Nicole M.
Nicole M. Alessandri Haber, Rye, NY US
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20110307966 | Mice Expressing Human Voltage-Gated Sodium Channels - Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a humanization of an extracellular loop of an endogenous Na | 12-15-2011 |
20120083000 | Neuropeptide Release Assay For Sodium Channels - Methods and compositions for using genetically modified non-human animals are provided, wherein the genetic modification comprises a humanization of the one or more extracellular pore loops of a Na | 04-05-2012 |
20130195878 | ANTI-ASIC1 ANTIBODIES AND USES THEREOF - The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders. | 08-01-2013 |
20140056907 | ANTI-ASIC1 ANTIBODIES AND USES THEREOF - The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. According to certain embodiments, the antibodies of the invention are selective for ASIC1 and do not bind other acid-sensing ion channels in the absence of ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders. | 02-27-2014 |
Nicole M. Avena, Clarksburg, NJ US
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20140315938 | COMPOSITIONS FOR CONTROLLING FOOD INTAKE AND USES THEREFOR - The present invention is directed to a combination treatment for: individuals who meet the definition of food addiction; individuals that are overweight or obese (e.g., a BMI≧25); individuals that have a binge eating disorder; or individuals who engage in a binge eating behavior. In particular embodiments, the combination therapy reduces the intake of fatty foods, sugar rich foods, or foods that are both fatty and sugar-rich (e.g., such as fast foods). | 10-23-2014 |
Nicole M. Chrusciel, New Britain, CT US
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20140214200 | Portable and Modular Prescription Drug Dispensing Device - A dispensing device for dispensing doses of non-individually packaged pills at a plurality of pre-specified dosing times includes a housing that holds a removable magazine, a dispensing unit and an electronic circuit. The removable magazine is configured to hold a stack of the non-individually packaged pills. The dispensing unit is configured to operate on the removable magazine to dispense a pre-specified dose of the pills upon receipt of a signal. The electronic circuit includes a timer that provides the signal at the pre-specified dosing times to activate the dispensing unit to dispense the pre-specified dose. | 07-31-2014 |
Nicole M. Durch, Fremont, CA US
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20120066868 | METHOD OF PRODUCING NATURALLY PURIFIED SALT PRODUCTS - Methods for producing naturally purified salt products are disclosed. In one embodiment, a method of producing a naturally purified salt product such as magnesium sulfate heptahydrate from a salt mixture is disclosed. In another embodiment, a high purity salt product is produced. In another embodiment, other products that are produced include naturally purified sodium chloride and magnesium chloride. | 03-22-2012 |
Nicole M. Fagen, Pleasant Valley, NY US
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20100023933 | MAINTENANCE ASSESSMENT MANAGEMENT - A computer-implemented method, system, and computer program product for assessing environment specific maintenance actions are provided. The method includes identifying a maintenance update for a specific environment including one or more computer systems, where the maintenance update addresses one or more known problems. The method also includes applying factors to determine an assessment index for the one or more known problems as a function of the specific environment. The assessment index indicates a level of installation criticality relative to the specific environment. The method further includes outputting an installation recommendation for the identified maintenance update in response to determining the assessment index. | 01-28-2010 |
Nicole M. Grosland, Iowa City, IA US
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20150141893 | CLUBFOOT ORTHOTIC - Devices and methods for treating clubfoot are disclosed. | 05-21-2015 |
Nicole M. Gryska, Woodbury, MN US
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20140346113 | BIOSEPARATION COMPOSITIONS AND METHODS FOR MAKING AND USING SAME - A composition for use in bioseparation. The composition includes a plurality of hollow particles having a siliceous surface. The composition further includes a surface-modifying agent bonded to the hollow particles. The surface-modifying agent includes a binding segment and a reactive segment. The binding segment includes a silyl group and the reactive segment includes a reactive nitrogen group. | 11-27-2014 |
Nicole M. Juhan, Morganton, NC US
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20110027312 | CHIMERIC PORCINE CIRCOVIRUS PCV2Gen-1Rep AND USES THEREOF - The present invention relates to a novel chimeric nucleic acid molecule of porcine circovirus (PCV2Gen-1Rep) that embraces a nucleic acid molecule encoding porcine circovirus type 2 (PCV2) which contains a nucleic acid sequence encoding a Rep protein of porcine circovirus type 1 (PCV1), particularly wherein the nucleic acid sequence encoding the Rep protein of PCV1 GO is an open reading frame (ORF) gene and, more particularly, wherein the ORF Rep gene is ORF1. A highly desirable chimeric nucleic acid molecule is constructed by replacing the ORF1 Rep gene of PCV2 by the ORF1 Rep gene of PCV1. The invention also encompasses the biologically functional plasmid or viral vector containing the unique chimeric nucleic acid molecules, suitable host cells transfected by the plasmid or vector, infectious chimeric porcine circoviruses that are produced by the suitable host cells, the process for the production of an immunogenic polypeptide product making use of the new chimera, viral vaccines that protect a pig against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2, methods of protecting a pig against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2, methods of preparing the unique chimera of PCV2Gen-1Rep and the like. This invention further includes a new method for improving the replication and titer of PCV2 in a cell culture. | 02-03-2011 |
Nicole M. Stengle, Minneapolis, MN US
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20140373647 | LIFTING MOTION EVALUATION - Locations of a person's hand, shoulder and hip in three-dimensional space are received from a three-dimensional position sensing device. A shortest distance from the location of the person's hand to a line between the location of the person's shoulder and the location of the person's hip is determined. The shortest distance is compared to a threshold to determine if the person is overreaching. When it is determined that the person is overreaching, a user interface is provided to indicate that the person was overreaching. Additional location information for points on the person's body are used to determine if the person is performing a high lift, a low reach or a twist. | 12-25-2014 |
Nicole M. Waybright, Silver Spring, MD US
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20100151442 | METHOD FOR DETECTING EMERGING PANDEMIC INFLUENZA - A method for detecting emerging pandemic influenza strains is provided. RT-PCR is used to detect HPAI followed by pyrosequencing to detect codons defining human or avian influenza signatures. This method screens for avian influenza viruses containing mutations suspected of making the virus more infective or virulent to humans. | 06-17-2010 |