Patent application number | Description | Published |
20120021049 | Single Daily Dosage Form for Prevention and Treatment of Metabolic Syndrome - The present invention is in the fields of medicine, pharmaceuticals, nutraceuticals, endocrinology and cardiology. The invention provides compositions comprising a statin, an inhibitor of the angiotensin converting enzyme, an antiplatelet compound and an anti-hyperglycemic compound for use in the treatment and/or prevention of cardiometabolic risk factors of Metabolic Syndrome and treatment and/or prevention of Metabolic Syndrome. The present invention provides for the use of such compositions in the manufacture of products for treatment and/or prevention of Metabolic Syndrome. The biguanide metformin of the composition could be present in extended release form allowing its use together with the other drugs in a single dosage form at low dose. This combination of drugs in a single daily dosage greatly improves compliance and adherence to treatment which is a critical factor for treating patients with Metabolic Syndrome. | 01-26-2012 |
20120095059 | Compositions and Methods for Treating Type II Diabetes and Related Disorders - The present invention relates to methods and compositions for treating type II diabetes. This invention discloses an orally administrable pharmaceutical formulation, as convenient therapy to reduce glucose levels in blood, preventing the development of diabetes and an earlier exhausting of the pancreas. In certain embodiments, the invention provides orally administerable combination pharmaceutical formulations, comprising at least one insulin sensitizer (e.g., a glitazone such as pioglitazone or rosiglitazone), at least one sulfonylurea (e.g., glimepiride), and at least one biguanide (e.g., metformin or a pharmaceutically acceptable salt or ester thereof, such as metformin HCl). The present invention also provides methods of treating type II diabetes and related disorders in a mammal, suitably a human, by administering to a mammal in need thereof one or more of the compositions of the present invention. | 04-19-2012 |
Patent application number | Description | Published |
20090102400 | METHOD FOR DRIVING A PTC ELECTRICAL LOAD ELEMENT - A method is intended to make it possible to drive a PTC electrical load element with a switching unit with the highest possible operational reliability. For this purpose, the electric current is switched off if a predetermined current threshold value is exceeded, the magnitude of the current threshold value being determined from the operating parameters of the load element. | 04-23-2009 |
20120119678 | METHOD FOR DRIVING A PTC ELECTRICAL LOAD ELEMENT - A method is intended to make it possible to drive a PTC electrical load element with a switching unit with the highest possible operational reliability. For this purpose, the electric current is switched off if a predetermined current threshold value is exceeded, the magnitude of the current threshold value being determined from the operating parameters of the load element. | 05-17-2012 |
20130314832 | OVERCURRENT PROTECTION DEVICE AND METHOD OF OPERATING A POWER SWITCH - An overcurrent protection device comprises a maximum-allowed-current unit and a power switch having a conductive state and a nonconductive state. The maximum-allowed-current unit determines a time-dependent maximum allowed current according to a supply voltage. The power switch assumes the nonconductive state in response to an indication that a current through the power switch is exceeding the maximum allowed current. A method of operating a power switch is also described. | 11-28-2013 |
20130321966 | OVERCURRENT PROTECTION DEVICE AND METHOD OF OPERATING A POWER SWITCH - An overcurrent protection device comprises a maximum-allowed-current unit and a power switch. The maximum-allowed-current unit determines a maximum allowed current in real-time. The maximum allowed current is determined at least partially on an instantaneous level of a load voltage. The load voltage is a voltage across a load to be powered. The power switch is connectable with a switch input to a voltage supply and with a switch output to the load, for providing power to said load. The power switch has a conductive state and a nonconductive state, and is arranged to assume the nonconductive state in response to an indication that a current through the power switch is exceeding the maximum allowed current. A method of operating a power switch is also described. | 12-05-2013 |
Patent application number | Description | Published |
20120068198 | HIGH DENSITY MULTI-CHIP LED DEVICES - High density multi-chip LED devices are described. Embodiments of the present invention provide high-density, multi-chip LED devices with relatively high efficiency and light output in a compact size. An LED device includes a plurality of interconnected LED chips and an optical element such as a lens. The LED chips may be arranged in two groups, wherein the LED chips within each group are connected in parallel and the groups are connected in series. In some embodiments, the LED device includes a submount, which may be made of ceramic. The submount may include a connection bus and semicircular areas to which chips are bonded. Wire bonds can be connected to the LED chips so that all the wire bonds are disposed on the outside of a group of LED chips to minimize light absorption. | 03-22-2012 |
20120069564 | MULTI-CHIP LED DEVICES - Multi-chip LED devices are described. Embodiments of the present invention provide multi-chip LED devices with relatively high efficiency and good color rendering. The LED device includes a plurality of interconnected LED chips and an optical element such as a lens. The optical element may be molded from silicone. The LED chips may be connected in parallel. In some embodiments, the LED device includes a submount, which may be made of a ceramic material such as alumina or aluminum nitride. Wire bonds can be connected to the LED chips so that all the wire bonds tend the outside of a group of LED chips. Various sizes and types of LED chips may be used, including vertical LED chips and sideview LED chips. | 03-22-2012 |
20120086024 | MULTIPLE CONFIGURATION LIGHT EMITTING DEVICES AND METHODS - Multiple configuration light emitting diode (LED) devices and methods are disclosed wherein LEDs within the device can be selectively configured for use in higher voltage, or variable voltage, applications. Variable arrangements of LEDs can be configured. Arrangements can include one or more LEDs connected in series, parallel, and/or a combination thereof. A surface over which one or more LEDs may be mounted can comprise one or more electrically and/or thermally isolated portions. | 04-12-2012 |
20120193660 | HORIZONTAL LIGHT EMITTING DIODES INCLUDING PHOSPHOR PARTICLES - Horizontal light emitting diodes include anode and cathode contacts on the same face and a transparent substrate having an oblique sidewall. A conformal phosphor layer having an average equivalent particle diameter d50 of at least about 10 μm is provided on the oblique sidewall. High aspect ratio substrates may be provided. The LED may be directly attached to a submount. | 08-02-2012 |
20120193661 | GAP ENGINEERING FOR FLIP-CHIP MOUNTED HORIZONTAL LEDS - A horizontal LED die is flip-chip mounted on a mounting substrate to define a gap that extends between the closely spaced apart anode and cathode contacts of the LED die, and between the closely spaced apart anode and cathode pads of the substrate. An encapsulant is provided on the light emitting diode die and the mounting substrate. The gap is configured to prevent sufficient encapsulant from entering the gap that would degrade operation of the LED. | 08-02-2012 |
20130141905 | LIGHT EMITTER DEVICES AND METHODS FOR IMPROVED LIGHT EXTRACTION - Light emitter devices with improved light extraction and related methods are disclosed. In one embodiment, the light emitter device can include a submount, at least one light emitting chip disposed over the submount, and a lens disposed over the light emitting chip. The lens can include a lens base that can have substantially the same geometry as a geometry of the submount. | 06-06-2013 |
20130322068 | LIGHT EMITTER PACKAGES, SYSTEMS, AND METHODS HAVING IMPROVED PERFORMANCE - Light emitter packages, systems, and methods having improved performance are disclosed. In one aspect, a light emitter package can include a submount that can include an anode and a cathode. A light emitter chip can be disposed over the submount such that the light emitter chip is mounted over at least a portion of the cathode and wirebonded to at least a portion of the anode. | 12-05-2013 |
20130322070 | LIGHT EMITTER PACKAGES, SYSTEMS, AND METHODS - Light emitter packages, systems, and methods having improved performance are disclosed. In one aspect, a light emitter package can include a submount that can include an anode and a cathode. A first light emitter chip can mounted over at least a portion of the cathode, and a second light emitter chip can be wirebonded to at least a portion of the anode. Multiple light emitter chips can be disposed between the first and second light emitter chips. | 12-05-2013 |
20150048393 | HIGH DENSITY MULTI-CHIP LED DEVICES - High density multi-chip LED devices are described. Embodiments of the present invention provide high-density, multi-chip LED devices with relatively high efficiency and light output in a compact size. An LED device includes a plurality of interconnected LED chips and an optical element such as a lens. The LED chips may be arranged in two groups, wherein the LED chips within each group are connected in parallel and the groups are connected in series. In some embodiments, the LED device includes a submount, which may be made of ceramic. The submount may include a connection bus and semicircular areas to which chips are bonded. Wire bonds can be connected to the LED chips so that all the wire bonds are disposed on the outside of a group of LED chips to minimize light absorption. | 02-19-2015 |
Patent application number | Description | Published |
20140271575 | ADULT CARDIAC STEM CELL POPULATION - The present invention relates to the identification, isolation, expansion and characterization of a specific type of adult cardiac stem cell. These adult stem cells are characterised in that they naturally express a specific pattern of markers, which can be used to assist with their isolation and expansion. The cells of the invention display an unprecedented capacity for providing, activating and/or inducing repair of damaged cardiac tissue. These adult stem cells may be used as therapeutic agents including, without limitation, for the regeneration of tissue, particularly for regeneration of damaged cardiac tissue, such as myocardium. | 09-18-2014 |
20160030485 | ADULT CARDIAC STEM CELL POPULATION - The present invention relates to the identification, isolation, expansion and characterization of a specific type of multipotent adult cardiac stem cell. These adult stem cells are characterised in that they naturally express a specific pattern of markers, which can be used to assist with their isolation and expansion. In particular, the cells express SOX17 and GATA4, but do not express Oct4, Nanog, c-kit and telomerase reverse transcriptase. These cells are able to differentiate into one or more of the following cell types: adipocytes, osteocytes, endothelial cells and/or smooth muscle cells. They also display an unprecedented capacity for immunoregulation as well as providing, activating and/or inducing repair of damaged cardiac tissue. These adult stem cells may be used as therapeutic agents including, without limitation, for the regeneration of tissue, particularly for regeneration of damaged cardiac tissue, such as myocardium. | 02-04-2016 |
Patent application number | Description | Published |
20130154349 | SYSTEM AND METHOD FOR POWER DISTRIBUTION - A direct current (DC) power distribution system is provided for an aircraft. The system includes a DC system bus configured to carry electrical power from a source of electrical power to a plurality of electrical loads. The electrical loads are onboard the aircraft. The DC system bus includes a load side. The system includes a plurality of power converter modules that are electrically coupled in series to the DC system bus on the load side of the DC system bus. The power converter modules are configured to be electrically attached to corresponding sub-sets of the electrical loads. At least one of the power converter modules is configured to be short circuited in response to a fault such that the at least one power converter module does not supply electrical power to the corresponding subset of the electrical loads. | 06-20-2013 |
20140055225 | LOAD TAP CHANGER - A load tap changer includes a mechanical switch, a semiconductor switch and an impedance branch or an uncontrolled semiconductor switch. The mechanical switch is connected to a power terminal of a voltage conversion device to carry an electric current and is activated to switch from a first tap to a second tap of the voltage conversion device when a tap change signal is received. The semiconductor switch is then connected between the first tap and the power terminal of the voltage conversion device when the tap change signal is received and is disconnected before the mechanical switch is connected to the second tap. The impedance branch or the uncontrolled semiconductor switch is connected between the second tap and the power terminal of the voltage conversion device before the mechanical switch is connected to the second tap. The impedance or the uncontrolled semiconductor switch is disconnected after the mechanical switch is connected to the second tap. | 02-27-2014 |
20140167508 | VOLTAGE SOURCE CURRENT CONTROLLED MULTILEVEL POWER CONVERTER - A power converter module including a voltage source current controlled power converter for providing unidirectional current having at least four output voltage levels is provided. The voltage source current controlled power converter includes an input terminal and an output terminal, and a first conductive path and a second conductive path is coupled in parallel to each other between the input terminal and the output terminal. Each of the conductive paths comprises at least one diode and at least one switch coupled in series to the respective conductive path. The at least one diode in the first conductive path are coupled closer to the input terminal and the at least one diode in the second conductive path are coupled closer to the output terminal. The voltage source current controlled power converter further includes at least two energy storage elements coupled between the first conductive path and the second conductive path. | 06-19-2014 |
20140185328 | APPARATUS AND METHOD FOR AVOIDING TRANSFORMER SATURATION - A controller for a power converter includes one or more controller modules operably linked to a transformer core of the power converter, to primary bridge switches of the power converter, and to secondary bridge switches of the power converter, wherein the one or more controller modules are configured to avoid saturation of the transformer core by modulating pulse widths of first electrical pulses sent to the primary bridge switches, based at least on measurements of DC components of current through primary and secondary windings adjacent the transformer core, and by modulating pulse widths of second electrical pulses sent to the secondary bridge switches, based at least on measurements of DC components of current through the primary and secondary windings. | 07-03-2014 |
20140191745 | APPARATUS AND METHOD FOR MITIGATING PERTURBATIONS IN A POWER CONVERTER - A power converter includes a plurality of switches that interconnect first and second input terminals of the power converter with first and second output terminals of the power converter. The switches are switched to convert power from the input terminals to the output terminals. During the switching, voltage spikes are mitigated by a first RLC branch connected from the first input terminal to the first output terminal and by a second RLC branch connected from the second input terminal to the second output terminal. | 07-10-2014 |