Kralj
Ales Kralj, Ljubljana SI
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20120156455 | GAS FILLED INSULATION CONSTRUCTION PANEL - A gas filled panel (GFP) intended for general use, especially in construction, mostly in prefabricated building envelopes, i.e., integrated facades. A panel of the first embodiment is characterized in that it is a two- or more-chamber panel made of at least approximately plan parallel chambers with a mutual distance larger than or equal 8 mm, preferably between 8 and 12 mm, filled with insulation gas, which is a binary or ternary mixture of gases from hydro-fluorocarbons (HFC), carbon dioxide and argon and the mixture has an average molecular mass higher than 50 and lower than 71. A panel of the second embodiment is characterized in that it is a three- or more-chamber panel made of at least approximately plan parallel chambers with a mutual distance larger than or equal 18 mm, preferably between 18 and 22 mm, filled with insulation gas, or a mixture of gases having an average molecular mass higher than 38 and lower than 50. | 06-21-2012 |
20130202845 | BUILDING PANEL AS STRUCTURE OF OUTER AND INNER PLATE WITH INTERMEDIATE INSULATION SPACE - The building panel is structure of outer ( | 08-08-2013 |
20140161999 | MULTI CHAMBER FILLED CONSTRUCTION PANEL - A Multi Chamber gas filled building panel is structured of essentially planar parallel inner ( | 06-12-2014 |
Jason Kralj US
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20100089757 | GRADIENT ELUTION ELECTROPHORESIS AND DETECTORLESS ELECTROPHORESIS APPARATUS - A microfluidic apparatus and method for performing electrophoretic separation of compounds. The apparatus comprises: a) A first container for containing a sample fluid; b) a second container for containing a separation buffer fluid; c) a channel of a first length having an inlet end and an outlet end, the inlet end connected to the first container and the outlet end connected to the second container; d) a voltage device electrically connected to the first container and the second container, the voltage device facilitating adjustment of the amount of voltage to the first container and the second container; e) a controller for controlling the velocity flow of the sample fluid through the channel from the first container towards the second container; and f) a measuring device for measuring the current through the channel. The method comprises the steps of: a) providing a separation buffer; b) providing a sample solution in fluid contact with the separation buffer; c) applying an electric field to the separation buffer; and d) producing a variable bulk flow of the separation buffer in a direction substantially aligned with said electric field. Fluid contact between the separation buffer and the sample solution is made through a separation column having a length in the range of from approximately 0.01 mm to approximately 5 mm. By the foregoing, compounds can be sequentially detected and quantified. | 04-15-2010 |
Jason G. Kralj, Washington, DC US
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20090282978 | Microfluidic Separators for Multiphase Fluid-Flow Based On Membranes - One aspect of the invention relates to fluid-phase separators and devices containing them. Another aspect of the invention relates to the use of said fluid-phase separators and devices containing them for separating individual phases from gas-liquid and liquid-liquid two-phase mixtures for a range of flow regimes. The present invention also relates to methods of making said fluid-phase separators and devices containing them. | 11-19-2009 |
Joel Kralj, Somerville, MA US
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20140295413 | SYSTEMS, METHODS, AND WORKFLOWS FOR OPTOGENETICS ANALYSIS - The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology. | 10-02-2014 |
Joel Kralj, Louisville, CO US
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20150285820 | OPTOGENETIC PROBES FOR MEMBRANE POTENTIAL - The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determine agents that can affect membrane potential of a target cell. | 10-08-2015 |
Joel M. Kralj, Somerville, MA US
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20130224756 | OPTOGENETIC PROBES FOR MEASURING MEMBRANE POTENTIAL - The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determine agents that can affect membrane potential of a target cell. | 08-29-2013 |
Marijeta Kralj, Zagreb HR
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20110257254 | Adamantane Derivatives Of Aza-Crown Ethers And Their Use In Treatment Of Tumor - The invention relates to adamantane diaza-crown ether derivatives and the use of mono and diaza-crown ether adamantine derivatives in treatment, especially in tumor treatment. Adamantane aza-crown ethers were obtained by reaction of the corresponding adamantane derived tosylates or adamantane acid chlorides with mono- and diaza-18-crown-6. The prepared compounds showed moderate (monoaza-18-crown-6) to strong (diaza-18-crown-6) antiproliferative and cytotoxic activity on several tumor cell lines, revealing their potential for inhibiting the growth of other tumor cells. | 10-20-2011 |
Marko Kralj, Polzela SI
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20110011120 | Refrigerator Cooling System - The present invention refers to an improved cooling system for a refrigerator, preferably a domestic refrigerator, comprising a cell in which is located at least one compartment for the storage of food below freezing point, with said compartment being cooled using at least one wire tube evaporator arranged on at least one wall of said cell. It is provided for according to the invention that a wire tube evaporator ( | 01-20-2011 |
Milos Kralj, Bellevue, WA US
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20140372356 | PREDICTIVE PRE-LAUNCH FOR APPLICATIONS - Systems and methods of pre-launching applications in a computer system, said applications being likely to be activated by a user from a terminated and/or suspended process state, are disclosed. The pre-launching of an application may be based on the assessed probability of the application being activated—as well as the level of availability of system resources to affect such pre-launching. Applications may be pre-launched based on these and other conditions/considerations, designed to improve the user's experience of a quick launch of applications in the background. Several prediction models are presented to provide a good estimate of the likelihood of an application being activated by a user. Such prediction models may comprise an adaptive predictor (based on past application usage situations) and/or a switch rate predictor (based on historic data of an application being switched and, possibly, having a decay rate applied to such switch rate measure). | 12-18-2014 |
20140373032 | PREFETCHING CONTENT FOR SERVICE-CONNECTED APPLICATIONS - Systems and methods of pre-fetching data for applications in a computer system that are terminated or suspended and may be pre-launched by the computer system are disclosed. The applications may employ data that is remote from the computer system and available from a third party content resource. A method for pre-fetching such remote data comprises associating a set of application with such data and/or its location; determining a set of pre-fetching conditions, determining which applications may be pre-fetched and pre-fetching the data, if pre-fetch conditions meet a desired pre-fetch policy. A predictive module or technique may be used to identify those applications which may be pre-launched. The present system may comprise a pre-fetch success module capable of measuring the success data for a current pre-fetch and associating such success data with an application to improve future pre-fetches. | 12-18-2014 |
Petra Kralj, Ljubljana SI
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20130338131 | PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION COMPRISING A LOW SOLUBLE PHARMACEUTICALLY ACTIVE INGREDIENT - The present invention belongs to the field of pharmaceutical industry and relates to a process for preparing a pharmaceutical composition comprising a pharmaceutically active ingredient (API) that is poorly soluble in water, a pharmaceutical composition obtained according to said process, to a dosage form comprising said pharmaceutical composition and to the use of said dosage forms for the treatment of hypercholesterolemia. | 12-19-2013 |
Slavko Kralj, Oestgeest NL
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20130143301 | BETA-GLUCOSIDASE I VARIANTS WITH IMPROVED PROPERTIES - The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase variants, compositions comprising beta-glucosidase variants, methods of using beta-glucosidase variants, and methods of identifying additional useful beta-glucosidase variants. | 06-06-2013 |
Slavko Kralj, Oegstgeest NL
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20120135500 | CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND STABILITY, AND USE THEREOF - The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof. | 05-31-2012 |
20120165290 | GLUCOOLIGOSACCHARIDES COMPRISING (ALPHA 1->4) AND (ALPHA 1->6) GLYCOSIDIC BONDS, USE THEREOF, AND METHODS FOR PROVIDING THEM - The invention relates to the field of poly- and oligosaccharides and their nutritional effects. In particular, it relates to the application of α-glucanotransferases in methods for preparing dietary fibers, including prebiotic oligosaccharides, and to novel oligosaccharides obtainable thereby. Provided is a method for producing a mixture of gluco-oligosaccharides having one or more consecutive (α1→6) glucosidic linkages and one or more consecutive (α1→4) glucosidic linkages, comprising contacting a poly- and/or oligosaccharide substrate comprising at least two (α1→4) linked D-glucose units with an ?-glucanotransferase capable of cleaving (α1→4) glucosidic linkages and making new (α1→4) and (α1→6) glucosidic linkages. Also provided are (isolated) gluco-oligosaccharides obtainable thereby, and their application in nutritional and cosmetic compositions. | 06-28-2012 |
20140302585 | CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND STABILITY, AND USE THEREOF - The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof. | 10-09-2014 |
Tomislav Kralj, Chardon, OH US
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20140077722 | LED Lamp System - Disclosed is an LED lamp system designed to fit into a fluorescent lamp fixture and to utilize a fluorescent lamp power supply contained in the fixture and receiving power from AC mains. The LED lamp system includes an LED driver which comprises a power factor corrected driver circuit for achieving a power factor of at least about 0.8. The LED driver further comprises a current control circuit, responsive to the presence of a three-wire magnetic ballast in the fluorescent lamp power supply, for increasing the LED operating current above the nominal rated LED operating current and to a level sufficient to achieve power factor of the LED driver of at least about 0.8. | 03-20-2014 |