Patent application number | Description | Published |
20090148455 | Anti-RANTES antibodies and methods of use thereof - The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5), thereby modulating the interaction between RANTES and one of more of its receptors, such as, e.g., CCR1, CCR3, CCR4 and CCR5, and/or modulating the biological activities of RANTES. The invention also relates to the use of these or any anti-RANTES antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder. | 06-11-2009 |
20090169561 | Anti-IP-10 antibodies and methods of use thereof - The invention relates to fully human antibodies, and fragments thereof, that bind to interferon-inducible-protein-10 (IP-10, CXCL10), thereby modulating the interaction between IP-10 and its receptor, CXCR3, and/or modulating the biological activities of IP-10. The invention also relates to the use of such anti-IP-10 antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder. | 07-02-2009 |
20100158922 | Anti-Interferon Gamma Antibodies and Methods of Use Thereof - The invention relates to fully human antibodies, and fragments thereof, that bind to human interferon gamma (hIFNγ), thereby modulating the interaction between IFNγ and its receptor, IFNγ-R, and/or modulating the biological activities of IFNγ. The invention also relates to the use of such anti-IFNγ antibodies in the prevention or treatment of immune-related disorders and in the amelioration of a symptom associated with an immune-related disorder. | 06-24-2010 |
20100183554 | Anti-CD3 Antibodies and Methods of Use Thereof - The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies directed to CD3. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided. | 07-22-2010 |
20100322941 | Human Anti-IP-10 Antibodies Uses Thereof - The invention relates to fully human antibodies, and fragments thereof, that bind to interferon-inducible-protein-10 (IP-IO, CXCL1O), thereby modulating the interaction between IP-IO and its receptor, CXCR3, and/or modulating the biological activities of IP-IO. The invention also relates to the use of such anti-IP-10 antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder. | 12-23-2010 |
20100330094 | Anti-IP-10 Antibodies and Methods of Use Thereof - The invention relates to fully human antibodies, and fragments thereof, that bind to interferon-inducible-protein-10 (IP-10, CXCL10), thereby modulating the interaction between IP-10 and its receptor, CXCR3, and/or modulating the biological activities of IP-10. The invention also relates to the use of such anti-IP-10 antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder. | 12-30-2010 |
20110065610 | Synthetic Polypeptide Libraries and Methods for Generating Naturally Diversified Polypeptide Variants - The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence. | 03-17-2011 |
20110118149 | Synthetic Polypeptide Libraries and Methods for Generating Naturally Diversified Polypeptide Variants - The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence. | 05-19-2011 |
20120184716 | Methods for the Generation of Multispecific and Multivalent Antibodies - The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co-expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non-human sequences, as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody. | 07-19-2012 |
20120201826 | Anti-RANTES Antibodies and Methods of Use Thereof - The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5), thereby modulating the interaction between RANTES and one of more of its receptors, such as, e.g., CCR1, CCR3, CCR4 and CCR5, and/or modulating the biological activities of RANTES. The invention also relates to the use of these or any anti-RANTES antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder. | 08-09-2012 |
20130216549 | Anti-IP-10 Antibodies and Uses Thereof - The invention relates to fully human antibodies, and fragments thereof, that bind to interferon-inducible-protein-10 (IP-10, CXCL10), thereby modulating the interaction between IP-10 and its receptor, CXCR3, and/or modulating the biological activities of IP-10. The invention also relates to the use of such anti-IP-10 antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder. | 08-22-2013 |
20130315914 | Anti-TLR4 Antibodies and Uses Thereof - Disclosed are antibodies that specifically bind Toll-like Receptor 4 (TLR-4), and to methods of using the anti-TLR4 antibodies as therapeutics and diagnostic agents. | 11-28-2013 |
20130317200 | Methods of Purifying Antibodies - The invention provides methods of purifying antibodies using various antibody-specific purification media to rapidly and efficiently separate mixtures of antibodies, antibody fragments and/or antibody components to isolate a desired antibody product from the mixture. The invention relates to the purification of bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, e.g., antibodies composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other a Lambda constant domain, including antibodies of different specificities that share a common heavy chain. The invention also provides the methods of efficiently purifying intact antibodies by separating the intact antibody from non-intact antibodies including free light chains. | 11-28-2013 |
20140051833 | Readily Isolated Bispecific Antibodies with Native Immunoglobulin Format - The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s). | 02-20-2014 |
20140179547 | Methods For The Generation Of Multispecific And Multivalent Antibodies - The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co-expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non-human sequences, as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody. | 06-26-2014 |
20140186362 | Anti-Interferon Gamma Antibodies And Methods Of Use Thereof - The invention relates to fully human antibodies, and fragments thereof, that bind to human interferon gamma (hIFNγ), thereby modulating the interaction between IFNγ and its receptor, IFNγ-R, and/or modulating the biological activities of IFNγ. The invention also relates to the use of such anti-IFNγ antibodies in the prevention or treatment of immune-related disorders and in the amelioration of a symptom associated with an immune-related disorder. | 07-03-2014 |
20140193399 | Anti-CD3 Antibodies And Methods Of Use Thereof - The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies directed to CD3. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided. | 07-10-2014 |
20140303354 | Anti-CD47 Antibodies and Methods of Use Thereof - The invention relates to monoclonal and/or monovalent antibodies that bind CD47. The invention relates to monoclonal and/or monovalent antibodies that bind CD19. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD47. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD19. | 10-09-2014 |
20150079099 | Anti-RANTES Antibodies - The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5), thereby modulating the interaction between RANTES and one of more of its receptors, such as, e.g., CCR1, CCR3, CCR4 and CCR5, and/or modulating the biological activities of RANTES. The invention also relates to the use of these or any anti-RANTES antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder. | 03-19-2015 |
Patent application number | Description | Published |
20090208010 | System for traceable decryption of bandwidth-efficient broadcast of encrypted messages and security module revocation method used for securing broadcasted messages - The present invention makes use of techniques such as those described by Boneh and Franklin to allow for the realisation of a pseudo-asymmetric encryption scheme whereby one public encryption corresponds to a plurality of private decryption keys. This scheme therefore provides a solution to the problem of inefficient use of bandwidth in asymmetrical encryption schemes which inherently require that a plurality of encryptions of data be broadcast to a plurality of receivers. The invention further ensures that the advantage of traceability, typical found in asymmetric encryption schemes, is maintained due to the characteristic that each receiver uses a unique traceable decryption key. The traceability thus achieved by the present invention allows for the revocation of a security module which has been involved in the abusive use of conditional access data, particularly by means of clones of security modules whose security has been compromised. | 08-20-2009 |
20110010574 | Security device meant to be connected to a processing unit for audio/video signal and method using such a device - The invention relates to a security device intended to be connected to a processing unit for an audio/video signal. This device comprises means to decrypt an audio/video stream, an interface of the ISO 7816 type and at least one high speed serial communication interface. It is characterised in that it includes a clock frequency detection module connected to a clock input of the 7816 interface, this detection module comprising means to distinguish the input frequency according to at least two different frequency ranges, the different frequency ranges activating the different communication functions. | 01-13-2011 |
20130103941 | METHOD FOR UPDATING DATA IN A SECURITY MODULE - A method for updating operating data in a security module associated to a user unit for processing digital data broadcast in a transport stream, said unit being connected to a conditional access system transmitting, in said transport stream, to the security module a first stream comprising management messages includes: broadcasting a second stream of operating data patch messages, adding to the first stream of management messages, a trigger message to direct the security module to a conditional access system transmitting a second stream transporting suitable operating data patch messages if a current version of the operating data in the security module requires an update, updating the operating data of the concerned security module with the operating data patch messages from the second stream, directing the security module towards the conditional access system transmitting another stream based on an identifier of the conditional access system in the security module. | 04-25-2013 |
20130279694 | SYSTEM AND METHOD TO RECORD ENCRYPTED CONTENT WITH ACCESS CONDITIONS - A television event may be consumed after been stored in a mass memory of a multimedia unit, but still fully relies on the security of a secure device. A conversion of a received content aims at firstly descrambling the content using control words included in entitlement control messages and immediately re-encrypting the descrambled content by a unique key generated specifically for this content. Access conditions attached to the entitlement control message containing the control word are temporarily stored and once the decryption is terminated, the secure device produces an information block. This information block containing for example access conditions and an identifier of the content is either stored into a secure memory of the secure device or stored in the mass memory with the encrypted content. The unique key is made up of a combination of a root key specific to the secure device and the information block. | 10-24-2013 |
20140033297 | APPARATUS FOR CONTROLLING PROCESSOR EXECUTION IN A SECURE ENVIRONMENT - Various embodiments described herein relate to apparatus for executing software in a secure computing environment. A secure processor can be used and configured to request a context swap from a first context to a second context when switching execution from a first portion of software to a second portion of software. A context manager, which can be in communication with the secure processor, can be configured to receive and initiate a requested context swap. A trust vector verifier, which can be in communication with the secure processor and the context manager, can be configured to load a trust vector descriptor upon command from a context manager. | 01-30-2014 |
20140282685 | SYSTEMS AND METHODS FOR PERFORMING TRANSPORT I/O - Systems and methods for implementing a Transport I/O system are described. Network encrypted content may be received by a device. The device may provide the network encrypted content to a secure processor, such as, for example, a smart card. The secure processor obtains a network control word that may be used to decrypt the network encrypted content. The secure processor may decrypt the network encrypted content to produce clear content. In embodiments, the secure processor may then use a local control word to generate locally encrypted content specific to the device. The device may then receive the locally encrypted content from the secure processor and proceed to decrypt the locally encrypted content using a shared local encryption key. The Transport I/O system ensures the protection of the network control word by maintaining the network control word on the secure processor. | 09-18-2014 |
20150016607 | SYSTEMS AND METHODS FOR PERFORMING TRANSPORT I/O - Systems and methods for implementing a Transport I/O system are described. Network encrypted content may be received by a device. The device may provide the network encrypted content to a secure processor, such as, for example, a smart card. The secure processor obtains a network control word that may be used to decrypt the network encrypted content. The secure processor may decrypt the network encrypted content to produce clear content. In embodiments, the secure processor may then use a local control word to generate locally encrypted content specific to the device. The device may then receive the locally encrypted content from the secure processor and proceed to decrypt the locally encrypted content using a shared local encryption key. The Transport I/O system ensures the protection of the network control word by maintaining the network control word on the secure processor. | 01-15-2015 |
20150016608 | SYSTEMS AND METHODS FOR PERFORMING TRANSPORT I/O - Systems and methods for implementing a Transport I/O system are described. Network encrypted content may be received by a device. The device may provide the network encrypted content to a secure processor, such as, for example, a smart card. The secure processor obtains a network control word that may be used to decrypt the network encrypted content. The secure processor may decrypt the network encrypted content to produce clear content, in embodiments, the secure processor may then use a local control word to generate locally encrypted content specific to the device. The device may then receive the locally encrypted content from the secure processor and proceed to decrypt the locally encrypted content using a shared local encryption key. The Transport I/O system ensures the protection of the network control word by maintaining the network control word on the secure processor. | 01-15-2015 |