Patent application number | Description | Published |
20130041017 | SIRNA-BASED THERAPY OF FIBRODYPLASIA OSSIFICANS PROGRESSIVA (FOP) - This invention is directed to mutated Activin A type I receptor proteins (ACVR1) and isolated nucleic acids encoding same. The invention also relates to compositions and methods for siRNA-based regulation of mutated ACVR1 expression in the treatment of Fibrodysplasia Ossificans Progressiva (FOP). | 02-14-2013 |
20130045186 | Method of Detecting and/or Identifying Adeno-Associated Virus (AAV) Sequences and Isolating Novel Sequences Identified Thereby - Adeno-associated virus rh.10 sequences, vectors containing same, and methods of use are provided. | 02-21-2013 |
20130052222 | INFLUENZA NUCLEIC ACID MOLECULES AND VACCINES MADE THEREFROM - Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more Influenza A serotpyes using the vaccines that are provided. | 02-28-2013 |
20130096942 | Discharge Decision Support System for Post Acute Care Referral - A system and method of recommending post-acute care services to a patient is described. The system and method include the steps of providing a plurality of questions relating to a patient, where each question has at least two selectable answers, and wherein each selectable answer has associated therewith a corresponding score, receiving one of the selectable answers for each of the plurality of questions, calculating a total score corresponding to the sum score of each of the answers selected, and generating a post-acute care referral if the total score meets a predetermined threshold value. | 04-18-2013 |
20130123750 | METHODS, COMPOSITIONS AND APPARATUS FOR DELIVERING HETEROLOGOUS MOLECULES TO CELLS - A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's micro vasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the foil length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex. | 05-16-2013 |
20130147477 | ENDOGENOUS MAGNETIZATION CONTRAST IN MRI - An endogenous source of magnetic resonance image contrast of biological tissues is provided by modeling a conventional magnetization transfer (CMT) spectrum using z-spectral data and generating magnetization transfer ratio maps from the magnetization transfer spectrum at a frequency of interest. A contribution by the CMT spectrum from the z-spectral data is removed and a direct water saturation component is modeled using the z-spectral data with removed CMT spectrum (z-spectral). When this modeled direct water saturation component contribution is removed from the z-spectral, then the remaining z-spectra reflects new contrast due to chemical exchange saturation transfer (CEST) and magnetization transfer/exchange effect from aliphatic protons probably associated with labile proteins, peptides and lipids, named as novel magnetization transfer (NMT). This technique can be used to illustrate subtle changes in biological tissue as a result of diseases states, provide better visibility of brain white matter plaques, provide improved CEST contrast, provide better visualization of proteins, peptides, and lipids in biological tissue using NMT contrast, improve segmentation of white matter and gray matter in brain images, and the like. | 06-13-2013 |
20130157962 | METHODS FOR INHIBITING GROWTH OF PROLACTIN-RESPONSIVE CANCER CELLS WITH CYCLOSPORINE A OR OTHER CYCLOPHILIN INHIBITORS - Methods are provided for inhibiting growth of prolactin-responsive cancer cells and treating prolactin-responsive malignancies via administration an agent such as cyclosporine A which directly inhibits an enzymatic activity of a cyclophilin. | 06-20-2013 |
20130158058 | HYPERCHOLESTEROLEMIA AND TENDINOUS INJURIES - This invention provides compositions and methods of inhibiting, suppressing, or treating a tendinous or musculoskeletal soft tissue injury. The invention further provides a method of ameliorating symptoms associated with a tendinous or musculoskeletal soft tissue injury. Additionally, the invention provides methods for evaluating the risk of developing a tendinous or musculoskeletal soft tissue injury. | 06-20-2013 |
20130165488 | Novel Thromboxane A2 (TP) Receptor Antagonists - The present invention relates to novel TP receptor antagonists, which optionally cross the blood-brain barrier of a mammal. The invention also provides methods for treating a disorder related to activation of TP receptor utilizing the compounds of the invention. | 06-27-2013 |
20130178440 | COMPOSITIONS AND METHODS FOR TREATING SKIN CANCER ASSOCIATED DISEASES - The invention provides compositions and methods for treating skin cancer associated diseases. Specifically, the invention relates to topically administering a signaling pathway inhibitor or a related compound to treat pre-cancerous skin lesions, skin tumors, and their associated diseases or disorders. | 07-11-2013 |
20130184441 | Detection of Neurodegenerative Disease - Provided are methods of assessing the absence or presence of a neurodegenerative disease in a subject comprising characterizing TDP-43 in a tissue sample of the subject. Also disclosed are methods for diagnosing a neurodegenerative disease in a subject, and methods for determining the efficacy of a drug against a neurodegenerative disease. Novel antibodies that bind to TDP-43 are also provided. | 07-18-2013 |
20130186758 | CURRENT-CARRYING NANOWIRE HAVING A NANOPORE FOR HIGH-SENSITIVITY DETECTION AND ANALYSIS OF BIOMOLECULES - Disclosed are devices that feature nanopores formed in graphene sheets, such as graphene ribbons. The graphene sheets include an edge irregularity, such as a zig-zag configuration, a chiral edge, or an armchair-configuration edge, which edges confer on the devices the ability to discriminate between different subunits of a macromolecule translocated through the nanpore. The disclosed devices and methods have application to DNA sequencing and analysis, among other applications. | 07-25-2013 |
20130189241 | REGULATED DELIVERY SYSTEMS FOR INNER EAR DRUG APPLICATION AND USES THEREOF - The invention relates to a controlled release delivery compositions and methods of using them for pathologies associated with Otorhinolaryngology and Head and Neck. Specifically, the invention relates to regulating drug delivery by the use of chitosan based matrices together with chitosanases. | 07-25-2013 |
20130190254 | POLYPEPTIDES THAT BIND MEMBRANE PROTEINS - Polypeptides which bind to the helical transmembrane region of membrane proteins are disclosed, as are methods for the design of polypeptides that bind to the transmembrane region of membrane proteins. Also provided are methods for the use of the disclosed polypeptides in various applications, as well as products made through the practice of the instant methods. | 07-25-2013 |
20130196346 | METHODS FOR DIAGNOSIS OF MYELODYSPLASTIC SYNDROMES (MDS) - The present invention relates to methods and kits for diagnosing, ascertaining the clinical course of myelodysplastic syndrome (MDS) and ascertaining response to a therapy regimen of myelodysplastic syndrome. Specifically the invention provides methods and kits useful in the diagnosis and determination of clinical parameters associated with MDS based on surface markers unique to MDS. | 08-01-2013 |
20130197068 | RNA Containing Modified Nucleosides and Methods of Use Thereof - This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules. | 08-01-2013 |
20130202173 | CLASSIFICATION OF BIOLOGICAL TISSUE BY MULTI-MODE DATA REGISTRATION, SEGMENTATION AND CHARACTERIZATION - A method and apparatus for classifying possibly vulnerable plaques from sets of DCE-MRI images includes receiving a set of MRI slice images obtained at respectively different times, where each slice image includes voxels representative of at least one region of interest (ROI). The images are processed to determine the boundaries of the ROIs and the voxels within the identified boundaries in corresponding regions of the images from each time period are processed to extract kinetic texture features. The kinetic texture features are then used in a classification process which classifies the ROIs as vulnerable or stable. | 08-08-2013 |
20130204069 | Compositions and Methods of Treating Tumors - Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed. | 08-08-2013 |