Stephanos
Stephanos Finitsis, Thessaloniki GR
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20110230908 | THROMBUS REMOVAL SYSTEM AND PROCESS - A device captures and assists in the removal of a thrombus in arteries, even in small arteries. The device uses a soft coil mesh to engage the surface of a thrombus, and a guidewire is used to retract the soft coil mesh with the captured thrombus. The soft coil is formed by an elongated microcoil element that forms the helical elements of a macrocoil element. The microcoil element provides a relatively elastic effect to the helical element forming the macrocoil and allows for control of gripping forces on the thrombus while reducing non-rigid contact of the device with arterial walls. | 09-22-2011 |
20110230909 | THROMBUS REMOVAL SYSTEM AND PROCESS - A device capable of capturing and facilitating the removal of a thrombus in blood vessels (or stones in biliary or urinary ducts, or foreign bodies) uses a soft coil mesh with the aid of a pull wire or string to engage the surface of a thrombus, and remove the captured thrombus. The soft coil mesh is formed by an elongated microcoil element that forms the helical elements of a macrocoil element. The microcoil element provides a relatively elastic effect to the helical elements forming the macrocoil and allows for control of gripping forces on the thrombus while reducing non-rigid contact of the device with arterial walls. The use of multiple coil mesh elements, delivered through a single lumen or multiple lumens, preferably with separate control of at least one end of each coil, provides a firm grasp on a distal side of a thrombus, assisting in non-disruptive or minimally disrupted removal of the thrombus upon withdrawal of the device. | 09-22-2011 |
Stephanos Kyrkaniders, Rochester, NY US
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20090217396 | Inflammation models in neurodegenerative and arthritic disorders - Disclosed are compositions and methods for inducing temporally conditional mediators or inflammation and the transgenic animals produced by these compositions and method that can be used as models of inflammatory disease. | 08-27-2009 |
Stephanos Kyrkanides, East Setauket, NY US
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20160046701 | COMPOSITIONS TARGETING THE SOLUBLE EXTRACELLULAR DOMAIN OF E-CADHERIN AND RELATED METHODS FOR CANCER THERAPY - The present invention is based, in part, on our discovery that targeting epitopes within one or more of the EC2-EC5 subdomains of E-cadherin results in the death of epithelial-derived tumor cells but not in the death of normal, healthy epithelial cells or non-epithelial cells including endothelial cells and fibroblasts. Accordingly, the compositions of the invention include polypeptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin and biologically active variants thereof; expression vectors and cells for expressing such polypeptides; and agents (e.g., antibodies) that target the EC2-EC5 subdomains. The methods of the invention include methods of identifying and producing polypeptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin or a biologically active variant thereof; method of generating agents, such as antibodies, that target these polypeptides; and methods of administering such agents or eliciting their production in vivo to treat epithelial cancers or reduce the risk of their occurrence or recurrence. | 02-18-2016 |
Stephanos Kyrkanides, Penfield, NY US
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20080226615 | Vectors having both isoforms of beta-hexosaminidase and uses of the same - Disclosed are compositions and methods related to delivering a nucleic acid to the central nervous system. | 09-18-2008 |
Stephanos Kyrkanides, Stony Brook, NY US
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20130287784 | Compositions Targeting the Soluble Extracellular Domain of E-Cadherin and Related Methods for Cancer Therapy - The present invention is based, in part, on our discovery that targeting epitopes within one or more of the EC2-EC5 subdomains of E-cadherin results in the death of epithelial-derived tumor cells but not in the death of normal, healthy epithelial cells or non-epithelial cells including endothelial cells and fibroblasts. Accordingly, the compositions of the invention include poly-peptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin and biologically active variants thereof; expression vectors and cells for expressing such polypeptides; and agents (e.g., antibodies) that target the EC2-EC5 subdomains. The methods of the invention include methods of identifying and producing polypeptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin or a biologically active variant thereof; methods of generating agents, such as antibodies, that target these polypeptides; and methods of administering such agents or eliciting their production in vivo to treat epithelial cancers or reduce the risk of their occurrence or recurrence. | 10-31-2013 |
20150037354 | COMBINATION THERAPIES INCLUDING INHIBITORS OF THE EXTRACELLULAR DOMAIN OF E-CADHERIN - The present invention is based on our work with E-cadherin, including soluble portions of this integral membrane glycoprotein. The compositions of the present invention include therapeutically effective amounts of a first agent that targets epitopes within one or more of the EC2-EC5 subdomains of the ectodomain of E-cadherin (including these domains in the shed sEcad fragment) and a second agent that inhibits one or more of: endothelial tube formation; angiogenesis; the human epidermal growth factor receptor family (i.e. HER1-4); an insulin-like growth factor 1 receptor (IGF-1R); any other receptor tyrosine kinase receptor family member; the P13K-MAPK pathway; and the P13K/Akt/mTOR pathway. The compositions can be used in the treatment of epithelial cancers and can be used to inhibit tumor growth and metastasis. The invention also features methods in which cancer is staged. | 02-05-2015 |
Stephanos Kyrkanides, Rochester, NY US
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20090028825 | Compositions and Methods for Studying and Treating Inflammatory Diseases and Disorders - Disclosed are compositions and methods that can be used in the treatment of diseases and disorders caused, exacerbated or otherwise affected by inflammation. | 01-29-2009 |
20100286233 | PERIPHERAL AND NEURAL INFLAMMATORY CROSSTALK - Disclosed are compositions and methods for the study and treatment of inflammatory disease, neurological disorders, bone disease, pain, and methods of making and using thereof. | 11-11-2010 |
Stephanos Kyrkanidies, Stony Brook, NY US
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20110165698 | COMPOSITIONS AND METHODS RELATING TO DETECTION OF SOLUBLE E-CADHERIN IN NEURODEGENERATIVE DISEASE - Disclosed herein are compositions and methods for diagnosing, detecting, or monitoring neural disease, conditions, or disorders involving detection of soluble E-cadherin. | 07-07-2011 |
Stephanos Loannidis, Waltham, MA US
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20110183954 | TRICYCLIC 2,4-DIAMINO-L,3,5-TRIAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER AND MYELOPROLIFERATIVE DISORDERS - The present invention relates to compounds of Formula (I): (I) and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds provide a treatment for myeloproliferative disorders and cancer. | 07-28-2011 |
Stephanos Papademetriou, Sunnyvale, CA US
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20130231533 | MEDICAL APPLICATIONS OF A MINIATURE VIDEOSCOPE - Endoscopes, particularly videoscopes, of small size and profile are applied to various medical devices such as intravascular catheters and feeding tubes. The endoscopes are of high flexibility, good resolution and low cost so as to be disposable after use. | 09-05-2013 |
20140235462 | METHODS AND COMPOSITIONS FOR NANOSTRUCTURE-BASED NUCLEIC ACID SEQUENCING - Provided herein are nanostructure-based sequencing methods and systems. | 08-21-2014 |
Stephanos Tryphonas, San Francisco, CA US
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20130159001 | SATISFYING SPECIFIED INTENT(S) BASED ON MULTIMODAL REQUEST(S) - Techniques are described herein that are capable of satisfying specified intent(s) based on multimodal request(s). A multimodal request is a request that includes at least one request of a first type and at least one request of a second type that is different from the first type. Example types of request include but are not limited to a speech request, a text command, a tactile command, and a visual command. A determination is made that one or more entities in visual content are selected in accordance with an explicit scoping command from a user. In response, speech understanding functionality is automatically activated, and audio signals are automatically monitored for speech requests from the user to be processed using the speech understanding functionality. | 06-20-2013 |
20140330570 | SATISFYING SPECIFIED INTENT(S) BASED ON MULTIMODAL REQUEST(S) - Techniques are described herein that are capable of satisfying specified intent(s) based on multimodal request(s). A multimodal request is a request that includes at least one request of a first type and at least one request of a second type that is different from the first type. Example types of request include but are not limited to a speech request, a text command, a tactile command, and a visual command. A determination is made that one or more entities in visual content are selected in accordance with an explicit scoping command from a user. In response, speech understanding functionality is automatically activated, and audio signals are automatically monitored for speech requests from the user to be processed using the speech understanding functionality. | 11-06-2014 |