Patent application number | Description | Published |
20100160737 | BRAIN RETRACTOR APPARATUS FOR MEASURING AND PREDICTING ELECTROPHYSIOLOGICAL PARAMETERS - Described is a surgical system for monitoring a patient's condition during surgery. One aspect is a non-contact EEG sensor. The non-contact EEG sensor can be used to predict the onset of physiological disorders. Another aspect includes the use of a plurality of pressure sensors to determine the pressure applied by retractors on the patient, including the brain and other organs. | 06-24-2010 |
20100234669 | Radiation/Drug Delivery Method and Apparatus - There is provided herein a brachytherapy delivery system for the internal delivery and positioning of therapeutic agent, most particularly, a discrete radiation emitting particulate, within or in proximity to a vertebral or other bony tumor. The system comprises an elongated bone cannula having a proximal and a distal end, the distal end being suitable for disposition within bone. The bone cannula further comprises a bore disposed longitudinally therethrough suitable to axially and slidably receive an elongated and cannulated therapy delivery apparatus through which the therapeutic agent is delivered. | 09-16-2010 |
20100260679 | METHOD AND APPARATUS FOR DETECTING AND REGULATING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) BY FORMING A HOMEOSTATIC LOOP EMPLOYING A HALF-ANTIBODY BIOSENSOR - A biosensor for detection of vascular endothelial growth factor (VEGF) hybridization uses an array of parallel capacitors to detect electrochemical binding of circulating VEGF to immobilized anti-VEGF monoclonal half-antibodies (a-VEGF mhAb). Binding of a-VEGF mhAb modulates the threshold voltage of a circuit, changing the impedance of the circuit. An electrode coated with a p-Si substrate enhances the affinity between the VEGF molecules. A fluid cell delivers VEGF samples onto the active surface of the chip. An array of parallel capacitors arranged in an interdigitated pattern detects the VEGF in the fluid. The detector provides an accurately measured and quantifiable rate of change of the VEGF molecules in vivo, providing real time feedback which is used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden and efficacy of the chemotherapy as part of a homeostatic loop for chemotherapy. | 10-14-2010 |
20100262375 | METHOD AND APPARATUS FOR FORMING A HOMEOSTATIC LOOP EMPLOYING AN APTAMER BIOSENSOR - A novel architecture solid-state biosensor for label-free detection of vascular endothelial growth factor (VEGF) hybridization is presented. The new device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. The detection mechanism is based on an electrochemical binding of circulating VEGF to an immobilized VEGF aptamer; whereby binding of these two compounds modulates the threshold voltage of a novel circuit, changing the impedance (capacitance) of the circuit. This novel circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the VEGF molecules and the aptamer. An apparatus forming a fluid cell is configured so as to enable the flow for delivering VEGF samples onto the active surface of the chip. The device has an array of parallel capacitors which act as an integrated, individual counter-electrode, computational apparatus which employs the sensory output over the time domain so as to enable detection, reporting and formation of a homeostatic loop for VEGF measurements. Moreover, this detector is able to provide an accurately measured and quantifiable rate of change of the VEGF molecules in-vivo, providing real time feedback of this important biomarker which may be used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden. | 10-14-2010 |
20110162979 | Method and Apparatus for Forming of an Automated Sampling Device for the Detection of Salmonella Enterica Utilizing an Electrochemical Aptamer Biosensor - An aptamer-based solid-state electrochemical biosensor for label-free detection of | 07-07-2011 |
20110166033 | Method and Apparatus for Forming of an Automated Sampling Device for the Detection of Salmonella Enterica Utilizing an Electrochemical Aptamer Biosensor - An aptamer-based solid-state electrochemical biosensor for label-free detection of | 07-07-2011 |
20110295159 | Method and Apparatus for an Implantable Inertial-Based Sensing System for Real-Time, In Vivo Detection of Spinal Pseudarthrosis and Adjacent Segment Motion - A vertebral processor designed to collect and interpret data from multiple surgically implanted accelerometers. Each accelerometer is surgically implanted into a vertebra of a patient utilizing a bone screw. Additional accelerometers are implanted in adjacent vertebrae. The data from the accelerometers is compared by an algorithm to determine the relative movement of the accelerometers implanted in adjacent vertebrae. Data is generated via the algorithm and compared against the expected behavior of the surgically implanted accelerometers as if they were connected to a rigid body, thus determining the level of success of a spinal fusion procedure for those adjacent segments. The apparatus may be utilized with or without spinal stabilization hardware, and with or without fusion cages or artificial discs. The vertebral processor is supplemented by an external system worn by the patient, which provides for an inductive charging power source and for data transfer. | 12-01-2011 |
20130203828 | PHARMACEUTICAL COMPOSITIONS COMPRISING POH DERIVATIVES - The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection. | 08-08-2013 |
20130210877 | PHARMACEUTICAL COMPOSITIONS COMPRISING POH DERIVATIVES - The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection. | 08-15-2013 |
20130303807 | PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES - The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents. | 11-14-2013 |
20130331422 | METHODS AND DEVICES FOR USING ISOPERILLY ALCOHOL - The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection. | 12-12-2013 |
20140303455 | MULTIPURPOSE CEREBROSPINAL FLUID SENSOR ASSEMBLY AND METHOD OF OPERATION OF THE SAME - A cerebrospinal fluid (CSF) monitoring device for the detection of obstructions in real time through the collection of pressure data from an on-board pressure sensor. This system is designed to integrate into medical devices equipped with a CSF drainage system, such as implantable shunts. CSF analysis data can be transmitted in real-time wirelessly to a physician or can be stored on-board in a memory card and retrieved wirelessly at a later time. Information from the CSF sensors can be used by physicians to monitor CSF conditions known to cause shunt malfunction/obstruction such as elevated protein concentrations, evidence of an on-going or recent hemorrhage such as presence of heme proteins, and concentrations of administered medications/drugs over time. It can be used to monitor for CSF infections, in which increased pressure, increased temperature, CSF high protein and low glucose, would be suggestive of CSF infections. | 10-09-2014 |
20140364471 | PHARMACEUTICAL COMPOSITIONS COMPRISING POH DERIVATIVES - The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene for sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection. | 12-11-2014 |
20140364472 | PHARMACEUTICAL COMPOSITIONS COMPRISING POH DERIVATIVES - The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection. | 12-11-2014 |