Kolmar
Harald Kolmar, Muhltal DE
Patent application number | Description | Published |
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20090130692 | Use of microproteins as tryptase - Disclosed are uses of microproteins preferably microproteins forming a cystine knot (i.e. belonging to the family of inhibitor cystine knot (ICK) polypeptides) or polynucleotides encoding said microproteins for the preparation of a pharmaceutical composition for treating or preventing a disease that can be treated or prevented by inhibiting the activity of tryptase as well as corresponding methods of treatment. Also disclosed are uses of the microproteins for inhibiting tryptase activity, for purifying tryptase, as a carrier molecule for tryptase and for deleting or quantifying tryptase in a sample, including corresponding diagnostic applications. Furthermore disclosed are fusion proteins comprising an inactive barnase as well as fusion proteins comprising barnase and a microprotein. Also encompassed are nucleic acid molecules encoding such a fusion protein, as well as corresponding vectors, host cells, preparation methods and uses of the fusion protein. Moreover, the present application discloses a crystal of a microprotein fused with barnase, preferably inactive barnase. The disclosure also refers to corresponding preparation methods for the crystal, structure analysis methods using the crystal data storage media comprising the structure data obtained, as well as to in silico methods using the structure data for characterizing the binding of microproteins to target molecules. Furthermore, disclosed are pharmaceutical compositions comprising the crystal and corresponding medical uses. | 05-21-2009 |
20090156476 | Dimeric or Multimeric Microproteins - Disclosed is a polypeptide comprising at least two microproteins, which preferably comprise an amino acid sequence having a specific binding activity to a target protein. Furthermore, disclosed are polynucleotides encoding such a polypeptide as well as pharmaceutical compositions and kits comprising said polypeptide or polynucleotide. Also disclosed herein are methods of treatments and second medical uses applying the disclosed polypeptide or polynucleotide. Additionally, the disclosure of the present application relates to a method for forming a covalent bond in a microprotein which can be used for producing the disclosed polypeptides. | 06-18-2009 |
20100267610 | Polypeptide comprising a knottin protein moiety - A polypeptide, with an amino acid sequence different from that of knottin protein, having a scaffold moiety with a helix moiety inserted in the scaffold moiety is described. The scaffold moiety comprises a knottin protein, or a fragment of knottin protein. | 10-21-2010 |
Harald Kolmar, Muehltal-Trautheim DE
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20140357514 | GENERAL STRATEGY FOR ANTIBODY LIBRARY SCREENING - A generally applicable method for the selective covalent attachment of a reporter molecule to a replicating entity that allows one to obtain specific binders from a single round of library screening is disclosed. For example, selective biotinylation of phage particles and yeast cells displaying a binder to any given target can be achieved via application of a coupled enzyme reaction that includes a peroxidase, an oxidase and a catalase. | 12-04-2014 |
Oliver Kolmar, Neubiberg DE
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20090306826 | Vibrating Plate System - A vibrating plate system comprises at least two vibrating plates are mechanically coupled to one another via a coupling device and a controlling transmitter for outputting control data to the vibrating plates. Each of the vibrating plates comprises a receiving device for receiving the control data, a drive mechanism for propelling the vibration plate forwardly and rearwardly, and a position determining device for determining the position of the relevant vibrating plate within the group. A rule memory is also provided in which control rules are stored. One control rule defines a correlation between a control measure for controlling the traveling mechanism according to the position of the vibrating plate and an item of control information given by the control data. In each vibrating plate, a single control device selects a suitable control rule according to the position of the vibrating plate and to the control measure. | 12-10-2009 |
20100254769 | Tamping Device - A vibrating plate serving as a tamping device comprises an upper mass ( | 10-07-2010 |
20100303546 | Soil Compacting Device with Automatic or Operator-Intuitive Adjustment of the Advance Vector - A vibrating plate comprises a vibration generator device, which can be controlled in such a manner that the direction of the action of force can be set at a number of locations, particularly in more than two locations. In addition, an advance adjusting device is provided for controlling the vibration generator device whereby the direction of the action of force is set in a position in which a maximum possible advance of the vibrating plate is reached. The direction of the action of force can be changed according to a change in the surroundings of the vibrating plate, particularly to the slope and/or the hardness of a subsoil to be compacted by a soil contact plate. Alternatively, the direction of the action of force can be changed according to the wishes of the operator. | 12-02-2010 |
Rainer Kolmar, Hoerdt DE
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20140127002 | MULTI-STAGE TURBOCHARGER ARRANGEMENT - A multi-stage turbocharger arrangement (TLA), having a high-pressure stage, the high-pressure turbine of which has an associated first bypass valve; and having a low-pressure stage which is arranged downstream as viewed in the flow direction of the exhaust gases and which has a low-pressure turbine and a second bypass valve, wherein at least one of the bypass valves is arranged in an associated, cooled housing module. | 05-08-2014 |