Patent application number | Description | Published |
20090041609 | High-strength discontinuously-reinforced titanium matrix composites and method for manufacturing the same - The invention relates to manufacturing the flat or shaped titanium matrix composite articles having improved mechanical properties such as lightweight plates, sheets for aircraft and automotive applications, heat-sinking lightweight electronic substrates, armor plates, etc. High-strength discontinuously-reinforced titanium metal matrix composite (TMMC) comprises (a) titanium matrix or titanium alloy as a major component, (b) ceramic and/or ≦50 vol. % intermetallic hard particles dispersed in matrix, (c) complex carbide- and/or boride particles at least partially soluble in matrix at sintering or forging temperatures such as ≦50 vol. % AlV | 02-12-2009 |
20100074788 | Fully-dense discontinuosly-reinforced titanium matrix composites and method for manufacturing the same - The invention is suitable for the manufacture of flat or shaped titanium matrix composite articles having improved mechanical properties such as lightweight plates and sheets for aircraft and automotive applications, etc. The method for manufacturing TMCC is comprised of the following steps: (a) preparing a basic powdered blend containing matrix alloy or titanium powders, dispersing ceramic and/or intermetallic powders, and powders of said complex carbide- and/or silicide particles, (b) preparing the Al—V master alloy containing ≦5 wt. % of iron, (c) preparing the Al—V—Fe master alloy fine powder having a particle size of ≦20 μm, (d) mixing the basic powdered blend with the master alloy powder to obtain a chemical composition of TMCC, (e) compacting the powder mixture at room temperature, (f) sintering at the temperature which provides at least partial dissolution of dispersed powders, (g) forging at 1500-2300° F., and (h) cooling. The resulting TMCC has density over 98% and closed discontinuous porosity after sintering that allows making hot deformation in air without encapsulating. | 03-25-2010 |
Patent application number | Description | Published |
20080247958 | Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use - A composition comprising an albumin-based colloid composition having at least one protected thiol region, method of making the same, and method for use, including treating hypovolemic conditions such as capillary leak syndrome and shock, are disclosed. The composition also is modified with an indicator reagent such as chromophores. | 10-09-2008 |
20100004178 | Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction - A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed. | 01-07-2010 |
20100056446 | NA+K+-ATPase-Specific Peptide Inhibitors/Activators of SRC and SRC Family Kinases - A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. | 03-04-2010 |
20110245167 | NaK-ATPase-Derived Peptide SRC Inhibitors and Ouabain Antagonists and Uses Thereof - A novel Src inhibitor that targets the Na/K-ATPase/Src receptor complex and antagonizes ouabain-induced protein kinase cascades and uses thereof are disclosed. | 10-06-2011 |
20120010144 | Peg-albumin composition having at least one protected thiol region as a platform for medications - This composition comprises a polyethylene glycol-albumin composition having at least one protected thiol region wherein the composition comprises PEG-AlbCys34 with Cys-34 preserved as a thiol. The albumin is linked to medications such as, antioxidants with a reduced sulfhydryl group through the Cys 34 residing on the albumin. The compositions are useful in treating patients. | 01-12-2012 |
20120302630 | Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof - Na/K-ATPase/Src ligands, assays and uses thereof are disclosed. | 11-29-2012 |
20130150294 | Na+/K+-ATPase-Specific Peptide Inhibitors/Activators of Src and Src Family Kinases - A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. | 06-13-2013 |
20140031419 | Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof - The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative. | 01-30-2014 |
20140128356 | Na/K-ATPase Ligand - Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described. | 05-08-2014 |
20140187484 | NA/K-ATPASE-DERIVED PEPTIDE SRC INHIBITORS AND OUABAIN ANTAGONISTS AND USES THEREOF - A novel Src inhibitor that targets the Na/K-ATPase/Src receptor complex and antagonizes ouabain-induced protein kinase cascades and uses thereof are disclosed. | 07-03-2014 |
20150133389 | Na+/K+-ATPase-Specific Peptide Inhibitors/Activators of Src and Src Family Kinases - A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. | 05-14-2015 |
20150233925 | Assays and Cell-Based Tests Using a Receptor Na/K-ATPase/Src Complex and Uses Thereof - Described herein are assays and complementary cell culture based tests, and uses thereof for determining agonists or antagonists of Na/K-ATPase/Src complex, and methods of treatment therewith. | 08-20-2015 |
20150272923 | Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof - The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative. | 10-01-2015 |
Patent application number | Description | Published |
20110088463 | PERFORMANCE ENHANCEMENT MEASUREMENT DEVICE FOR JOINTS - A measurement device includes a housing, a sensor disposed in the housing to measure a force exerted on the housing and generate a signal representing the force exerted on the housing, and a digital display for receiving the signal from the sensor and presenting a visual output to a user based upon the force exerted on the housing. | 04-21-2011 |
20120283603 | Photonic and Thermal Kinetic Energy Therapeutic Device, System and Method - An apparatus includes a housing having a treatment surface, a light source disposed adjacent the treatment surface and configured to emit dynamic photonic energy, a thermal element disposed adjacent the treatment surface and configured to emit dynamic thermal kinetic energy, and a controller disposed in the housing, the controller in communication with the light source and the thermal element to vary a plurality of parameters of the light source and the thermal element to control the characteristics of the dynamic photonic energy and the dynamic thermal kinetic energy emitted thereby. The treatment surface can also house a variety of sensors that can capture a variety of physical and chemical data, which is integrated with a malleable energy composition and delivery system that co-ordinates with the treatment progress. | 11-08-2012 |
20150246243 | SMART LASER BIO-SENSOR AND BIO-THERAPEUTIC DEVICE SYSTEM AND METHODS - An apparatus includes a housing having a treatment surface, a light source disposed adjacent the treatment surface and configured to emit dynamic photonic energy, a thermal element disposed adjacent the treatment surface and configured to emit dynamic thermal kinetic energy, and a controller disposed in the housing, the controller in communication with the light source and the thermal element to vary a plurality of parameters of the light source and the thermal element to control the characteristics of the dynamic photonic energy and the dynamic thermal kinetic energy emitted thereby. The treatment surface can also house a variety of sensors that can capture a variety of physical and chemical data, which is integrated with a malleable energy composition and delivery system that co-ordinates with the treatment progress. | 09-03-2015 |