Somasundaram
Somasundaram Kumaravel, Bangalore IN
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20130274286 | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NMPRTase) INHIBITOR FOR GLIOMA THERAPY - The present invention relates to identification of a compound which inhibits the enzyme NMPRTase and glioma cancer cell growth and further used for glioma therapy. Pre-B-cell colony enhancing factor 1 gene (PBEF1) encodes nicotinamide phosphoribosyltransferase (NMPRTase), which catalyses the rate limiting step in the salvage pathway of NAD metabolism in mammalian cells. PBEF1 transcript and protein levels have been shown to be elevated in glioblastoma and a chemical inhibitor of NMPRTase has been shown to specifically inhibit cancer cells. Here a structure based drug discovery approach has been reported with an aim to develop novel inhibitors for glioblastoma therapy. Present invention relates to virtual screening using docking of ligands from a large library of 13,000 compounds against NMPRTase as the macromolecular target resulting in short listing of 34 possible ligands, of which six were tested experimentally, using the NMPRTase enzyme inhibition assay and further with the glioma cell viability assays. Of these, two compounds were found to be significantly efficacious in inhibiting the conversion of nicotinamide to NAD, and out of which one compound, 3-amino-2-benzyl-7-nitro-4-(2-quinolyl-)-1,2-dihydroisoquinolin-1-one, was found to inhibit the growth of a PBEF1 over expressing glioma derived cell line U87 also. | 10-17-2013 |
20130280707 | TOP2A INHIBITION BY TEMOZOLOMIDE AND ITS PREDICTIVE VALUE OF GBM PATIENTS SURVIVAL - The present invention provides a TOP2A inhibition by temozolomide useful for predicting glioblastoma patient's survival. Glioblastoma (GBM) is the most common, malignant primary adult brain tumor. The conventional treatments for GBM, include surgery, radiation, and chemotherapy which have only modestly improved patient survival. The patients with GBM expressing higher TOP2A transcript levels had better prognosis. More interestingly, the present invention reports that temozolomide is an inhibitor of TOP2A activity in vitro. The present invention further shows that siRNA knock down of TOP2A rendered a glioma cell line resistant to temozolomide chemotherapy. Thus it is demonstrated for the first time that temozolomide is a TOP2A inhibitor and establishes that TOP2A transcript levels determines the chemosensitivity of glioblastoma to temozolomide therapy thus explaining the very high levels of TOP2A transcript being a good prognostic indicator in GBM patients receiving temozolomide chemotherapy. | 10-24-2013 |
Somasundaram Niranjayan, Culver City, CA US
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20130322426 | TIMING SYNCHRONIZATION OF WIRELESS NETWORKS - A single wireless slave node may be in a timing virtual network (TVN) with neighboring wireless slave nodes. The single wireless slave node may store information indicative of the identity, link propagation delay, and channel signature of each of its neighboring wireless slave nodes. The single wireless slave node may repeatedly update a timing estimate based on the stored information and by performing a physical layer fast reference signal broadcast transmission and reception. | 12-05-2013 |
Somasundaram Ramesh Babu, Chennai IN
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20150193709 | SYSTEM AND METHOD FOR IT SOURCING MANAGEMENT AND GOVERNANCE COVERING MULTI GEOGRAPHY, MULTI SOURCING AND MULTI VENDOR ENVIRONMENTS - The present invention relates to the field of IT Sourcing Management and more specifically to the IT sourcing management and governance (SMG) covering multi geography, multi sourcing and multi vendor environments at an enterprise level. The enterprise governance solution with core sourcing management functional components includes a contract compliance management module, a IT spend visibility management and reporting module, a value driver management and reporting module, a contract compliance audit management module, a contract evaluation analysis module, a performance management module, with underlying governance processes such as organization change management, stake holder relationship management, governance, compliance and risk management, performance management, service delivery management, service quality management, communication management and reporting. The SMG solution enhances and optimizes relationship between the customer and the vendor organizations by utilizing the core modules regardless of the scope, objectives, contracts, IT sourcing programs, vendors, service delivery locations and region, country and business units. | 07-09-2015 |
Somasundaram Sangeetha, Tamil Nadu IN
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20090131420 | Novel Heterocyclic Analogs of Biphenyl Ethers - The present invention relates to novel compounds of formula (I) and their pharmaceutically acceptable salts and compositions. The present invention more particularly provides novel heterocyclic analogs of biphenyl ethers of the general formula (I). | 05-21-2009 |
Somasundaram Valliyappan, Spring, TX US
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20140185972 | Bearing Assembly for a Drilling Tool - A bearing assembly for a drilling tool. A radial bearing assembly for use in a drilling tool may include a bushing having a generally cylindrical body with an inner surface. The radial bearing assembly may also include a sleeve configured to couple to a rotatable shaft of the drilling tool and configured to rotate within the bushing. The sleeve has (i) a plurality of spiral projections extending laterally in a direction away from a longitudinal axis of the radial bearing assembly and (ii) a plurality of flow paths, where a flow path of the plurality of flow paths is defined between a pair of adjacent spiral projections. | 07-03-2014 |
20140262524 | DOWNHOLE TURBINE MOTOR AND RELATED ASSEMBLIES - A turbine drive may include a rotor that includes multiple turbine blades arranged in one or more turbine stages, as well as a stator cooperating with the rotor to direct fluid against the turbine blades and convert hydraulic, kinetic energy into rotational energy. The rotor may be fixed to the shaft to rotate synchronously therewith. The stator may be formed of multiple components that can be coupled together to define the stator and encompass the turbine blades of the turbine stages of the rotor. Two stator halves may each include vanes for positioning above and below a corresponding turbine stage, to direct fluid against the turbine blades. The stator may also be connected to a housing that encompasses the stator. Longitudinal slots and tabs on the stator and housing may hold the stator stationary relative to the housing. | 09-18-2014 |