Mckerracher
Lisa Mckerracher, Montreal CA
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20080233098 | RHO Family Antagonists and Their Use to Block Inhibition of Neurite Outgrowth - The invention relates to an antagonist of one or more of Rho family members having ability to elicit neurite outgrowth from cultured neurons in an assay method which includes culturing neurons on a substrate that incorporates a growth-inhibiting amount of Rho family member and exposing the cultured neurons to a candidate Rho family member antagonist agent to permit neuron growth. Candidates which elicit neurite outgrowth from the cultured neurons are thus identified as Rho family antagonists. | 09-25-2008 |
20080269120 | ADP-ribosyl transferase fusion variant proteins - The present invention relates to novel chimeric C3-like Rho antagonists and their use for promoting repair and neuron survival in injured mammalian central and peripheral nervous system and for treating or preventing cancer. | 10-30-2008 |
20090053190 | Treatment of macular degeneration with ADP-ribosyl transferase fusion protein therapeutic compositions - The Rho family GTPases regulates axon growth and regeneration. Inactivation of Rho with C3, a toxin from | 02-26-2009 |
Lisa Mckerracher, Ile Des Soeurs CA
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20090136573 | Methods for Making and Delivering Rho-Antagonist Tissue Adhesive Formulations to the Injured Mammalian Central and Peripheral Nervous Systems and uses Thereof - The present invention provides methods for making, delivering and using formulations that combine a therapeutically active agent(s) (such as for example a Rho antagonist(s)) and a flowable carrier component capable of forming a therapeutically acceptable matrix in vivo (such as for example tissue adhesives), to injured nerves to promote repair and regeneration and regrowth of injured (mammalian) neuronal cells, e.g. for facilitating axon growth at a desired lesion site. Preferred active agents are known Rho antagonists such as for example C3, chimeric C3 proteins, etc. or substances selected from among known trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compounds or Rho kinase inhibitors. The system for example may deliver an antagonist(s) in a tissue adhesive such as, for example, a fibrin glue or a collagen gel to create a delivery matrix in situ. A kit and methods of stimulating neuronal regeneration are also included. | 05-28-2009 |
20090285833 | CLOSTRIDIUM BOTULINUM C3 EXOTRANSFERASE COMPOSITIONS AND METHODS FOR TREATING TUMOUR SPREADING - Pharmaceutical compositions, each consisting of a cell-permeable fusion protein conjugate of a polypeptidic cell-membrane transport moiety and a | 11-19-2009 |
Lisa Mckerracher, Lle Des Soeurs Verdun CA
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20090142325 | COMPOSITIONS AND METHODS FOR TREATING TUMOUR SPREADING - There is provided a method of prevention or inhibition of uncontrolled proliferation of a cancer comprising administration to a mammal of a therapeutically effective amount of a pharmaceutical composition comprising a cell-permeable fusion protein conjugate comprising a polypeptidic cell-membrane transport moiety and a | 06-04-2009 |
Lisa Mckerracher, Hallandale Beach, FL US
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20150297643 | INHIBITION OF RHO AND OR ROCK AND CELL TRANSPLANTATION - The present disclosure provides a multi-treatment combination to improve recovery after spinal cord injury or neurotrauma comprising: (a) Cell transplantation at the site of spinal cord injury and (b) Surgical delivery of BA-210. The combined treatment allows cells to be transplanted in the injury site during the acute trauma period, a time when the inflammatory response to neurotrauma adversely effects survival of transplanted cells. Early therapy delivered during critical care treatment after neurotrauma is essential for successful restorative therapy. The multi-treatment combination also provides a method to ensure that multi-potent transplanted cells do not become tumorigenic. | 10-22-2015 |
Richard Mckerracher, Waterloo CA
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20140176361 | IDENTIFICATION AND REMOVAL OF A FALSE DETECTION IN A RADAR SYSTEM - In one aspect, a method to identify and remove a false detection includes receiving a detection from a constant false alarm rate (CFAR) processor, performing a first similarity measure on adjacent coherent integration time values (CITs) corresponding to the detection, performing a second similarity measure on neighbor CITs corresponding to the detection, determining if at least one of the first or second similarity measure is below a threshold and discarding the detection if at least one of the first or second similarity measures is below the threshold. | 06-26-2014 |
Richard Mckerracher, Ontario CA
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20090302945 | LINEARIZING TECHNIQUE FOR POWER AMPLIFIERS - Embodiments described herein relate to amplification circuits. In some embodiments the amplification circuit includes a power amplifier, a feedforward error compensation loop, and phase feedback and amplitude feedback error compensation loops nested within the feedforward loop. The two nested feedback loops provide a “pre-cleaning” action, which reduces the amount of rejection required in the feedforward loop. In some embodiments, the amplification circuit includes a power amplifier and an enhanced feedforward loop comprising a phase control circuit that maintains a phase balance needed to reduce distortion in the output signal of the amplification circuit. In some embodiments, the amplification circuit includes a power amplifier, a feedforward error compensation loop, and phase feedback and amplitude feedback error compensation loops nested within the feedforward loop and the feedforward loop comprises the phase control circuit. | 12-10-2009 |
Rick Mckerracher, Waterloo CA
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20140197984 | VIRTUAL ANTENNA EXTENSION FOR SAMPLED APERTURE ARRAYS - A high frequency surface wave radar (HFSWR) system with improved performance. Two or more transmitters including separate transmitting antennas ( | 07-17-2014 |