Patent application number | Description | Published |
20090011980 | Method of Treating Parkinson's Disease in Humans by Direct Infusion of Glial Cell-Line Derived Neurotrophic Factor Into the Zona Incerta - A method of treating Parkinson's disease in humans is disclosed, wherein glial cell-line derive neurotrophic factor (GDNF) is chronically administered directly to the SNc and at least one subthalamic region or, alternatively, to the SNc, at least one sub thalamic region, and at least one putaminal region of the brain of a human in need of treatment thereof. In one aspect of the present invention the GDNF is infused directly into at least one caudal zona incerta and at least one postero-dorsal putamen of the brain through indwelling intraparenchymal brain catheters connected to an implantable pump. | 01-08-2009 |
20090030373 | Method and Apparatus for Fluid Delivery - Fluid delivery apparatus is described for the delivery of fluids to regions of the body, especially for delivery to regions of the brain. The apparatus includes a first length of implantable tubing having a first end and a first fluid connector portion attached to the first end of the first length of implantable tubing. The first fluid connector portion is releaseably connectable to a complementary second fluid connector portion. An implantable housing is also provided for enclosing and protecting the first fluid connector portion. The implantable housing is openable to provide access to the first fluid connector portion. For example, the housing may have a hinged lid or cover portion. A corresponding method is also described. | 01-29-2009 |
20090048508 | Rf coil assembly for use in magnetic resonance imaging - An RF coil assembly for use with magnetic resonance imaging (MRI) apparatus is described. The RF coil assembly comprises one or more coil elements capable of receiving electromagnetic radiation and is capable of being directly attached to a stereotactic base ring. The RF coil assembly may comprise a localiser box having fiducial markers. A corresponding attachment apparatus is also described for optimising the attachment position of a stereotactic base ring to a subject's head. The attachment apparatus comprises one or more fixing elements that allow the attachment apparatus to be releasably attached to a stereotactic base ring. In one embodiment, the internal dimensions of the attachment apparatus are selected to be substantially the same as the internal dimensions of an RF coil assembly. Corresponding methods are also described. | 02-19-2009 |
20090082758 | Implantable Fluid Distribution Device and Method of Fluid Delivery - An implantable fluid distribution device is described. The device includes a first inlet for receiving fluid under pressure from a remote pump. A plurality of outlets are also provided, each outlet being connectable to a fluid delivery catheter. A valve mechanism is arranged to control the passage of fluid from the first inlet to the plurality of outlets. Apparatus including the fluid distribution device, an implantable pump and a plurality of drug delivery catheters is also described. The fluid distribution device can be used to delivery drug to multiple regions in the body and the sequential delivery of drugs to different sites in the brain is disclosed. | 03-26-2009 |
20100042070 | NEUROLOGICAL APPARATUS COMPRISING A PERCUTANEOUS ACCESS DEVICE - Apparatus for delivering therapeutic agents to the central nervous system of a subject is described. The apparatus comprises at least one intracranial catheter and a percutaneous access device. The percutaneous access device comprises a body having at least one extracorporeal surface and at least one subcutaneous surface, the body defining at least one port for connection to an implanted intracranial catheter. The port is accessible from the extracorporeal surface of the device, but is provided with a seal such as a rubber bung between the lumen of the port and the extracorporeal surface. The percutaneous access device may have more than two ports and/or a flange. A method of implanting the percutaneous access device is also described. | 02-18-2010 |
20110009879 | APPARATUS FOR STEREOTACTIC NEUROSURGERY - A skull mount ( | 01-13-2011 |
20110131808 | BRAIN ELECTRODE - An electrode, in particular a deep brain stimulating (DBS) electrode or a deep brain lesioning electrode, a method for manufacturing an electrode and use of the electrode, and a directional electrode. | 06-09-2011 |
20130279784 | METHOD AND APPARATUS FOR ANALYSING IMAGES - A method is described for determining brain shift, such as the brain shift that occurs following a neurosurgical intervention. The method includes taking a first image of the brain of a subject, the first image showing the position of blood vessels in the brain relative to a reference position. A second image of the brain that has been acquired following an intervention on the subject is also taken. This second image has been acquired using computed tomography imaging apparatus. The second image shows the position of blood vessels in the brain relative to the reference position. Brain shift is then determined from the shift in position of the blood vessels in at least one region of interest of the brain, with respect to the reference position, between the first and second images. Corresponding apparatus is also described. | 10-24-2013 |
20130296246 | COMPOSITION - The invention relates to a composition comprising albumin and a therapeutic agent, particularly a gene therapy vector. The composition is useful in the treatment of glioma. | 11-07-2013 |
20140236128 | METHOD AND APPARATUS FOR FLUID DELIVERY - A method for delivering fluid to a brain of a subject using a modular fluid delivery apparatus is described. The method comprises taking a subject having a first part of the modular fluid delivery apparatus subcutaneously implanted therein, the first part of the modular fluid delivery apparatus comprising a first end having a first fluid connector portion attached thereto and a second end being connected to one or more catheters implanted within the brain of the subject. The method also comprises taking a second part of the modular fluid delivery apparatus, the second part comprising a third end comprising a second fluid connector portion. The method further comprises making an incision in the subject to gain access to the first fluid connector portion of the first part of the modular fluid delivery apparatus, and connecting the first fluid connector portion to the second fluid connector portion. | 08-21-2014 |
20140371679 | DRUG DELIVERY APPARTAUS - Percutaneous access apparatus is described that includes a percutaneous fluid access device having an extracorporeal portion, one or more ports accessible from the extracorporeal portion and a septum for sealing each port. A connector device having one or more hollow needles is attachable to the percutaneous fluid access device. The apparatus also includes an attachment mechanism for attaching the connector device to the extracorporeal portion and an actuation mechanism that, after the connector device has been attached to the extracorporeal portion, can be used to drive the one or more hollow needles through the septum to establish fluid communication between the one or more hollow needles and the one or more ports. The apparatus may be used for neurosurgery applications. | 12-18-2014 |
20150018799 | DRUG STORAGE APPARATUS - Fluid storage apparatus for medical use is described that includes a length of tubing having a first end and a second end. A first sealable connector portion is provided at the first end and a second sealable connector portion is provided at the second end. The volume of fluid that can be stored within the apparatus is known and an infusate or therapeutic agent is contained within the apparatus. In this manner, a known volume of therapeutic agent can be infused to a patient. The use in neurosurgical applications is described. | 01-15-2015 |
20150037437 | GLIOMA TREATMENT - A chemotherapy agent or a pharmaceutical composition including chemotherapy agent and artificial cerebrospinal fluid, wherein the chemotherapy agent at a concentration of between 0.01 mg/ml and 0.7 mg/ml for use in the treatment of brain cancer and a method of treating a glioma including administering a chemotherapy agent via convection enhanced delivery | 02-05-2015 |
20150040995 | MEDICAL FLUID CONNECTOR APPARATUS - A medical fluid connector is described that includes a first fluid connector portion that can be connected to a second fluid connector portion. The first fluid connector portion includes a first locking member, a lumen and a septum for sealing the lumen. The second fluid connector portion includes a second locking member, a lumen and a hollow needle that is retained in and protrudes from the aperture at the end of the lumen. The variation in cross-sectional area of the fluid path through the fluid connector portion is less than 1 mm | 02-12-2015 |