Knop, US
Dave Knop, Gainesville, FL US
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20130244331 | RECOMBINANT VIRUS PRODUCTION USING MAMMALIAN CELLS IN SUSPENSION - The invention generally provides methods for producing recombinant AAV viral particles using cells grown in suspension. The invention provides recombinant AAV particles for use in methods for delivering genes encoding therapeutic proteins, and methods for using the recombinant AAV particles in gene therapy. | 09-19-2013 |
David Knop, Gainesville, FL US
Patent application number | Description | Published |
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20110229971 | RECOMBINANT VIRUS PRODUCTION USING MAMMALIAN CELLS IN SUSPENSION - The invention generally provides methods for producing recombinant AAV viral particles using cells grown in suspension. The invention provides recombinant AAV particles for use in methods for delivering genes encoding therapeutic proteins, and methods for using the recombinant AAV particles in gene therapy. | 09-22-2011 |
20130171719 | RECOMBINANT AAV PRODUCTION IN MAMMALIAN CELLS - The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co-infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are suitable for high-titer, large-scale production of infectious rAAV. | 07-04-2013 |
Felipe Knop, Poughkeepsie, NY US
Patent application number | Description | Published |
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20080288645 | COMPUTER PROGRAM PRODUCT USING TWO DIFFERENT PROGRAMS TO DETERMINE STATE OF A NETWORK NODE TO ELIMINATE MESSAGE RESPONSE DELAYS IN SYSTEM PROCESSING - The determination of node and/or adapter liveness in a distributed network data processing system is carried out via one messaging protocol that can be assisted by a second messaging protocol which is significantly less susceptible to delay, especially memory blocking delays encountered by daemons running on other nodes. The switching of protocols is accompanied by controlled grace periods for needed responses. This messaging protocol flexibility is also adapted for use as a mechanism for controlling the deliberate activities of node addition (birth) and node deletion (death). | 11-20-2008 |
20080291837 | COMPUTER PROGRAM PRODUCT FOR DETERMINATION OF REMOTE ADAPTER AND/OR NODE LIVENESS - The determination of node and/or adapter liveness in a distributed network data processing system is carried out via one messaging protocol that can be assisted by a second messaging protocol which is significantly less susceptible to delay, especially memory blocking delays encountered by daemons running on other nodes. The switching of protocols is accompanied by controlled grace periods for needed responses. This messaging protocol flexibility is also adapted for use as a mechanism for controlling the deliberate activities of node addition (birth) and node deletion (death). | 11-27-2008 |
20080298267 | AUTOMATIC CONFIGURATION OF NETWORK FOR MONITORING - A system, method and computer readable medium are provided for configuring network interfaces grouped into nodes for monitoring functionality. According to the method, a base address and subnet mask for the network interfaces are received, and a monitoring address is automatically generated for each of the network interfaces based on the base address, the subnet mask, and the nodes. The monitoring addresses is generated such that the monitoring address for each of the network interfaces is on a different subnet than the monitoring addresses for all of the other network interfaces in the same node as that network interface. Additionally, the monitoring addresses are assigned to the network interfaces for use by the monitoring process, with each of the monitoring addresses being assigned by being added as an additional network interface address of its network interface. Also provided is a method for monitoring functionality of network interfaces and providing fault recovery. | 12-04-2008 |
20090129397 | CLUSTER BRING-UP IN A DISTRIBUTED TOPOLOGY LIVENESS SYSTEM - A method is provided for establishing clusters in a distributed data processing environment having a plurality of nodes. The frequency of messages sent for the purpose of cluster formation is selected based on ranking of the nodes. Higher ranking nodes transmit such messages more frequently than lower ranking nodes. Lower ranked nodes thus are provided with an opportunity to join a cluster without first having to transmit their own messages to effectuate the joining. | 05-21-2009 |
Felipe Knop, Lagrangeville, NY US
Patent application number | Description | Published |
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20080270823 | FAST NODE FAILURE DETECTION VIA DISK BASED LAST GASP MECHANISM - A method for communicating node liveness in a multinode data processing system employs an operating system function that provides a degree of self-awareness in “sensing” an imminent but still pending failure as the basis for providing special flag signals over a channel which employs nonvolatile storage in a heartbeat signaling path. | 10-30-2008 |
20090245518 | SECURE COMMUNICATIONS IN COMPUTER CLUSTER SYSTEMS - A system to improve communication security in cluster machine processing may include interconnected computers that can jointly process data. The system may also include a shared secret key used by each of the interconnected computers to encrypt, decrypt, and/or authenticate data being sent, or received, from one of the interconnected computers to another of the interconnected computers. The system may further include a new shared secret key used by each of the interconnected computers to encrypt, decrypt, and/or authenticate data being sent, or received, from one of the interconnected computers to another of the interconnected computers. In addition, the new shared secret key may coexist with the shared secret key without adversely affecting the joint processing of data performed by the plurality of interconnected computers. | 10-01-2009 |
20110258306 | Lock acquisition among node of divided cluster - The acquisition of a lock among nodes of a divided cluster is disclosed. A method is performable by each of at least one node of the cluster. A node waits for a delay corresponding to its identifier. The node asserts intent to acquire the lock by writing its identifier to X and Y variables where another node has failed to acquire the lock. The node waits for another node to acquire the lock where the other node has written to X, and proceeds where Y remains equal to its own identifier. The node waits for another node to acquire the lock where the other node has written to a Z variable, and writes its own identifier to Z and proceeds where the other node has failed. The node writes a value to Y indicating that it is acquiring the lock, and maintains acquisition by periodically writing to Z. | 10-20-2011 |
Gregory H. Knop, Nevada, IA US
Patent application number | Description | Published |
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20110283881 | CYLINDER BLOCK ASSEMBLY FOR A HYDRAULIC DEVICE - A cylinder block assembly for a hydraulic device. The cylinder block assembly includes a cylinder block with a plurality of piston bores disposed therethrough. Circumferential grooves are disposed around the piston bore such that an elastic bushing may be disposed within the piston bore using a slip fit so that when the elastic material deforms the material deforms into the circumferential groove. By deforming into the circumferential groove the elastic bushing is locked in place and axial movement of the bushing in the bore is prevented. | 11-24-2011 |
Jacek M. Knop, Owego, NY US
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20090188804 | Plating method - Methods for depositing a metal or metal alloy on a substrate and articles made with the methods are described. The metal or metal alloy is deposited on the substrate electrolytically. The current is periodically interrupted during deposition to improve throwing power and reduce nodule formation on the metal or metal alloy deposit. | 07-30-2009 |
Richard H. Knop, Beach Park, IL US
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20120214252 | COMPOSITION, DEVICE AND METHOD FOR COLORIMETRIC DETECTION OF AN ANALYTE USING IMPRINTED POLYMERS AND PHOTOCHROMIC SWITCH MOLECULES - The invention provides various compositions, devices, and methods useful for detecting an analyte by colorimetric readout. The compositions and devices include polymers constructed to have pores specifically imprinted to provide for capture of an analyte in the pores; nanoparticles layered on the polymers; and photochromic optical switch molecules coated on the nanoparticles. Capture of the analyte in the pores of the polymer results in a change in the spatial relation of the nanoparticles layered on the polymer, which in turn causes the photochromic optical switch molecules coated thereon to undergo a change in energy state corresponding to a visible change in the optical spectra of the photochromic optical switch molecules. | 08-23-2012 |
20140242722 | ARTICLE AND METHOD FOR DETECTION OF A DRUG IN A LIQUID MEDIUM - An article is provided for the detection of a drug in a liquid medium. The article includes a polymer having pores specifically imprinted to provide for capture of a drug in the pores, nanoparticles, and photochromic optical switch molecules. Capture of the drug in the pores of the polymer results in a change in the spatial relation of the nanoparticles in the polymer, causing the photochromic optical switch molecules to undergo a change in energy state which corresponds to a change in spectra of the photochromic optical switch molecules, thereby providing for detection of the drug. | 08-28-2014 |
Robert Knop, Fremont, CA US
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20080289967 | SUBSTRATE GRIPPER WITH INTEGRATED ELECTRICAL CONTACTS - A substrate holding and transporting assembly is disclosed. The substrate holding and transporting assembly includes a base plate and a pair of clamps connected to the base plate in a spaced apart orientation, the spaced apart orientation of the pair of clamps enable support of a substrate with at least two independent points. The substrate holding and transporting assembly also includes an electrode assembly connected to the base plate at a location that is substantially between the pair of clamps. The electrode assembly defined to impart an electrical contact to the substrate when present and held by the pair of clamps. | 11-27-2008 |
Steve Knop, Maple Grove, MN US
Patent application number | Description | Published |
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20110054249 | APPARATUS, SYSTEM AND METHOD OF MINIMALLY INVASIVE REPAIR OF PELVIC ORGAN PROLAPSE - A system for repair of a prolapsed organ in a patient includes a support and a deployment instrument having a handle extending from a barrel and a trigger offset from the handle, the trigger is operable to advance the support out of the barrel of the deployment instrument and into the patient. | 03-03-2011 |
20130079587 | SYNTHETIC URETHRA WITH CLOSURE DEVICE - An incontinence treatment device includes a section of synthetic urethra and a closure device attached to the section of synthetic urethra. The section of synthetic urethra provides a flow diameter and is configured to be spliced into a natural urethra such that the flow diameter is aligned with a lumen of the natural urethra for passage of urine. The closure device is attached to the section of synthetic urethra and operable to coapt the flow diameter to allow a user to impede the passage of urine and be continent. | 03-28-2013 |
20130079588 | SYNTHETIC URETHRA AND CLOSURE DEVICE ATTACHABLE AROUND THE SYNTHETIC URETHRA - An incontinence treatment device includes a synthetic urethra and a cuff separate from the synthetic urethra. The synthetic urethra provides a flow diameter that is configured to be spliced into a natural urethra such that the flow diameter is aligned with a lumen of the natural urethra for passage of urine. A closure device includes a pump communicating between a reservoir and the cuff. The cuff is attachable around an outer circumference of the synthetic urethra. The pump is operable to move a liquid from the reservoir to inflate the cuff, the inflated cuff adapted to circumferentially compress and constrict the flow diameter of the synthetic urethra. | 03-28-2013 |