María Del Carmen
María Del Carmen Abrahantes Pérez, Ciudad De La Habana CU
Patent application number | Description | Published |
---|---|---|
20110218138 | Pharmaceutical composition containing polypeptide fragments of serralysins - The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1-100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's “in vivo” administration has antitumoral, antiangiogenic and protective effect against malignant tumors. | 09-08-2011 |
María Del Carmen Arévalo Morales, Santiago CL
Patent application number | Description | Published |
---|---|---|
20130209346 | CARBON ELECTRODE FROM HIGH ELECTROCATALYTIC ACTIVITY WASTES: METHOD FOR OBTAINING AND APPLICATION - The present invention refers to a procedure for obtaining a carbon electrode from acid cell wastes with extremely high electrocatalytic activity that can be used as cathode or anode for various applications such as electrochemistry, electroplating, electrolytic refining, etc. One of its most interesting applications is in the field of sensor electrodes. The process comprises the stages of: a) extraction of the carbon from the cell and then removing its covering; b) boiling in distilled water between 5 and 30 minutes; c) washing the electrode with detergent, preferably neutral; d) sanding and washing with boiling water and then with detergent until no residue is obtained; e) sonicating between 5 and 30 minutes in distilled water; f) subjecting the electrode to washing with petroleum ether or other highly nonpolar solvent; g) sonicating and washing with organic solvents from low to high polarity, ending with water and changing the water until clean water is obtained; h) boiling the electrode in a solution containing a strong oxidant and acid pH during 5 minutes to one hour; i) repeating the washing and sonication procedure if necessary; j) polishing in the conventional manner for its use; and k) if desired, it can be inserted in teflon or PVC to insulate part of the surface. The electric connection can be made by making an inner thread in the carbon. | 08-15-2013 |
María Del Carmen Cuevas Marchante, Madrid ES
Patent application number | Description | Published |
---|---|---|
20110118343 | Antitumoral Macrolides - Antitumoral compounds of general formula I: | 05-19-2011 |
20110207674 | ANTITUMORAL COMPOUNDS - Antitumoral compounds of Formula I, and pharmaceutically acceptable salts, derivatives, tautomers, prodrugs or stereoisomers thereof | 08-25-2011 |
20120190870 | ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS - Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus | 07-26-2012 |
20130040921 | ANTICANCER STEROIDAL LACTONES UNSATURATED IN POSITION 7 (8) - A compound of general formula (I), wherein R | 02-14-2013 |
María Del Carmen Domínguez Horta, Ciudad De La Habana CU
Patent application number | Description | Published |
---|---|---|
20090171069 | Peptides And Apl-Type Derivatives Of Hsp60 And Pharmaceutical Compositions - Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis. | 07-02-2009 |
20100144642 | PEPTIDES AND APL-TYPE DERIVATIVES OF HSP60 AND PHARMACEUTICAL COMPOSITIONS - Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis. | 06-10-2010 |
20120035106 | USE OF APL-TYPE PEPTIDE FOR TREATING INTESTINAL INFLAMMATORY DISEASES AND TYPE 1 DIABETES - The present invention is related with the field of the medicine, particularly with the use of an APL peptide or its analogues derived from the human heat shock protein of 60 kDa, for the manufacture of a pharmaceutical composition for the treatment of Crohn's disease, ulcerative colitis and diabetes mellitus type 1. This peptide is biodistributed into the gastrointestinal tract and also promotes the induction of apoptosis in activated intestinal lamina propria and peripheral blood T cells of patients with Crohn's disease. Furthermore, this peptide induces apoptosis in mononuclear cells of patients with diabetes mellitus type 1. | 02-09-2012 |
María Del Carmen Domínguez Horta, Ciudad De La Habana CU
Patent application number | Description | Published |
---|---|---|
20100144642 | PEPTIDES AND APL-TYPE DERIVATIVES OF HSP60 AND PHARMACEUTICAL COMPOSITIONS - Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis. | 06-10-2010 |
María Del Carmen Durántez Delgado, Pamplona-Navarra ES
Patent application number | Description | Published |
---|---|---|
20110268757 | USE OF PHENOL-SOLUBLE MODULINS FOR VACCINE DEVELOPMENT - The invention relates to methods for increasing immunogenicity of an antigenic peptide by means of its covalent coupling to a modulin derived peptide (PSM, phenol soluble modulin). In particular, the binding of PSMα, PSMγ and PSMδ peptides to an antigen (from a pathogen or a tumor associated protein) increases the capacity of the antigen to activate an immune response in vivo. Thus, the PSMα, PSMγ and PSMδ peptides bound to these antigens may be used in the development of vaccines for preventing or treating infectious diseases or cancer | 11-03-2011 |
María Del Carmen Escobedo Lucea, Valencia ES
Patent application number | Description | Published |
---|---|---|
20120078136 | DEVICE FOR COLLECTING SEMEN SAMPLES - The invention relates to a device for collecting semen samples, which is configured such that the patient/donor can perform ejaculation and the corresponding semen collection in his own home, for subsequent transfer to a medical centre or laboratory where the semen can be analyzed. The invention is characterized in that it consists of a preferably plastic cylindrical tube including mouth that is provided with a peripheral flange having a rounded edge in order to allow the condom into which the patient/donor ejaculates to be securely fastened thereto, and a closure cover that is screwed onto the cylindrical tube in order to press and secure the semen-filled condom housed inside said tube. | 03-29-2012 |
María Del Carmen Fäbregas Cleveria, Madrid ES
Patent application number | Description | Published |
---|---|---|
20120135041 | IMMUNOSUPPRESSOR BASED ON THE BLOCKAGE OF TCR-NCK INTERACTION - The present invention relates to a compound of structural formula (I) and its derivatives for use as medicinal drugs. They are preferably immunosuppressive agents, with mechanism of action based on the blockage of TCR-Nck interaction. | 05-31-2012 |
María Del Carmen Masdeu Margalef, Donostia - San Sebastian ES
Patent application number | Description | Published |
---|---|---|
20120196885 | NEW HISTONE DEACETYLASE INHIBITORS BASED SIMULTANEOUSLY ON TRISUBSTITUTED 1H-PYRROLES AND AROMATIC AND HETEROAROMATIC SPACERS - The present invention refers to compounds derived from trisubstituted 1H-pyrrole rings and aromatic rings, which have the following formula (I): | 08-02-2012 |
María Del Carmen Méndez Fernández, Oviedo ES
Patent application number | Description | Published |
---|---|---|
20120270823 | AUREOLIC ACID DERIVATIVES, THE METHOD FOR PREPARATION THEREOF AND THE USES THEREOF - Aureolic acid derivatives, process for obtaining them and uses thereof. This invention provides a bacterial strain that produces compound belonging to the family of aureolic acids useful in the treatment of cancer or nervous system diseases. | 10-25-2012 |
María Del Carmen Montoliu Félix, Valencia ES
Patent application number | Description | Published |
---|---|---|
20130177932 | EX-VIVO METHOD FOR THE EARLY DIAGNOSIS OF MINIMAL HEPATIC ENCEPHALOPATHY BY MEANS OF THE DETERMINATION OF THE 3-NITROTYROSINE IN SERUM - An ex-vivo method for the early diagnosis of minimal hepatic encephalopathy by means of determining serum 3-nitrotyrosine relates to an ex-vivo method for the detection and early diagnosis of minimal hepatic encephalopathy (MHE) in patients with liver diseases, including cirrhosis, based on the presence of specific serum biomarkers, specifically by means of determining 3-nitrotyrosine (3-NT), which comprises obtaining serum or plasma obtained from the blood of patients and controls, and determining whether or not the measurement of the concentration of 3-nitrotyrosine obtained is greater than a specific level. | 07-11-2013 |