Santin, US
Alessandro Santin, Little Rock, AR US
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20080279872 | Immunotherapeutic methods targeted toward stratum corneum chymotryptic enzyme - The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies. | 11-13-2008 |
20090010842 | Methods for the early diagnosis of ovarian cancer - The present invention discloses the protease stratum corneum chymotryptic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies. | 01-08-2009 |
20110213337 | Methods for the early diagnosis of ovarian cancer - The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of hepsin protease. The detected proteases are themselves specifically over-expressed in certain cancers, and the presence of their genetic precursors may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment. | 09-01-2011 |
Alessandro Santin, Orange, CT US
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20110086056 | Methods for the early diagnosis of ovarian cancer - The present invention discloses the protease hepsin is specifically over-expressed in ovarian and other malignancies. A number of hepsin peptides can induce immune responses to hepsin, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies. There is also provided a hepsin protein variant that is useful as a marker for ovarian cancer cells, prostate cancer cells or kidney cancer cells. | 04-14-2011 |
Alessandro D. Santin, Orange, CT US
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20090291047 | Therapy with clostridium perfringens enterotoxin to treat ovarian and uterine cancer - The invention discloses high levels of receptors for | 11-26-2009 |
20110223181 | Gene expression profiling in primary ovarian serous papillary tumors and normal ovarian epithelium - Provided herein are methods for treating ovarian serous papillary carcinoma by delivering | 09-15-2011 |
20120071421 | THERAPY WITH CLOSTRIDIUM PERFRINGENS ENTEROTOXIN TO TREAT OVARIAN AND UTERINE CANCER - The invention discloses high levels of receptors for | 03-22-2012 |
20130244900 | Gene Expression Profiling in Primary Ovarian Serous Papiliary Tumors and Normal Ovarian Epithelum - Provided herein are methods for detecting ovarian serous papillary carcinoma in an individual. A tumor sample from the individual is examined for gene product expression levels of a group of genes consisting of transforming growth factor beta receptor III, platelet-derived growth factor receptor alpha, SEMACAP3, ras homolog gene family member I (ARHI), thrombospondin 2, and disabled-2/differentially expressed in ovarian carcinoma 2 (Dab2/DOC2) Gene products which are down-regulated compared to those in a control individual indicate the presence of ovarian serous papillary carcinoma | 09-19-2013 |
Alessandro D. Santin, Little Rock, AR US
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20080199885 | Overexpression of mammaglobin B in ovarian and endometrial tumors - a new diagnostic and therapeutic marker - The invention involves the discovery that the mammaglobin B gene is the single most overexpressed gene in primary ovarian serous papillary cancer over normal ovarian epithelium among over 14,000 genes tested. It is expressed over 800-fold higher in primary ovarian tumors than normal ovarian epithelium. Mammaglobin B gene expression was detected in endometrioid, mucinous, undifferentiated, serous papillary, clear cell, and mixed histology ovarian tumors. The protein can be found in blood and ascites fluid, and a simple blood test for the presence of mammaglobin B protein can provide early detection of ovarian and other cancers. The invention provides a method of screening for cancer involving detecting mammaglobin B in a fluid sample. | 08-21-2008 |
20090117140 | Human papilloma virus dominant CD4 T cell epitopes and uses thereof - Provided herein are methods of determining immunodominant T cell epitopes within a protein expressed in an individual and immunotherapy directed towards a protein in an individual using these determined epitopes. The method comprises administering autologous dendritic cells pulsed with a recombinant protein to the individual, establishing T-cell lines therefrom and incubating the T cell lines with representative peptides from the protein to measure and identify those peptides from the protein inducing the T cell response. Also provided are synthetic or recombinant peptides or immunogenic compositions thereof comprising the identified peptide(s) or peptides of similar sequence and a method of preventing or treating a pathophysiological condition. | 05-07-2009 |
Andrew W. Santin, Newton, MA US
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20080258523 | FESTOONED TRIM CLIP SYSTEM AND METHOD FOR ATTACHING FESTOONED CLIPS TO A SUBSTRATE - This invention provides a single or multi-ganged clip that can be grouped into a festooned arrangement. That is, a plurality of clips are arranged together into a discrete assembly along a line of extension so that a human or automated handler can retrieve a grouping, separate one-clip-at-a-time from the grouping, and apply the separated clip to a mold cavity or other assembly structure. Each clip can include a base with opposing ends aligned in the direction of extension and transverse to an elongation direction for a connecting segment (if any) between ganged clip members. In an illustrative embodiment, these base ends include opposing male and female connectors. In this embodiment the male connector is a cylinder with an axis that extends transverse to the direction of elongation and the female connector defines a conforming cylindrical inner diameter, which allows it to nest over the male cylinder. A gap opening is provided at the far edge of the female connector to provide clearance for the base that connects the male cylinder to the clip member base end. This gap can be sized to allow a predetermined range of angular rotation of the male connector within the female connector. Clips can be stored as discrete groupings that are stacked in a container, or paid out in a continuous grouping from a spool. | 10-23-2008 |
20090064471 | LOW-PROFILE UPHOLSTERY CLIP FOR ATTACHING A BEAD TO A FOAM SUBSTRATE - This invention provides a low-profile clip adapted to secure a listing bead to a foam substrate. Such a low-profile clip employs a novel geometry and is constructed from a material that affords resilience, durability, high resistance to a wide range of temperatures during field use and seat assembly and ease of bead installation with high pull-out strength. In an illustrative embodiment, the clip includes a base and a pair of legs extending upwardly from the base and defining therebetween a central region constructed and arrangement to capture the listing bead. Each of the legs extends upwardly from the base to a top barb that defines a gap narrower than central region. In this embodiment, the legs each extend upwardly from the base at a first angle of approximately 80 to 85 degrees and therefrom to each of the respective barbs at a second angle, with respect to a plane parallel to the base of approximately 88 to 90 degrees. Each of the legs has an approximate thickness taken along a direction of the parallel line of between approximately 1.0 and 2.0 millimeters. In this manner the clip exhibits high performance while defining an overall height from tops of the legs to a bottom of the base of approximately ten millimeters or less making the clip particularly desirable for use in modern, thinner foam substrates. The clip can be part of a festooned arrangement and can be constructed from a blended polycarbonate. | 03-12-2009 |
20120110797 | FESTOONED TRIM CLIP SYSTEM AND METHOD FOR ATTACHING FESTOONED CLIPS TO A SUBSTRATE - This invention provides a single or multi-ganged clip that can be grouped into a festooned arrangement. Clips are grouped into a discrete assembly along a line of extension so that a handler can retrieve a grouping, separate one-clip-at-a-time, and apply the separated clip to an assembly structure. Each clip can include a base with opposing ends aligned in the direction of extension and transverse to an elongation direction for a connecting segment (if any) between ganged clip members. In one embodiment, these ends include opposing male and female connectors. The male connector is a cylinder with an axis extending transverse to the direction of elongation and the female connector defines a conforming cylindrical inner diameter, which allows it to nest over the male cylinder. An opening at the far edge of the female connector provides clearance for the base that connects the male cylinder to the clip member base end. | 05-10-2012 |
20130247338 | FESTOONED TRIM CLIP SYSTEM AND METHOD FOR ATTACHING FESTOONED CLIPS TO A SUBSTRATE - This invention provides a single or multi-ganged clip that can be grouped into a festooned arrangement. Each clip includes a base with opposing ends aligned in the direction of extension and transverse to an elongation direction for a connecting segment between ganged clip members. The base ends include opposing male and female connectors. The male connector is a cylinder with an axis that extends transverse to the direction of elongation and the female connector defines a conforming cylindrical inner diameter, which allows it to nest over the male cylinder. A gap opening at the far edge of the female connector provides clearance for the base that connects the male cylinder to the clip member base end. This gap is sized to allow a range of angular rotation of the male connector within the female connector. Clips can be dispensed in a continuous grouping/segment from a spool. | 09-26-2013 |
Ernest Santin, Beverly, MA US
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20080262531 | NASAL INSERTS - A device for nasal insertion may include an open-ended tubular element. The tubular element may extend along a central tube axis between a first end and a second end, the first end being larger than the second end. The tubular element may define at least one groove along a lateral wall of the tubular element. | 10-23-2008 |
20130296809 | Nasal Congestion, Obstruction Relief, and Drug Delivery - A nasal insert may include a wall in the shape of a tube, the wall including a first end defining a first orifice and a second end defining a second orifice. The first end may have a diameter, diagonal measurement, or cross-sectional area larger than that of the second end. The first end may define at least one break in the wall, so that the first end incompletely encircles the first orifice. The second end may completely encircle the second orifice. | 11-07-2013 |
Ernest M. Santin, Wenham, MA US
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20110151083 | CARTRIDGES FOR STORING FOOD MATERIALS AND METHODS AND APPARATUS FOR PROCESSING FOOD MATERIALS STORED WITHIN SUCH CARTRIDGES - The present invention relates in general to cartridges for storage and processing of pre-formulated food materials, and methods and apparatus for processing the food materials stored within such cartridges. More particularly, the present invention relates to a unique, fully recyclable food cartridge, comprising an annular cylindrical container within which the pre-formulated food material is sealed for storage and cooking, an integral burst disk, a discharge die located above the burst disk and a sensory device with information for controlling the thermo-mechanical processing of the food materials stored within such food storage cartridge by the method and apparatus. The method includes the steps of inserting the cartridge into the apparatus, causing the apparatus to heat and pressurize the annular container until the burst disk ruptures and collapsing the cartridge into a thin, recyclable disk by means of application of controlled pressure on the lower annulus of the container to assist in the ejection of the cooked food through the discharge die. | 06-23-2011 |