Marie-Caroline
Marie-Caroline Dumez-Vinit, St. Jean De Marsacq FR
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20140207726 | SYSTEM FOR RECOMMENDING HELICOPTER ENGINE MAINTENANCE - The invention relates to a system for recommending maintenance of helicopter engines depending on the technical condition of the engine, the standard replacement of parts between engines, and the replacement of parts with different parts. The system comprises: a centralized database storing data relating to (i) working condition and working condition indicators, (ii) modifications of the engines, (iii) maintenance plans for the engines, (iv) causes of unscheduled events, (v) maintenance applied to the engines, and (vi) instantiated configurations; means for acquiring the working condition indicators and for updating the working condition data; means for identifying maintenance to be applied to the engines depending on the data; means for generating an alarm for identified maintenance to be performed; means for the digitally-signed updating of the applied maintenance and configuration data according to maintenance operations; and means for deactivating an alarm once the maintenance associated with the alarm is completed. | 07-24-2014 |
Marie-Caroline Husson Ollagnier, Paris FR
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20160136103 | Pharmaceutical Composition in the Form of Granules for the Treatment of Metabolic Disorders in Children - The present invention relates to a pharmaceutical composition for pediatric use and having controlled release, for treating metabolic disorders involving urea in children, said composition being in the form of granules behaving like a pseudofluid, said granules including a core consisting of sucrose, cellulose or isomalt particles, and of at least one active ingredient, said active ingredient having a water solubility of 200 g/L to 630 g/L of water, and at least one coating agent covering said core, the mean diameter of the microgranules being 0.1 mm to 1.2 mm and the granules having an angle of repose of less than 30. | 05-19-2016 |
Marie-Caroline Jacques-Cordonnier, Uberach FR
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20160002175 | Pyrimidine-2,4-Diamine Derivatives for Treatment of Cancer - A compound of formula (I), or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1. | 01-07-2016 |
Marie-Caroline Le Bousse-Kerdiles, Bourg-La-Reine FR
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20140349312 | IN VITRO MODELLING OF HAEMATOPOIETIC STEM CELL MEDULLARY NESTS: A TOOL FOR STUDYING THE REGULATION OF HAEMATOPOIESIS, EVALUATING THE NESTING POTENTIAL OF A HAEMATOPOIETIC GRAFT AND TESTING THE PHARMACOTOXICOLOGY OF MEDICAMENTS - The present invention relates to a culture support for cultivating hematopoietic stem cells (HSCs) and/or hematopoietic progenitors (HPs), comprising a calcium biomaterial, osteoclasts, endothelial cells and mesenchymatous stem cells (MSCs) and/or osteoblasts and/or adipocytes. The present invention also relates to a method for preparing such a culture support, and an in vitro HSC and/or HP cultivation method. The use of such a culture support for studying cellular mechanisms involved in hematopoiesis and/or differentiation of HSC/HPs and/or for studying the efficacy and/or the toxicity of a medicament candidate is also described. | 11-27-2014 |