Patent application number | Description | Published |
20130109019 | HAPTEN CONJUGATES FOR TARGET DETECTION | 05-02-2013 |
20130260379 | SIGNALING CONJUGATES AND METHODS OF USE - Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods. | 10-03-2013 |
20140147906 | ANTIBODY CONJUGATES - Antibody/signal-generating moiety conjugates are disclosed that include an antibody covalently linked to a signal-generating moiety through a heterobifunctional polyalkyleneglycol linker. The disclosed conjugates show exceptional signal-generation in immunohistochemical and in situ hybridization assays on tissue sections and cytology samples. In one embodiment, enzyme-metallographic detection of nucleic acid sequences with hapten-labeled probes can be accomplished using the disclosed conjugates as a primary antibody without amplification. | 05-29-2014 |
20140205995 | MOLECULAR CONJUGATE - A method is disclosed for making a conjugate of two molecules using a hydrazide thiol linker. In a particular working embodiment, an Fc-specific antibody-enzyme conjugate is made using the method and demonstrated to provide exceptional staining sensitivity and specificity in immunohistochemical and in situ hybridization assays. | 07-24-2014 |
20140323336 | HAPTENS, HAPTEN CONJUGATES, COMPOSITIONS THEREOF AND METHOD FOR THEIR PREPARATION AND USE - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. | 10-30-2014 |
Patent application number | Description | Published |
20080268462 | Haptens, hapten conjugates, compositions thereof and method for their preparation and use - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. | 10-30-2008 |
20100136652 | Molecular Conjugate - A method is disclosed for making a conjugate of two molecules using a hydrazide thiol linker. In a particular working embodiment, an Fc-specific antibody-enzyme conjugate is made using the method and demonstrated to provide exceptional staining sensitivity and specificity in immunohistochemical and in situ hybridization assays. | 06-03-2010 |
20100184087 | Haptens, hapten conjugates, compositions thereof and method for their preparation and use - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. | 07-22-2010 |
20100297725 | Haptens, hapten conjugates, compositions thereof and method for their preparation and use - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. | 11-25-2010 |
20130122516 | DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY - Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section. | 05-16-2013 |
Patent application number | Description | Published |
20080261611 | Sparsed U-TDOA Wireless Location Networks - In an overlay, U-TDOA-based, Wireless Location System, LMUs typically co-located with BTSs, are used to collect radio signaling both in the forward and reverse channels. Techniques are used to compensate for sparse LMU deployments where sections of the U-TDOA service area are uplink demodulation or downlink beacon discovery limited. | 10-23-2008 |
20080261614 | Sparsed U-TDOA Wireless Location Networks - In an overlay, U-TDOA-based, Wireless Location System, LMUs typically co-located with BTSs, are used to collect radio signaling both in the forward and reverse channels. Techniques are used to compensate for sparse LMU deployments where sections of the U-TDOA service area are uplink demodulation or downlink beacon discovery limited. | 10-23-2008 |
20090149132 | Detection of Time of Arrival of CDMA Signals in a Wireless Location System - In a Wireless Location System (WLS) deployed in connection with a CDMA-based wireless communications system, Location Measurement Units are used to collect multi-path corrupted radio signaling for use in time difference of arrival (TDOA) and hybrid positioning methods. Signal processing techniques are used to enhance the WLS's ability to determine the minimally time-delayed multi-path component and thus increase the accuracy of the TDOA location in CDMA-based wireless communications systems. The signal processing includes a filtering technique for reducing the leading sidelobes of the cross-correlation function as well as a leading edge discovery procedure. | 06-11-2009 |
20100039326 | Variable Coherence Integration for the Location of Weak Signals - In a network-based Wireless Location System (WLS), geographically distributed Location Measurement Units (LMUs) must be able to detect and use reverse channel (mobile to network) signals across multiple BTS coverage areas. By using Matched Replica correlation processing with the local and reference signals subdivided into discrete segments prior to correlation, the effects of mobile clock drift and Doppler shifts can be mitigated allowing for increased processing gain. | 02-18-2010 |
20120015670 | Hybrid GNSS and TDOA Wireless Location System - A method and apparatus for position determination is provided using measurements from both Global Positioning System (GPS) receivers and terrestrial-based Uplink Time Difference of Arrival (UTDOA) receivers. The method involves the transformation of downlink satellite measurements into equivalent UTDOA measurements by computing comparable cross-correlation coefficients and time differences of arrival with respect to a UTDOA reference station. The method includes a weighting operation whereby the relative weights of the UTDOA measurements and the relative weights of the GPS measurements are adjusted based on a theoretical scaling followed by empirical adjustments. The method further involves the efficient computation and combining of metrics that are used to minimize the weighted error between candidate location solutions and the UTDOA and GPS measurements. | 01-19-2012 |