formed between the first expandable diaphragm and the second flexible diaphragms. The pump may further include electrolysis electrodes within the first chamber for causing generation of a gas therein and to thereby expand the expandable diaphragm so that fluid is forced from the second chamber into a cannula. | 12-17-2009 |
20100004639 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of an implantable electrolytic pump include an electrolysis chamber, a drug chamber and an osmosis chamber, the osmosis chamber having a first portion in contact with the drug chamber and a second portion exposed to facilitate contact with a surrounding fluid. The pump further includes a cannula for conducting liquid from the drug chamber and electrolysis electrodes within the electrolysis chamber for causing generation of a gas therein, the electrolysis and drug chambers being in contact such that gas electrolysis within electrolysis chamber forces fluid from the drug chamber into the cannula, contact between the drug chamber and the osmosis chamber permitting fluid admitted into the osmotic chamber from the surrounding fluid to offset volume loss from the drug chamber and prevent buildup of vacuum pressure thereon. | 01-07-2010 |
20100305550 | MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS - Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball. | 12-02-2010 |
20110144617 | MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS - Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, a cannula in fluid communication with the reservoir, and means for forcing fluid from the reservoir into the cannula. Circuitry for controlling the means for forcing fluid from the reservoir into the cannula may be included. | 06-16-2011 |
20110144619 | MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS - Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. A valve for maintaining a constant flow rate through the cannula independent of the pressure applied to the device may be included. | 06-16-2011 |
20110202032 | DRUG-DELIVERY PUMPS WITH DYNAMIC, ADAPTIVE CONTROL - In various embodiments, actuation of a drug-delivery pump is controlled based on a change in a condition of the pump. | 08-18-2011 |
20110275987 | PISTON-DRIVEN DRUG PUMP DEVICES - In piston-pump drug-delivery devices, changes in friction between the piston and vial in which it moves may be reduced and/or compensated for by suitable surface coatings and/or feedback control. | 11-10-2011 |
20120041427 | ELECTROLYTICALLY DRIVEN DRUG PUMP DEVICES - Electrolytically driven drug pump devices may be configured so as to ensure sustained contact of the electrolysis electrodes with the electrolyte, thereby improving the reliability and/or pump capacity of the devices. | 02-16-2012 |
20120211095 | Molded and Packaged Elastomeric Check Valve - Elastomeric check valves for use, e.g., in small pump devices, may include a molded elastomeric valve body forming a pocket that extends from an opening at the valve inlet to a terminus inside the valve body, and having a slit extending from the terminus to a valve outlet. | 08-23-2012 |
20120234433 | INSTRUMENT AND METHODS FOR FILLING AN IMPLANTED DRUG PUMP - A tool for refilling an implantable pump having at least one reservoir. The tool includes a plurality of independent fluid channels; a fluid reservoir in fluid communication with a first one of the fluid channels; at least one pump fluidly coupled to the fluid channels, the at least one pump and the independent fluid channels differing from each other in number, wherein (i) a pump is configured to apply positive pressure to the first fluid channel so as to drive fluid from the fluid reservoir therethrough, and (ii) a pump is configured to apply negative pressure to the second fluid channel; and a connector for removably connecting the fluid channels to the at least one reservoir. | 09-20-2012 |
20120277733 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of an implantable electrolytic pump include a first expandable diaphragm and a second flexible diaphragm, and first and second chambers each for containing a fluid, wherein the first expandable diaphragm separates the first and second chambers and provides a fluid barrier therebetween, and the second chamber is formed between the first expandable diaphragm and the second flexible diaphragms. The pump may further include electrolysis electrodes within the first chamber for causing generation of a gas therein and to thereby expand the expandable diaphragm so that fluid is forced from the second chamber into a cannula. | 11-01-2012 |
20120323218 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of an implantable electrolytic pump include an electrolysis chamber, a drug chamber and an osmosis chamber, the osmosis chamber having a first portion in contact with the drug chamber and a second portion exposed to facilitate contact with a surrounding fluid. The pump further includes a cannula for conducting liquid from the drug chamber and electrolysis electrodes within the electrolysis chamber for causing generation of a gas therein, the electrolysis and drug chambers being in contact such that gas electrolysis within electrolysis chamber forces fluid from the drug chamber into the cannula, contact between the drug chamber and the osmosis chamber permitting fluid admitted into the osmotic chamber from the surrounding fluid to offset volume loss from the drug chamber and prevent buildup of vacuum pressure thereon. | 12-20-2012 |
20130000119 | MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS - Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball. | 01-03-2013 |
20130090676 | Instruments and Methods for Surgical Sizing and Marking - A surgical sizer for creating a tissue pocket for an implantable medical device may include a replica of the device and a (preferably ergonomic) handle portion, optionally with marking features that facilitate marking the tissue for precise implant placement and alignment. | 04-11-2013 |
20130102962 | IMPLANTABLE DRUG-DELIVERY DEVICES, AND APPARATUS AND METHODS FOR FILLING THE DEVICES - In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device. | 04-25-2013 |
20130116664 | IMPLANTABLE DRUG PUMPS AND REFILL DEVICES THEREFOR - Implanted drug pump devices can be refilled via a fill port in the drug reservoir that includes a self-resealable septum. | 05-09-2013 |
20130116666 | IMPLANTABLE DRUG PUMPS AND REFILL DEVICES THEREFOR - A system for refilling the drug reservoir of an implanted drug pump device may facilitate wireless data exchange between the refill system and the implanted device, e.g., to verify proper drug selection prior to commencement of the refill process. | 05-09-2013 |
20130276974 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump. | 10-24-2013 |
20140074058 | DRUG-DELIVERY PUMP WITH DYNAMIC, ADAPTIVE CONTROL - In various embodiments, actuation of a drug-delivery pump is controlled based on a change in a condition of the pump. | 03-13-2014 |
20140311912 | FLOW SENSORS WITH MODULAR MICROFLUIDIC CHANNELS AND METHODS OF MANUFACTURE - Modular microfluidic channel structures for conducting liquid from a reservoir include a sensor for monitoring a parameter (such as flow rate or pressure) relating to liquid flowing therethrough. The microfluidic channel generally comprises a thermally insulating substrate made of one or more materials such as, e.g., glass, fused silica, parylene, and/or silicone. | 10-23-2014 |
20140332997 | FLEXIBLE MANUFACTURE OF POLYMERIC TUBING - Tubular polymeric structures are formed by creating a convex mold conforming to a fluid pathway design, depositing a coating of polymer over the mold, and in situ removing the mold without drawing it against the polymer. | 11-13-2014 |
20140371674 | VENTED IMPLANTABLE DRUG-DELIVERY DEVICE AND RELATED METHODS - An implantable device has an outer shell that includes an aperture through the housing of the device and, spanning the aperture, a membrane structure permeable to gas but not to liquid. In this way, excess gas may be vented from the device. The membrane and aperture are designed to discourage or even prevent tissue ingrowth. | 12-18-2014 |
20140374245 | ELECTROLYSIS RECOMBINATION MASK AND RELATED METHODS - A recombination mask integrated onto an electrolysis chip tunes electrolysis parameters by masking off portions of the electrodes exposed to an electrolyte solution. This prevents electrolysis gases from reaching the catalyst on the electrodes and recombining. | 12-25-2014 |