Platt, GB
Adam Platt, Congleton GB
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20120009177 | GENE EXPRESSION MARKERS FOR PREDICTING RESPONSE TO INTERLEUKIN-6 RECEPTOR-INHIBITING MONOCLONAL ANTIBODY DRUG TREATMENT - This invention provides methods, compositions, and kits relating to gene product biomarkers where gene expression levels are correlated with therapeutic response of rheumatoid arthritis patients to treatment with an IL-6 receptor antagonist, such as an IL6-R antibody. The methods, compositions, and kits of the invention can be used to identify rheumatoid arthritis patients who are likely, or not likely, to respond to IL-6 receptor antagonist treatments. | 01-12-2012 |
Adam Platt, Ely GB
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20110262462 | POLYMORPHISM MARKERS FOR PREDICTING RESPONSE TO INTERLEUKIN-6 RECEPTOR-INHIBITING MONOCLONAL ANTIBODY DRUG TREATMENT - The present invention provides single nucleotide polymorphisms (SNPs) associated with clinical responsiveness of rheumatoid arthritis patients to treatment with an interleukin-6 receptor antibody such as tocilizumab, and methods of using such SNPs for predicting clinical response to treatment with the antibody. | 10-27-2011 |
Adam Samuel Platt, Congleton GB
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20140080134 | LIPOCALIN 2 AS A BIOMARKER FOR IL-17 INHIBITOR THERAPY EFFICACY - The present invention provides the use of lipocalin 2 (LCN2) as a biomarker for IL-17 mediated diseases and for monitoring the response of a patient to anti-IL-17 therapy. | 03-20-2014 |
Alan Platt, Manchester GB
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20090071367 | Coating compositions for marking substrates - The present invention provides coating compositions for marking substrates, which comprises a colour former, an amine salt of an organic metal compound, a binder, a solvent, and optionally additional components, wherein the amine salt of the organic metal compound is of formula (I) in which X is silicon or boron, and E and F are the same or different and are selected from the group consisting of a, b, c, d, e, f, g, h in which R | 03-19-2009 |
20090214835 | Aqueous-based and transparent coatings for marking substrates - The present invention provides a composition, which comprises an aqueous-based solvent and forms a transparent colourless coating, which yields markings of high contrast on exposure to energy. It also provides a process for the preparation of these compositions, substrates coated with these compositions and a process for their preparation, a process for preparing marked substrates using these compositions and marked substrates obtainable by the latter process. | 08-27-2009 |
20090220749 | Coating Compositions Comprising a Latent Activator for Marking Substrates - The present invention provides a composition, which comprises a latent activator. It also provides a process for the preparation of these compositions, substrates coated with these compositions and a process for their preparation, a process for preparing marked substrates using these compositions and marked substrates obtainable by the latter process. | 09-03-2009 |
Albert Edward Platt, Oxfordshire GB
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20090124519 | Liquid delivery apparatus and method - Liquid delivery apparatus and methods, in particular for the production of high-density arrays, wherein a partial drop of liquid is deposited from a capillary ( | 05-14-2009 |
Anthony Platt, Eastleigh GB
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20100223644 | Program guide optimization system - A method and system of optimizing strings comprised in program guide data for transmission is described. The method includes sharing, in the program guide data, a plurality of strings, each string among the plurality of strings including a shared sorting key, implementing an order access of a sorted sharing index, wherein the program guide data and the shared sorting key are comprised in the same data storage structure. Related methods and apparatus are also described. | 09-02-2010 |
Anthony Platt, Devizes GB
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20110126235 | Program guide optimization system - A method and system of optimizing strings comprised in program guide data for transmission is described. The method includes sharing, in the program guide data, a plurality of strings, each string among the plurality of strings including a shared sorting key, implementing an order access of a sorted sharing index, wherein the program guide data and the shared sorting key are comprised in the same data storage structure. Related methods and apparatus are also described. | 05-26-2011 |
Anthony Platt, Hampshire GB
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20090125943 | Program guide optimization system - A method and system of optimizing strings comprised in program guide data for transmission is described. The method includes sharing, in the program guide data, a plurality of strings, each string among the plurality of strings including a shared sorting key, implementing an order access of a sorted sharing index, wherein the program guide data and the shared sorting key are comprised in the same data storage structure. Related methods and apparatus are also described. | 05-14-2009 |
Bettina Platt, Aberdeen GB
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20110041191 | Animal model, and products and methods useful for the production thereof - The present invention relates to a transgenic animal suitable for modelling Alzheimer's Disease. The present invention also relates to cells and gametes of the transgenic animal of the invention, along with nucleic acids and vectors suitable for generating the transgenic animal. Methods of generating the transgenic animal are also described, along with screening methods utilizing the transgenic animal. | 02-17-2011 |
20140377382 | CANNABINOID-CONTAINING PLANT EXTRACTS AS NEUROPROTECTIVE AGENTS - The invention relates to the use of cannabinoid-containing plant extracts in the prevention or treatment of neural degeneration. In particular, the invention relates to use of one or more cannabinoid-containing plant extracts in the prevention or treatment of neural degeneration, wherein the one or more cannabinoid-containing plant extracts comprise: | 12-25-2014 |
Bettina Platt, Abendeenshire GB
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20100239693 | CANNABINOID-CONTAINING PLANT EXTRACTS AS NEUROPROTECTIVE AGENTS - The invention relates to the use of cannabinoid-containing plant extracts in the prevention or treatment of neural degeneration. In particular, the invention relates to use of one or more cannabinoid-containing plant extracts in the prevention or treatment of neural degeneration, wherein the one or more cannabinoid-containing plant extracts comprise: i) a cannabinoid-containing fraction; and ii) a non-cannabinoid containing fraction. | 09-23-2010 |
Frances M. Platt, Oxfordshire GB
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20100137365 | Long chain N-alkyl compounds and oxa-derivatives thereof - Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C | 06-03-2010 |
20110184019 | Long chain N-Alkyl compounds and oxa-derivatives thereof - Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C | 07-28-2011 |
Frances Mary Platt, Oxford GB
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20100022620 | EPITOPE REDUCTION THERAPY - The present invention provides the use of an inhibitor of glycolipid biosynthesis in the manufacture of a medicament for the treatment of a glycolipid-mediated autoimmune disease. | 01-28-2010 |
20140080769 | SUBSTRATE REDUCTION THERAPY - The present invention provides a compound which is an inhibitor of sphingolipid biosynthesis for use in the treatment of a disease which has a secondary Niemann-Pick type C disease like cellular phenotype. | 03-20-2014 |
20140303208 | PHARMACEUTICALLY ACTIVE PIPERIDINE DERIVATIVES - Compounds of formula (I): | 10-09-2014 |
Ian Thomas Platt, Billinge GB
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20130151190 | TECHNIQUES FOR AUTOMATED INSTALLATION TESTING AND REPORTING FOR ANALYTICAL INSTRUMENTS - Automated installation processing of a mass spectrometer is described. Software is executed providing a user interface for controlling the installation process. Manual setup operations in connection with physical installation of the mass spectrometer are performed. Instrument level testing of the mass spectrometer is performed. The instrument level testing includes automating execution of a first test sequence in response to a first user interface selection. The first test sequence includes one or more performance tests whereby mass spectral data characterizing observed performance of the mass spectrometer is compared to predetermined performance criteria. System level testing of functionality of the mass spectrometer in combination with one or more other components is performed upon successful completion of said instrument level testing. The system level testing includes automating execution of a second test sequence in response to a second user interface selection. System level testing is performed after successful completion of instrument level testing. | 06-13-2013 |
20140239171 | TECHNIQUES FOR AUTOMATED PERFORMANCE MAINTENANCE TESTING AND REPORTING FOR ANALYTICAL INSTRUMENTS - Techniques are described for performing performance maintenance on a mass spectrometer. Pre-maintenance testing is performed that automating execution of a test sequence in response to a first user interface selection. The maintenance activity performed upon completion of said pre-maintenance testing. Post-maintenance testing is preformed upon completion of said maintenance activity. The post-maintenance testing includes automating execution of the test sequence in response to a second user interface selection. A benchmark comparison is performed to determine whether performance of the mass spectrometer has degraded as a result of performing the maintenance activity, wherein said benchmark comparison is performed automatically in response to completing said post-maintenance testing. | 08-28-2014 |
Jonathan Platt, Cambridge GB
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20120191507 | System for unifying and collaborating new product development activities across a disparate set of users - A Portfolio and Project Management and new product development system is disclosed. In particular, the system in one embodiment includes a user, a user computing device, a client application, an operating system, a network interface, a server, a software-as-a-service (“SaaS”) platform, applications such as contact lists, documents, mail, etc., project management software which contains various views and sub-views, and sets of rules and criteria that interact with the project management software to manage the project management software output. In particular, the system of the present invention provides additional intelligence for customizing project management solutions for environments that use structured development methodologies, such as a stage and checkpoint process. Additionally, the system allows for real-time status updates and consistent reporting structures thereby increasing efficiency and project oversight at higher levels within an organization Furthermore, the system of the present invention allows for simultaneously editing by multiple users. | 07-26-2012 |
Mark Platt, Loughborough Leicestershire GB
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20140315328 | SYSTEM AND METHOD FOR THE DETECTION OF ANALYTES BY CONTROLLED AGGREGATION NANOPARTICLES - A method for detecting an analyte in a sample, the method comprising contacting the analyte in a sample with nanoparticles comprising a capture probe for capturing said analyte, the capture probe being configured to act as a centre for controlled aggregation of nanoparticles with said analyte to form an aggregate of predefined form, detecting the analyte by detecting the shape and/or size of the aggregate is provided. Also provided are nanoparticles comprising a capture probe for capturing an analyte, wherein the capture probe is configured to act as a centre for controlled aggregation of nanoparticles with the analyte to form an aggregate of particular detectable size and/or shape, and an assay. | 10-23-2014 |
20150183655 | MICROPARTICLES AND A SYTEM AND METHOD FOR THE SYNTHESIS OF MICROPARTICLES - There is provided a method of producing microparticles using an emulsion based synthesis route including: Providing a first fluid phase and a second fluid phase, wherein the first fluid phase is a continuous phase and the second fluid phase is a dispersed phase comprising a dispersed material, wherein the continuous phase is immiscible with the dispersed phase; Mixing the first continuous phase and the second dispersed phase in the presence of a surfactant in a shear device to form an emulsion of droplets of controllable size and having a narrow drop size distribution; Drying the emulsion to form microparticles of controllable size and having narrow size distribution, and wherein the microparticles may comprise spherical, crumpled, dimpled, porous or hollow microparticles morphology. Also provided is a system including shear device and drying arrangement. Also provided are micro particles of controllable size and morphology formed by the method. | 07-02-2015 |
Mark Platt, Loughborough GB
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20140021105 | NON-LINEAR MAGNETOPHORETIC SEPARATION DEVICE, SYSTEM AND METHOD - A flow enhanced method and system for flow non-linear magnetophoresis (F-NLM) is described. By tuning an external field frequency and the flow rate the migration velocities of different bead types may be caused to differ by several orders of magnitude over an extended range of frequencies to allow for separation of particles. Use of such efficiency in separation in bio-separation and similar assays is described. | 01-23-2014 |
Mary Frances Platt, Oxford GB
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20100204162 | SUBSTRATE REDUCTION THERAPY - The present invention provides a compound which is an inhibitor of sphingolipid biosynthesis for use in the treatment of a disease which has a secondary Niemann-Pick type C disease like cellular phenotype. | 08-12-2010 |
Simon Philip Platt, Preston GB
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20140158893 | METHOD AND APPARATUS FOR NEUTRON DETECTION - Embodiments of the present invention provide a neutron spectrometry system, comprising a plurality of semiconductor detector portions arranged in close proximity, wherein the detector portions are arranged in at least two non-parallel axes, wherein each detector portion is arranged to output a detection signal indicative of energy deposited in the detector portion by ionising particles induced in the device by incident neutrons, and a control unit arranged to receive the plurality of detection signals, and to allocate detection signals to one or more of a plurality of channels based on a number of substantially coincident detection signals for determining a spectrum of incident neutrons based thereon. | 06-12-2014 |
Stephen John Platt, Cheshire GB
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20120136586 | Acquisition Method and Apparatus for Mass Spectrometer Data - A method and apparatus for acquiring data from a mass spectrometer and its transmission to a computer system including a data acquisition engine, a network interface and a throughput optimization module which includes a ring buffer and a protocol stack. A compression engine may be provided between the acquisition engine and the ring buffer. The ring buffer is configured as a number of segments containing portions of memory matching the size of data words from the acquisition engine. When a segment is full of data corresponding to the words, or is partially full and has received data containing an end of scan marker, the number of words in the segment is written into a header word in the segment and the data in that segment are moved to the protocol stack. Subsequent data is received by the next segment in the buffer. | 05-31-2012 |
20150090872 | Mass Spectrometer - A hardware module which operatively carries out a method of compressing mass spectral data, the method comprising: receiving a first signal output from an ion detector of a mass spectrometer; processing the first signal to a digital signal at an output being data frame types representative of the first signal output; temporarily storing the data frame types in a memory block and reading a data frame from the memory block and determining its data frame type and according to its data frame type compressing the data frame according to one or more compression algorithms to generate a compressed data output stream. | 04-02-2015 |
Terence Christopher Platt, Berkshire GB
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20100308222 | Multifunction Edge Device for Powered Doors - An edge device for an elevator door includes an elongate array of infrared transmitters and/or receivers and a proximate elongate array of illuminable elements, both arrays extending for a substantial part of the length of the door. The illuminable elements are adapted to be illuminated when the door is in motion. The two arrays are disposed in a common carrier structure, being either vertically interleaved or extending vertically in parallel with each other. | 12-09-2010 |
Terence Christopher Platt, Binfield Berks GB
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20080204229 | Safety Sensing System for a Powered Door System - A safety sensing system includes an apparatus for use in a doorway having a powered door slidable for closure of the doorway. The apparatus includes radiation transmitters and/or receivers for providing a curtain of detection beams across the doorway, and is formed as a composite structure that includes: a fixative member connectable by securing means to a side of the doorway at a door frame, the fixative member including a first portion of a mating connection means; and, a housing containing a plurality of the transmitters and/or receivers along its length, and including a second portion of the mating connection means for attaching the sealed housing to the fixative member The mating connection means allows the housing to be removed and replaced while the fixative member remains in situ. | 08-28-2008 |
Terrence Christopher Platt, Binfield GB
Thomas William Platt, Walsall GB
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20130000203 | DOOR ASSEMBLIES | 01-03-2013 |
Winston Platt, Stirling GB
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20090203487 | CONTINUOUSLY VARIABLE TORQUE VECTORING AXLE ASSEMBLY - A vehicle driveline having an axle assembly with an input pinion, which is configured to receive a rotary input, a input ring gear, which is meshingly engaged with the input pinion, a first output member, a second output member and a power distribution system. The first output member is configured to drive a first vehicle wheel on a first side of a vehicle. The second output member is configured to drive a second vehicle wheel on a second side of the vehicle opposite the first side. The power distribution system is driven by the input ring gear and distributes drive torque between the first and second output members. The power distribution system includes a first continuously variable transmission. A method for operating a vehicle driveline is also provided. | 08-13-2009 |
20110224044 | TORQUE VECTORING AXLE ASSEMBLY - A vehicle driveline with an axle assembly having an input member, a first output member, a second output member and a power distribution system that includes a transmission and a differential. The differential has first and second differential outputs. The first differential output is coupled directly to the first output member. The transmission is configured to control rotary power transmitted through the differential to the first and second output members. The axle assembly is operable in a first mode, which has no effect on a torque transmitted from the second differential output to the second output member, a second mode, which reduces the torque that is transmitted from the second differential output to the second output member, and a third mode that increases the torque that is transmitted from the second differential output to the second output member. | 09-15-2011 |