Patent application number | Description | Published |
20110262893 | SEPARATING TARGET ANALYTES USING ALTERNATING MAGNETIC FIELDS - The invention generally relates to using magnetic particles and alternating magnet fields to separate a target analyte from a sample. In certain embodiments, methods of the invention involve contacting a sample with magnetic particles including first moieties specific for a target analyte, thereby forming target/particle complexes in the sample, flowing the sample through a channel including second moieties attached to at least one surface of the channel, applying alternating magnetic fields to the flowing sample to result in target/particle complexes being brought into proximity of the surface to bind the second moieties and unbound particles remaining free in the sample, binding the target/particle complexes to the second moieties, and washing away unbound particles and unbound analytes of the sample. | 10-27-2011 |
20110262925 | METHODS FOR ISOLATING A TARGET ANALYTE FROM A HETEROGENEOUS SAMPLE - The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample. | 10-27-2011 |
20110262926 | EXTRACTING LOW CONCENTRATIONS OF BACTERIA FROM A SAMPLE - The invention generally relates to conducting an assay on a sample that isolates a bacterium from the sample, in which the assay isolates as low as about 1 CFU/ml of bacteria in the sample. | 10-27-2011 |
20110262927 | ANALYZING BACTERIA WITHOUT CULTURING - The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most | 10-27-2011 |
20110262932 | COMPOSITIONS - The invention generally relates to compositions that include magnetic particles bound to pathogens in a body fluid. | 10-27-2011 |
20110262933 | COMPOSITIONS AND METHOD FOR ISOLATING MID-LOG PHASE BACTERIA - The invention generally relates to compositions and methods for isolating mid-log phase bacteria. In certain embodiments, the invention provides a magnetic particle conjugated to an antibody that includes an epitope specific for mid-log phase bacteria. | 10-27-2011 |
20110262989 | ISOLATING A TARGET ANALYTE FROM A BODY FLUID - The invention generally relates to using magnetic particles and magnets to isolate a target analyte from a body fluid sample. In certain embodiments, methods of the invention involve introducing magnetic particles including a target-specific binding moiety to a body fluid sample in order to create a mixture, incubating the mixture to allow the particles to bind to a target, applying a magnetic field to capture target/magnetic particle complexes on a surface, and washing with a wash solution that reduces particle aggregation, thereby isolating target/magnetic particle complexes. | 10-27-2011 |
20110263833 | COMPOSITIONS FOR ISOLATING A TARGET ANALYTE FROM A HETEROGENEOUS SAMPLE - The invention generally relates to compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen. | 10-27-2011 |
20140170727 | AFFINITY MEDIUM USING FIXED WHOLE CELLS - Separation media comprising a support and crosslinked whole cells fixed to the support. The separation media are useful in affinity columns for the separation of the antibodies from a solution, particularly for the separation of polyclonal antibodies that have been raised against the same type of whole cells. In an embodiment, the whole cells are whole bacterial cells. | 06-19-2014 |
20140171340 | METHODS FOR RAISING ANTIBODIES - The present invention generally relates to methods of generating antibodies against a species of pathogen that involve identifying the pathogen that is most genetically representative of member of pathogen species and using the identified pathogen to generate an antibody. | 06-19-2014 |