Patent application number | Description | Published |
20130210037 | METHODS OF DIAGNOSING AND TREATING AUTISM - The present invention provides diagnostic methods for determining the risk of developing an autism spectrum disorder (ASD) in a fetus or child by detecting in a biological sample from the mother antibodies that bind to one or more biomarkers selected from the group consisting of lactate dehydrogenase (LDH), guanine deaminase (GDA), collapsin response mediator protein 1 (CRMP1), stress-induced phosphoprotein 1 (STIP1), alpha subunit of the barbed-end actin binding protein Cap Z (CAPZA2), Y Box Binding Protein 1 (YBX1), eukaryotic translation and elongation factor 1A1 (EEF1A1), microtubule-associated protein Tau (MAPT), dihydropyrimidinase-like protein 2 (DPYSL2), dynamin 1-like protein (DNM1L), radixin (RDX), moesin (MSN), and ezrin (EZR). The invention further provides methods of preventing or reducing the risk of a fetus or child developing an ASD by administering to the mother an agent that blocks the binding of maternal antibodies to the one or more fetal biomarkers listed above or by removing from the mother antibodies that bind to the one or more fetal biomarkers. | 08-15-2013 |
20130210673 | Polypeptide Display Libraries and Methods of Making and Using Thereof - Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed. | 08-15-2013 |
20130210699 | Methods and Compositions for Diagnosing and Treating Cervical Intraepithelial Neoplasia and Cervical Cancer - Disclosed herein are methods and compositions for diagnosing and treating diseases associated with a loss of cystatin E/M expression including cervical intraepithelial neoplasia and cervical cancer. Genetic mutations and exonic deletions which result in a loss of cystatin E/M expression are also disclosed. | 08-15-2013 |
20130211542 | SYNTHESIS OF NANOTOPOGRAPHIC BIOMIMETIC MEMBRANES FOR TISSUE CULTURE, ENGINEERING AND PROSTHETICS APPLICATIONS - The present invention provide methods for preparing nanostructured membranes. The methods include: providing a substrate with a charged silanized surface; forming a multilayered membrane containing at least two polyelectrolytes; inducing polyelectrolyte phase separation; crosslinking the multilayered membrane; and covalently linking the multilayered membrane to the silanized surface. Methods for fabricating membrane replicas are also disclosed, as well as devices such as cell- and tissue-culture substrates that contain the membranes and membrane replicas. Resulting materials exhibit topographic features and compliance of the extracellular matrix in vivo. | 08-15-2013 |
20130214284 | METHOD FOR THE REUSE OF GALLIUM NITRIDE EPITAXIAL SUBSTRATES - A method for the reuse of gallium nitride (GaN) epitaxial substrates uses band-gap-selective photoelectrochemical (PEC) etching to remove one or more epitaxial layers from bulk or free-standing GaN substrates without damaging the substrate, allowing the substrate to be reused for further growth of additional epitaxial layers. The method facilitates a significant cost reduction in device production by permitting the reuse of expensive bulk or free-standing GaN substrates. | 08-22-2013 |
20130214461 | Three-Dimensional Wafer-Scale Batch-Micromachined Sensor and Method of Fabrication for the Same - A vibratory sensor is fabricated as a three-dimensional batch-micromachined shell adapted to vibrate and support elastic wave propagation and wave precession in the shell or membrane and at least one driving electrode and preferably a plurality of driving electrodes directly or indirectly coupled to the shell to excite and sustain the elastic waves in the shell. The pattern of elastic waves is determined by the configuration of the driving electrode(s). At least one sensing electrode and preferably a plurality of sensing electrodes are provided to detect the precession of the elastic wave pattern in the shell. The rotation of the shell induces precession of the elastic wave pattern in the shell which is usable to measure the rotation angle or rate of the vibratory sensor. | 08-22-2013 |
20130215264 | END-TO-END VISUAL RECOGNITION SYSTEM AND METHODS - We describe an end-to-end visual recognition system, where “end-to-end” refers to the ability of the system of performing all aspects of the system, from the construction of “maps” of scenes, or “models” of objects from training data, to the determination of the class, identity, location and other inferred parameters from test data. Our visual recognition system is capable of operating on a mobile hand-held device, such as a mobile phone, tablet or other portable device equipped with sensing and computing power. Our system employs a video based feature descriptor, and we characterize its invariance and discriminative properties. Feature selection and tracking are performed in real-time, and used to train a template-based classifier during a capture phase prompted by the user. During normal operation, the system scores objects in the field of view based on their ranking. | 08-22-2013 |
20130215955 | APPARATUS AND METHOD FOR DETECTING COMMUNICATIONS FROM MULTIPLE SOURCES - A method, apparatus, and computer program for detecting sequences of digitally modulated symbols transmitted by multiple sources are provided. A real-domain representation that separately treats in-phase and quadrature components of a received vector, channel gains, and a transmitted vector transmitted by the multiple sources is determined. The real-domain representation is processed to obtain a triangular matrix. In addition, at least one of the following is performed: (i) hard decision detection of a transmitted sequence and demapping of corresponding bits based on a reduced complexity search of a number of transmit sequences, and (ii) generation of bit soft-output values based on the reduced complexity search of the number of transmit sequences. The reduced complexity search is based on the triangular matrix. | 08-22-2013 |
20130216609 | Controlled Release Antimicrobial Compositions and Methods for the Treatment of Otic Disorders - Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s). | 08-22-2013 |
20130219991 | GAS CHROMATOGRAPHY RECOMPOSITION-OLFACTOMETRY FOR CHARACTERIZATION OF AROMA MIXTURES - A method for the in-instrument recombination of volatiles using a gas chromatograph with mass spectrometry and olfactometry detection is described. Compounds that are introduced into the modified GC are separated conventionally on an analytical capillary GC column. The elution profile of volatiles can be segmented, analyzed and arbitrarily combined. In-line with the GC column, a pneumatic flow switch and splitter are connected to a detector and olfactometer. A cold trap allows the user to build a mixture of separated volatiles that is held until the cryotrap is rapidly heated, releasing the mixture for a subject to smell at the olfactory port and to evaluate. The instrument allows for characterization of the aroma quality of specific fractions of aroma volatiles obtained from foods, flowers or beverages without the need for pure chemical standards or the calculation of individual compound concentrations or sensory thresholds. | 08-29-2013 |
20130220594 | TUBE-IN-TUBE DEVICE USEFUL FOR SUBSURFACE FLUID SAMPLING AND OPERATING OTHER WELLBORE DEVICES - The present invention provides for a tube-in-tube system comprising: (a) an outer conduit having a proximal end and a distal end, and (b) an inner conduit having a proximal end and a distal end, wherein the inner conduit is disposed within the outer conduit, wherein the proximal end of the inner conduit is in fluid communication with a first aperture, and the proximal end of the outer conduit is in fluid communication with a second aperture, and the distal ends of the inner and outer conduits are in fluid communication with each other and to a third aperture. The present invention also provides for a split toroidal borehole clamp. | 08-29-2013 |
20130220833 | BIOMARKER NORMALIZATION - A fluid sample is measured with a tear film measuring system that includes a processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device configured to perform analyses of osmolarity and of one or more biomarkers within the sample fluid, wherein the analysis of biomarkers includes normalization of biomarker concentration values. | 08-29-2013 |
20130221102 | APPARATUS AND METHOD FOR DISPERSIVE FOURIER-TRANSFORM IMAGING - A barcode reading apparatus and method in which the spectrum of a probe light is first Fourier-transformed into space, directed upon a barcode, and then Fourier-transformed converting the spectrally encoded barcode pattern to a time domain waveform. In one implementation, the Fourier transformation from the spectrum domain into a spatial domain is performed by a dispersive element, while the Fourier transformation from the spectrally encoded barcode pattern to a time domain waveform is performed by group-velocity dispersion (GVD). The temporally encoded barcode pattern is detected by a photodetector, digitized by a digitizer, and analyzed by a digital signal processor. The invention is applicable to a number of fields which involve the reading of one- and two-dimensional barcodes, displacement sensing, surface measurements, measurement of width and gap, flow cytometry, reading of optical media, presense or absence detection, and other related fields. | 08-29-2013 |
20130221415 | Field-Effect P-N Junction - This disclosure provides systems, methods, and apparatus related to field-effect p-n junctions. In one aspect, a device includes an ohmic contact, a semiconductor layer disposed on the ohmic contact, at least one rectifying contact disposed on the semiconductor layer, a gate including a layer disposed on the at least one rectifying contact and the semiconductor layer and a gate contact disposed on the layer. A lateral width of the rectifying contact is less than a semiconductor depletion width of the semiconductor layer. The gate contact is electrically connected to the ohmic contact to create a self-gating feedback loop that is configured to maintain a gate electric field of the gate. | 08-29-2013 |
20130224100 | ELECTROMAGNETIC MIXING FOR NITRIDE CRYSTAL GROWTH - A method and apparatus for bulk Group-III nitride crystal growth through inductive stirring in a sodium flux growth technique. A helical electromagnetic coil is closely wound around a non-conducting cylindrical crucible containing a conductive crystal growth solution, including both precursor gallium and sodium, wherein a nitrogen-containing atmosphere can be maintained at any pressure. A seed crystal is introduced with the crystal's growth interface submerged slightly below the solution's surface. Electrical contact is made to the coil and an AC electrical field is applied at a specified frequency, in order to create eddy currents within the conductive crystal growth solution, resulting in a steady-state flux of solution impinging on the submerged crystal's growth interface. | 08-29-2013 |
20130224302 | POROUS PHOTONIC CRYSTALS FOR DRUG DELIVERY TO THE EYE - A minimally invasive controlled drug delivery system for delivering a particular drug or drugs to a particular location of the eye, the system including a porous film template having pores configured and dimensioned to at least partially receive at least one drug therein, and wherein the template is dimensioned to be delivered into or onto the eye. | 08-29-2013 |
20130225611 | Compositions and Methods for Reducing Cancer Cell Proliferation and Modulating Importin-Beta Function - The present disclosure provides methods of reducing proliferation of cancer cells. The methods include contacting the cancer cells with a 2,4-diaminoquinazoline compound. Also provided are methods of modulating importin-beta function (e.g., importin-beta-mediated nuclear import) in eukaryotic cells. The methods include contacting the eukaryotic cells with a 2,4-diaminoquinazoline compound. Pharmaceutical formulations that include a 2,4-diaminoquinazoline compound are also provided. | 08-29-2013 |
20130226016 | SYSTEM AND METHOD FOR RECONSTRUCTING CARDIAC ACTIVATION INFORMATION - An example system and method of reconstructing cardiac activation information are disclosed. An analysis signal and a reference signal are processed to determine whether there is a first point of change in a first selected-order derivative of the analysis signal with respect to a first selected-order derivative of the reference signal above a first threshold. The analysis signal and the reference signal are processed to determine whether there is a second point of change in a second selected-order derivative of the analysis cardiac signal with respect to a second selected-order derivative of the reference cardiac signal above a second threshold. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal. | 08-29-2013 |
20130243201 | EFFICIENT CONTROL OF SOUND FIELD ROTATION IN BINAURAL SPATIAL SOUND - A sound reproduction method and apparatus for determining the desired orientation of the listener's head in a sound field. The method includes the steps of receiving input signals representative of output signals from a plurality of microphones positioned at a location to sample a sound field at points representing possible locations of a listener's left and right ears if said listener was positioned in said sound field at said location, and processing the input signals to generate a composite signal that simulates a rotation of the sound field about the listener's head. | 09-19-2013 |
20130251943 | NANOWIRE-POLYMER COMPOSITE ELECTRODES - A method for producing flexible, nanoparticle-polymer composite electrodes is described. Conductive nanoparticles, preferably metal nanowires or nanotubes, are deposited on a smooth surface of a platform to produce a porous conductive layer. A second application of conductive nanoparticles or a mixture of nanoparticles can also be deposited to form a porous conductive layer. The conductive layer is then coated with at least one coating of monomers that is polymerized to form a conductive layer-polymer composite film. Optionally, a protective coating can be applied to the top of the composite film. In one embodiment, the monomer coating includes light transducing particles to reduce the total internal reflection of light through the composite film or pigments that absorb light at one wavelength and re-emit light at a longer wavelength. The resulting composite film has an active side that is smooth with surface height variations of 100 nm or less. | 09-26-2013 |
20130259179 | METHOD AND APPARATUS FOR GENERATING NUCLEAR FUSION USING CRYSTALLINE MATERIALS - Gently heating a pyroelectric crystal in a deuterated atmosphere can generate fusion under desktop conditions. The electrostatic field of the crystal is used to generate and accelerate a deuteron beam (>100 keV and >4 nA), which, upon striking a deuterated target, produces a neutron flux over 400 times the background level. The presence of neutrons within the target is confirmed by pulse shape analysis and proton recoil spectroscopy. Several elements of the system may be modified, including the configuration of the crystal or crystals, the composition of the surrounding environment and the target, the use of multiple probe tips, and the composition of the probe tip. | 10-03-2013 |
20130267035 | Isotopic Chemical Analysis using Optical Spectra from Laser Ablation - This disclosure provides systems, methods, and apparatus related to performing isotopic analysis of a sample. In one aspect a method includes applying laser energy to a region of a sample with a laser to generate a plasma and recording a spectrum generated by a plurality of molecular species in the plasma with a device. | 10-10-2013 |
20130274438 | Analogs of ShK Toxin and Their Uses in Selective Inhibition of Kv1.3 Potassium Channels - Analogs of ShK toxin and methods for using such ShK analogs. The ShK analogs generally comprise ShK toxin attached to a chemical entity (e.g. an atom, molecule, group, residue, compound, moiety, etc.) that has an anionic charge. The ShK analogs may be administered to human or non-human animal subjects to cause inhibition of potassium channels or to otherwise treat diseases or disorders. In some embodiments, the chemical entity to which the ShK toxin is attached may be chosen to provide selective inhibition of certain potassium channels (e.g., Kv1.3 channels) over other potassium channels (e.g., Kv1.1 channels). In come embodiments, the chemical entity to which the ShK toxin is attached may include a fluorophore and such fluorophore-tagged ShK analogs may be used in flow cytometry alone, or in conjunction with class II tetramers that can detect autoreactive cells. | 10-17-2013 |
20130281490 | Disubstituted Beta-lactones as Inhibitors of N-Acylethanolamine Acid Amidase (NAAA) - The present invention provides compounds and pharmaceutical compositions for inhibiting N-acylethanolamine acid amidase (NAAA). Inhibition of NAAA is contemplated as a method to sustain the levels of palmitoylethanolamide (PEA) and oleylethanolamide (OEA), two substrates of NAAA, in conditions characterized by reduced concentrations of PEA and OEA. The invention also provides methods for treating inflammatory diseases and pain, and other disorders in which decreased levels of PEA and OEA are associated with the disorder. | 10-24-2013 |
20130288970 | COMPOSITIONS AND METHODS FOR THE DELIVERY OF OXYGEN - H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O | 10-31-2013 |
20130305199 | IN-PLACE RESYNTHESIS AND REMAPPING TECHNIQUES FOR SOFT ERROR MITIGATION IN FPGA - In-place resynthesis for static memory (SRAM) based Field Programmable Gate Arrays (FPGAs) toward reducing sensitivity to single event upsets (SEUs). Resynthesis and remapping are described which have a low overheard and improve FPGA designs without the need of rerouting LUTs of the FPGA. These methods include in-place reconfiguration (IPR), in-place X-filling (IPF), and in-place inversion (IPV), which reconfigure LUT functions only, and can be applied to any FPGA architecture. In addition, for FPGAs with a decomposable LUT architecture (e.g., dual-output LUTs) an in-place decomposition (IPD) method is described for remapping a LUT function into multiple smaller functions leveraging the unused outputs of the LUT, and making use of built-in hard macros in programmable-logic blocks (PLBs) such as carry chain or adder. Methods are applied in-place to mapped circuits before or after routing without affecting placement, routing, and design closure. | 11-14-2013 |
20130316342 | Genetic Barcodes - Herein are described multicolor FISH probe sets termed “genetic barcodes” targeting several cancer or disease-related loci to assess gene rearrangements and copy number changes in tumor cells. Two, three or more different fluorophores are used to detect the genetic barcode sections thus permitting unique labeling and multilocus analysis in individual cell nuclei. Gene specific barcodes can be generated and combined to provide both numerical and structural genetic information for these and other pertinent disease associated genes. | 11-28-2013 |
20130330875 | NANONEEDLE PLASMONIC PHOTODETECTORS AND SOLAR CELLS - The present disclosure provides a method for a catalyst-free growth mode of defect-free Gallium Arsenide (GaAs)-based nanoneedles on silicon (Si) substrates with a complementary metal-oxide-semiconductor (CMOS)-compatible growth temperature of around 400° C. Each nanoneedle has a sharp 2 to 5 nanometer (nm) tip, a 600 nm wide base and a 4 micrometer (μm) length. Thus, the disclosed nanoneedles are substantially hexagonal needle-like crystal structures that assume a 6° to 9° tapered shape. The 600 nm wide base allows the typical micro-fabrication processes, such as optical lithography, to be applied. Therefore, nanoneedles are an ideal platform for the integration of optoelectronic devices on Si substrates. A nanoneedle avalanche photodiode (APD) grown on silicon is presented in this disclosure as a device application example. The APD attains a high current gain of 265 with only 8V bias. | 12-12-2013 |
20130331530 | CONJUGATED COPOLYMERS CHIRAL SIDE CHAIN FOR ORGANIC THIN FILM TRANSISTORS - Embodiments of the invention include polymers comprising a regioregular conjugated main chain section having an enantiopure or enantioenriched chiral side chain, as well as methods and materials for producing such polymers. Illustrative methods include regioselectively preparing a monomer that includes an enantiopure or enantioenriched chiral side group, and then reacting these monomers to produce a polymer that comprises a regioregular conjugated main chain section having an enantiopure or enantioenriched chiral side chains. In illustrative embodiments of the invention, the regioregular conjugated main chain section can contain a repeat unit that includes a dithiophene and a pyridine. | 12-12-2013 |
20130337066 | Membrane Encapsulated Nanoparticles and Method of Use - Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. Further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles are also provided. | 12-19-2013 |
20130337473 | CELL IDENTIFICATION SYSTEMS AND METHODS USING FUNCTIONALIZED MICROPALLET ARRAYS - Cell identification systems and methods using micropallet arrays are disclosed. According to one embodiment, a cell identification strategy involves detecting the expression patterns of markers that are expressed on cells to uniquely identify different cell populations within heterogeneous mixtures of cells. The cell markers may be on the cell surface or intracellular in location. The cell markers are interrogated using monoclonal antibodies (mAbs) that are directly conjugated to flourophores. The mAb-flourophore conjugates are used to detect the presence or absence and relative level of expression of each of the cell markers using laser scanning confocal microscopy. | 12-19-2013 |
20130344527 | Compositions and Methods for Modification of Biomolecules - The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids). | 12-26-2013 |
20130344600 | COMPOSITIONS COMPRISING NANOSTRUCTURES FOR CELL, TISSUE AND ARTIFICIAL ORGAN GROWTH, AND METHODS FOR MAKING AND USING SAME - The invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and/or cell growth, e.g., for bone, kidney or liver growth, and uses thereof, e.g., for in vitro testing, in vivo implants, including their use in making and using artificial organs, and related therapeutics. The invention provides lock-in nanostructures comprising a plurality of nanopores or nanotubes, wherein the nanopore or nanotube entrance has a smaller diameter or size than the rest (the interior) of the nanopore or nanotube. The invention also provides dual structured biomaterial comprising micro- or macro-pores and nanopores. The invention provides biomaterials having a surface comprising a plurality of enlarged diameter nanopores and/or nanotubes. | 12-26-2013 |
20140011705 | DETECTION OF PROTEASE AND PROTEASE ACTIVITY USING A SINGLE NANOCRESCENT SERS PROBE - This invention pertains to the in vitro detection of proteases using a single peptide-conjugate nanocrescent surface enhanced Raman scattering (SERS) probes with at least nanomolar sensitivity. The probe enables detection of proteolytic activity in extremely small volume and at low concentration. In certain embodiments the probes comprise an indicator for the detection of an active protease, where the indicator comprises a nanocrescent attached to a peptide, where said peptide comprises a recognition site for the protease and a Raman tag attached to the peptide. | 01-09-2014 |
20140011861 | Materials and Methods for Determining Diagnosis and Prognosis of Prostate Cancer - Materials and methods related to diagnosing and/or determining prognosis of prostate cancer. | 01-09-2014 |
20140012789 | PROBLEM SOLVING BY PLASTIC NEURONAL NETWORKS - More realistic neural networks are disclosed that are able to learn to solve complex problems though a decision making network, modeled as a virtual entity foraging in a digital environment. Specifically, the neural networks overcome many of the limitations in prior neural networks by using rewarded STDP bounded with rules to solve a complex problem. | 01-09-2014 |
20140017297 | Administration of Growth Factors for the Treatment of CNS Disorders - A method and system that is directed to the local delivery of growth factors to the mammalian CNS to treat CNS disorders associated with neuronal death and/or dysfunction is described. | 01-16-2014 |
20140018253 | GENE EXPRESSION PANEL FOR BREAST CANCER PROGNOSIS - The invention described in the application relates to a panel of gene expression markers for node-negative, ER-positive, HER2-negative breast cancer patients. The invention thus provides methods and compositions, e.g., kits and/or microarrays, for evaluating gene expression levels of the markers and methods of using such gene expression levels to evaluate the likelihood of relapse of a node-negative, ER-positive, HER2-negative breast cancer patient. Such information can be used in determining treatment options for patients. | 01-16-2014 |
20140023737 | Modulation of Oxidative Stress, Inflammation, and Impaired Insulin Sensitivity with Grape seed Extract - Method for modulating oxidative stress, inflammation, and impaired insulin sensitivity in a subject by using a grape seed extract, the method being useful in modulating post-prandial oxidative stress, inflammation, and impaired insulin sensitivity in patients suffering from Metabolic Syndrome (MetS). | 01-23-2014 |
20140027638 | REGENERATIVE RECEIVER ARCHITECTURES FOR MILLIMETER-WAVE AND SUB-MILLIMETER-WAVE IMAGING AND COMMUNICATION - A millimeter and sub-millimeter wavelength receiver imaging apparatus and method which directly generates a time encoded digital signal for an imaging pixel in response to interoperation of a digital quench circuit, an envelope detector, and a regenerative oscillator coupled to an antenna. The device utilizes the fact that oscillator startup time in a regenerative oscillator is inversely proportional to injected pixel image power. A digital quench circuit, such as a latch, is coupled for activating and deactivating the regenerative oscillator in response to receiving an output from an envelope threshold circuit, and for generating a time encoded digital signal in response to pixel amplitude during millimeter and sub-millimeter wavelength imaging. Receiver embodiments are described for both fundamental frequency operation (DRR) and for multi-frequency imaging (IRR). | 01-30-2014 |
20140030717 | VALVELESS MICROFLUIDIC DEVICE - Provided are methods, devices and systems for analyte detection using a microfluidic device. | 01-30-2014 |
20140037785 | PREBIOTIC OLIGOSACCHARIDES - The present invention provides galacto-oligosaccharide compositions that preferentially stimulate growth of specific | 02-06-2014 |
20140051863 | FLUORESCENT PROBES FOR DETECTION OF COPPER - The invention provides fluorescent sensors for the selective detection of a metal such as copper. The sensors may be considered to be derivatives of cyanine, fluorescein, rhodamine, rhodol, Tokyo green, or BODIPY. The sensors find particular use in detecting copper in cells and living animals. | 02-20-2014 |
20140057969 | Oncovector Nucleic Acid Molecules and Methods of Use - Provided herein are non-viral nucleic acid vectors, including non-viral oncovectors, that are autonomously replicating plasmids (ARPs). The non-viral nucleic acid vectors exhibit fusogenic activity and can exhibit other anti-tumor or cytotoxic activities. Also provided herein are methods and uses of the non-viral nucleic acid vectors for treating cancer. | 02-27-2014 |
20140060636 | End-Group-Directed Self-Assembly of Organic Compounds Useful for Photovoltaic Applications - The present invention provides for an organic compound comprising electron deficient unit covalently linked to two or more electron rich units. The present invention also provides for a device comprising the organic compound, such as a light-emitting diode, thin-film transistor, chemical biosensor, non-emissive electrochromic, memory device, photovoltaic cells, or the like. | 03-06-2014 |
20140084266 | SEMI-TRANSPARENT, TRANSPARENT, STACKED AND TOP-ILLUMINATED ORGANIC PHOTOVOLTAIC DEVICES - An electro-optic device includes a first electrode, an active layer formed over and electrically connected with the first electrode, a buffer layer formed over and electrically connected with the active layer, and a second electrode formed directly on the buffer layer. The second electrode includes a plurality of nanowires interconnected into a network of nanowires. The buffer layer provides a physical barrier between the active layer and the plurality of nanowires to prevent damage to the active layer while the second electrode is formed. | 03-27-2014 |
20140098006 | SYSTEMS, METHODS, AND DEVICES FOR HIGHLY INTERACTIVE LARGE IMAGE DISPLAY AND MANIPULATION ON TILED DISPLAYS - Display units which can be arranged to form a single arrayed display system, thereby allowing the display of much larger images than can be shown on a single display. Each display unit can include an image display, a communication mechanism, such as a network interface card or wireless interface card, and an image display module, such as a video card and an image processor. Each display module can be configured to selectively process and display portions of large digital images. | 04-10-2014 |
20140103295 | NANOWIRE PHOTODETECTOR AND IMAGE SENSOR WITH INTERNAL GAIN - A 1D nanowire photodetector device includes a nanowire that is individually contacted by electrodes for applying a longitudinal electric field which drives the photocurrent. An intrinsic radial electric field to inhibits photo-carrier recombination, thus enhancing the photocurrent response. Circuits of 1D nanowire photodetectors include groups of photodetectors addressed by their individual 1D nanowire electrode contacts. Placement of 1D nanostructures is accomplished with registration onto a substrate. A substrate is patterned with a material, e.g., photoresist, and trenches are formed in the patterning material at predetermined locations for the placement of 1D nanostructures. The 1D nanostructures are aligned in a liquid suspension, and then transferred into the trenches from the liquid suspension. Removal of the patterning material places the 1D nanostructures in predetermined, registered positions on the substrate. | 04-17-2014 |
20140120082 | MODULATION OF NKG2D - The present invention relates to methods and compositions for treating and/or preventing autoimmune and/or inflammatory disease. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D. | 05-01-2014 |
20140121990 | Secure Informatics Infrastructure for Genomic-Enabled Medicine, Social, and Other Applications - A system is disclosed in which human genomes are stored in databases or in a cloud based computer system, which is secure and private and then downloaded to personal devices for possible peer-to-peer interactions for health care applications, as well as for social and other applications. The use of the system is directed to fully sequenced genomes and includes protocols that are constructed to mimic in vitro biological tests to conduct genomic analysis instead of generic computational techniques, which tend to be impractical as they require performance of online computation over the entire genome. Three specific examples of protocols or techniques for privacy-preserving testing on fully sequenced genomes included are: 1) privacy-preserving genetic paternity testing, 2) privacy-preserving personalized medicine testing, and 3) privacy-preserving genetic compatibility testing. | 05-01-2014 |
20140127718 | IDENTIFICATION OF SECRETED PROTEINS AS DETECTION MARKERS FOR CITRUS DISEASE - Secreted proteins as detection markers for insect vector and graft transmitted citrus disease are described. Method and kits for detecting the secreted proteins are provided. | 05-08-2014 |
20140142028 | TARGETED ANTIMICROBIAL MOIETIES - This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species. | 05-22-2014 |
20140148378 | ANTIBACTERIAL PEPTIDES - The present invention relates to antibacterial peptides and analogs thereof, e.g., originating from, derived from, isolated and/or purified from mammalian milk, that reduce, inhibit and/or prevent the growth or proliferation of a bacterial organism. | 05-29-2014 |
20140149055 | MULTI-PLANE METHOD FOR THREE-DIMENSIONAL PARTICLE IMAGE VELOCIMETRY - A multi-planar velocimetry approach to characterize 3D incompressible flows based on 2D perpendicular (or otherwise complementary) velocity fields is described. Two-dimensional velocity fields acquired on the planes are reconstructed into a 3D velocity field through interpolation and the imposition of a fluid incompressibility constraint. | 05-29-2014 |
20140204092 | CLASSIFICATION OF HIGH DIMENSIONAL DATA - A method for classification of high dimensional data on graphs based on the Ginzburg-Landau functional. The method applies L | 07-24-2014 |
20140247115 | NANOSTRUCTURE-INITIATOR MASS SPECTROMETRY BIOMETRICS - Several embodiments described herein are drawn to methods of identifying an analyte on a subject's skin, methods of generating a fingerprint, methods of determining a physiological change in a subject, methods of diagnosing health status of a subject, and assay systems for detecting an analyte and generating a fingerprint, by nanostructure-initiator mass spectrometry (NIMS). | 09-04-2014 |
20140249140 | Nerve Agent Antidotes - The present invention includes compositions that are useful in treating, ameliorating, or preventing nerve agent poisoning. The present invention also includes methods of preventing, treating or ameliorating nerve agent poisoning in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition of the invention. The present invention also includes methods of preventing, treating or ameliorating a seizure induced by a disease or disorder in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition of the invention. The present invention also comprises a kit comprising compositions of the invention. | 09-04-2014 |
20140249620 | ULTRA-LOW FRACTIONAL AREA COVERAGE FLOW DIVERTER FOR TREATING ANEURYSMS AND VASCULAR DISEASES - A flow diverter is described and fabricated using ultra-thin porous thin-film Nitinol, and is configured for implantation to a treatment site within a vessel for significant reduction in an intra-aneurismal flow velocity and vorticity. Using small size pores in a coverage area of only 10%, a 90% reduction in flow velocity into a pseudo-aneurysm can be achieved, with an almost immediate cessation of flow into an anatomical feature such as aneurysm sac in vivo. The size of the holes can be tailored to be any shape and range in size from 1-400 μm using photolithography and from 5-1000 nm using ebeam lithography. | 09-04-2014 |
20140260615 | LEVER MECHANISMS FOR ANTI-PHASE MODE ISOLATION IN MEMS TUNING-FORK STRUCTURES - A MEMS resonator includes two resonating masses having an anti-phase and in-phase resonance mode, each mode having a resonance frequency, and an anti-phase resonance levering system coupled to the two resonating masses to stiffen and/or dampen the in-phase resonance mode while leaving the anti-phase resonance mode compliant. This effectively raises the in-phase resonance frequency above the anti-phase resonance frequency, and potentially creates a large frequency separation between the two resonance modes. This reduces the energy transfer between the two modes, allowing for robustness to external acceleration, because the in-phase mode is of a higher frequency. The anti-phase resonance levering system is disposed between the two resonating masses as an internal levering mechanism, or is disposed around the two resonating masses as an external levering mechanism. | 09-18-2014 |
20140273099 | METHODS AND DEVICES FOR NON-THERMAN POLYMERASE CHAIN REACTION - Methods and devices for non-thermal PCR amplification of nucleic acid sequences. An electrical potential is applied to cause non-thermal separation of strands of a double-stranded nucleic acid or double-stranded nucleic acid/primer extension product. | 09-18-2014 |
20140293683 | MAGNETO-RESISTIVE EFFECT ELEMENT | 10-02-2014 |
20140350087 | Oncovector Nucleic Acid Molecules and Methods of Use - Provided herein are non-viral nucleic acid vectors, including non-viral oncovectors, that are autonomously replicating plasmids (ARPs). The non-viral nucleic acid vectors exhibit fusogenic activity and can exhibit other anti-tumor or cytotoxic activities. Also provided herein are methods and uses of the non-viral nucleic acid vectors for treating cancer. | 11-27-2014 |