Patent application number | Description | Published |
20080254109 | LOCALIZED MYOCARDIAL INJECTION METHOD FOR TREATING ISCHEMIC MYOCARDIUM - This invention relates to a method of treating ischemic or diseased myocardium by injecting a therapeutic agent, such as a gene, protein, cell or drug, into normal myocardium, preferably adjacent to an ischemic zone in the heart of a subject. The method is useful for inducing angiogenesis and collateral blood vessel formation to improve cardiac function in subjects with ischemic heart disease. The method can also be used to promote tissue regeneration in such subjects. | 10-16-2008 |
20080260798 | ALIGNED SCAFFOLDS FOR IMPROVED MYOCARDIAL REGENERATION - The present invention relates to a biocompatible, three-dimensional scaffold useful to grow cells and to regenerate or repair tissue in predetermined orientations. The scaffold is particularly useful for regeneration and repair of cardiac tissue. The scaffold contains layers of alternating A-strips and S-strips, wherein the A-strips within each layer are aligned parallel to each other and preferentially promote cellular attachment over attachment to the S-strips. Methods of producing and implanting the scaffold are also provided. | 10-23-2008 |
20090131882 | MEDICAL DEVICE FOR DELIVERING PATCHES - The present invention relates to a medical device and method for treating the body tissue of a patient. The present invention is also directed to a method of making the medical device and a method of using the medical device. More particularly, the invention relates to a medical device which is inserted into the body for delivery of therapeutic patches to the surface of a body lumen, organ or cavity. Specifically, the medical device has an umbrella-like or a basket-like expandable assembly; and a therapeutic patch. The expandable assembly is capable of changing from a retracted position to an expanded position. The expandable assembly can be self-expanding or non-self-expanding. In one embodiment, the medical device comprises an elongated member; an umbrella-like expandable assembly which has a plurality of wire elements; and a therapeutic patch. The therapeutic patch comprises a sheet having two opposing surfaces wherein one of the surface comprises an adhesive material and at least one biologically active material. The other opposing surface is disposed onto the plurality of wire elements of the umbrella-like expandable assembly. In another embodiment, the medical device comprises an elongated member, a basket-like expandable assembly having a plurality of wire elements; and a therapeutic patch. The therapeutic patch is disposed onto the plurality of wire elements of the basket-like expandable assembly. | 05-21-2009 |
20090131906 | METHOD, SYSTEM, APPARATUS, AND KIT FOR REMOTE THERAPEUTIC DELIVERY - A therapeutic delivery catheter system method or kit for delivery of therapeutic to a target location is provided. In various embodiments of the present invention the invention may include a catheter with a therapeutic delivery lumen and a therapeutic delivery orifice. The lumen and the orifice may be in fluid communication with each other and may be configured such that therapeutic delivered therethrough may be done at pressures mimicking pressures existing or otherwise normal at the target locations receiving the therapeutic. In some embodiments the catheter may be part of a kit that may include instructions regarding the proper manner of operation of the catheter. These instructions may include suggested target pressures for therapeutic delivery as well as delivery times, and suggested lengths of time for the device to reside at the target area after delivery to allow for proper uptake of the therapeutic. | 05-21-2009 |
20090138074 | DECELLULARIZED EXTRACELLULAR MATRIX OF CONDITIONED BODY TISSUES AND USES THEREOF - The invention is directed to an apparatus, such as a medical device, having a surface coated or covered with a decellularized extracellular matrix or having a component comprising the decellularized extracellular matrix for implantation into a subject, preferably a human. In one embodiment of the invention, a decellularized extracellular matrix is used to form a bodily implant such as a vein, an artery, an esophagus, or a ventricular restraining device. In some embodiments of the invention, the decellularized extracellular matrix is configured to be a time released therapeutic. In another embodiment of the invention, a decellularized extracellular matrix forms an aneurysm treatment device, such as an aneurysm coil, a seal, a pouch, or a filler. In a further embodiment of the invention, decellularized extracellular matrix is used to embolize lesions, tumors, or vessels. Methods for making the tissue regeneration scaffold and methods for manufacturing a coated or covered medical device having a component comprising decellularized extracellular matrix of body tissues are also provided. | 05-28-2009 |
20090138076 | MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENTS - The present invention is generally directed to medical devices, and more specifically to medical devices that are at least partially insertable or implantable into the body of a patient. The medical devices generally comprise (a) a therapeutic agent, more typically, a high-molecular-weight therapeutic agent, and (b) at least one polymeric layer, which typically acts to control the release of the therapeutic agent from the medical device. Also disclosed herein are methods of making such medical devices. | 05-28-2009 |
20090180965 | METHODS FOR REPAIR AND REGENERATION OF BONE MARROW - The invention is directed to a method for treating a tissue or organ in a subject by directly administering an effective amount of an exogenous, decellularized extracellular matrix or a mixture of extracellular matrix and mesenchymal stem cells into the intended site of activity, such as bone marrow cavity. In one embodiment, the invention provides methods of treating bone marrow to increase the number of circulating progenitor and stem cells. In some other embodiments of the invention, the decellularized extracellular matrix to be directly administered is configured to be a time released therapeutic. | 07-16-2009 |
20100092448 | LOCAL CONTROL OF INFLAMMATION - A medical device includes a carrier and an agent. The agent is formulated to control inflammation of biological tissue, such as heart tissue, and is releasably coupled to the carrier. The carrier is configured to be disposed in operative proximity to the biological tissue to be treated by the agent. In one embodiment, the carrier is configured to release the agent or otherwise deliver the agent to the biological tissue, thus controlling inflammation of the tissue. Also, a method to improve healing of biological tissue includes placing a medical device proximate to the heart of a patient, where the medical device has a carrier and an agent configured to control inflammation, the agent is releasably coupled to the carrier. In one embodiment, the method includes causing the agent to be released from the carrier. | 04-15-2010 |
20100291182 | Drug-Loaded Fibers - Implants and methods for the delivery of a therapeutic agent to a target location within a patient's body are disclosed. The implants include a fiber comprising a polymeric material and having a diameter of up to about twenty microns, and a first therapeutic agent within the fiber. The therapeutic agent is substantially in particulate form. The implants are of a variety of configurations, such as individual fibers, yarns, ropes, tubes, and patches. | 11-18-2010 |
20110130715 | Device and Method for Delivering Micronized Therapeutic Agents in the Body - The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site. | 06-02-2011 |
20110196340 | LOADING AND RELEASE OF WATER-INSOLUBLE DRUGS - A medical device, polymer composition, and method for delivering substantially water-insoluble drugs to tissue at desired locations within the body. At least a portion of the exterior surface of the medical device is provided with a polymer coating. Incorporated in the polymer coating is a solution of at least one substantially water-insoluble drug in a volatile organic solvent. The medical device is positioned to a desired target location within the body, whereupon the drug diffuses out of the polymer coating. | 08-11-2011 |
20110319987 | MEDICAL IMPLANT - Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties. | 12-29-2011 |
20120010589 | LOCAL DELIVERY OF THERAPEUTIC AGENT TO HEART VALVES - The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve. | 01-12-2012 |
20120040137 | FIBER COMPOSITE STRUCTURE - Disclosed are fiber composite structures comprising a matrix material and at least one polymeric fiber in contact with the matrix material. The fiber(s) are preferably characterized by a diameter of up to about 20 microns. In certain embodiments, the fiber(s) comprise a therapeutic agent in an amount that exceeds the solubility limit of the therapeutic agent in the fiber polymer. In some embodiments, the fiber(s) comprise an inner radial portion and an outer radial portion. | 02-16-2012 |
20120143300 | MEDICAL IMPLANT - Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties. | 06-07-2012 |
20120239001 | LOADING AND RELEASE OF WATER-INSOLUBLE DRUGS - A medical device, polymer composition, and method for delivering substantially water-insoluble drugs to tissue at desired locations within the body. At least a portion of the exterior surface of the medical device is provided with a polymer coating. Incorporated in the polymer coating is a solution of at least one substantially water-insoluble drug in a volatile organic solvent. The medical device is positioned to a desired target location within the body, whereupon the drug diffuses out of the polymer coating. | 09-20-2012 |
20120299223 | DRUG LOADED FIBERS - Implants and methods for the delivery of a therapeutic agent to a target location within a patient's body are disclosed. The implants include a fiber comprising a polymeric material and having a diameter of up to about twenty microns, and a first therapeutic agent within the fiber. The therapeutic agent is substantially in particulate form. The implants are of a variety of configurations, such as individual fibers, yarns, ropes, tubes, and patches. | 11-29-2012 |
20130071463 | IMPLANTS FOR POSTOPERATIVE PAIN - Medical implants and methods useful in treating postoperative pain are described. The implants comprise one or more electrospun drug-loaded fibers, which fibers comprise a drug useful in the treatment of pain. The implants are implanted at sites of interest including joint capsules, bones, and subcutaneous spaces, and are secured with tissue flaps or fasteners. | 03-21-2013 |
20130158652 | MEDICAL IMPLANTS - Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties. | 06-20-2013 |
20130164348 | MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENTS - The present invention is generally directed to medical devices, and more specifically to medical devices that are at least partially insertable or implantable into the body of a patient. The medical devices generally comprise (a) a therapeutic agent, more typically, a high-molecular-weight therapeutic agent, and (b) at least one polymeric layer, which typically acts to control the release of the therapeutic agent from the medical device. Also disclosed herein are methods of making such medical devices. | 06-27-2013 |
20130304029 | LOADING AND RELEASE OF WATER-INSOLUBLE DRUGS - A medical device, polymer composition, and method for delivering substantially water-insoluble drugs to tissue at desired locations within the body. At least a portion of the exterior surface of the medical device is provided with a polymer coating. Incorporated in the polymer coating is a solution of at least one substantially water-insoluble drug in a volatile organic solvent. The medical device is positioned to a desired target location within the body, whereupon the drug diffuses out of the polymer coating. | 11-14-2013 |
20130304177 | Drug Eluting Medical Implant - Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties. | 11-14-2013 |
20130317600 | DRUG ELUTING MEDICAL IMPLANT - Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties. | 11-28-2013 |
20140100644 | DRUG-ELUTING MEDICAL IMPLANTS - Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties. | 04-10-2014 |
20140121762 | MEDICAL IMPLANT - Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties. | 05-01-2014 |
20140172074 | STENT WITH REINFORCED JOINTS - The present invention relates generally to stents for insertion into bodily lumens that include at least one strand that forms a self-expanding tubular structure. Specifically, these strands form a plurality of intersections at which one portion of the strand is in proximity to another portion of the same or different strand. More specifically, at least some of those intersections include a plurality of reinforcement members. | 06-19-2014 |
20140199364 | DRUG LOADED FIBERS - Implants and methods for the delivery of a therapeutic agent to a target location within a patient's body are disclosed. The implants include a fiber comprising a polymeric material and having a diameter of up to about twenty microns, and a first therapeutic agent within the fiber. The therapeutic agent is substantially in particulate form. The implants are of a variety of configurations, such as individual fibers, yarns, ropes, tubes, and patches. | 07-17-2014 |
20150073388 | DRUG DELIVERY SYSTEMS AND RELATED METHODS - The present invention provides systems and methods for the targeted delivery of a therapeutic agent using expandable devices that are temporarily or permanently placed within the body. Such therapeutic agents may be delivered as a coating on the outer surface of the expandable device. Once positioned at a desired location within the body, the device is expanded such that its drug-coated outer surface establishes direct contact with a target tissue. The expanded device remains in contact with the target tissue for a pre-determined amount of time prior to being withdrawn from the body. Delivery of the therapeutic agent using the expandable device may be followed, or preceded, by delivery of a second expandable device to the same location within the body. | 03-12-2015 |