Patent application number | Description | Published |
20080212261 | Energy storage devices and composite articles associated with the same - Embodiments of the invention relate to energy storage devices, e.g., capacitors and batteries, that may include a composite article of elongated conductive structures embedded in a polymer matrix. In some embodiments, a liquid containing ionic species may be dispersed within the polymer matrix of the article. The liquid may contact the elongated conductive structures within the polymer matrix. When the composite article is used as an energy storage device, the large surface area at the interface between the elongated conductive structures and the liquid can provide high energy storage. Embodiments of the invention enable storing energy using a composite article that exhibits both high and low temperature stability, high cyclic repeatability, and mechanical flexibility. The composite article can also be non-toxic, biocompatible and environmentally friendly. Thus, the composite article may be useful for a variety of energy storage applications, such as in the automotive, RFID, MEMS and medical fields. | 09-04-2008 |
20090197308 | Enzymatic synthesis of sulfated polysaccharides - A method of sulfating a polysaccharide is provided. The method can include providing a reaction mixture comprising at least one O-sulfotransferase (OST) enzyme and 3′-phosphoadenosine 5′-phosphosulfate (PAPS); incubating a polysaccharide substrate with the reaction mixture, wherein production of the sulfated polysaccharide from the polysaccharide substrate is catalyzed by the OST enzyme with a conversion of the PAPS to adenosine 3′,5′-diphosphate (PAP); and providing a reaction condition which modifies PAP to reduce an inhibitory effect of PAP on the polysaccharide sulfation. | 08-06-2009 |
20090220606 | TREATMENT AND PREVENTION OF ABNORMAL CELLULAR PROLIFERATION - This invention provides a method for inhibiting or preventing the abnormal growth of cells, including transformed cells, by administering an effective amount of O-acylated heparin derivative. Abnormal growth of cells refers to cell growth independent of normal regulatory mechanism (e.g. loss of contact inhibition). This includes the abnormal growth of: (1) tumor cells (tumors); (2) benign and malignant cells of other proliferative disease in which aberrant cellular proliferation occurs; (3) aberrant smooth muscle cell proliferation, such as might occur following treatment for coronary atherosclerosis such as angioplasty or the insertion of a stent into an occluded vessel. | 09-03-2009 |
20100004196 | HEPARAN SULFATE PROTEOGLYCAN COMPOSITION AND USE THEREOF - The present invention relates to method for the preparation of glycosaminoglycan compositions, isolated glycosaminoglycan compositions obtainable therefrom, glycosaminoglycan compositions, kits and use thereof. More specifically, the present invention provides a method for isolating glycosaminoglycan compositions of the invention from human follicular fluid. The compositions, related methods and uses according to the present invention are useful in the treatment and/or prevention of thrombotic diseases, cell proliferation disorders, proteolysis and inflammation mediated cell invasion and infertility. | 01-07-2010 |
20100239673 | Blood compatible nanomaterials and methods of making and using the same - The invention provides blood compatible nanomaterials, biomaterials prepared therewith and blood compatible medical devices fabricated using the biomaterials of the invention. The invention further provides methods of making and using the nanomaterials, biomaterials and medical devices of the invention for the diagnosis, prevention and treatment of medical conditions. The invention further provides methods of using room temperature ionic liquids to make blood compatible nanomaterials. | 09-23-2010 |
20110070440 | Artificial Organelle On A Digital Microfluidic Chip Used To Redesign The Biological Activities of Heparan Sulfate - Using digital microfluidics, recombinant enzyme technology, and magnetic nanoparticles, a functional prototype of an artificial Golgi organelle is described. Analogous to the natural Golgi, which is responsible for the enzymatic modification of glycosaminoglycans immobilized on proteins, this artificial Golgi enzymatically modifies glycosaminoglycans, such as heparan sulfate (HS) chains, immobilized onto magnetic nanoparticles. Sulfo groups were transferred from adenosine 3′-phosphate 5′-phosphosulfate to the 3-hydroxyl group of the D-glucosamine residue in an immobilized HS chain using D-glucosaminyl 3-O-sulfotransferase. After modification, the nanoparticles with immobilized HS exhibited increased affinity for fluorescently labeled antithrombin III as detected by confocal microscopy. Since the biosynthesis of HS involves an array of specialized glycosyl transferases, epimerase, and sulfotransferases, this approach should mimic the synthesis of HS in vivo. Furthermore, our method demonstrates the feasibility of investigating the effects of multi-enzyme systems on the structure of final glycan products for HS-based glycomic studies. | 03-24-2011 |
20110190402 | SYNTHETIC WOOD COMPOSITE - The invention is directed a synthetic wood composite comprising biomimetic macromolecules and methods for the preparation thereof. | 08-04-2011 |
20110305903 | SHEATHED NANOTUBE FIBER AND METHOD OF FORMING SAME - Embodiments of the invention provide a cellulose-sheathed carbon nanotube fiber. One aspect of the invention provides a sheathed nanotube fiber comprising: a carbon nanotube fiber; and a cellulose sheath extending co-axially along at least a first portion of a length of the carbon nanotube fiber. Another aspect of the invention provides a method of forming a sheathed carbon nanotube fiber, the method comprising: co-electrospinning a carbon nanotube fiber gel core within a cellulose solution sheath. | 12-15-2011 |
20120157669 | K5 HEPAROSAN FERMENTATION AND PURIFICATION - A method for the production of heparosan from fermentation culture of | 06-21-2012 |
20120322114 | ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES - Heparosan is sulfated at the iduronic acid residue by providing a reaction mixture comprising C5 epimerase to convert glucuronic acid to iduronic acid, and at least one O-sulfotransferase (OST) enzyme and 3′-phosphoadenosine 5′-phosphosulfate (PAPS). | 12-20-2012 |