Patent application number | Description | Published |
20080249108 | Chemical Compounds - The invention relates to methods for the treatment of medical conditions comprising administering an effective amount of a compound of formula (I): | 10-09-2008 |
20080262041 | Beta-Lactams for Treatment of Cns Disorders - The present invention relates to novel compounds of formula (I): | 10-23-2008 |
20080269208 | Pyridine Derivatives and Their Use in the Treatment of Psychotic Disorders - There are provided according to the invention novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof: | 10-30-2008 |
20080280969 | Novel Compounds - The invention provides a compound of formula (I), pharmaceutical compositions thereof, and methods of treatment using the same. | 11-13-2008 |
20080306122 | Novel Compounds - Compounds of formula (I) wherein the variables are defined herein, pharmaceutical compositions thereof and methods for treatment using the same. | 12-11-2008 |
20090192194 | Cyclic Amine Derivatives, Processes For Their Preparation, And Pharmaceutical Compositions Containing Them - A compound of formula (I) | 07-30-2009 |
20100099680 | PTERIDINONE DERIVATIVES AS P13-KINASES INHIBITORS - New compounds of Formula (1) are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney. | 04-22-2010 |
20100105754 | 5-(4PHENYL)PROLINAMIDE FOR TREATMENT OF EPILEPSY - The invention provides a compound of formula (I), a solvate, a salt or prodrug thereof, | 04-29-2010 |
20100152175 | Pyridine Derivatives and Their Use in The Treatment of Psychotic Disorders - There are provided according to the invention novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: | 06-17-2010 |
20100261687 | SUBSTITUTED PIPERIDINES AS CCR3 ANTAGONISTS - Object of the present invention are novel substituted compounds of the formula 1, | 10-14-2010 |
20110015193 | 1, 5-DIHYDRO-PYRAZOLO (3, 4-D) PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MUDULATORS FOR THE TREATMENT OF CNS DISORDERS - The invention relates to novel substituted pyrazolopyrimidines. Chemically, the compounds are characterised by general Formula (I): with R | 01-20-2011 |
20110021550 | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation - Compounds of formula (I) wherein the groups R1 to R8 have the meanings indicated in the description, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof have valuable pharmacological properties, which make them useful for the treatment of cardiovascular and related disorders. | 01-27-2011 |
20110082137 | NEW COMPOUNDS FOR THE TREATMENT OF CNS DISORDERS - The invention relates to novel 1,6-disubstituted pyrazolopyrimidinones of formula (I), | 04-07-2011 |
20110098335 | NOVEL COMPOUNDS - The invention provides a compound of formula (I), a solvate, a salt or prodrug thereof, | 04-28-2011 |
20110184000 | 1-HETEROCYCLYL-1,5-DIHYDRO-PYRAZOLO[3,4-D] PYRIMIDIN-4-ONE DERIVATES AND THEIR USE AS PDE9A MODULATORS - The invention relates to novel 1,6-disubstituted pyrazolopyrimidinones, Formula (I) with is a mono-, bi- or tri-cyclic heterocyclyl group, the ring members of which are carbon atoms and at least 1, preferably 1, 2 or 3, heteroatom(s), which are selected from the group of nitrogen, oxygen and sulphur, which is in the form of —S(O) | 07-28-2011 |
20110212960 | NEW COMPOUNDS FOR THE TREATMENT OF CNS DISORDER - The invention relates to novel pyrazolopyrimidinones according to formula (I). | 09-01-2011 |
20120004252 | NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF - The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. | 01-05-2012 |
20120046304 | TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION - The present invention relates to compounds defined by formula I | 02-23-2012 |
20120115863 | COMPOUNDS FOR THE TREATMENT OF CNS DISORDERS - The invention relates to novel cycloalkyl- or cycloalkenyl-substituted pyrazolopyrimidinones of formula (I), wherein Ā is selected from the group A | 05-10-2012 |
20120202829 | 6-Cycloalkyl-pyrazolopyrimidinones for the Treatment of CNS Disorders - The invention relates to novel 6-Cycloalkyl-pyrazolopyrimidinones according to formula (I). | 08-09-2012 |
20120316159 | BICYCLIC RING SYSTEM SUBSTITUTED SULFONAMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS - This invention relates to bicyclic ring system substituted sulfonamide functionalized phenols of general formula 1, | 12-13-2012 |
20120329773 | BICYCLIC RING SYSTEM SUBSTITUTED AMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS - This invention relates to bicyclic ring system substituted amide functionalized phenols of general formula 1, | 12-27-2012 |
20130023517 | Therapeutic methods employing substituted piperidines which are CCR3 antagonists - Object of the present invention are novel substituted compounds of the formula 1, | 01-24-2013 |
20130040955 | 6-CYCLOALKYL-PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF CNS DISORDERS - The invention relates to novel pyrazolopyrimidinones according to formula (I). | 02-14-2013 |
20130040971 | 6-CYCLOALKYL-PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF CNS DISORDERS - The invention relates to novel pyrazolopyrimidinones according to formula (I) | 02-14-2013 |
20130053404 | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation - The present invention relates to compounds defined by formula I | 02-28-2013 |
20130090338 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS - The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD and pain diseases. | 04-11-2013 |
20130123241 | NOVEL CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS - The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of formula (I) wherein HET is a group selected from among formulas (IIa) (IIb) (IIc) (IId) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD and pain diseases. | 05-16-2013 |
20130143905 | NOVEL ANTAGONISTS FOR CCR2 AND USES THEREOF - The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of formula (I) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. | 06-06-2013 |
20130150354 | NEW SELECTIVE CCR2 ANTAGONISTS - The present invention relates to novel and selective antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD as well as pain. | 06-13-2013 |
20130172348 | NOVEL AND SELECTIVE CCR2 ANTAGONISTS - The present invention relates to novel and selective antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD as well as pain. | 07-04-2013 |
20130184299 | CCR2 ANTAGONISTS AND USES THEREOF - The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. | 07-18-2013 |
20130197011 | Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament - Substituted phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones which are glycine transporter-1 (GlyT1) inhibitors. These are useful for the treatment of schizophrenia, Alzheimer's Disease and other neurological and psychiatric disorders. | 08-01-2013 |
20130217728 | NEW CCR2 ANTAGONISTS - The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of formula (Ia) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. | 08-22-2013 |
20130324517 | CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD - The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. | 12-05-2013 |
20140045856 | 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes - The invention relates to 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalene derivatives of general formula (I) which are inhibitors of phosphodiesterase 2 and/or 10, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention. | 02-13-2014 |
20140045857 | 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes - The invention relates to 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalene derivatives of general formula (I) which are inhibitors of phosphodiesterase 2 and/or 10, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention. | 02-13-2014 |
20140073641 | 1-HETEROCYCLYL-1,5-DIHYDRO-PYRAZOLO[3,4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS - The invention relates to novel 1,6-disubstituted pyrazolopyrimidinones, wherein i.) the nitrogen atom of the pyrazolo-group that is next to the pyrimidino-group is attached to a non-aromatic, organic heterocycle having at least one ring hetero atom selected from O, N and S and ii.) to the C-atom between the two nitrogen atoms of the pyrimidinone-ring a second substituent is bound via an optionally substituted methylene-bridge. According to one aspect of the invention the new compounds are for the manufacture of medicaments, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. The new compounds are also for the manufacture of medicaments for the treatment of Alzheimer's disease. | 03-13-2014 |
20140235661 | NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF - The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. | 08-21-2014 |
20140323492 | CCR2 RECEPTOR ANTAGONISTS - The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. | 10-30-2014 |
20140336374 | PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF CCR2 ANTAGONISTS - The present invention relates to a process for the production of novel antagonists for CCR2 (CC chemokine receptor 2) and intermediates thereof. | 11-13-2014 |
20140343065 | New Somatostatin receptor subtype 4 (SSTR4) agonists - 3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4. | 11-20-2014 |
20140350025 | COMPOUNDS FOR THE TREATMENT OF CNS DISORDERS - The invention relates to novel 1,6-disubstituted pyrazolopyrimidinones of formula (I), | 11-27-2014 |
20150025088 | 6-CYCLOALKYL-PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF CNS DISORDERS - The invention relates to novel 6-Cycloalkyl-pyrazolopyrimidinones according to formula (I). | 01-22-2015 |