Patent application number | Description | Published |
20090098103 | Modified factor VII polypeptides and uses thereof - Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics. | 04-16-2009 |
20090291890 | Factor VII polypeptides that are modified and uses thereof - Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics. | 11-26-2009 |
20100166729 | Modified factor VII polypeptides and uses thereof - Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics. | 07-01-2010 |
20120244139 | Modified proteases that inhibit complement activation - Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorder. | 09-27-2012 |
20120308540 | Modified factor IX polypeptides and uses thereof - Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics. | 12-06-2012 |
20130177541 | Modified factor IX polypeptides and uses thereof - Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics. | 07-11-2013 |
20140030247 | Modified factor X polypeptides and uses thereof - Modified therapeutic proteins are provided. In particular modified Factor X polypeptides, which includes the Factor X zymogen, Factor Xa and other forms of Factor X, and uses thereof are provided. | 01-30-2014 |
20140234290 | MODIFIED FACTOR X POLYPEPTIDES AND USES THEREOF - Modified therapeutic proteins are provided. In particular modified Factor X polypeptides, which includes the Factor X zymogen, Factor Xa and other forms of Factor X, and uses thereof are provided. | 08-21-2014 |
20140242062 | MODIFIED PROTEASES THAT INHIBIT COMPLEMENT ACTIVATION - Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorders. | 08-28-2014 |
20140322191 | MODIFIED FACTOR IX POLYPEPTIDES AND USES THEREOF - Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics. | 10-30-2014 |
Patent application number | Description | Published |
20140046030 | ANTIBODIES COMPRISING SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE - Provided herein are antibodies comprising non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their production and methods of their use. The antibodies are useful for methods of treatment and prevention, methods of detection and methods of diagnosis. | 02-13-2014 |
20140051836 | Modified Fc Proteins Comprising Site-Specific Non-Natural Amino Acid Residues, Conjugates of the Same, Methods of Their Preparation and Methods of Their Use - Provided herein are modified Fc proteins comprising non-natural amino acid residues at site-specific positions, conjugates of the modified Fc proteins for therapy or diagnosis, compositions comprising the modified Fc proteins and conjugates thereof, methods of their production and methods of their use. The modified Fc proteins and conjugates are useful for methods of treatment and prevention, methods of detection and methods of diagnosis. | 02-20-2014 |
20140066598 | Modified Amino Acids - Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids. The polypeptides, antibodies and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis. | 03-06-2014 |
20140315245 | EXPRESSION OF BIOLOGICALLY ACTIVE PROTEINS IN A BACTERIAL CELL-FREE SYNTHESIS SYSTEM USING BACTERIAL CELLS TRANSFORMED TO EXHIBIT ELEVATED LEVELS OF CHAPERONE EXPRESSION - The present disclosure describes methods and systems for improving the expression of a properly folded, biologically active protein of interest in a cell free synthesis system. The methods and systems use a bacterial cell free extract having an active oxidative phosphorylation system, and include an exogenous protein chaperone. The exogenous protein chaperone can be expressed by the bacteria used to prepare the cell free extract. The exogenous protein chaperone can be a protein disulfide isomerase and/or a peptidyl-prolyl cis-trans isomerase. The inventors discovered that the combination of a protein disulfide isomerase and a peptidyl-prolyl cis-trans isomerase produces a synergistic increase in the amount of properly folded, biologically active protein of interest. | 10-23-2014 |
20150017187 | ANTIBODIES COMPRISING MULTIPLE SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE - Provided herein are antibodies comprising multiple non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their production and methods of their use. The antibodies are useful for methods of treatment and prevention, methods of detection and methods of diagnosis. | 01-15-2015 |
20150071923 | MODIFIED ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODIES AND METHODS OF USE THEREOF - Provided herein are modified anti-EGFR antibodies and nucleic acid molecules encoding modified anti-EGFR antibodies. Also provided are methods of treatment and uses using modified anti-EGFR antibodies. | 03-12-2015 |
Patent application number | Description | Published |
20080288096 | Digital media player with circuitry for avoiding refreshing a database of metadata associated with digital media content - A digital media player with circuitry for avoiding refreshing a database of metadata associated with digital media content is disclosed. In one embodiment, a digital media player storing a database of metadata associated with digital media content determines whether a removable memory device was connected with the digital media player while the digital media player was powered down. The digital media player refreshes the database only if it is determined that the removable memory device was connected with the digital media player while the digital media player was powered down. In another embodiment, the digital media player determines whether the digital media content stored on the removable memory device changed since the database was last updated. The digital media player refreshes the database if it is determined that the digital media content stored on the removable memory device changed since the database was last updated. | 11-20-2008 |
20080288097 | Method for improving a digital media player experience - A method for improving a digital media player experience is disclosed. In one embodiment, a digital media player storing a media transfer protocol database determines that digital media content stored on a removable memory device connected with the digital media player changed since the media transfer protocol database was last updated. The digital media player then refreshes the media transfer protocol database with metadata associated with the digital media content stored in the removable memory device. In another embodiment, a digital media player stores digital media content in the removable memory device, stores auxiliary information associated with the digital media content in a memory of the digital media player, and stores the auxiliary information in the removable memory device. In this way, the auxiliary information is portable with the removable memory device and accessible by a second digital player when the removable memory device is placed in communication with the second digital player. | 11-20-2008 |
20080288098 | Method for avoiding refreshing a database of metadata associated with digital media content - A method for avoiding refreshing a database of metadata associated with digital media content is disclosed. In one embodiment, a digital media player storing a database of metadata associated with digital media content determines whether a removable memory device was connected with the digital media player while the digital media player was powered down. The digital media player refreshes the database only if it is determined that the removable memory device was connected with the digital media player while the digital media player was powered down. In another embodiment, the digital media player determines whether the digital media content stored on the removable memory device changed since the database was last updated. The digital media player refreshes the database if it is determined that the digital media content stored on the removable memory device changed since the database was last updated. | 11-20-2008 |
20080288099 | Digital media player with improved user experience - A digital media player with improved user experience is disclosed. In one embodiment, a digital media player storing a database of metadata associated with digital media content determines whether a removable memory device was connected with the digital media player while the digital media player was powered down. The digital media player refreshes the database only if it is determined that the removable memory device was connected with the digital media player while the digital media player was powered down. In another embodiment, the digital media player determines whether the digital media content stored on the removable memory device changed since the database was last updated. The digital media player refreshes the database if it is determined that the digital media content stored on the removable memory device changed since the database was last updated. | 11-20-2008 |