Paige
Anthony Reid Paige, Jupiter, FL US
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20140050893 | AIRFOIL COMPONENTS CONTAINING CERAMIC-BASED MATERIALS AND PROCESSES THEREFOR - A process for producing airfoil components containing ceramic-based materials and having a tip cap. The process entails forming an airfoil portion of the component from an airfoil portion material that contains a precursor of a ceramic-based material. The airfoil portion material defines concave and convex walls of the airfoil portion, and the concave and convex walls define a tip region of the airfoil portion and at least one cavity within the airfoil portion. At least a first ply is formed that contains a precursor of a ceramic-based material, and the first ply at least partially closes the cavity at the tip region of the airfoil portion. The airfoil portion material and the first ply are then cured so that the first ply forms a tip cap that closes the cavity and the precursors of the airfoil portion material and first ply are converted to the ceramic-based materials thereof. | 02-20-2014 |
Anthony Reid Paige, Cincinnati, OH US
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20150192027 | TURBINE BLADE SEALING STRUCTURE - A turbine blade sealing structure for a ceramic matrix composite component is provided. The turbine sealing structure includes at least one top ply abutting a top portion of a shank. The at least one top ply extends out over the top portion of the shank. The turbine sealing structure includes at least one side ply abutting a side portion of the shank. The at least one side ply extends along a side portion of the shank. The at least one top ply and at least one side ply form an angel wing and a skirt with on the shank of the ceramic matrix composite component | 07-09-2015 |
Bryan Paige, Jonesville, MI US
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20100251873 | QUICK-FIX CAPO HAVING DUAL ADJUSTABILITY MODES FOR USE WITH A STRINGED MUSICAL INSTRUMENT, AND METHOD OF USING SAME - A capo is structured and configured to permit rapid installation and tightening thereof on a stringed instrument. The capo includes a yoke with a central support member, a string-contacting clamping bar which is pivotally attached to the yoke, and a spring-loaded release member which fits into a first hollow bore in the central support member of the yoke. The capo also includes a substantially Y-shaped saddle member having a stem which slidably fits through a second hollow bore of the central support member, and an adjustment member for positioning the saddle member in the yoke. The engagement/release member is releasably held in position against the adjustment member by spring pressure. Rapid positioning of the saddle member is enabled by both coarse and fine adjustment of the adjustment member, made possible by buttressed threads present both inside of the engagement/release member and outside of a threaded shaft of the adjustment member. | 10-07-2010 |
Christopher J. Paige, Toronto CA
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20100056468 | Pyrimidine Derivatives As Anticancer Agents - The present invention includes methods of treating or preventing cancer by administering an effective amount of 6-substituted pyrimidine derivatives of the Formula I to a subject need thereof: | 03-04-2010 |
20100291043 | IL-12 IMMUNOTHERAPY FOR CANCER - Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as leukemia. | 11-18-2010 |
20140370039 | IL-12 IMMUNOTHERAPY FOR CANCER - Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as leukemia. | 12-18-2014 |
Daniel Paige, Ankeny, IA US
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20150314482 | VOLUMETRIC MIXER WITH WATER TANK AND OIL TANK INSIDE AGGREGATE BIN - A mobile concrete mixing unit has an aggregate bin divided into two compartments by a water tank provided within the aggregate bin. A hydraulic reservoir is provided within the water tank in order to cool the hydraulic fluid within the hydraulic reservoir and warm the water within the water tank. The water tank also helps to keep the aggregate warm and flowable when used in low temperatures. A lower portion of the water tank includes sides that slope inwardly so that aggregate within the bin can drop freely onto a conveyor belt without bridging between the water tank and the sidewalls of the aggregate bin. | 11-05-2015 |
David Paige, Newcastle Upon Tyne GB
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20110041612 | PIPELINE INSPECTION APPARATUS AND METHOD - Ultrasonic pipeline inspection apparatus which utilises two different wave modes (e.g. a horizontally polarised shear mode and a symmetric Lamb wave mode) to discriminate different defect types by comparing corresponding signals collected from defects. EMATs may detect the signals. The detected amplitudes of the collected signals from both wave modes are compared to calculate a ratio, which may be compared with a distribution of ratio values for known defects to evaluate the type of defect detected. The apparatus may be a sensor module mountable on a pipeline vehicle and having a plurality of sensors distributed around its periphery. | 02-24-2011 |
David Martin Paige, Newcastle-Upon-Tyne GB
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20130125654 | METHOD FOR PIPELINE INSPECTION - A method for pipeline inspection is provided comprising carrying out an inspection run in which a pipeline inspection apparatus travels inside a pipeline, wherein sensors on the apparatus are configured to conduct an in-line inspection of wall material along a length of the pipeline. The method further comprises initiating a first inspection mode to produce a primary inspection data set, wherein the first inspection mode comprises an inspection of the pipeline wall material upstream and downstream of a location of a dented region in the pipeline, selectively initiating a second inspection mode to produce a secondary inspection data set, wherein the second inspection mode comprises an inspection of the pipeline wall material in the dented region in the length of the pipeline, and combining the primary and the secondary inspection data sets to provide a direct assessment for the presence of cracks and/or corrosion in wall material along the pipeline. | 05-23-2013 |
Douglas J. Paige, Lakewood, OH US
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20120118058 | METHODS AND APPARATUSES FOR MEASURING PROPERTIES OF A SUBSTANCE IN A PROCESS STREAM - A flow-through sensing apparatus includes a flow-head and a sensor that are configured to be selectively coupled through use of a quick-disconnect mechanical coupling. When the sensor is coupled with the flow-head, the sensor cooperates with the flow-head to at least partially define a sensing chamber. The sensor is configured to determine a process parameter, such as refractive index, regarding a substance in the sensing chamber. | 05-17-2012 |
Glenn B. Paige, Hickory, NC US
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20130042940 | FILL CAP FOR A DRINK CONTAINER - A fill cap for a drink container for receiving an open end of a drink bottle. The fill cap includes a cylindrical collar and an annular flange extending radially inwardly from the cylindrical collar. A valve structure is connected to and surrounded by the annular flange and in includes a pair of generally planar lip members. Each lip member has an outer portion adjoining the inner edge of the flange and the lip members converge at an angle axially downwardly to inner edges where the lip members adjoin each other at a slit. A pair of opposing side walls extend from the flange to edges of the lip members located axially downwardly from the flange. The slit is configured to receive the bottle neck therethrough. | 02-21-2013 |
Jeremy Paige, La Jolla, CA US
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20140220560 | METHODS FOR RNA DETECTION AND QUANTIFICATION - The present invention relates to novel nucleic acid molecules, called aptamers, that bind specifically to a small molecule fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described. | 08-07-2014 |
Jeremy S. Paige, La Jolla, CA US
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20120252699 | COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE - The present invention relates to novel fluorophores and their use in combination with novel nucleic acid molecules, called aptamers, that bind specifically to the fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described. | 10-04-2012 |
Lee Paige, Richmond Hill CA
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20090294471 | PROGRAMMABLE AEROSOL DISPENSER - Disclosed is an aerosol dispensing for dispensing a metered amount of an aerosol for dispersion in an area of use unit having a main body. The aerosol dispensing unit according to the present invention includes a reservoir within the main body for holding an aerosol, an outlet in fluid communication with the reservoir and arranged to dispense a metered amount of the aerosol upon activation of a trigger device, and an audio output system adapted to play a sound in response to the activation of said trigger device. The aerosol is preferably one of a deodorizing agent and a disinfectant. The trigger device is adapted to be activated either by a sensor used to detect a person within a given area, and activate the trigger device upon detection of the person, or alternatively, a timer is operatively connected to the trigger device to dispense the metered amount of aerosol and play the sound at timed intervals. | 12-03-2009 |
Lisa A. Paige, Hillsborough, NC US
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20090318369 | BIOMARKERS FOR ALZHEIMER'S DISEASE AND METHODS USING THE SAME - The present invention provides various biomarkers of Alzheimer's Disease (AD). The present invention also provides various methods of using the biomarkers, including methods for diagnosis of AD, methods of determining predisposition to AD, methods of monitoring progression/regression of AD, methods of assessing efficacy of compositions for treating AD, methods of screening compositions for activity in modulating biomarkers of AD, methods of treating AD, as well as other methods based on biomarkers of AD. | 12-24-2009 |
20100197626 | Biomarkers for Depression and Methods Using the Same - The present invention provides various biomarkers of depression. The present invention also provides various methods of using the biomarkers, including methods for diagnosis of depression, methods of determining predisposition to depression, methods of monitoring progression/regression of depression, methods of assessing efficacy of compositions for treating depression, methods of screening compositions for activity in modulating biomarkers of depression, methods of treating depression, as well as other methods based on biomarkers of depression. | 08-05-2010 |
Lisa M. Paige, San Antonio, TX US
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20150257972 | APPARATUS AND METHOD FOR PROVIDING EMERGENCY CPR FUNCTIONALITY ON A PATIENT SUPPORT SURFACE - Emergency CPR systems for patient support systems utilizing backup battery power. | 09-17-2015 |
Michael G. Paige, Bloomfield Hills, MI US
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20100084125 | MICROCLIMATE CONTROL SYSTEM - A heating/cooling garment is provided that comprises a microclimate system, as well as methods of manufacturing and using same. | 04-08-2010 |
Mikell Paige, Fairfax, VA US
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20100130579 | CANCER THERAPY - The present invention relates to methods of inducing expression of an epigenetically silenced gene, RASSF1A, in cells, particularly human cells, such as cancer cells. It also relates to methods of treating an individual, prophylactically or therapeutically, for cancer in which RASSF1A is epigenetically silenced. | 05-27-2010 |
20130236532 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISEASES - The present application discloses compositions and methods useful for treating and preventing inflammation associated with inflammatory diseases and disorders. | 09-12-2013 |
20140135325 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING - The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell. | 05-15-2014 |
Mikell A. Paige, Fairfax, VA US
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20110152339 | FLUORESCENT REGULATORS OF RASSF1A EXPRESSION AND HUMAN CANCER CELL PROLIFERATION - The invention provides methods for the treatment of cancer in a subject comprising administering a dansyl-carbazole compound. | 06-23-2011 |
20110230442 | NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS - Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have superior blocking efficacy, for instance in displacing the radioligand [ | 09-22-2011 |
20110269733 | Silent Desensitizers of Neuronal nAChR and Methods of Use Thereof - One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine receptor. | 11-03-2011 |
20110281836 | Silent desensitizers of neuronal NACHR and methods of use thereof - One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine receptor. | 11-17-2011 |
20140323461 | Phenyl-Substituted Nicotinic Ligands, and Methods of Use Thereof - Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction, pain, obesity, schizophrenia, epilepsy, mania and manic depression, anxiety, Alzheimer's disease, learning deficit, cognition deficit, attention deficit, memory loss, Lewy Body Dementia, Attention Deficit Hyperactivity Disorder (ADHD), Parkinson's disease, Huntington's disease, Tourette's syndrome, amyotrophic lateral sclerosis, inflammation, stroke, spinal cord injury, dyskinesias, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, autism, mutism, trichotillomania, hypothermia, and disorders of sleep. | 10-30-2014 |
20140378428 | 2,5-Disubstituted-Pyridyl Nicotinic Ligands, and Methods of Use Thereof - Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia. | 12-25-2014 |
Mindy Paige, Wauseon, OH US
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20140326695 | Bottle Having Axially Opposed Frustoconical Portions - A bottle extends along a longitudinal axis and includes a base, a body extending from the base, a shoulder extending from the body, and a neck extending from the shoulder and having a neck finish. The body has lower and upper frustoconical portions axially opposed to one another and having straight external surfaces. | 11-06-2014 |
Nicholas Paige, Springfield, VT US
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20150101085 | COMPENSATION FOR CANONICAL SECOND ORDER SYSTEMS FOR ELIMINATING PEAKING AT THE NATURAL FREQUENCY AND INCREASING BANDWIDTH - The present invention adds gain and phase into a canonical second order system in order to mitigate the adverse effects of unwanted resonance, where the gain is added to the forward path of a control loop of the system and is a ratio of the square of the system and mechanism frequencies, and the phase lead (H-factor) is added to the feedback path of the control loop of the system and is a complex ratio of these frequencies which includes a dc-component (H | 04-09-2015 |
Robert Paige, Enoch, UT US
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20110268282 | System and Method for Monitoring Compliance of Sound Levels When Playing Content in Theater Auditoriums - The present invention relates to systems and methods for monitoring compliance with sound volumes in auditoriums. The method includes setting a baseline sound measurement for an audio receiver located in an auditorium. The baseline sound measurement is based on a baseline sample signal broadcast over a baseline period from a sound system, and received by the audio receiver. A sound level standard is defined for content. A live sound measurement is determined over a sampling period of live content broadcast from the sound system. It is then determined if the live sound measurement complies with the sound level standard for content. Notification is provided for non-compliance with the sound level standard for content to a party sourcing the live content. | 11-03-2011 |
Stephen F. Paige, Ocala, FL US
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20140283849 | Jaw Range Limiter and Method for Weight Loss - A dental apparatus for limiting how far a person can open their mouth to hamper eating is disclosed. A first tooth interface is affixed to at least one upper tooth and a second tooth interface is affixed to at least one lower tooth in proximity to the first tooth interface. A range limiting device having at least two sections, such as two triangular shaped sections, is sequentially linked from a first section of the range limiting device to a last section of the range limiting device. Each section of the range limiting device is movably affixed to an opposing tooth interface, such that the device movably interconnects the first tooth interface and the second tooth interface, thereby allowing the person to completely close their mouth, and limiting the person to opening their mouth to a range less than fully opened. | 09-25-2014 |
William Michael Paige, Pullenvale AU
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20110047051 | DONATION METHOD - A method of donating to a beneficiary is disclosed. The method includes presenting online, using computational means of an administrator, a product donated by a donor. The product is associated with at least one beneficiary. The administrator receives payment for the product from the buyer, a beneficiary or an intermediary for the sale of the product. The administrator, when payment is received from the buyer or the intermediary, sends a donation deducted from the payment to the beneficiary. | 02-24-2011 |