Patent application number | Description | Published |
20080268052 | Collagen preparation and method of isolation - Collagen compositions, methods for preparing those collagen compositions, and graft compositions formed from those collagen compositions are provided. In particular, methods of isolating collagen that exhibits an enhanced rate of polymerization and enhanced microstructural and mechanical properties upon polymerization, such collagen compositions, and graft compositions formed from such collagen compositions are provided. | 10-30-2008 |
20090011021 | Engineered Extracellular Matrices - The invention relates to engineered matrices comprising collagen fibrils with specific characteristics, including, but not limited to, a specific fibril area fraction (i.e., density) and/or a specific elastic or linear modulus (i.e., stiffness). The invention also relates to methods of preparation and use of the matrices. | 01-08-2009 |
20090175922 | THREE DIMENSIONAL PURIFIED COLLAGEN MATRICES - Cell culture scaffolds presenting a more biologically relevant microenvironment are disclosed. More particularly, these cell culture scaffolds comprise three-dimensional matrices/biomaterials that are created from solubilized collagen compositions using controlled conditions to have the desired microstructure and mechanical properties. The engineered purified collagen based matrix compositions of the present invention can be used alone or in combination with cells as a tissue graft construct to enhance the repair of damaged or diseased tissues. | 07-09-2009 |
20090280180 | COLLAGEN-BASED MATRICES WITH STEM CELLS - Collagen based-matrices and methods of their use are described. More particularly, collagen-based matrices for differentiating stem cells and progenitor cells, and for producing and isolating blood vessels and vascularized graft constructs are described. | 11-12-2009 |
20100041135 | Gastric Submucosal Tissue as a Novel Diagnostic Tool - A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing fastidious organisms is described. Submucosal tissue used in accordance with the present invention supports the proliferation of cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation. | 02-18-2010 |
20120027732 | THERMOREVERSIBLE COLLAGEN - This invention relates to collagen formulations. More particularly, this invention relates to thermoreversible collagen formulations and methods of their use and preparation. | 02-02-2012 |
20120094376 | Engineered Extracellular Matrices Control Stem Cell Behavior - A composition for culturing stem cells is provided. The composition comprises an engineered purified collagen based matrix that has been formed under controlled conditions to have the desired microstructure and mechanical properties. The engineered purified collagen based matrix compositions of the present invention can be used alone or in combination with cells as a tissue graft construct to enhance the repair of damaged or diseased tissues. | 04-19-2012 |
20120115222 | COMPOSITION AND METHOD FOR MAINTENANCE, DIFFERENTIATION, AND PROLIFERATION OF STEM CELLS - Compositions and methods for the proliferation, differentiation, and maintenance of stem cells are described. Preferred are the use of hematopoietic stem cells in combination with a collagen matrix. | 05-10-2012 |
20120141417 | Collagen Preparation and Method of Isolation - Collagen compositions, methods for preparing those collagen compositions, and graft compositions formed from those collagen compositions are provided. In particular, methods of isolating collagen that exhibits an enhanced rate of polymerization and enhanced microstructural and mechanical properties upon polymerization, such collagen compositions, and graft compositions formed from such collagen compositions are provided. | 06-07-2012 |
20120171768 | COLLAGEN-BASED MATRICES FOR VESSEL DENSITY AND SIZE REGULATION - Collagen based-matrices and methods of their use are described. More particularly, collagen-based matrices and methods for regulating vessel density and size within collagen-based matrices are described. | 07-05-2012 |