Patent application number | Description | Published |
20080317741 | Biomarkers For Anti-Nogo-A Antibody Treatment in Spinal Cord Injury - This disclosure of this invention confirms, at the level of gene expression, the injured spinal cord and motor cortex as the primary sites of action of the anti-Nogo-A antibody treatment applied intrathecally. The disclosure further provides methods for predicting the response of a subject to a medicament comprising an anti-Nogo-A antibody. | 12-25-2008 |
20090162367 | Nucleotide and protein sequences of Nogo genes and methods based thereon - The present invention relates to the gene, $i(Nogo), its encoded protein products, as well as derivatives and analogs thereof. Production of Nogo proteins, derivatives, and antibodies is also provided. The invention further relates to therapeutic compositions and methods of diagnosis and therapy. | 06-25-2009 |
20090181023 | Nogo-a binding with enhanced affinity and pharmaceutical use thereof - The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG or human NiG-D20 or human NogoA_342-357 with a dissociation constant <1000 nM, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment of nerve repair; a pharmaceutical composition comprising said binding molecule; and a method of treatment of diseases associated with nerve repair | 07-16-2009 |
20110008334 | NOGO-A BINDING WITH ENHANCED AFFINITY AND PHARMACEUTICAL USE THEREOF - The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG or human NiG-D20 or human NogoA_342-357 with a dissociation constant, 1000 nM, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment of a nerve repair, a pharmaceutical composition comprising said binding molecule; and a method of treatment of nerve repair; a pharmaceutical composition comprising said binding molecule; and a method of treatment of diseases associated with nerve repair. | 01-13-2011 |
20110027284 | NOGO-A BINDING MOLECULES AND PHARMACEUTICAL USE THEREOF - The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG with a dissociation constant<1000 nM, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment of a disease of the peripheral (PNS) and/or central (CNS) nervous system; a pharmaceutical composition comprising said binding molecule; and a method of treatment of a disease of the peripheral (PNS) and/or central (CNS) nervous system. | 02-03-2011 |
20110059110 | ANTIBODY (11C7) ANTI NOGO-A AND ITS PHARMACEUTICAL USE - This invention relates to molecules, such as for example monoclonal antibodies or Fab fragments thereof, which are capable of binding to the human NogoA polypeptide or human NiG or human NiG- or human NogoA_623-640 with a dissociation constant, 1000 nM; polynucleotides encoding such a binding molecule; an expression vector comprising such polynucleotides; the use of such a binding molecule in the treatment of nerve repair, a pharmaceutical composition comprising such a binding molecule; and to a method of treatment of diseases associated with nerve repair. | 03-10-2011 |
20110086034 | NUCLEOTIDE AND PROTEIN SEQUENCES OF NOGO GENES AND METHODS BASED THEREON - The present invention relates to the gene, $i(Nogo), its encoded protein products, as well as derivatives and analogs thereof. Production of Nogo proteins, derivatives, and antibodies is also provided. The invention further relates to therapeutic compositions and methods of diagnosis and therapy. | 04-14-2011 |
20120171215 | NOGO-A BINDING MOLECULES AND PHARMACEUTICAL USE THEREOF - The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG with a dissociation constant <1000 nM, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment of a disease of the peripheral (PNS) and/or central (CNS) nervous system; a pharmaceutical composition comprising said binding molecule; and a method of treatment of a disease of the peripheral (PNS) and/or central (CNS) nervous system. | 07-05-2012 |
20130136737 | Uses of NOGO-A Inhibitors and Related Methods - The present invention is directed to Nogo-A antagonists useful for the control of blood glucose or blood insulin levels in a subject and related use and formulation thereof. In particular, the invention is directed to Nogo-A antagonists useful for the prevention, repression or treatment insulin secretion deficiency and related methods and pharmaceutical formulations. In particular, the invention relates to Nogo-A antagonists useful in the treatment of diabetes mellitus. | 05-30-2013 |
Patent application number | Description | Published |
20100218684 | HEATING DEVICE WITH AN INTEGRATED THERMOBLOCK FOR A BEVERAGE PREPARATION MACHINE - An in-line heating device for a liquid food or beverage preparation machine in which liquid is circulated through the heating device and then guided into a brewing chamber. This heating device includes a thermoblock with a metal mass that incorporates an inlet, an outlet and a heating chamber extending therebetween to form a passage for guiding the liquid circulating through the mass, with the mass arranged to accumulate heat and to supply heat to the liquid; and one or more electric components that are rigidly secured onto or into the thermoblock and that are connected to a printed circuit board or a flex-print arranged to control the thermoblock. The electric components are rigidly connected to the printed circuit board or flex-print, in particular via rigid connector pins or blades or rigid plug and socket members. | 09-02-2010 |
20100282090 | INTEGRATED HEATER FOR A BEVERAGE PREPARATION DEVICE - An integrated in-line heater for a liquid food or beverage preparation machine, in which liquid is circulated through the heater and then guided into a brewing chamber for brewing a food or beverage ingredient, for instance within a pod or capsule, supplied into the brewing chamber. An upstream part of the brewing chamber may be formed by the heater. One or more electric components may be incorporated into the heater and rigidly connected to a printed circuit board. The heater may have a tubular inner core that is eccentric with respect to a tubular or prismatic outer member which form together a helicoidal heating chamber of variable cross-section. | 11-11-2010 |
20110041696 | MODULAR ASSEMBLY OF A BEVERAGE PREPARATION MACHINE - A process for manufacturing a beverage preparation machine by providing a group of components a) to f), with the components including a brewing unit for receiving an ingredient of the beverage and for guiding an incoming flow of liquid, through the ingredient to a beverage outlet; b) an in-line heater for heating the flow of liquid to be supplied to the brewing unit; c) a pump for pumping the liquid through the heater; d) one or more fluid connecting members for guiding the liquid from a source of liquid to the beverage outlet; e) an electric control unit for receiving instructions from a user via an interface and for controlling the heater and pump; and f) one or more electric sensors for sensing at least one operational characteristic of the brewing unit, the heater, the pump, a liquid reservoir, an ingredient collector, a flow of the liquid, a pressure of the liquid and a temperature of the liquid, and for communicating the characteristic(s) to the control unit. Components a) to f) for assembling the beverage machine are connected by pre-assembling at least two or three modules, with each module being fully automatically assembled from at least two of components a) to f), wherein the components of the fully automatically preassembled modules are configured to be automatically seizable, orientable, positionable and fully connectable to each other in one or more automatic assembly steps. | 02-24-2011 |
20140022044 | HEATING DEVICE WITH AN INTEGRATED THERMOBLOCK FOR A BEVERAGE PREPARATION MACHINE - A liquid food of beverage preparation machine that includes an electric supply circuit connectable to an electric power source; a heater powered by the electric supply circuit; and a thermal fuse device in thermal communication with the heater and associated with the electric supply circuit, the fuse device being arranged to interrupt the electric supply circuit from the power source when the heater exceeds a temperature limit. The thermal fuse device is reversible and includes a switch for automatically interrupting the electric supply circuit when the heater exceeds the temperature limit, the switch being operable by a user to close the electric supply circuit when the heater has a temperature that has returned below the temperature limit. | 01-23-2014 |
20140026759 | HEATING DEVICE WITH AN INTEGRATED THERMOBLOCK FOR A BEVERAGE PREPARATION MACHINE - A liquid food or beverage preparation machine that includes a fluid arrangement and a printed circuit board for controlling one or more functions of the fluid arrangement, with the printed circuit board being enclosed within a substantially impervious housing to protect the printed circuit board from fluid or vapor emissions from the fluid arrangement. | 01-30-2014 |
20140053733 | INTEGRATED HEATER FOR A BEVERAGE PREPARATION DEVICE - An in-line heater for a liquid food or beverage preparation machine, in which machine liquid is circulated through the heater and then guided into a brewing chamber for brewing a food or beverage ingredient supplied into said brewing chamber. The heater has a body incorporating an inlet, an outlet and a heating chamber extending therebetween, with the inlet, outlet and heating chamber forming together a rigid passage for guiding the liquid circulating through the body, and one or more electric components that are secured on or in the body and connected to a printed circuit board arranged to control the heater. The one or more electric components are rigidly connected to the printed circuit board. | 02-27-2014 |