Patent application number | Description | Published |
20150360224 | MICROFLUIDIC DEVICES, SYSTEMS, AND METHODS FOR EVALUATING TISSUE SAMPLES - A microfluidic device for evaluating a tissue sample can include a tissue chamber, a liquid inlet channel, a liquid outlet channel, and at least one of components (1)-(3). The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet and outlet channels can be in fluid communication with the tissue chamber. Components (1)-(3) can include: (1) a deformable membrane disposed within the tissue chamber and being configured to oscillate, upon application of pressure thereto, to mechanically compress the tissue sample; (2) first and second electrodes disposed about the tissue chamber and being configured such that delivery of electrical energy thereto creates an electrical gradient across the tissue chamber; and (3) at least one deformable wall, which partially defines the tissue chamber and is configured to stretch either uniaxially or biaxially upon application of negative pressure to the tissue chamber. | 12-17-2015 |
20150362411 | MICROFLUIDIC DEVICES, SYSTEMS, AND METHODS FOR IMAGING TISSUE SAMPLES - One aspect of the present disclosure can include a microfluidic device for imaging a tissue sample. The device can include a tissue chamber, a liquid inlet channel, and a liquid outlet channel. The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet channel can be fluid communication with the tissue chamber. The liquid outlet channel can be in fluid communication with the tissue chamber. The tissue chamber can be sized and dimensioned to completely immobilize the tissue sample during imaging. | 12-17-2015 |
Patent application number | Description | Published |
20080269846 | DEVICE FOR TREATMENT OF BLOOD VESSELS USING LIGHT - Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member. | 10-30-2008 |
20090182357 | DEVICE FOR INTERMITTENTLY OBSTRUCTING A GASTRIC OPENING AND METHOD OF USE - The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member includes an apron member surrounding a first occluding member, which is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device of the present invention is arranged transluminally, with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve. In certain embodiments, a reservoir may be included for releasing a substance of interest, for example for releasing insulin from a reservoir disposed in the distal member. Sensors, actuators, and data transmission devices may also be included. | 07-16-2009 |
20090182358 | DEVICE FOR INTERMITTENTLY OBSTRUCTING A GASTRIC OPENING AND METHOD OF USE - The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member includes an apron member surrounding a first occluding member, which is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device of the present invention is arranged transluminally, with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve. In certain embodiments, a reservoir may be included for releasing a substance of interest, for example for releasing insulin from a reservoir disposed in the distal member. Sensors, actuators, and data transmission devices may also be included. | 07-16-2009 |
20090198210 | DEVICE FOR INTERMITTENTLY OBSTRUCTING A GASTRIC OPENING AND METHOD OF USE - The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member includes an apron member surrounding a first occluding member, which is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device of the present invention is arranged transluminally, with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve. In certain embodiments, a reservoir may be included for releasing a substance of interest, for example for releasing insulin from a reservoir disposed in the distal member. Sensors, actuators, and data transmission devices may also be included. | 08-06-2009 |
20100274330 | DEVICE FOR TREATMENT OF BLOOD VESSELS USING LIGHT - Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member. | 10-28-2010 |
20110077464 | MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES AND METHODS FOR MANUFACTURING SAME - A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation. | 03-31-2011 |
20120149986 | MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES - A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation. | 06-14-2012 |