Patent application number | Description | Published |
20090289016 | REDUCING WATER PURIFICATION MATERIAL, METHOD FOR PRODUCING REDUCING WATER PURIFICATION MATERIAL, METHOD FOR TREATING WASTEWATER, AND WASTEWATER TREATMENT APPARATUS - A reducing water purification material having a reducing iron-based precipitate selected from green rust, iron ferrite, reducing iron hydroxide, and a mixture thereof. A wastewater treatment process having steps of adding a reducing iron compound to wastewater, leading the wastewater to which the reducing iron compound is added to a reaction tank and forming a precipitate, separating the formed precipitate by a solid-liquid separation to obtain a sludge, and alkalinizing all or a portion of the separated sludge to form an alkaline sludge followed by returning to the reaction tank, wherein in the precipitation step, the wastewater to which the reducing iron compound is added and the alkaline sludge are mixed and are allowed to react in a non-oxidizing atmosphere under alkaline condition to form a reducing iron compound precipitate as the precipitate, thereby incorporating contaminants in the precipitate to remove the contaminants from the wastewater. | 11-26-2009 |
20100000924 | REDUCING WATER PURIFICATION MATERIAL, METHOD FOR PRODUCING REDUCING WATER PURIFICATION MATERIAL, METHOD FOR TREATING WASTEWATER, AND WASTEWATER TREATMENT APPARATUS - A reducing water purification material having a reducing iron-based precipitate selected from green rust, iron ferrite, reducing iron hydroxide, and a mixture thereof. A wastewater treatment process having steps of adding a reducing iron compound to wastewater, leading the wastewater to which the reducing iron compound is added to a reaction tank and forming a precipitate, separating the formed precipitate by a solid-liquid separation to obtain a sludge, and alkalinizing all or a portion of the separated sludge to form an alkaline sludge followed by returning to the reaction tank, wherein in the precipitation step, the wastewater to which the reducing iron compound is added and the alkaline sludge are mixed and are allowed to react in a non-oxidizing atmosphere under alkaline condition to form a reducing iron compound precipitate as the precipitate, thereby incorporating contaminants in the precipitate to remove the contaminants from the wastewater. | 01-07-2010 |
Patent application number | Description | Published |
20130101581 | ANTIBODY CONSTANT REGION VARIANT - The present inventors carried out dedicated research to generate antibody constant regions with reduced Fcγ receptor-binding activity by altering amino acid sequences in the antibody constant region. As a result, the present inventors successfully identified novel constant region sequences with reduced Fcγ receptor-binding activity compared to conventional antibody constant regions. | 04-25-2013 |
20140093496 | Fc-gamma-RIIb-SPECIFIC Fc ANTIBODY - An objective of the present invention is to provide a polypeptide containing an Fc region having maintained or decreased binding activities towards both allotypes of FcγRIIa, types H and R, and having enhanced FcγRIIb-binding activity in comparison with a parent polypeptide; a pharmaceutical composition containing the polypeptide; an agent for treating or preventing immunological inflammatory diseases that includes the pharmaceutical composition; a production method thereof; and a method for maintaining or decreasing binding activities towards both allotypes of FcγRIIa and enhancing the FcγRIIb-binding activity. Specifically, it is found that a polypeptide containing an antibody Fc region that has an alteration of substituting Pro at position 238 (EU numbering) with Asp or Leu at position 328 (EU numbering) with Glu enhances FcγRIIb-binding activity, and maintains or decreases binding activities towards both allotypes of FcγRIIa, types H and R. It is also found that a polypeptide containing an antibody Fc region that contains an alteration of substituting Pro at position 238 (EU numbering) with Asp and several other alterations, enhances FcγRIIb-binding activity, and maintains or decreases binding activities towards both allotypes of FcγRIIa, types H and R. | 04-03-2014 |
20140105889 | METHOD FOR ALTERING PLASMA RETENTION AND IMMUNOGENICITY OF ANTIGEN-BINDING MOLECULE - The present invention demonstrated that the modification of the Fc region of an antigen-binding molecule into an Fc region that does not form in a neutral pH range a heterotetramer complex containing two molecules of FcRn and an active Fcγ receptor improved the pharmacokinetics of the antigen-binding molecule and reduced the immune response to the antigen-binding molecule. The present invention also revealed methods for producing antigen-binding molecules having the properties described above, and successfully demonstrated that pharmaceutical compositions containing as an active ingredient such an antigen-binding molecule or an antigen-binding molecule produced by a production method of the present invention have excellent features over conventional antigen-binding molecules in that when administered, they exhibit improved pharmacokinetics and reduced in vivo immune response. | 04-17-2014 |
20140199294 | HETERODIMERIZED POLYPEPTIDE - The present inventors produced a heterodimerized polypeptide having an Fc region formed from two polypeptides with different amino acid sequences (a first polypeptide and a second polypeptide), and succeeded in producing a heterodimerized polypeptide containing an Fc region with improved Fc region function compared to that of a homodimer in which the Fc region is composed of only the first polypeptide or only the second polypeptide by conventional technology. | 07-17-2014 |
20140363428 | THERAPEUTIC ANTIGEN-BINDING MOLECULE WITH A FcRn-BINDING DOMAIN THAT PROMOTES ANTIGEN CLEARANCE - The present invention provides: a modified FcRn-binding domain having an enhanced affinity for the Fc Receptor neonatal (FcRn) at neutral pH; an antigen-binding molecule comprising said FcRn-binding domain, which has low immunogenicity, high stability and form only a few aggregates; a modified antigen-binding molecule having an increased FcRn-binding activity at neutral or acidic pH without an increased binding activity at neutral pH for a pre-existing anti-drug antibody; use of the antigen-binding molecules for improving antigen-binding molecule-mediated antigen uptake into cells; use of the antigen-binding molecules for reducing the plasma concentration of a specific antigen; use of the modified FcRn-binding domain for increasing the total number of antigens to which a single antigen-binding molecule can bind before its degradation; use of the modified FcRn-binding domain for improving pharmacokinetics of an antigen-binding molecule; methods for decreasing the binding activity for a pre-existing anti-drug antibody; and methods for producing said antigen-binding molecules. | 12-11-2014 |
20150203577 | MOUSE FcgammaRII-SPECIFIC Fc ANTIBODY - The present inventors have successfully found a large number of Fc variants with remarkably increased binding activity against and/or binding selectivity for mouse FcγRII by introducing amino acid alteration(s) to the Fc region. | 07-23-2015 |
20150210763 | MODIFIED Fc REGION OF ANTIBODY - Polypeptides with improved stability as compared to that of a parent polypeptide were successfully obtained by modifying at least one amino acid in a loop region of the antibody Fc region. Furthermore, by combining multiple amino acid modifications in the loop region, polypeptides with maintained or enhanced FcγR-binding activity as well as improved thermal stability, polypeptides with decreased FcγR-binding activity as well as improved thermal stability, and polypeptides with not only improved thermal stability and adjusted FcγR-binding activity but also decreased aggregate content, as compared to those of a parent polypeptide, were successfully obtained. | 07-30-2015 |
20150299296 | FCgammaRIIB-SPECIFIC FC REGION VARIANT - An objective of the present invention is to provide an Fc region variant with enhanced FcγRIIb-binding activity, and/or enhanced binding selectivity to FcγRIIb compared to FcγRIIa (type R), as compared to those of a polypeptide containing an Fc region to which an amino acid alteration(s) has not been introduced; a polypeptide which includes the Fc region variant; a pharmaceutical composition containing the polypeptide; preventing therapeutic or preventive agent for immunological inflammatory diseases that includes the pharmaceutical composition; a production method thereof; and a method of enhancing FcγRIIb-binding activity and also enhancing binding selectivity to FcγRIIb compared to FcγRIIa (type R). | 10-22-2015 |
20150344570 | HETERODIMERIZED POLYPEPTIDE - The present inventors produced a heterodimerized polypeptide having an Fc region formed from two polypeptides with different amino acid sequences (a first polypeptide and a second polypeptide), and succeeded in producing a heterodimerized polypeptide containing an Fc region with improved function compared to that of a homodimer in which the Fc region is composed of only the first polypeptide or the second polypeptide by conventional technology. | 12-03-2015 |
20160039912 | Fc REGION VARIANT - A polypeptide containing an antibody Fc region variant which has an amino acid sequence in which an amino acid alteration at position 238 according to EU numbering is combined with other specific amino acid alteration(s), was found to have decreased binding activities to all activating FcγRs, in particular FcγRIIa (R type), while maintaining its FcγRIIb-binding activity, when compared to a polypeptide containing a native IgG Fc region. | 02-11-2016 |
20160046693 | Antigen-Binding Molecule for Promoting Disappearance of Antigen via Fc gamma RIIB - The present invention provides antigen-binding molecules containing (i) an antigen-binding domain whose antigen-binding activity varies depending on ion concentration conditions, (ii) an FcγR-binding domain having Fcγ RIIb-selective binding activity, and (iii) an FcRn-binding domain having FcRn-binding activity under an acidic pH range condition, and methods of decreasing plasma antigen concentration as compared to before administering the molecule, which include the step of administering the molecule. | 02-18-2016 |
Patent application number | Description | Published |
20120134733 | PLATEN AND IMAGE RECORDING APPARATUS - A platen, which supports the recording paper to be transported, includes a first portion having an upper surface on which an ink discharged from nozzles disposed thereover can be landed, first ribs which are provided to extend in a transport direction in an area of the upper surface and which support the recording paper on an upper side beyond the upper surface, and a second portion which is provided on at least one of an upstream side and a downstream side of the first portion. | 05-31-2012 |
20140092188 | Sheet Feeder and Image Recording Apparatus Equipped with the Sheet Feeder - A sheet feeder, including: a sheet supply roller configured to supply a sheet to a sheet feeding path; a sheet feed roller configured to feed the sheet supplied to the sheet feeding path by the sheet supply roller to a downstream side in a sheet feeding direction in which the sheet is fed; a discharge roller configured to discharge the sheet fed by the feed roller to a downstream side in the sheet feeding direction; a drive motor configured to drive a first shaft for rotating the feed roller; a first transmitting mechanism configured to transmit a rotary motion of the first shaft to a second shaft for rotating the discharge roller; and a second transmitting mechanism configured to transmit a rotary motion of the second shaft to a third shaft for rotating the sheet supply roller. | 04-03-2014 |
20140232054 | CONVEYING DEVICE AND IMAGE RECORDING APPARATUS - A conveying device includes: a conveyor for conveying a sheet; a path defining member having a first conveying surface that guides the sheet; and a sensor device for sensing the sheet. The sensor device includes: a sensor casing provided on the path defining member and including a second conveying surface that guides the sheet and a main wall whose outer surface is exposed from the path defining member and contiguous to the first conveying surface; a movable member including (i) a contact portion projecting to a second-conveying-surface side of the main wall through an opening formed in the main wall and (ii) a sensed portion located in the sensor casing and moved by the sheet conveyed on the second conveying surface while contacting the contact portion; and a signal output device, provided in the sensor casing, for sensing the sensed portion to output a signal related to its position. | 08-21-2014 |
20140232058 | TRANSPORTING APPARATUS - A transporting apparatus includes a base unit made of resin, a tray configured to support a sheet, a transporting section supported by an upper portion of the base unit and configured to transport the sheet, and a feeding section supported by a lower portion of the base unit and including a feeding roller configured to contact an upper surface of the sheet supported by the tray and to feed the sheet toward the transporting section. The base unit is integrally formed with an inner-side guide which defines an inner side of a curved path which is configured to guide the sheet fed by the feeding section to the transport section. | 08-21-2014 |
20140232059 | TRANSPORT APPARATUS AND IMAGE RECORDING APPARATUS - A transport apparatus includes a transport roller having a first supported portion and a second supported portion at positions separated in a first direction, and configured to abut against a sheet, rotate in a second direction about a rotation axis extending in the first direction, and transport the sheet; a first support member configured to rotatably support the transport roller, the first support member having a first receiving portion which is in the form of a circular arc and configured to abut against a portion in a circumferential direction of an outer periphery of the first supported portion; and a second support member configured to rotatably support the transport roller, the second support member having a second receiving portion which is in the form of a circular arc and configured to abut against a portion in a circumferential direction of an outer periphery of the second supported portion. | 08-21-2014 |
20140232784 | Inkjet Recording Apparatus - An inkjet recording device is described in which maintenance is performed by a maintenance unit upon a recording head. The maintenance unit is located on a base unit. The base unit includes a wall portion supporting a plurality of gear shafts protruding in a width direction from the wall portion. | 08-21-2014 |
20140232789 | INKJET RECORDING APPARATUS - An inkjet recording apparatus includes a support member having a plurality of ribs and supporting the sheet; a head disposed above the support member and ejecting ink to the sheet supported by the support member; and at least one contact portion disposed upstream of the head and configured to come in contact with the sheet so as to make the sheet a waved shape. The support member includes a first support portion comprising at least one first guide portions disposed corresponding to the at least one contact portion, and a plurality of second guide portions disposed corresponding to the plurality of ribs and disposed above the plurality of first guide portions. The support member further comprises a second support portion comprising a third guide portion disposed downstream of the first support portion. | 08-21-2014 |
20140232798 | INK-JET RECORDING APPARATUS - An ink-jet recording apparatus includes: a base member a conveyor unit supported by the base member, for conveying a sheet in a conveying direction parallel to a first direction; and a recording unit, supported by the base member for ejecting ink when the recording unit is opposed to the sheet in a second direction perpendicular to the first direction. The base member is divided into a first base portion that supports the conveyor unit and the recording unit, a second base portion contiguous to the first base portion and located downstream of the first base portion in the conveying direction, and a third base portion contiguous to the second base portion and located downstream of the second base portion in the conveying direction. A stiffness of the second base portion is less than that of each of the first base portion and the third base portion. | 08-21-2014 |
20140232799 | Inkjet Recording Apparatus Having Frame for Supporting Carriage - In an inkjet recording apparatus, a support frame has a support part, and supports a carriage on a first surface of the support part. A pinch roller is disposed on a second surface side of the support part, the second surface being opposite from the first surface. A conveying roller is disposed opposite to the support frame relative to the pinch roller and in confrontation with the pinch roller. A roller holder is disposed on the second surface side of the support part and supporting the pinch roller. An urging member is interposed between the roller holder and the support part, and urges the roller holder to press the pinch roller against the conveying roller. The carriage is in contact with the first surface of the support part while the urging member is in contact with the second surface of the support part. | 08-21-2014 |
20140232800 | Conveyor Device and Image Recording Apparatus - A conveyor device may include first and second conveyor units, and a movable member. The first conveyor unit includes a first roller that contacts an upper surface of a sheet and a second roller that contacts a lower surface of the sheet. The second conveyor unit includes a third roller that contacts the lower surface of the sheet and a fourth roller that contacts the upper surface of the sheet. The first and second rollers and the third and fourth rollers nip and convey the sheet along a conveyance path. When the movable member is located in a first position, the first roller contacts the second roller and the third roller contacts the fourth roller. When the movable member moves to the second position, the first roller is moved away from the second roller and the third roller is moved away from the fourth roller. | 08-21-2014 |
20140232801 | INK-JET RECORDING APPARATUS - An ink-jet recording apparatus includes: a base member; a conveyor unit for conveying a sheet in a first direction; and a recording unit for ejecting ink when opposed to a sheet in a second direction. The base member includes: a first side base portion; a second side base portion; a center base portion located between the first side base portion and the second side base portion in a third direction; first and second side walls extending in the first direction and projecting in the second direction from opposite edge portions of the center base portion in the third direction; and a main board connecting the first side wall and the second side wall and configured to support the conveyor unit and the recording unit. The main board is greater in stiffness than the first side wall and the second side wall. | 08-21-2014 |
20150070455 | IMAGE RECORDING APPARATUS - An image recording apparatus includes: a roller pair for conveying a sheet in a conveying direction along a conveyance path; a head for ejecting liquid; a platen opposite the head; contact portions, spaced apart from each other in a widthwise direction and opposite the platen, for contacting the sheet between the roller pair and nozzles of the head; first and second guide members disposed upstream of the roller pair in the conveying direction and disposed in the conveyance path nearer to the head and the platen, respectively; a rotatable lever including an arm protruding from the first guide member toward the second guide member into the conveyance path; and a sensor for detecting rotation of the lever. The arm in the widthwise direction overlaps at least one of the contact portions. | 03-12-2015 |
20150090561 | CONVEYING DEVICE - A conveying device includes: opposed first and second rollers disposed to a first path; a roller holder supporting the second roller and movable between a first position where the second roller contacts the first roller and a second position where the second roller is spaced apart from the first roller; and opposed first and second guide members defining a second path merged with the first path. The first guide member is movable between a third position where the first guide member is spaced apart from the second guide member at a predetermined distance and a fourth position where their distance is less than the predetermined distance. The first guide member includes a guide portion for contacting and moving the roller holder from the first position to the second position in response to movement of the first guide member from the third position to the fourth position. | 04-02-2015 |
20150091981 | INKJET RECORDING APPARATUS - An inkjet recording apparatus and method of operation are disclosed. One such apparatus includes a carriage configured to support a recording head that is configured to eject ink from nozzles onto a recording medium to be conveyed, and a first support member supporting the carriage. The carriage is movable in a scanning direction orthogonal to a transporting direction of the recording medium. The apparatus further includes a second support member configured to support the first support member and a transporting roller extending in the scanning direction and rotatable to transport the recording medium in the transporting direction. The apparatus also includes a bearing disposed at the second support member and supporting the transporting roller rotatably, the bearing comprising a contact portion that contacts the first support member. | 04-02-2015 |
20150321491 | Image Recording Apparatus - A sheet feeder, including: a sheet supply roller configured to supply a sheet to a sheet feeding path; a sheet feed roller configured to feed the sheet supplied to the sheet feeding path by the sheet supply roller to a downstream side in a sheet feeding direction in which the sheet is fed; a discharge roller configured to discharge the sheet fed by the feed roller to a downstream side in the sheet feeding direction; a drive motor configured to drive a first shaft for rotating the feed roller; a first transmitting mechanism configured to transmit a rotary motion of the first shaft to a second shaft for rotating the discharge roller; and a second transmitting mechanism configured to transmit a rotary motion of the second shaft to a third shaft for rotating the sheet supply roller. | 11-12-2015 |
20160089899 | Image Recording Apparatus - An image recording apparatus includes: a recording section configured to record an image on a sheet conveyed in a conveyance direction in a conveyance route; and an abutment member having a plurality of abutment portions which are arranged apart from each other in a width direction orthogonal to the conveyance direction so that the plurality of abutment portions abut against the sheet convened in the conveyance route respectively, and a connecting portion connecting adjacent abutment portions among the plurality of abutment portions. The connecting portion twists so as to rotate with the width direction as a rotation axis, under a condition that the plurality of abutment portions abuts against the sheet. | 03-31-2016 |
20160089903 | Image Recording Apparatus - An image recording apparatus includes: a recording section which records an image on a sheet conveyed in a conveyance direction in a conveyance route; a first abutment member having a plurality of first abutment portions arranged apart from each other in a width direction orthogonal to the conveyance direction, and configured to abut against the sheet conveyed in the conveyance route; a first supporting member which supports the first abutment member; and a plurality of second abutment members which are supported by the first supporting member at both sides in the width direction, respectively, of the first abutment member, at a distance from the first abutment member, and each of which has a second abutment portion capable of contacting with the sheet conveyed in the conveyance route. | 03-31-2016 |
20160090252 | SHEET CONVEYING DEVICE - A slider moving in a sliding direction between first and second positions shifts a second path-defining member, relative to a first path-defining member, between first and second states. A pair of movable members each disposed on a corresponding side of a slider in a width direction is movable individually in the sliding direction to shift between third and fourth states. The movable members, when both in the third state, position the slider to the first position and, when both in the fourth state, position the slider to the second position. Each movable member supports a corresponding widthwise end of the slider immovably in the sliding direction and movably in the width direction. A support frame supporting the second path-defining member supports a widthwise central portion of the slider movably in the sliding direction and rotatably on a plane parallel to the sliding direction and the width direction. | 03-31-2016 |
20160090254 | SHEET CONVEYING DEVICE AND IMAGE RECORDING APPARATUS - A sheet conveying device includes a flap pivoting between a first state to contact a first path-defining member and a second state to be separated from a first path-defining member. The first path-defining member, which faces a second path-defining member in a facing direction, includes a guide surface for guiding a sheet conveyed along a first conveying path, a contact surface positioned farther from the second path-defining member in the facing direction than the guide surface and configured to contact the flap in the first state, and an inclined surface positioned downstream of the contact surface in a conveying direction and inclined such that an upstream end thereof in the conveying direction is closer to the second path-defining member in the facing direction than a downstream end thereof. The upstream end of the inclined surface is closer to the second path-defining member in the facing direction than the contact surface. | 03-31-2016 |