Patent application number | Description | Published |
20080233050 | Diagnostic and therapeutic optical agents - Disclosed herein are compounds that may be characterized by some as cyanine and indocyanine dye bioconjugates. Compounds disclosed herein may be utilized (e.g., in the form of a pharmaceutically acceptable composition) in a number of medical procedures, such as in the visualization and detection of tumors. | 09-25-2008 |
20080275017 | AROMATIC SULFENATES FOR TYPE I PHOTOTHERAPY - Novel sulfenate derivatives and their bioconjugates for phototherapy of tumors and other lesions. The sulfenates of the present invention are designed to absorb low-energy ultraviolet, visible, or near-infrared (NIR) region of the electromagnetic spectrum. The phototherapeutic effect is caused by direct interaction of free radicals, the reactive intermediate produced upon photofragmentation of the sulfenate moiety, with the tissue of interest. | 11-06-2008 |
20080299038 | Luminescent Metal Complexes for Monitoring Renal Function - Some embodiments of the present invention may be said to be directed to metal complexes of Formula I, wherein at least one of X | 12-04-2008 |
20080312539 | Methods of Using Optical Agents - In certain aspects, the invention relates to processes for using renally excretable optical agents to detect one or more tissues of the renal system of a surgical patient. In certain aspects, the invention relates to a kit including a biocompatible composition containing one or more optical agents and instructions for using the optical agent(s) in a process of the present invention. | 12-18-2008 |
20090010851 | Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function - The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X | 01-08-2009 |
20090016965 | INTERNAL IMAGE ANTIBODIES FOR OPTICAL IMAGING AND THERAPY - Methods using internal image antibodies for photodiagnosis and/or phototherapy. The internal image antibodies are conjugated with a photoactive molecule such as a dye or photosensitizer, to target specific regions, such as biological receptors. The photoactive molecules are then activated for diagnosis or therapy. Advantageously, the internal image antibody is specific for a biological receptor, but does not require isolation of the receptor to prepare the antibody, and provides the desired specificity and selectivity for targeted diagnosis or therapy. | 01-15-2009 |
20090035363 | Photoactive Compounds and Compositions and Uses Thereof - Photoactive compounds and compositions, as well as methods of using the same. For example, compositions of the invention may be used in Type 1 phototherapy, Type 2 phototherapy, or a combination of Types 1 and 2 phototherapy. | 02-05-2009 |
20090036502 | Thiadiazole Compounds and Uses Thereof - Thiadiazole compounds, compositions, bioconjugates, and methods for targeting and photoactivation at target sites. | 02-05-2009 |
20090198053 | Pyrazine Derivatives and Uses Thereof in Renal Monitoring - The present invention relates to pyrazine derivatives such as those represented by Formulas (I) and (II) below. X | 08-06-2009 |
20090263327 | MINIMALLY INVASIVE PHYSIOLOGICAL FUNCTION MONITORING AGENTS - Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo. | 10-22-2009 |
20090304583 | PATHOLOGICAL TISSUE DETECTION AND TREATMENT EMPLOYING TARGETED BENZOINDOLE OPTICAL AGENTS - Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues. A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management. | 12-10-2009 |
20100010223 | Pyrazine derivatives, Methods of use, and methods for preparing same - The present invention relates to methods for producing N,N′-alkylated diaminopyrazines. | 01-14-2010 |
20100021382 | Pyrazine Derivatives and Uses Thereof - Disclosed herein are pyrazine derivatives and methods of using the same. | 01-28-2010 |
20100022449 | RECEPTOR-AVID EXOGENOUS OPTICAL CONTRAST AND THERAPEUTIC AGENTS - Cyanine and indocyanine dye compounds and bioconjugates are disclosed. The present invention includes several cyanine and indocyanine dyes, including bioconjugates of the same, with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of compounds of the invention allows favorable delivery to tumor cells as compared to larger molecular weight imaging agents. Further, use of a biocompatible organic solvent such as dimethylsulfoxide may be said to assist in maintaining the fluorescence of compounds of the invention. The compounds and bioconjugates herein disclosed are useful in a variety of medical applications including, but not limited to, diagnostic imaging and therapy, endoscopic applications for the detection of tumors and other abnormalities, localized therapy, photoacoustic tumor imaging, detection and therapy, and sonofluorescence tumor imaging, detection and therapy. | 01-28-2010 |
20100047173 | Methods for Using Optical Agents - In certain embodiments, the present invention is directed to novel processes for using hepatobiliary cleared optical agents to detect one or more tissues of the biliary tract of a surgical patient. In certain embodiments, the invention is directed to kits that include one or more optical agents and instructions for using the agent(s), for example, in a process of the invention. | 02-25-2010 |
20100105899 | Integrated Photoactive Small Molecules and Uses Thereof - This invention is directed to the general method of transforming non-photoactive bioactive small molecule compounds of known structure and function into photoactive analogs of the small molecules which exhibit both photoactivity and the original biological targeting activity. The general method for the design of the photoactive analogs of the small molecules includes: (a) selecting a desired bioactive molecule; (b) identifying the region of the molecule that contains an aromatic or a heteroaromatic motif; and (c) either replacing said motif with a photoactive functional group of similar size, or modifying said motif to make it photoactive. Other aspects include photoactive analog compounds and photodiagnostic and phototherapeutic uses thereof. | 04-29-2010 |
20100113756 | LUMINESCENT METAL COMPLEXES FOR MONITORING RENAL FUNCTION - Some embodiments of the present invention may be said to be directed to metal complexes of Formula I wherein at least one of X | 05-06-2010 |
20100196460 | Integrated Photoactive Agents for Real-Time Monitoring of Hemostasis - The present invention discloses a number of photoactive compounds designed to bind and inhibit serine proteases. Compounds disclosed herein may be utilized in a number of appropriate medical diagnostic and/or therapeutic procedures such as the monitoring of hemostasis, imaging and/or treatment of vulnerable plaques, and/or tumor imaging and/or treatment. | 08-05-2010 |
20100222547 | Integrated Photoactive Peptides and Uses Thereof - This invention is directed to the general method of transforming bioactive compounds of known structure and function into photoactive molecules such that the original biological activity is retained. The molecules resulting from the integration of two fundamental properties of photoactivity and biological function into a single molecular entity are hereinafter generally referred to as ‘integrated photoactive analogs’ or ‘integrated photoactive peptides or pseudopeptides.” The general method for the design of integrated photoactive analogs principally involves: (a) selecting a desired bioactive peptide or pseudopeptide; (b) identifying the region of the molecule that contains an aromatic or a heteroaromatic motif; and (c) either replacing said motif with a photoactive functional group of similar size, or modifying said motif to render it photoactive. Other aspects include photoactive analog compounds and photodiagnostic and phototherapeutic uses thereof. | 09-02-2010 |
20100233091 | Pyrazine Derivatives with Extended Conjugation and Methods of Using the same in Optical Applications - The present invention relates to pyrazine derivatives capable of absorbing and emanating spectral energy in the visible and/or near infrared spectrum. Pyrazine derivatives of the invention may be administered to a patient in the form of a pharmaceutically acceptable composition and utilized in medical (e.g., diagnostic imaging) procedures. | 09-16-2010 |
20110130707 | Thiadiazole Compounds and Uses Thereof - Thiadiazole compounds, compositions, bioconjugates, and methods for targeting and photoactivation at target sites. | 06-02-2011 |
20110177006 | Dithienofuran Dyes for Imaging and Therapy - The invention provides optical agents, including compositions, preparations and formulations, and methods of using and making optical agents. Optical agents of the present invention include dyes, and derivatives thereof, having a fused ring backbone structure having dithienofuran core. In some embodiments, dyes of the present invention are dithienofuran dyes having a dithienofuran core optionally functionalized to provide useful optical, biological, pharmacokinetic and/or physical properties. | 07-21-2011 |
20110177007 | Dithienopyrrole Dyes for Imaging and Therapy - The invention provides optical agents, including compositions, preparations and formulations, and methods of using and making optical agents. Optical agents of the present invention include dyes, and derivatives thereof, having a fused ring backbone structure having dithienopyrrole core. In some embodiments, dyes of the present invention are dithienopyrrole dyes having a dithienopyrrole core optionally functionalized to provide useful optical, biological, pharmacokinetic and/or physical properties. | 07-21-2011 |
20110196231 | Fused Ring Thiophene Dyes for Imaging and Therapy - The invention provides optical agents, including compositions, preparations and formulations, and methods of using and making optical agents. Optical agents of the present invention include oligomer dyes, and derivatives thereof, having a fused ring backbone structure having an oligothiophene core. In some embodiments, oligomer dyes of the present invention are fused ring thiophene dyes having an oligothiophene core comprising a plurality of fused thiophene, thiophene-oxide, and/or thiophene-dioxide rings, optionally functionalized to provide useful optical, biological, pharmacokinetic and/or physical properties. The compounds are dithieno[3,2-b;2′,3′-d]thiophene derivatives. | 08-11-2011 |
20120041479 | Tissue Sealant Compositions, Vascular Closure Devices, and Uses Thereof - The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures. | 02-16-2012 |
20120100078 | Pyrazine Derivatives and Uses Thereof in Renal Monitoring - The present invention relates to pyrazine derivatives such as those represented by Formulas I and II below. | 04-26-2012 |
20120129879 | Compounds and Compositions for Use in Phototherapy and in Treatment of Ocular Neovascular Disease and Cancers - The invention relates generally to anti-angiogenesis agents and related methods of using to anti-angiogenesis agents for biomedical applications including direct monotherapy and combination therapy for treatment of an angiogenesis related condition. In an embodiment, the invention provides a class of opioid compounds and structurally related opioid derivatives exhibiting anti-VEGF activity for use in therapeutic procedures, including phototherapy. Opioid compounds and structurally related opioid derivatives of the invention may be administered alone or in combination with administration of a phototherapy agent and/or other therapeutic agent. | 05-24-2012 |
20130136698 | INTEGRATED PHOTOACTIVE AGENTS AND USES THEREOF - The present invention discloses a number of photoactive compounds designed to bind and inhibit serine proteases. Compounds disclosed herein may be utilized in a number of appropriate medical diagnostic and/or therapeutic procedures such as the monitoring of hemostasis, imaging and/or treatment of vulnerable plaques, and/or tumor imaging and/or treatment. | 05-30-2013 |
20130137976 | Functional, Cross-Linked Nanostructures for Tandem Optical Imaging and Therapy - The present invention provides optical agents comprising optically functional cross linked supramolecular structures and assemblies useful for tandem optical imaging and therapy. Supramolecular structures and assemblies of the present invention include optically functional shell-cross linked micelles wherein optical functionality is achieved via incorporation of one or more linking groups that include one or more photoactive moieties. The present invention further includes imaging and therapeutic methods using one or more optical agents of the present invention including optically functional shell cross-linked micelles having an associated therapeutic agent. | 05-30-2013 |
20130210156 | Uniform, Functionalized, Cross-Linked Nanostructures for Monitoring pH - Described herein are optical agents, including compositions, preparations and formulations, for monitoring the pH of a fluid. Optical agents described herein include photonic nanostructures and nanoassemblies including supramolecular structures, such as shell cross-linked micelles, that incorporate at least one linking group comprising one or more photoactive moieties that provide functionality as exogenous agents for a range of pH monitoring applications. Optical agents described herein comprise supramolecular structures having linking groups imparting useful optical and structural functionality. In an embodiment, for example, the presence of linking groups function to covalently cross link polymer components to provide a cross-linked shell stabilized supramolecular structure, and also impart useful optical functionality, for example by functioning as a fluorophore. | 08-15-2013 |
20140039191 | Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function - The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X | 02-06-2014 |