Patent application number | Description | Published |
20090093414 | Hyaluronic Acid-Methotrexate Conjugate - An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group. | 04-09-2009 |
20110051076 | SPECTACLES-TYPE IMAGE DISPLAY DEVICE - A spectacles-type image display device having an image output unit that includes a display element that displays images and is disposed on a spectacle frame and a reflection unit that is disposed adjacent to at least one of spectacle lenses and reflects the image light that is output from the image output unit toward the eyeball so that the viewer can see a virtual image of the image is provided. The reflection unit is a reflection member having a positive refractive power and an effective luminous flux that is output from the image output unit and reaches the eyeball of the viewer is configured so that the width of the luminous flux perpendicular to an optical axis is minimum at the reflection unit with respect to the optical axis cross-section parallel to an incident surface of the optical axis relative to the reflection unit. | 03-03-2011 |
20110182940 | METHOD FOR PRODUCING PURIFIED INFLUENZA VIRUS ANTIGEN - The present invention aims to provide a method which enables efficient removal of impurities such as the host proteins from an influenza virus culture liquid by a simple operation, allowing separation and purification of an influenza virus antigen. | 07-28-2011 |
20110245276 | PHOTOSTABILIZED PHARMACEUTICAL COMPOSITIONS - A crosslinking reaction and a reaction for reducing molecular weight that take place in a hyaluronic acid-methotrexate conjugate upon irradiation with light are suppressed to improve the photostability of the conjugate. Specifically, a substance having a quenching effect and/or a radical scaveng effect is added to a pharmaceutical composition containing the hyaluronic acid-methotrexate conjugate. | 10-06-2011 |
20130134301 | PRISM OPTICAL SYSTEM, AND IMAGE DISPLAY APPARATUS AND IMAGING APPARATUS INCORPORATING THE PRISM OPTICAL SYSTEM - The invention provides a prism optical system comprising at least four optical surfaces, each having optical functions. At least two of the four optical surfaces are each a rotationally asymmetric surface, and one of two surfaces on which light is incident or from which light exits out is capable of one transmission and two internal reflections. | 05-30-2013 |
20130182317 | PRISM OPTICAL SYSTEM, AND IMAGE DISPLAY APPARATUS AND IMAGING APPARATUS INCORPORATING THE SAME - The invention provides a prism optical system includes a prism in which a space formed by at least two optical surfaces mutually decentered with respect to an axial chief ray of an incident light beam is filled up with a medium having a refractive index of greater than 1. At least two optical surfaces are rotationally asymmetric surfaces, five internal reflections take place inside the prism, and there is an intermediate image formed inside the prism, which image is in turn formed outside the prism. | 07-18-2013 |
20140138426 | WIRE BONDING APPARATUS AND BONDING METHOD - Provided is a wire bonding apparatus capable of performing high-speed wedge wire bonding, the apparatus including: a bonding tool having a through hole and a pressing surface for pressing a wire; a clamper for holding the wire; and a control unit. The control unit includes: wire tail extension unit that moves the bonding tool, after wedge bonding of the wire to a first lead, upward and along a second straight line connecting a second pad and a second lead, and causes the wire to extend from the through hole in a direction along the second straight line from the second pad to the second lead; and tail cut unit that, after causing the wire tail to extend, cuts the wire tail by moving the bonding tool in the direction along the second straight line connecting the second pad and the second lead while the clamper is closed. | 05-22-2014 |
20140297637 | THREE-DIMENSIONAL TIME SERIES DATA - A system, device, computer program product, and/or method generates display data that allows a user to ascertain relationship between related electronic information from among sent and received electronic information. The three-dimensional time series data processing system selects one electronic information, extracts electronic information relating to the selected electronic information from the electronic information, calculates relevance between the sender of the selected electronic information and the sender of the extracted electronic information, and generates three-dimensional time series data for three-dimensionally rending a relationship between the selected electronic information and the extracted electronic information as positional information of the respective extracted electronic information in a virtual three-dimensional space, where the sender, the send time and the relevance are axes. In addition, the three-dimensional time series data processing system renders three-dimensional time series data for relevance of electronic information in cylindrical coordinates and displays the data while modifying a viewing angle. | 10-02-2014 |
20150087083 | BONDING APPARATUS AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - Provided is a flip-chip bonding apparatus ( | 03-26-2015 |