Patent application number | Description | Published |
20080233617 | Process for the Preparation of a Aspartate and Derived Amino Acids Like Lysine, Threonine, Isoleucine, Methionine, or Homoserine Employing Microorganism with Enhanced Isocitrate Lyase and/or Malate Synthase Expression - The present invention relates to increasing the product of aspartate or aspartate-derived metabolites by boosting the activity of the glyoxylate shunt. This is accomplished by increasing the activity of glyoxylate shunt specific enzymes and decreasing the activity of reactions consuming glyoxylate and its precursors. | 09-25-2008 |
20080286840 | Microorganisms Comprising Enzymes Express with Low Gamma-Elimination Activity - A microorganism in which enzymes are expressed that have one or several of the following activities cystathionine-γ-synthases and/or phosphohomoserine sulfhydrylase and/or acylhomoserine sulfhydrylases and that have at the same time low γ-elimination activity is disclosed and also relates to recombinant enzymes that have one or several of the following activities cystathionine-γ-synthase and/or phosphohomoserine and/or acylhomoserine sulfhydrylase, have at the same time low γ-eliminase activity and are used for the fermentative production of amino acids, in particular, methionine. | 11-20-2008 |
20080311632 | Methods for Producing Methionine by Culturing a Microorganism Modified to Enhance Production of Cysteine - A method of producing methionine, derivatives or precursors thereof comprising culturing a microorganism modified to enhance production of cysteine in a culture medium comprising a source of carbon and a source of sulfur and recovering methionine from the culture medium. A microorganism for fermentative production of methionine or its derivatives in which production of methionine or derivatives thereof, wherein the microorganism enhances production of cysteine. | 12-18-2008 |
20090029424 | Recombinant enzyme with altered feedback sensitivity - The present invention relates to the use of recombinant homoserine transsuccinylase enzymes with altered feedback sensitivity (MetA*) and possibly recombinant S-adenosyl methionine synthetase enzymes with reduced activity (MetK*) for the production of methionine, its precursors or derivatives thereof. | 01-29-2009 |
20090029431 | PROCESS FOR THE PREPARATION OF 1,3-PROPANEDIOL BY A RECOMBINANT MICRO-ORGANISM IN THE ABSENCE OF COENZYME B12 OR ONE OF ITS PRECURSORS - The invention concerns a method for preparing 1,3-propanediol from a carbon-containing substance, said method comprising a step which consists in culturing a recombinant micro-organism not producing coenzyme B12 in the absence of coenzyme B12 or one of its precursors. The invention also concerns a nucleic acid coding for a glycerol dehydratase whereof the catalytic activity is independent of the presence of coenzyme B12 or one of its precursors and a nucleic acid coding for a 1,3-propanol dehydrogenase intervening in the synthesis of 1,3-propanediol. The invention further concerns recombinant vectors and host cells comprising said nucleic acids and the polypeptides coded by the latter. | 01-29-2009 |
20090075347 | Production of Bacterial Strains Cross Reference To Related Applications - The present invention provides methods to enhance production of desired products and increase the growth rate of a bacterial strain by inactivating an endogenous arcA and optionally overexpressing a ppc gene. | 03-19-2009 |
20090142843 | Glucose Transport Mutants For Production Of Biomaterial - A method is disclosed for restoring a Glu | 06-04-2009 |
20090155867 | Glycolic Acid Production by Fermentation from Renewable Resources - The present invention provides a method for the biological production of glycolic acid from a fermentable carbon source in a microorganism. In one aspect of the present invention, a process for the conversion of glucose to glycolic acid is achieved by the use of a recombinant organism comprising a host | 06-18-2009 |
20090156430 | PROMOTER AND PLASMID SYSTEM FOR GENETIC ENGINEERING - This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a terminator sequence, the plasmids containing variants of glucose isomerase promoters for varying levels of protein expression. The materials and methods are useful for genetic engineering in microorganisms, especially where multiple genetic insertions are sought. | 06-18-2009 |
20090325245 | Ethanolamine Production by Fermentation - The present invention provides a bacterium and a method for the biological production of ethanolamine from a fermentable carbon source. In one aspect of the present invention, a process for the conversion of glucose to ethanolamine is achieved by the use of a recombinant bacterium transformed i) to express a serine decarboxylase enzyme to convert serine to ethanolamine ii) to inactivate the ethanolamine consuming pathways and iii) to increase 3-phosphoglycerate availability. In another aspect of the present invention, the process for the production of ethanolamine from glucose using a recombinant | 12-31-2009 |
20100047879 | PRODUCING METHIONINE WITHOUT N-ACYL-METHIONINE - The present invention relates to a method for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulphur. The microorganism and/or the culture medium and/or the process parameters were modified in a way that the accumulation of the by-product N-acyl-methionine (NAM) is reduced. The isolation of methionine or its derivatives from the fermentation medium is also claimed. | 02-25-2010 |
20100086982 | PROCESS FOR THE BIOLOGICAL PRODUCTION OF n-BUTANOL WITH HIGH YIELD - The present invention provides a method for the biological production of n-butanol at high yield from a fermentable carbon source. In one aspect of the present invention, a process for the conversion of glucose to n-butanol is achieved by the use of a recombinant organism comprising a host | 04-08-2010 |
20100129892 | PROCESS FOR THE PREPARATION OF 1,3-PROPANEDIOL BY A RECOMBINANT MICRO-ORGANISM IN THE ABSENCE OF COENZYME B12 OR ONE OF ITS PRECURSORS - The invention concerns a method for preparing 1,3-propanediol from a carbon-containing substance, said method comprising a step which consists in culturing a recombinant micro-organism not producing coenzyme B12 in the absence of coenzyme B12 or one of its precursors. The invention also concerns a nucleic acid coding for a glycerol dehydratase whereof the catalytic activity is independent of the presence of coenzyme B12 or one of its precursors and a nucleic acid coding for a 1,3-propanol dehydrogenase intervening in the synthesis of 1,3-propanediol. The invention further concerns recombinant vectors and host cells comprising said nucleic acids and the polypeptides coded by the latter. | 05-27-2010 |
20100137655 | PROCESS FOR THE BIOLOGICAL PRODUCTION OF 1,3-PROPANEDIOL FROM GLYCEROL WITH HIGH YIELD - The present invention provides a method for the anaerobic production of 1,3 propanediol, by culturing a | 06-03-2010 |
20100261239 | METABOLICALLY ENGINEERED MICROORGANISM USEFUL FOR THE PRODUCTION OF 1,2-PROPANEDIOL - Microorganism useful for the production of 1,2-propanediol from a carbon source, wherein said microorganism is characterized by:
| 10-14-2010 |
20100279369 | METABOLICALLY ENGINEERED MICROORGANISM USEFUL FOR THE PRODUCTION OF ACETOL - This invention concerns a microorganism useful for the production of acetol from a simple carbon source, wherein said microorganism is characterized by:
| 11-04-2010 |
20100285547 | NEW MICRO-ORGANISMS FOR THE PRODUCTION OF 1,2-PROPANEDIOL OBTAINED BY A COMBINATION OF EVOLUTION AND RATIONAL DESIGN - The present invention concerns a new method combining evolution and rational design for the preparation of a strain of micro-organism for the production of 1,2-propanediol from a carbon source. | 11-11-2010 |
20100330636 | PROCESS FOR THE BIOLOGICAL PRODUCTION OF N-BUTANOL WITH HIGH YIELD - The present invention provides a method for the biological production of n-butanol at high yield from a fermentable carbon source. In one aspect of the present invention, a process for the conversion of glucose to n-butanol is achieved by the use of a recombinant organism comprising a host | 12-30-2010 |
20100330678 | PROCESS FOR THE STABLE GENE INTERRUPTION IN CLOSTRIDIA - The present invention is related to a new method for interrupting multiple DNA sequences in Clostridia, even in genes recognized to be essential for the optimal growth of Clostridii by using a counter-selectable marker that would pinpoint the cells that have lost the plasmid and acquired a modified function that permits survival without the interrupted gene. This method is easy to perform and applicable at an industrial level. This method is useful to modify several genetic loci in Clostridia in a routine manner. This method is based on a replicative vector carrying at least two marker genes. | 12-30-2010 |
20110014666 | POLYPEPTIDE HAVING GLYOXALASE III ACTIVITY, POLYNUCLEOTIDE ENCODING THE SAME AND USES THEREOF - The present invention relates to a novel polypeptide having the enzymatic activity of conversion of methylglyoxal to lactic acid in a single step (known as glyoxalase III activity), a polynucleotide having a nucleotide sequence encoding such polypeptide and uses thereof. | 01-20-2011 |
20110046014 | PROMOTER AND PLASMID SYSTEM FOR GENETIC ENGINEERING - This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a terminator sequence, the plasmids containing variants of glucose isomerase promoters for varying levels of protein expression. The materials and methods are useful for genetic engineering in microorganisms, especially where multiple genetic insertions are sought. | 02-24-2011 |
20110118434 | METHOD FOR POLYMERISING GLYCOLIC ACID WITH MICROORGANISMS - The present invention relates to a method for producing and preparing polyglycolate (PGA) from genetically engineered organisms. More specifically, the invention relates to a method comprising two steps; 1) culturing, in a medium containing glycolic acid or not, the microorganism expressing at least one gene encoding an enzyme(s) that converts glycolate into glycolyl-CoA, and a gene encoding polyhydroxyalkanoate (PHA) synthase which uses glycolyl-CoA as a substrate, 2) recovering the polyglycolate polymer. | 05-19-2011 |
20110151530 | ENZYMATIC PRODUCTION OF 2-HYDROXY-ISOBUTYRATE (2-HIBA) - The present invention concerns a new method for the biological preparation of 2-hydroxy-isobutyrate (2-HIBA), including a fermentation method with microorganisms modified to favour production of 2-HIBA from renewable resources. The invention also concerns the modified microorganisms used in such fermentation method. | 06-23-2011 |
20110201070 | MICROORGANISMS AND METHODS FOR PRODUCTION OF 1,2-PROPANEDIOL AND ACETOL - The present invention concerns a modified microorganism with an increased methylglyoxal reductase activity, and its use for the preparation of 1,2-propanediol and/or acetol. In particular this increased methylglyoxal reductase activity is obtained by increasing the expression of specific genes from microorganisms. | 08-18-2011 |
20110217744 | USE OF SUCROSE AS SUBSTRATE FOR FERMENTATIVE PRODUCTION OF 1,2-PROPANEDIOL - The present invention is relative to a method for producing 1,2-propanediol by fermentation, comprising: cultivating a microorganism producing 1,2-propanediol in an appropriate medium comprising a source of sucrose, and recovering the 1,2-propanediol being produced, wherein the microorganism is able to utilize sucrose as sole carbon source for the production of 1,2-propanediol. In a preferred aspect of the invention, the source of sucrose is obtained from plant biomass, and is in particular sugar cane juice. | 09-08-2011 |
20110262980 | MICRO-ORGANISMS FOR THE PRODUCTION OF ACETOL OBTAINED BY A COMBINATION OF EVOLUTION AND RATIONAL DESIGN - The present invention concerns a new method combining evolution and rational design for the preparation of a strain of micro-organism for the production of acetol from a simple carbon source. The said method comprises:
| 10-27-2011 |
20110294178 | METHOD FOR THE PREPARATION OF DIOLS - The present invention concerns a new method for the biological preparation of a diol comprising culturing a microorganism genetically modified for the bioproduction of an aliphatic diol, wherein the microorganism comprises a metabolic pathway for the decarboxylation of a hydroxy-2-keto-aliphatic acid metabolite with an enzyme having a 2-keto acid decarboxylase activity, the product obtained from said decarboxylation step being further reduced into the corresponding aliphatic diol, and wherein the microorganism is genetically modified for the improved production of said hydroxy-2-keto-aliphatic acid metabolite. | 12-01-2011 |
20120015849 | Method of Creating a Library of Bacterial Clones with Varying Levels of Gene Expression - The present invention relates to a method of creating DNA libraries that include an artificial promoter library and/or a modified ribosome binding site library and transforming bacterial host cells with the library to obtain a population of bacterial clones having a range of expression levels for a chromosomal gene of interest. | 01-19-2012 |
20120058531 | CONTINUOUS CULTURE FOR 1,3-PROPANEDIOL PRODUCTION USING HIGH GLYCERINE CONCENTRATION - The present invention concerns a new method for the production of 1,3-propanediol comprising culturing a microorganism on a culture medium with high glycerine content. The invention also concerns a new microorganism, or strain of microorganism, adapted for the production of 1,3-propanediol from medium comprising high glycerine content. | 03-08-2012 |
20120122166 | MUTANT METHYLGLYOXAL SYNTHASE (MGS) FOR THE PRODUCTION OF A BIOCHEMICAL BY FERMENTATION - The present invention concerns a method for the production of a biochemical selected among lactic acid, acetol and 1,2-propanediol, comprising culturing a microorganism modified for an improved production of the biochemical selected among lactic acid, acetol and 1,2-propanediol in an appropriate culture medium and recovery of the desired biochemical which may be further purified wherein the microorganism expresses a methylglyoxal synthase (MGS) enzyme which activity is not inhibited by orthophosphate. | 05-17-2012 |
20120122169 | MUTANT YQHD ENZYME FOR THE PRODUCTION OF A BIOCHEMICAL BY FERMENTATION - The present invention concerns a method for the production of a biochemical selected among acetol and 1,2-propanediol, 1,3-propanediol, ethylene glycol and 1,4-butanediol comprising culturing a microorganism modified for an improved production of the biochemical selected among acetol and 1,2-propanediol, 1,3-propanediol, ethylene glycol and 1,4-butanediol in an appropriate culture medium and recovery of the desired biochemical which may be further purified wherein the microorganism expresses a YqhD enzyme which catalytic efficiency toward NADPH is increased. | 05-17-2012 |
20120135487 | MUTANT GLYCEROL DEHYDROGENASE (GLYDH) FOR THE PRODUCTION OF A BIOCHEMICAL BY FERMENTATION - The present invention concerns a method for the production of 1,2-propanediol, comprising culturing a microorganism modified for an improved production of 1,2-propanediol in an appropriate culture medium and recovery of the 1,2-propanediol which may be further purified wherein the microorganism expresses a glycerol dehydrogenase (GlyDH) enzyme the inhibition of which activity by NAD+ and/or its substrate and/or its product is reduced. | 05-31-2012 |
20120178136 | FERMENTATION PROCESS FOR PRODUCING GLYCOLIC ACID - The present invention relates to a process of fermentation for producing glycolic acid under specific pH conditions with an increase of the pH during fermentation. The invention relates more particularly to a method for producing glycolic acid by fermentation, which comprises culturing a microorganism having glycolic acid producing ability in an appropriate culture medium with a carbon source, and under specific pH conditions with an increase of the pH during fermentation, and recovery of glycolic acid from the culture medium. | 07-12-2012 |
20120190116 | PROCESS FOR CHROMOSOMAL INTEGRATION AND DNA SEQUENCE REPLACEMENT IN CLOSTRIDIA - The present invention is related to a new method for replacing or deleting DNA sequences in Clostridia, with high efficiency, easy to perform and applicable at an industrial level. This method is useful to modify several genetic loci in Clostridia in a routine manner. This method is based on a replicative vector carrying at least two marker genes. | 07-26-2012 |
20120288907 | Glucose Transport Mutants for Production of Biomaterial - A method is disclosed for restoring a Glu | 11-15-2012 |
20120315682 | METHOD FOR PRODUCING HIGH AMOUNT OF GLYCOLIC ACID BY FERMENTATION - The present invention relates to an improved method for the bioconversion of a fermentable carbon source to glycolic acid by a recombinant microorganism bearing new genetic modifications such as ΔldhA, ΔmgsA, ΔarcA, and ΔlldP, ΔglcA, ΔyjcG and combination of them allowing a production with higher yield, titer and productivity. | 12-13-2012 |
20130089903 | USE OF INDUCIBLE PROMOTERS IN THE PRODUCTION OF GLYCOLIC ACID - The present invention relates to use of inducible promoters in the production of glycolic acid by fermentation. The present invention concerns a method for the production of glycolic acid in a fermentative process comprising the following steps:
| 04-11-2013 |
20130183726 | METHODS FOR PRODUCING METHIONINE BY CULTURING A MICROORGANISM MODIFIED TO ENHANCE PRODUCTION OF CYSTEINE - A method of producing methionine, derivatives or precursors thereof includes culturing a modified microorganism in a culture medium comprising a source of carbon and a source of sulfur; and recovering methionine from the culture medium, wherein said modified microorganism has an increased expression of cysE gene encoding serine acetyltransferase, metH gene encoding methionine synthase and metF gene encoding 5,10-methylenetetrahydrofolate reductase compared to expression of the cysE, metH and metF genes in an unmodified microorganism. | 07-18-2013 |
20130309737 | METHOD FOR THE PREPARATION OF 1,3-PROPANEDIOL FROM SUCROSE - The present invention concerns a microorganism genetically modified for the bioproduction of 1,3-propanediol from sucrose, wherein the microorganism comprises:
| 11-21-2013 |
20140377825 | PROCESS FOR THE BIOLOGICAL PRODUCTION OF n-BUTANOL WITH HIGH YIELD - The present invention provides a method for the biological production of n-butanol at high yield from a fermentable carbon source. In one aspect of the present invention, a process for the conversion of glucose to n-butanol is achieved by the use of a recombinant organism comprising a host | 12-25-2014 |