Patent application number | Description | Published |
20120015343 | METHODS FOR INCREASING ISOLATION YIELDS OF CELLULAR PRODUCTS - Methods of isolating cellular products, such as pancreatic islets, may be used in diabetes research and therapeutic transplantation. The methods may involve providing a donor tissue having desired cells and undesired cells, perfusing the donor tissue with a perfusion solution, developing edema during perfusion of the donor tissue to form a swelled tissue, and separating the desired cells from undesired cellular material to obtain a cellular product. The methods may also include disrupting the tissue, and separating the desired cells from undesired cellular material to obtain the cellular product. The methods may result in an increased yield of cellular product that retains sufficient functional integrity to be useful as a transplantation resource. | 01-19-2012 |
20120148542 | MACHINE PERFUSION WITH COMPLEMENT INHIBITORS - Methods for perfusing one or more organs, tissues or the like (hereinafter “organs”) with a composition comprising at least one complement inhibitor to sustain, maintain or improve the viability of the organs before and/or during transplantation. | 06-14-2012 |
20120276519 | CANNULA - Disclosed is a cannula including a first clamping portion, a second clamping portion and a force applying portion configured to apply at least two different clamping forces across the first clamping portion and the second clamping portion when the cannula is in a closed state. The first clamping portion includes a first gear, the second clamping portion includes a second gear, and the first gear and the second gear are in meshing engagement. | 11-01-2012 |
20120276620 | PORTABLE ORGAN TRANSPORTATION SYSTEM - Disclosed is portable organ transportation system including a mobile cart and an organ container. At least one of the mobile cart and the organ container include a latch for releasably attaching the organ container to the mobile cart. The organ container may be a portable organ preservation device or a portable organ perfusion apparatus. | 11-01-2012 |
20120277681 | Living Donor Cannula - A cannula includes a first circumferential portion, a second circumferential portion, and a seal with a first clamping surface. The first circumferential portion and the second circumferential portion are configured to mutually cooperate to support a circumference of vasculature, and form a second clamping surface. The first clamping surface and the second clamping surface are configured to cooperate to secure an end of the vasculature. | 11-01-2012 |
20120277687 | LIVING DONOR CANNULA - Disclosed is a cannula including a first circumferential portion, a second circumferential portion, and a seal with a first clamping surface. The first circumferential portion and the second circumferential portion are configured to mutually cooperate to support a circumference of vasculature, and form a second clamping surface. The first clamping surface and the second clamping surface are configured to cooperate to secure an end of the vasculature. | 11-01-2012 |
20120315618 | ASSESSING, MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS/TISSUES - Methods for ex vivo perfusion of organs (and/or tissues) with a perfusate designed to condition the organ with the desired effect being that upon transplant, said organ, having been administered said perfusate, is less likely to experience delayed graft function, deleterious effects of ischemia/reperfusion injury, including inflammatory reactions, and/or other detrimental responses that can injure the organ or recipient including precipitating or enhancing an immunological reaction from the recipient with the potential of compromising the graft's and/or recipients short teen and/or long term health and proper functionality while monitoring, sustaining and/or restoring the viability of the organ and preserving the organ for storage and/or transport. | 12-13-2012 |
20140017657 | ORGAN TRANSPORT APPARATUS WITH SAMPLE COMPARTMENTS - An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a coolant container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment. | 01-16-2014 |
20140017662 | ORGAN PERFUSION APPARATUS WITH DOWNSTREAM FLOW CONTROL - An organ perfusion apparatus may include at least two tubes connected to an organ or tissue. A method of perfusing an organ or tissue may include connecting a first end of each of the at least two tubes to an organ or tissue, applying a fluid motive force to a perfusion fluid in the two tubes to force the fluid through the two tubes into the organ or tissue, and perfusing the organ or tissue through the at least two tubes such that the fluid motive force, provided by, e.g., a pump, and backpressure generated by the organ or tissue, establishes a flow balance between the at least two tubes. The flow balance may be altered without altering the fluid motive force that is applied. | 01-16-2014 |
20140017664 | TEMPERATURE SENSING IN ORGAN PRESERVATION APPARATUS - A temperature sensor for monitoring an organ or tissue is configured to measure a temperature inside of a container configured to contain the organ or tissue. The temperature sensor is disposed exterior to the organ container and the temperature sensor is a non-contact temperature sensor. The temperature sensor may be part of an apparatus for perfusing, transporting, and/or storing an organ or tissue. A coolant container may have an aperture through which the temperature sensor measures a temperature of at least one of the organ or tissue or a perfusate fluid surrounding the organ or tissue. The temperature sensor is preferably an infrared temperature sensor. Multiple temperature sensors may be provided that measure the temperature organ or tissue or perfusate fluid surrounding the organ or tissue, for example in case one of the temperature sensors fails. | 01-16-2014 |
20140017665 | ORGAN TRANSPORTER WITH OXYGEN GENERATION - An apparatus for perfusing an organ or tissue includes a perfusion circuit for perfusing the organ or tissue; an oxygenator for oxygenating perfusate that circulates through the perfusion circuit; and an oxygen supply device such as an oxygen concentrator or an oxygen generator configured to supply oxygen to the oxygenator. A method of perfusing an organ or tissue includes producing oxygen from a device such as an oxygen concentrator and an oxygen generator; supplying the produced oxygen, preferably as the oxygen is produced, to a perfusate to oxygenate the perfusate; and perfusing the organ or tissue with the oxygenated perfusate. The produced oxygen preferably has a concentration greater than the oxygen concentration in air. | 01-16-2014 |
Patent application number | Description | Published |
20120072231 | METHODS, SYSTEMS, AND APPARATUS FOR OPTIMIZING EFFECTS OF TREATMENT WITH MEDICATION USING MEDICATION COMPLIANCE PATTERNS - Methods, systems, and apparatus monitor medication usage data for one patient or a population of patients, which can be processed to determine compliance patterns. Such methods and systems can associate, analyze, organize and present medication usage data, compliance patterns, and correlations between compliance patterns and outcomes data for electronic analysis or analysis by a caretaker. Such methods, systems, and apparatus permit analysis of compliance patterns to enable, for example, establishment or adjustment of safe and effective treatment regimens. | 03-22-2012 |
20120203573 | METHODS, SYSTEMS, AND APPARATUS FOR OPTIMIZING EFFECTS OF TREATMENT WITH MEDICATION USING MEDICATION COMPLIANCE PATTERNS - Methods, systems, and apparatus monitor medication usage data for one patient or a population of patients, which can be processed to determine compliance patterns. Such methods and systems can associate, analyze, organize and present medication usage data, compliance patterns, and correlations between compliance patterns and outcomes data for electronic analysis or analysis by a caretaker, Such methods, systems, and apparatus permit analysis of compliance patterns to enable, for example, establishment or adjustment of safe and effective treatment regimens, and may include feedback systems for ensuring authenticity of medication and/or effects of medication on a patient. | 08-09-2012 |
20130177897 | TRANSPORTATION BAG FOR USE WITH AN ORGAN TRANSPORTER - A bag includes an organ transporter compartment to contain an organ transporter disposed in the transporter compartment. The bag may include openings to access portions of the organ transporter, such as a battery or power cable, when the organ transporter is disposed in the bag. The bag may also include a frame and handles. The handles may include structure adapted to mate with handles on the organ transporter. The bag may also include a single cover that provides access to multiple compartments with their own internal covers. Also, the bag may include windows to view documents stored in the bag and/or to view and/or display control panels on the organ transporter. | 07-11-2013 |
20140272923 | TRANSPORTER WITH A GLUCOSE SENSOR FOR DETERMINING VIABILITY OF AN ORGAN OR TISSUE - An apparatus for perfusing an organ or tissue includes a perfusion circuit for perfusing the organ or tissue with a perfusate; and a sensor operatively connected to the perfusion circuit. The sensor includes a solid support to which is attached a recognition molecule that permits detection of the target agent. The recognition molecule specifically binds to the target agent in the presence of the target agent but not significantly to other agents. The sensor also includes an enzyme that can catalyze the conversion of a substance to glucose. In the presence of the target agent the enzyme can convert the substance into glucose, which can then be detected and optionally measured by the sensor. | 09-18-2014 |
20140278468 | APPARATUS AND METHOD FOR OPTIMIZING TREATMENT USING MEDICATION COMPLIANCE PATTERNS AND GLUCOSE SENSOR - Methods and apparatus monitor medication usage data for one patient or a population of patients, which can be processed to determine compliance patterns. Such methods and systems can associate, analyze, organize and present medication usage data, compliance patterns, and correlations between compliance patterns and outcomes data for electronic analysis or analysis by a caretaker. Such methods and apparatus permit analysis of compliance patterns to enable, for example, establishment or adjustment of safe and effective treatment regimens, and may include feedback systems for ensuring authenticity of medication and/or effects of medication on a patient. Such methods and apparatus also permit detection of medication in a biological sample of the patient through a medication monitor having a detection device, such as a skin-prick device, and a glucose sensor that can detect a target agent in the biological sample. | 09-18-2014 |
Patent application number | Description | Published |
20100221696 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 09-02-2010 |
20110039253 | APPARATUS AND METHOD FOR MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 02-17-2011 |
20110053256 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 03-03-2011 |
20110059429 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 03-10-2011 |
20110129810 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 06-02-2011 |
20110129908 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 06-02-2011 |
20110183310 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 07-28-2011 |
20110300611 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 12-08-2011 |
20110300612 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 12-08-2011 |
20110300613 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 12-08-2011 |
20110300614 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 12-08-2011 |
20110300615 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 12-08-2011 |
20130109006 | APPARATUS AND METHOD FOR MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS | 05-02-2013 |
20160042084 | APPARATUS AND METHOD FOR MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS - Methods of monitoring, maintaining, and/or restoring viability of at least one organ in a perfusion apparatus are disclosed. The methods include monitoring data comprising information relating to events occurring while at least one organ is present in a perfusion apparatus to form a data record. And they further include connecting the perfusion apparatus to a network through wiring or wirelessly, and continuously uploading the data record to a database at a location away from the perfusion apparatus in such a manner that a database computer that obtains the data record from the database can at least one of manage, track, monitor, and diagnose the at least one organ in the perfusion apparatus in real-time based upon the information in the data record. | 02-11-2016 |
Patent application number | Description | Published |
20090025061 | CONDITIONAL PEER-TO-PEER TRUST IN THE ABSENCE OF CERTIFICATES PERTAINING TO MUTUALLY TRUSTED ENTITIES - A method, apparatus, and electronic device for protecting digital rights are disclosed. A network interface may receive a rights representation for a set of digital content from a source entity. A processor may conditionally accept the set of digital content. A memory may store a local blacklist identifying the source entity if a rights event occurs. | 01-22-2009 |
20100306548 | SYSTEM AND METHOD FOR SECURING THE LIFE-CYCLE OF USER DOMAIN RIGHTS OBJECTS - In a method for enabling support for backwards compatibility in a User Domain, in one of a Rights Issuer (RI) and a Local Rights Manager (LRM), a Rights Object Encryption Key (REK) and encrypted REK are received from an entity that generated a User Domain Authorization for the one of the RI and the LRM and the REK is used to generate a User Domain Rights Object (RO) that includes the User Domain Authorization and the encrypted REK. | 12-02-2010 |
20110083189 | SYSTEM AND METHOD FOR ENFORCING DIGITAL RIGHTS MANAGEMENT RULES - A method for enforcing digital rights management (DRM) rules in a first device is disclosed. In the method the first device receives a message that includes a rights object (RO) having a digital signature, directly from a source device. The first device determines an identity of a signing entity from the message including the RO having the digital signature. The signing entity is an entity that digitally signed the RO. The first device processes the message including the RO having the digital signature using the identity of the signing entity and an information state to enforce DRM rules in the first device. | 04-07-2011 |
20110161147 | STIMULUS/RESPONSE-BASED BINDING OF IDENTIFIERS ACROSS INFORMATION DOMAINS WHILE MAINTAINING CONFIDENTIALITY - Disclosed are methods for extracting and using information about an entity that has a presence in a number of information domains. The entity has separate identifiers in each of several domains. Various techniques are described that bind together the identifiers of the entity across the domains. The results of the binding are provided to an interested party that can review information extracted about the entity's behavior in the multiple domains. The interested party is not given access to information that would compromise the confidentiality of the entity. A trusted broker has access to information about the behavior of the entity in the several domains. The broker analyzes that information and provides the analysis to the interested party, again without compromising the confidentiality of the entity. An “incentivizer” works with the broker to extract from the domains information that would be useful in binding together the different identifiers of the entity. | 06-30-2011 |
20110161471 | INCENTING DIVULGENCE OF INFORMATION FOR BINDING IDENTIFIERS ACROSS INFORMATION DOMAINS WHILE MAINTAINING CONFIDENTIALITY - Disclosed are methods for extracting and using information about an entity that has a presence in a number of information domains. The entity has separate identifiers in each of several domains. Various techniques are described that bind together the identifiers of the entity across the domains. The results of the binding are provided to an interested party that can review information extracted about the entity's behavior in the multiple domains. The interested party is not given access to information that would compromise the confidentiality of the entity. A trusted broker has access to information about the behavior of the entity in the several domains. The broker analyzes that information and provides the analysis to the interested party, again without compromising the confidentiality of the entity. An “incentivizer” works with the broker to extract from the domains information that would be useful in binding together the different identifiers of the entity. | 06-30-2011 |
20110161472 | CLIENT-BASED BINDING OF IDENTIFIERS ACROSS INFORMATION DOMAINS WHILE MAINTAINING CONFIDENTIALITY - Disclosed are methods for extracting and using information about an entity that has a presence in a number of information domains. The entity has separate identifiers in each of several domains. Various techniques are described that bind together the identifiers of the entity across the domains. The results of the binding are provided to an interested party that can review information extracted about the entity's behavior in the multiple domains. The interested party is not given access to information that would compromise the confidentiality of the entity. A trusted broker has access to information about the behavior of the entity in the several domains. The broker analyzes that information and provides the analysis to the interested party, again without compromising the confidentiality of the entity. An “incentivizer” works with the broker to extract from the domains information that would be useful in binding together the different identifiers of the entity. | 06-30-2011 |
20110161473 | ANALYTICS-BASED BINDING OF IDENTIFIERS ACROSS INFORMATION DOMAINS WHILE MAINTAINING CONFIDENTIALITY - Disclosed are methods for extracting and using information about an entity that has a presence in a number of information domains. The entity has separate identifiers in each of several domains. Various techniques are described that bind together the identifiers of the entity across the domains. The results of the binding are provided to an interested party that can review information extracted about the entity's behavior in the multiple domains. The interested party is not given access to information that would compromise the confidentiality of the entity. A trusted broker has access to information about the behavior of the entity in the several domains. The broker analyzes that information and provides the analysis to the interested party, again without compromising the confidentiality of the entity. An “incentivizer” works with the broker to extract from the domains information that would be useful in binding together the different identifiers of the entity. | 06-30-2011 |
20110161474 | BROKERING INFORMATION ACROSS INFORMATION DOMAINS WHILE MAINTAINING CONFIDENTIALITY - Disclosed are methods for extracting and using information about an entity that has a presence in a number of information domains. The entity has separate identifiers in each of several domains. Various techniques are described that bind together the identifiers of the entity across the domains. The results of the binding are provided to an interested party that can review information extracted about the entity's behavior in the multiple domains. The interested party is not given access to information that would compromise the confidentiality of the entity. A trusted broker has access to information about the behavior of the entity in the several domains. The broker analyzes that information and provides the analysis to the interested party, again without compromising the confidentiality of the entity. An “incentivizer” works with the broker to extract from the domains information that would be useful in binding together the different identifiers of the entity. | 06-30-2011 |
20120007991 | METHOD AND APPARATUS FOR PROVIDING AND DETERMINING INTEGRITY OF VIDEO - A method and apparatus for providing and determining integrity of video is provided herein. During operation, a trusted unit such as a computer housed within a securable trunk of a vehicle generates or receives data on stimuli applied to a camera and receives video purportedly taken by that camera, as means for the trusted unit or an independent entity to determine if time periods of the stimuli correspond to responses seen or heard within the video. | 01-12-2012 |
20120284506 | METHODS AND APPARATUS FOR PREVENTING CRIMEWARE ATTACKS - A central server configured to mediate communications including establishing secure online sessions between user-controlled devices and 3 | 11-08-2012 |
20130035944 | PERSONALIZING COMMUNICATIONS BASED ON AN ESTIMATED SENSITIVITY LEVEL OF THE RECIPIENT - A “message broker” personalizes messages based on the recipient's estimated “privacy sensitivity.” By carefully estimating the sensitivity, the message broker can achieve the advantages of personalized messaging without incurring the disadvantages of offending or scaring away the recipient. In a first set of embodiments, messages are sent to a recipient, and information about the recipient's responses is collected and analyzed. The sensitivity level of the recipient is estimated based on this collected information. In a second set of embodiments, messages are sent that include an offer in which an incentive will be given to the recipient in exchange for allowing a certain type of access to specific information associated with the recipient. In a third set of embodiments, the message broker sends messages that request information associated with the recipient, but the messages do not include explicit offers to give incentives in exchange for the information. | 02-07-2013 |
20130036173 | PERSONALIZING COMMUNICATIONS USING ESTIMATES OF THE RECIPIENT'S SENSITIVITY LEVEL DERIVED FROM RESPONSES TO COMMUNICATIONS - A “message broker” personalizes messages based on the recipient's estimated “privacy sensitivity.” By carefully estimating the sensitivity, the message broker can achieve the advantages of personalized messaging without incurring the disadvantages of offending or scaring away the recipient. In a first set of embodiments, messages are sent to a recipient, and information about the recipient's responses is collected and analyzed. The sensitivity level of the recipient is estimated based on this collected information. In a second set of embodiments, messages are sent that include an offer in which an incentive will be given to the recipient in exchange for allowing a certain type of access to specific information associated with the recipient. In a third set of embodiments, the message broker sends messages that request information associated with the recipient, but the messages do not include explicit offers to give incentives in exchange for the information. | 02-07-2013 |
20130036174 | PERSONALIZING COMMUNICATIONS BASED ON AN ESTIMATED SENSITIVITY LEVEL OF THE RECIPIENT - A “message broker” personalizes messages based on the recipient's estimated “privacy sensitivity.” By carefully estimating the sensitivity, the message broker can achieve the advantages of personalized messaging without incurring the disadvantages of offending or scaring away the recipient. In a first set of embodiments, messages are sent to a recipient, and information about the recipient's responses is collected and analyzed. The sensitivity level of the recipient is estimated based on this collected information. In a second set of embodiments, messages are sent that include an offer in which an incentive will be given to the recipient in exchange for allowing a certain type of access to specific information associated with the recipient. In a third set of embodiments, the message broker sends messages that request information associated with the recipient, but the messages do not include explicit offers to give incentives in exchange for the information. | 02-07-2013 |
20150121551 | SYSTEM AND METHOD FOR SECURING THE LIFE-CYCLE OF USER DOMAIN RIGHTS OBJECTS - In a method for enabling support for backwards compatibility in a User Domain, in one of a Rights Issuer (RI) and a Local Rights Manager (LRM), a Rights Object Encryption Key (REK) and encrypted REK are received from an entity that generated a User Domain Authorization for the one of the RI and the LRM and the REK is used to generate a User Domain Rights Object (RO) that includes the User Domain Authorization and the encrypted REK. | 04-30-2015 |
20150312233 | System and Method to Enable PKI- and PMI- Based Distributed Locking of Content and Distributed Unlocking of Protected Content and/or Scoring of Users and/or Scoring of End-Entity Access Means - Added - A central server configured with an Attribute Authority (“AA”) acting as a Trusted Third Party mediating service provider and using X.509-compatible PKI and PMI, VPN technology, device-side thin client applications, security hardware (HSM, Network), cloud hosting, authentication, Active Directory and other solutions. This ecosystem results in real time management of credentials, identity profiles, communication lines, and keys. It is not centrally managed, rather distributes rights to users. Using its Inviter-Invitee protocol suite, Inviters vouch for the identity of Invitees who successfully complete the protocol establishing communication lines. Users establish and respond to authorization requests and other real-time verifications pertaining to accessing each communication line (not end point) and sharing encrypted digital files. These are auditable, brokered, trusted-relationships where such relationships/digital agreements can each stand-alone (for privacy) or can leverage build-up of identity confidence levels across relationships. The service is agnostic to how encrypted user content is transported or stored. | 10-29-2015 |
20150381580 | SYSTEM AND METHOD TO USE A CLOUD-BASED PLATFORM SUPPORTED BY AN API TO AUTHENTICATE REMOTE USERS AND TO PROVIDE PKI- AND PMI- BASED DISTRIBUTED LOCKING OF CONTENT AND DISTRIBUTED UNLOCKING OF PROTECTED CONTENT - A security system for authenticating users and protecting content that provides an application program interface (API) with a Cloud Platform integration (Platform) for use by enterprise businesses, government entities, systems integrators, independent software vendors, small business, individuals and others (“Entities”) to extend the security capabilities of PKI- and PMI-systems to authenticated external users and protected content. | 12-31-2015 |
20160057120 | SYSTEM AND METHOD TO ENABLE PKI- AND PMI- BASED DISTRIBUTED LOCKING OF CONTENT AND DISTRIBUTED UNLOCKING OF PROTECTED CONTENT AND/OR SCORING OF USERS AND/OR SCORING OF END-ENTITY ACCESS MEANS - ADDED - A central server configured with an Attribute Authority (“AA”) acting as a Trusted Third Party mediating service provider and using X.509-compatible PKI and PMI, VPN technology, device-side thin client applications, security hardware (HSM, Network), cloud hosting, authentication, Active Directory and other solutions. This ecosystem results in real time management of credentials, identity profiles, communication lines, and keys. It is not centrally managed, rather distributes rights to users. Using its Inviter-Invitee protocol suite, Inviters vouch for the identity of Invitees who successfully complete the protocol establishing communication lines. Users establish and respond to authorization requests and other real-time verifications pertaining to accessing each communication line (not end point) and sharing encrypted digital files. These are auditable, brokered, trusted-relationships where such relationships/digital agreements can each stand-alone (for privacy) or can leverage build-up of identity confidence levels across relationships. The service is agnostic to how encrypted user content is transported or stored. | 02-25-2016 |
Patent application number | Description | Published |
20120314856 | IMPLICITLY CERTIFIED PUBLIC KEYS - Methods, systems, and computer programs for using an implicit certificate are described. In some aspects, an implicit certificate is accessed. The implicit certificate is associated with an entity and generated by a certificate authority. The implicit certificate includes a public key reconstruction value of the entity. Certificate authority public key information is accessed. The certificate authority public key information is associated with the certificate authority that issued the implicit certificate. A first value is generated based on evaluating a hash function. The hash function is evaluated based on the certificate authority public key information and the public key reconstruction value of the entity. A public key value of the entity can be generated or otherwise used based on the first value. | 12-13-2012 |
20120317412 | IMPLICITLY CERTIFIED DIGITAL SIGNATURES - Methods, systems, and computer programs for using an implicit certificate are disclosed. In some aspects, a message and an implicit certificate are accessed. The implicit certificate is associated with an entity. A modified message is generated by combining the message with a value based on the implicit certificate. A digital signature can be generated based on the modified message and transmitted to a recipient. In some aspects, a digital signature from an entity and a message to be verified based on the digital signature are accessed. An implicit certificate associated with the entity is accessed. A modified message is generated by combining the message with a value based on the implicit certificate. The message is verified based on the digital signature and the modified message. | 12-13-2012 |
20130124870 | CRYPTOGRAPHIC DOCUMENT PROCESSING IN A NETWORK - Data received over a network is processed by a server. The processing includes determining identity information corresponding to an identity associated with a document represented by document data received over an input port of the server from a sender. At the server, a private key is computed based on: a master private key, and the identity information. At the server digital information is computed based at least in part on the document data using the computed private key. The digital information is stored in a storage medium accessible to the server in association with the identify information. | 05-16-2013 |
20130287207 | MULTIPLE HASHING IN A CRYPTOGRAPHIC SCHEME - Methods, systems, and computer programs for producing hash values are disclosed. A first hash value is obtained by applying a first hash function to a first input. The first input can be based on an implicit certificate, a message to be signed, a message to be verified, or other suitable information. A second hash value is obtained by applying a second hash function to a second input. The second input is based on the first hash value. The second hash value is used in a cryptographic scheme. In some instances, a public key or a private key is generated based on the second hash value. In some instances, a digital signature is generated based on the second hash value, or a digital signature is verified based on the second hash value, as appropriate. | 10-31-2013 |
20130290712 | HASHING PREFIX-FREE VALUES IN A SIGNATURE SCHEME - Methods, systems, and computer programs for producing hash values are disclosed. A prefix-free value is obtained based on input data. The prefix-free value can be based on an implicit certificate, a message to be signed, a message to be verified, or other suitable information. A hash value is obtained by applying a hash function to the prefix-free value. The hash value is used in a cryptographic scheme. In some instances, a public key or a private key is generated based on the hash value. In some instances, a digital signature is generated based on the hash value, or a digital signature is verified based on the hash value, as appropriate. | 10-31-2013 |
20130290713 | HASHING PREFIX-FREE VALUES IN A CERTIFICATE SCHEME - Methods, systems, and computer programs for producing hash values are disclosed. A prefix-free value is obtained based on input data. The prefix-free value can be based on an implicit certificate, a message to be signed, a message to be verified, or other suitable information. A hash value is obtained by applying a hash function to the prefix-free value. The hash value is used in a cryptographic scheme. In some instances, a public key or a private key is generated based on the hash value. In some instances, a digital signature is generated based on the hash value, or a digital signature is verified based on the hash value, as appropriate. | 10-31-2013 |
20140372765 | Hashing Prefix-Free Values in a Signature Scheme - Methods, systems, and computer programs for producing hash values are disclosed. A prefix-free value is obtained based on input data. The prefix-free value can be based on an implicit certificate, a message to be signed, a message to be verified, or other suitable information. A hash value is obtained by applying a hash function to the prefix-free value. The hash value is used in a cryptographic scheme. In some instances, a public key or a private key is generated based on the hash value. In some instances, a digital signature is generated based on the hash value, or a digital signature is verified based on the hash value, as appropriate. | 12-18-2014 |