Mctiernan
Brian J. Mctiernan, Sewickley, PA US
Patent application number | Description | Published |
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20120230859 | MARAGING STEEL ARTICLE AND METHOD OF MANUFACTURE - A fully dense, powder-metallurgy produced maraging steel alloy article of prealloyed powder for use as a tool for high temperature applications. The article in the as-produced condition having a hardness less than 40 HRC to provide machinability and thereafter the article upon maraging heat treatment having a hardness greater than 45 HRC. A method for producing this article comprises compacting prealloyed powder to produce a fully dense article having a hardness less than 40 HRC and thereafter maraging heat treating to a hardness greater than 45 HRC. | 09-13-2012 |
Charles F. Mctiernan, Pittsburgh, PA US
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20130204166 | CUSTOM DESIGNED MICROBUBBLE CONTRAST AGENTS AND TECHNIQUES OF ULTRASOUND DELIVERY OPTIMIZED FOR GENE THERAPY - The invention pertains to a lipid-based microbubble stably binding a plurality of nucleic acids, and a method of delivering the microbubble and nucleic acids to a specific target site using ultrasound. The delivered nucleic acids create transgenic cells (i.e., for example, a transgenic tumor cell), wherein the transgenic cell expresses the proteins encoded by the delivered nucleic acids. This technology provides a significant improvement for microbubble-drug delivery platforms as known microbubble do not efficiently bind nucleic acids. The improvements described herein include but are not limited to identifying proper lipid proportionality ratios and/or cationic surfactant layers that provide an optimum mechanical index compatible with ultrasonics. Microbubble perfusion and/or nucleic acid delivery may be performed by a combination of imaging and ultrasound/microbubble targeted delivery to simultaneously perform low power two-dimensional imaging and high power microbubble destruction. Such systems are useful in therapeutics and/or diagnostics. For example, the data disclosed herein shows proof of principle in conjunction with the delivery of therapeutic siRNA molecules to slow tumor growth. | 08-08-2013 |
Kevin Mctiernan, Castro Valley, CA US
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20120096145 | MULTI-TIER INTEGRATED SECURITY SYSTEM AND METHOD TO ENHANCE LAWFUL DATA INTERCEPTION AND RESOURCE ALLOCATION - A system, method, and apparatus for intercepting data streams such as packets on a network. In one embodiment, the method includes: receiving at a network surveillance system (NSS), a target to be intercepted on the network; creating a target identification (target ID) for the target, wherein the target ID is unique to the NSS in order to track data streams of the target during subsequent processing, such as extraction of content and metadata, in the NSS; intercepting the data streams of the target on the network; tagging the data streams of the target that are intercepted from the network with a respective target ID; transmitting the data streams of the target to the NSS for subsequent analysis; and distributing the data streams across a scalable quantity of data processing engines in the NSS. | 04-19-2012 |
20120259975 | AUTOMATIC PROVISIONING OF NEW USERS OF INTEREST FOR CAPTURE ON A COMMUNICATION NETWORK - A system, method, and apparatus for collecting data streams, such as data packets, on a network, such as the Internet, are disclosed. A metadata portion of at least one of the data streams is analyzed on the network and evaluated using a metadata processing engine to identify a relationship between at least two of the plurality of data streams, e.g., a relationship between multiple users of a network, regardless of whether the users are currently of interest or if they are not of interest. An interface manager can receive an information of a new user of interest, evaluate the new user of interest for redundancy against existing known users of interest of the NMS; then communicate the information of the new user of interest to at least one access device to collect data streams associated with the new user of interest. | 10-11-2012 |