Mcnaughton
Alyn Mcnaughton, Murieston GB
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20130209555 | Formulations and Dosage Forms of Oxidized Phospholipids - The current disclosure provides pharmaceutical compositions containing an oxidized phospholipid, such as 1-hexadecyl-2-(4′-carboxybutyl)-glycero-3-phosphocholine (VB-201) and a thermosoftening carrier, e.g., a poloxamer. The pharmaceutical compositions may further comprise an anti-adherent agent, such as talc and/or a thixotropic agent. The current disclosure further provides processes for preparing the pharmaceutical compositions. The disclosure further provides capsules containing the pharmaceutical compositions. Uses of such pharmaceutical compositions and capsules in treating inflammatory disorders are also disclosed. | 08-15-2013 |
Brandon H. Mcnaughton, Ann Arbor, MI US
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20120164680 | Asynchronous Magnetic Bead Rotation Sensing Systems and Methods - Described herein are various methods, devices and systems for performing asynchronous magnetic bead rotation (AMBR) to detect and monitor cellular growth and/or behavior. Cluster rotation of magnetic particles for AMBR is descried. In particular, described herein are systems for the parallel analysis of multiple wells of a sample plate. Also described herein are methods for controlling the illumination and imaging of rotating magnetic particles. | 06-28-2012 |
20130337455 | Multi-Mode Separation for Target Detection and Cell Growth Monitoring - Sandwich separation is based on forming a sandwich complex with a magnetic bead, buoyant bead, and a target. Once a sandwich formation is created, the sandwich can be separated using its dual physical properties, namely magnetism and buoyancy. Sandwich separation is highly specific, allows for removal of the beads that do not have any attached target, and reduces the number of background beads. Sandwich separation can also be used to allow for target detection in raw specimen. Also, improvement of detection capability is accomplished by performing AMBR measurements on a solid interface, where the rotational period speeds up and allows for dramatically reduced time-to-result. | 12-19-2013 |
20140248632 | Magnetically Induced Microspinning for Super-Detection and Super-Characterization of Biomarkers and Live Cells - Identification, quantification and characterization of biological micro- and nano-systems is enabled by magnetically spinning these natural, non-magnetic systems with the aid of induced magnetization. Biofriendly magnetic micro- and nano-labels enable magnetorotation in extremely weak electromagnetic fields. The spinning of these micromotors can be observed by a simple, CD-like, optical tracking system. The spinning frequency response enables real-time monitoring of single (cancer) cell morphology, with sub-microscopic resolution, yielding previously undeterminable information. Likewise, it enables super-low detection limits for any (cancer) biomarker. | 09-04-2014 |
Brandon H. Mcnaughton, Ypsilanti, MI US
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20080220411 | NON-LINEAR ROTATION RATES OF REMOTELY DRIVEN PARTICLES AND USES THEREOF - The present invention relates to biological sensors. In particular, the present invention relates to the use of remotely driven nonlinear rotation of particles (e.g., magnetic particles) for detection of cells such as microorganisms (e.g., bacteria and viruses). The present invention further relates to the use of remotely driven nonlinear rotation of particles for measurement of physical properties of a solution (e.g., viscosity). | 09-11-2008 |
Brian R. Mcnaughton, Rochester, NY US
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20100233106 | SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION - The present invention relates to small molecule modulators of melanin expression and methods of making the small molecules. Also disclosed are methods of increasing pigmentation in a cell which involve providing compounds of the present invention and contacting a cell with the compounds under conditions effective to induce melanin expression in the cell, thereby increasing pigmentation. The present invention also relates to compositions containing compounds of the present invention and a carrier. | 09-16-2010 |
20100266677 | NUCLEIC ACID BINDING COMPOUNDS AND METHODS OF USE - The present invention relates to homo- and hetero-dimer compounds formed by a disulfide, sulfinyl thio, or olefin bond between two monomers. A method of making a homo- or hetero-dimer compound is also disclosed. The present invention also relates to monomer compounds capable of forming homo- or hetero-dimer compounds, as well as oligomers formed via linkage of one or more dimers. Also disclosed are methods of inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-I RNA frameshifting stem-loop and a (CUG)n expanded repeat stem-loop are disclosed, as are methods of treating diseases associated with these target RNA molecules. The dimer compounds can also be used for selectively detecting presence of the target RNA molecule in a sample. | 10-21-2010 |
Brian R. Mcnaughton, Fort Collins, CO US
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20140011214 | DETECTION OF BIOPOLYMER INTERACTIONS, CANCER CELLS, AND PATHOGENS USING SPLIT-SUPERCHARGED GFP - Systems and methods for detecting protein-protein interactions and/or detecting a targeted cell using a split supercharged protein reporter system are described. | 01-09-2014 |
20140186265 | MULTIFUNCTIONAL BACTERIOPHAGE FOR DELIVERY OF THERAPEUTIC AGENTS AND IMAGING REAGENTS - This invention relates to modified bacteriophage useful for the delivery of macromolecular biopolymers and nanoparticles to target cells, e.g., disease cells, and their use in cell-selective identification and imaging, as well as the treatment and prevention of diseases and other medical conditions. | 07-03-2014 |
Brian R. Mcnaughton, Cambridge, MA US
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20110112040 | SUPERCHARGED PROTEINS FOR CELL PENETRATION - Compositions, systems and related methods for delivering a supercharged protein or a complex of a supercharged protein and therapeutic agent (e g, nucleic acid, peptide, small molecule) to cells are disclosed. Superpositively charged proteins may be associated with nucleic acids (which typically have a net negative charge) via electrostatic interactions. The systems and methods may involve altering the primary sequence of a protein in order to “supercharge” the protein (e g, to generate a superpositively-charged protein). The compositions may be used to treat proliferative diseases, infectious diseases, cardiovascular diseases, inborn errors in metabolism, genetic diseases, etc. | 05-12-2011 |
20120100569 | SUPERCHARGED PROTEINS FOR CELL PENETRATION - Compositions, preparations, systems, and related methods for delivering a supercharged protein, or a complex of a supercharged protein and an agent (e.g., nucleic acids, peptides, proteins, small molecules) to cells are provided. Such systems and methods include the use of supercharged proteins. For example, superpositively charged proteins may be associated with nucleic acids (which typically have a net negative charge) via electrostatic interactions. In some embodiments, such systems and methods involve altering the primary sequence of a protein in order to “supercharge” the protein (e.g., to generate a superpositively-charged protein). In some embodiments, complexes comprising supercharged proteins and one or more agents to be delivered are useful as therapeutic agents. In some embodiments, complexes and/or pharmaceutical compositions thereof are administered to a subject in need thereof. The inventive complexes or pharmaceutical compositions thereof may be used to treat proliferative diseases, infectious diseases, cardiovascular diseases, inborn errors in metabolism, genetic diseases, etc. | 04-26-2012 |
Bruce Mcnaughton, Leuven BE
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20150335257 | Hyperdrive and Neuroprobes for Stimulation Purposes - A kit of parts for electrical stimulation and/or recording of activity of excitable cells in a tissue is described. The kit of parts comprises on the one hand a probe guiding means comprising a plurality of accommodation channels, each channel being adapted for accommodating a probe device having a plurality of stimulation means and/or recording means located on a die. At least one of the plurality of accommodation channels has a curved shape. The kit of parts also comprises at least one probe device for electrical stimulation and/or recording of activity of excitable cells in a tissue, the probe device comprising a plurality of stimulation means and/or recording means located on a die having a thinned and etched surface for providing flexibility to the probe device. | 11-26-2015 |
Bruce L. Mcnaughton, Lethbridge CA
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20160022168 | BRAIN STATE DEPENDENT THERAPY FOR IMPROVED NEURAL TRAINING AND REHABILITATION - The disclosure provides an apparatus and method for assessing brain plasticity by measuring electrical brain biomarkers, for example, with a near real-time analysis of electrical brain biomarkers, where an increase or decrease in at least one biomarker is indicative of a state of brain plasticity in response to a stimulus or treatment. Brain plasticity can be measured with or without an added stimuli, for example, to determine the best time for learning. Also provided is a method for treating a neurological disease or trauma by applying an electrical or drug stimulus to a patient, where the stimulus is increased or decreased depending on the changes of electrical brain biomarker of the patient. This treatment can occur in near real-time, so a course of treatment can be tailored immediately to a patient's needs. | 01-28-2016 |
Bruce Leslile Mcnaughton, Lethbridge CA
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20140137715 | MICROTOME CHAMBER, SAMPLE HOLDER AND SAMPLE PROCESSING METHOD - The disclosure relates to the automatic staining, imaging, cutting and collection of samples in a sample-processing device, in particular in a microtome. It provides a general-purpose sample holder, which comprises fluid exchange means for, e.g., surface staining and washing of a specimen. Furthermore, it provides a microtome chamber comprising sample collection means. A directional flow is used in the microtome chamber to transport a cut section of the specimen to a sample collection chamber. The present microtome chamber is especially useful to automatically collect delicate microtome samples, such as thin fresh tissue slices prepared by a vibratome. The microtome chamber may further comprise a sample holder receptacle and means to transport fluids to and from the fluids exchange means of the sample holder. | 05-22-2014 |
Craig Mcnaughton, Kirkcaldy GB
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20080266399 | IMAGE PROCESSING APPARATUS AND METHOD - An image processing device including an encoder processor and a decoder circuit. The encoder processor receives image data from a sensor and encodes the data with padding data if a series of bytes indicative of command sequence occur within the image data. The decoder circuit receives the image data and the padding data, and removes the padding data from within the image data. | 10-30-2008 |
James L. Mcnaughton, Salisbury, MD US
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20090324786 | Underwater Pressure Arc Discharge System for Disinfection of Food and Food Products - A method for reducing and/or eliminating bacterial contamination in a food product includes immersing the food product in the tank containing a fluid and discharging a pressure arc beneath the surface of the fluid wherein the pressure arc is effective in disrupting cell equilibrium and/or inactivating the bacteria. A system for use in the method includes an electrical input/output system, a reflector, the reflector reflecting an output charge between two oppositely charged electrodes, and a fluid filled tank. The method and system are effective in the reduction of food-borne bacterial contaminants particularly in or on poultry, red meat, and/or pork. | 12-31-2009 |
James L. Mcnaughton, Quantico, MD US
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20090081317 | Microbiocidal Control in the Processing of Meat-Producing Four-Legged Animals - Methods of processing four-legged slaughter animals for consumption as meat and/or meat product(s) are described. The methods comprise (I) contacting exterior surfaces of the live animal at least once when the animal is en route to being slaughtered but before it is killed by exsanguination, with a microbiocidal solution, or (II) contacting a carcass of the animal, after exsanguination, with a microbiocidal solution, or (III) contacting at least one raw meat product and/or at least one processed meat product derived from the carcass at least once with a microbiocidal solution, or (IV) conducting any two or all three of (I), (II), and (III). In each case the microbiocidal solution is, independently, comprised of: (a) water having a bromine residual derived from (i) at least one bromine source, (ii) at least one alkali metal base, and/or at least one alkaline earth metal base, and (iii) at least one halogen stabilizer; or (b) water having a bromine residual derived from (i) ammonium bromide, and/or at least one alkali metal bromide, and/or at least one alkaline earth metal bromide, and (ii) at least one alkali metal hypohalite and/or at least one alkaline earth metal hypohalite; or (c) water having a bromine residual derived from a mixture or combination of any one or more of (a) and any one or more of (b); the bromine residual in each of (a), (b), and (c) being sufficient to provide microbiocidal activity. | 03-26-2009 |
20090110768 | Microbiocidal Control in the Processing of Meat-Producing Four-Legged Animals - Methods of processing four-legged slaughter animals for consumption as meat and/or meat product(s) are described. The methods comprise: I) contacting exterior surfaces of the live animal at least once with a microbiocidal solution formed from mixing together at least (i) water and (ii) at least one 1,3-dibromo-5,5-dialkylhydantoin, such contacting occurring at least once when the animal is en route to being slaughtered but before it is killed by exsanguination; or II) contacting the carcass of the animal, after exsanguination, with a microbiocidal solution formed from mixing together at least (i) water and (ii) at least one 1,3-dibromo-5,5-dialkylhydantoin or III) contacting at least one raw meat product and/or at least one processed meat product derived from the carcass. The contacting can be done one or more times in each of I), II), and III). Considerable advantages, which are described, are realized when using such methods. | 04-30-2009 |
20110136882 | MICROBIOCIDAL CONTROL IN THE PROCESSING OF MEAT-PRODUCING FOUR-LEGGED ANIMALS - Methods of processing four-legged slaughter animals for consumption as meat and/or meat product(s) are described. The methods comprise I) contacting exterior surfaces of the live animal at least once with a microbiocidal solution formed from mixing together at least (i) water and (ii) at least one N,N′-bromochloro-5,5-dialkylhydantoin, such contacting occurring at least once when the animal is en route to being slaughtered but before it is killed by exsanguination; or II) contacting the carcass of the animal, after exsanguination, with a microbiocidal solution formed from mixing together at least (i) water and (ii) at least one N,N′-bromochloro-5,5-dialkylhydantoin or III) contacting at least one raw meat product and/or at least one processed meat product derived from the carcass. The contacting can be done one or more times in each of I), II), and III). Considerable advantages, which are described, are realized when using such methods. | 06-09-2011 |
20110189338 | MICROBIOCIDAL CONTROL IN THE PROCESSING OF MEAT-PRODUCING FOUR-LEGGED ANIMALS - Methods of processing four-legged slaughter animals for consumption as meat and/or meat product(s) are described. The methods comprise I) contacting exterior surfaces of the live animal at least once with a microbiocidal solution formed from mixing together at least (i) water and (ii) at least one 1,3-dibromo-5,5-dialkylhydantoin, such contacting occurring at least once when the animal is en route to being slaughtered but before it is killed by exsanguination; or II) contacting the carcass of the animal, after exsanguination, with a microbiocidal solution formed from mixing together at least (i) water and (ii) at least one 1,3-dibromo-5,5-dialkylhydantoin or III) contacting at least one to raw meat product and/or at least one processed meat product derived from the carcass. | 08-04-2011 |
James L. Mcnaughton, Denver, CO US
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20130033984 | SYSTEM AND METHOD FOR REMOTELY CONTROLLING NETWORK OPERATORS - A system and method for controlling communications networks. Network performance information is gathered from a first communications network using performance information packet data packets. A network operator of the first communications network is controlled from a secondary communications network using the performance information packet data packets. Changes to the network operator are implemented based on instructions included in the performance information packet data packets. | 02-07-2013 |
James L. Mcnaughton, Lenexa, KS US
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20090196185 | System and method for characterizing communication network capacity in a geographic area - A system for characterizing network capacity that stores premise addresses of subscribers and weighted values for the corresponding capacity of the network. Geographic areas containing subscribers are displayed and portions or all of them may be selected by a user. The system generates first descriptors for the selected geographic areas. The system generates an average capacity for the premise addresses for the selected geographic areas and the first descriptors are assigned to corresponding elements of a first matrix based on the weighted value for the calculated average capacity for the premise addresses. The system generates a second matrix representing the relationship of all of the premise addresses and their respective capacity in the selected geographic area based on spatial population descriptors. The system further generates a third matrix using mathematical DCT formulas representing the overall capacity of the network in a geographic area. | 08-06-2009 |
20120182864 | SYSTEM AND METHOD FOR LOAD BALANCING NETWORK RESOURCES USING A CONNECTION ADMISSION CONTROL ENGINE - A system and method for load balancing network resources. Network performance information regarding data flow through a network is gathered using performance information packet data packets. The data flow is distributed through access points of the network using connection control admission control engines. The distributing includes routing the data flow to more efficiently use the network resources based on the PIP data packets. | 07-19-2012 |
20120236729 | SYSTEM AND METHOD FOR PROVISIONING RESOURCES OF A PACKET NETWORK BASED ON COLLECTED NETWORK PERFORMANCE INFORMATION - A system and method for provisioning resources of a packet network, including monitoring at least one network performance information parameter associated with communications of data packets. The at least one network performance information parameter(s) may be compared with at least one respective threshold value indicative of degradation of communications of the data packets. A determination may be made that the network performance information parameter(s) crosses the respective threshold value(s). In response to determining that the network performance information parameter(s) crosses the respective threshold value(s), a network resource may be provisioned to compensate for the degradation of communications of the data packets. | 09-20-2012 |
20130322249 | SYSTEM AND METHOD FOR IMPROVING NETWORK PERFORMANCE USING A CONNECTION ADMISSION CONTROL ENGINE - The disclosed embodiments include a method, apparatus, and computer program product for modifying a three-dimensional geocellular model. For example, one disclosed embodiment includes a system that includes at least one processor and at least one memory coupled to the at least one processor. The memory stores instructions that when executed by the at least one processor performs operations that includes gathering network performance information regarding data flow communicated with a client of a network over a plurality of connections utilizing performance information packets; and automatically balancing the data flow of the plurality of connections between access points of the network that are available to the client using connection admission control engines. | 12-05-2013 |
20140050106 | SYSTEM AND METHOD FOR HANDLING COMMUNICATIONS REQUESTS - A system and method for handling communications requests. Network performance information of a communications network is gathered using PIP data packets to determine a status of a number of nodes of the communications network. Available bandwidth through connections of the communications network are determined based on the PIP data packets. The available bandwidth for a number of customers is allocated for new connections and utilized bandwidth through the connections as the utilized bandwidth changes across the communications network. | 02-20-2014 |
20140297847 | System and Method for Tracking Application Resource Usage - A system and method for tracking application resource usage. Network performance information of a communications network is gathered using performance information packet data packets. The network performance information is communicated to an application. Instructions in the application are executed in response to receiving the network performance information. | 10-02-2014 |
James Lloyd Mcnaughton, Lenexa, KS US
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20110135074 | SYSTEM AND METHOD FOR PROVIDING MULTI-PROVIDER TELECOMMUNICATIONS SERVICES OVER A PASSIVE OPTICAL NETWORK - A method for providing access to a passive optical network for services to homes or businesses from two or more telecommunications service providers and a billing means is described. A first service provider connects to a point of presence at one side of passive optical network. The provider transmits the appropriate services through this network to an authorization receiver. The authorization receiver is used to receive a periodic authorization code from the network provider to enable the appropriate services from the service provider to be transmitted to a subscriber at a home or business. The authorization receiver enables an optical fiber path to be established for the services to flow to and from the home or business. The authorization code that is transmitted through the network also provides an unambiguous means to provide a billing record such that the service provider can be billed by the network provider on an individual service address connected basis in conjunction with a record of houses passed and not yet connected. | 06-09-2011 |
20130089188 | System and Method for Providing Multi-Provider Telecommunications Services Over a Passive Optical Network - A method for providing access to a passive optical network for services to homes or businesses from two or more telecommunications service providers and a billing means is described. A first service provider connects to a point of presence at one side of passive optical network. The provider transmits the appropriate services through this network to an authorization receiver. The authorization receiver is used to receive a periodic authorization code from the network provider to enable the appropriate services from the service provider to be transmitted to a subscriber at a home or business. The authorization receiver enables an optical fiber path to be established for the services to flow to and from the home or business. The authorization code that is transmitted through the network also provides an unambiguous means to provide a billing record such that the service provider can be billed by the network provider on an individual service address connected basis in conjunction with a record of houses passed and not yet connected. | 04-11-2013 |
Jerry Mcnaughton, Houston, TX US
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20110198379 | SLUDGE AND SEDIMENT REMOVAL SYSTEM BY REMOTE ACCESS - A compound conduit containing inner and outer conduits with apertures in the former that are angled to direct jets of fluid in a rearward direction from the inner conduit into the annular space is used to draw sludge or undesirable material from a vessel without imposing a vacuum on the system. In conjunction with the compound conduit is a rotary tube seal that allows the conduit to be mounted to an orifice in a tank wall and pivoted or rotated over a range of angles. A tubing drive mechanism grasps the tubing at locations well removed from the distal end and causes the tubing to travel in the direction of the tubing axis. The gripping members in the mechanism engage the sides of the tubing and are capable of shifting position relative to each other to accommodate changes in the curvature of the tubing. | 08-18-2011 |
20110198815 | SLUDGE AND SEDIMENT REMOVAL SYSTEM BY REMOTE ACCESS - A compound conduit containing inner and outer conduits with apertures in the former that are angled to direct jets of fluid in a rearward direction from the inner conduit into the annular space is used to draw sludge or undesirable material from a vessel without imposing a vacuum on the system. In conjunction with the compound conduit is a rotary tube seal that allows the conduit to be mounted to an orifice in a tank wall and pivoted or rotated over a range of angles. A tubing drive mechanism grasps the tubing at locations well removed from the distal end and causes the tubing to travel in the direction of the tubing axis. The gripping members in the mechanism engage the sides of the tubing and are capable of shifting position relative to each other to accommodate changes in the curvature of the tubing. | 08-18-2011 |
Michael Mcnaughton, Leuven BE
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20140213586 | VIRAL REPLICATION INHIBITORS - The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds. | 07-31-2014 |
Neil Mcnaughton, Cumminstown GB
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20120243945 | METHOD, APPARATUS AND SYSTEM FOR ATTACHING AN ANCHOR MEMBER TO A FLOOR OF A BODY OF WATER - A remotely operable drilling apparatus ( | 09-27-2012 |
Robbie Mcnaughton, North Ryde AU
Stephen J. Mcnaughton, Charlottesville, VA US
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20120226568 | Bar Bandit - A method and system for streamlining the customer experience at a live event or in a bar/restaurant setting thru the use of an electronic device; the process may include the use of a chip embedded in/bar code imprinted on a bracelet worn by the customer or displayed on an electronic device. When seating is limited, this check-in process will also allow the customer to reserve the next available table. The vendor can page each checked-in guest via the Bar Bandit system when their table becomes available; this will eliminate the need for a physical restaurant pager. The Bar Bandit system will allow the acceleration of any portion of the client service experience; this may include any of the following: interaction w/the ordering system, payment processing & paging the server. | 09-06-2012 |