Patent application number | Description | Published |
20090246819 | Assay Methods Using Chemiluminescent Detection of Peroxidase - Methods for generating chemiluminescence rapidly by reaction of at least one compound comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups with a peroxidase enzyme and a peroxide are disclosed. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase enzymes or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs. Use of the methods provides rapid signal generation, achieving a plateau intensity in under one minute. The substrate can be provided in a composition which demonstrates unexpectedly long storage stability. | 10-01-2009 |
20100173429 | METHODS USING NOVEL CHEMILUMINESCENT LABELS - Methods using chemiluminescent label compounds and chemiluminescent labeled conjugates are provided. The compounds comprise an acridan ring bearing an exocyclic ketene dithioacetal group and further contain a labeling substituent which permits attachment to compounds of interest. The novel chemiluminescent compounds and labeled conjugates are convenient to prepare, are highly stable, and generate chemiluminescence rapidly on demand. The compounds and conjugates are useful in assays of an analyte in a sample and in assays employing labeled specific binding pairs. | 07-08-2010 |
20100190271 | METHODS USING NOVEL CHEMILUMINESCENT LABELS - Methods using chemiluminescent label compounds and chemiluminescent labeled conjugates are provided. The compounds comprise an acridan ring bearing an exocyclic ketene dithioacetal group and further contain a labeling substituent which permits attachment to compounds of interest. The novel chemiluminescent compounds and labeled conjugates are convenient to prepare, are highly stable, and generate chemiluminescence rapidly on demand. The compounds and conjugates are useful in assays of an analyte in a sample and in assays employing labeled specific binding pairs. | 07-29-2010 |
20100267071 | SOLUTION PHASE HOMOGENEOUS ASSAYS - Methods, reagents, kits and systems are disclosed for determining an analyte in a sample suspected of containing the analyte where all reagents are soluble in aqueous solution. One assay method includes treating a sample suspected of containing the analyte under conditions such that if the analyte is present, an activator is brought into reactive configuration with a chemiluminescent compound to activates it. The sample is also treated with an agent to reduce signal not related to analyte. Finally, the sample is treated with a trigger solution thereby producing light from the activated chemiluminescent compound. No reagents are associated with a surface or other solid phase. | 10-21-2010 |
20100273189 | NON SEPARATION ASSAYS WITH SELECTIVE SIGNAL INHIBITORS - Methods, reagents, kits and systems are disclosed for determining an analyte in a sample, the assay method comprising forming a reaction mixture in an aqueous solution, by adding a chemiluminescent-labeled immobilized specific binding member, an activator-labeled specific binding member, a selective signal inhibiting agent, and a sample, wherein the chemiluminescent-labeled immobilized specific binding member and activator-labeled specific binding member bind to analyte present in the sample to form a binding complex, and adding to the reaction mixture a trigger solution to release a detectable chemiluminescent signal correlated to the amount of the analyte-bound binding complex present in the reaction mixture. | 10-28-2010 |
20150212005 | SOLUTION PHASE HOMOGENEOUS ASSAYS - Methods, reagents, kits and systems are disclosed for determining an analyte in a sample suspected of containing the analyte where all reagents are soluble in aqueous solution. One assay method includes treating a sample suspected of containing the analyte under conditions such that if the analyte is present, an activator is brought into reactive configuration with a chemiluminescent compound to activates it. The sample is also treated with an agent to reduce signal not related to analyte. Finally, the sample is treated with a trigger solution thereby producing light from the activated chemiluminescent compound. No reagents are associated with a surface or other solid phase. | 07-30-2015 |
Patent application number | Description | Published |
20120159939 | ELECTRIC PUMP - A system for lubricating transmission components with hydraulic fluid includes a pump and a motor coupled to the pump. The pump has an inlet port that receives hydraulic fluid and an outlet port from which hydraulic fluid is pumped to the transmission components. A pump pressure is regulated by adjusting a motor torque of the motor, and the motor torque is set by commands based on a look-up table or a formula. | 06-28-2012 |
20120174570 | TRANSMISSION HYDRAULIC CONTROL SYSTEM HAVING FLOW AUGMENTATION - A system for providing pressurized hydraulic fluid includes an engine driven main pump and an electrical motor driven auxiliary pump. The auxiliary pump provides hydraulic fluid at line pressure to shift control subsystems during a vehicle launch while the main pump provides hydraulic fluid to cooler or lubrication subsystems during the vehicle launch. A pressure regulation valve regulates the pressure of the hydraulic fluid from the main pump. Once the main pump reaches a critical speed, the main pump provides hydraulic fluid at line pressure to the hydraulic control system and the auxiliary pump is turned off. | 07-12-2012 |
20130015254 | TEMPERATURE DEPENDENT VARIABLE FLOW ORIFICE - A variable flow orifice for a hydraulic control system in a transmission includes a shape memory alloy that selectively increases and decreases the size of an orifice. The deformation of the shape memory alloy, and therefore the size of the orifice, is a function of the temperature of the transmission. During cold conditions the orifice size is increased and during normal operating conditions the size of the orifice is decreased. | 01-17-2013 |
20130160445 | SHAPE MEMORY ALLOY ACTUATOR - A device or actuator includes a first component made of Shape Memory Alloy (SMA) that applies force to a second component of the device to provide a controllable actuator. The SMA component is selectively energized by using active electric current through it. | 06-27-2013 |
20130192704 | MEMS VALVE OPERATING PROFILE - A MEMS fluid control system is provided having a micro-electro-mechanical system. The system includes a plurality of ports, a cavity, a valve, an actuator, and a pair of electrical contacts. The plurality of ports are in communication with the cavity, the valve is disposed in the cavity, and the valve is connected to the actuator. The system further includes a hydraulic circuit having a pressure supply line in communication with a first of the plurality of ports, a control line in communication with a second of the plurality of ports, and an exhaust line in communication with a third of the plurality of ports. The valve includes an elongated portion and a blocking portion, the blocking portion includes a first, a second, and a third portions. | 08-01-2013 |
20130234568 | STEPPER MOTOR WITH COMMON SOLENOID CURRENT DRIVER - A stepper motor assembly includes a unipolar winding stepper motor, four drivers, and a transmission control module. The stepper motor has four coil parts. Each driver has a transistor connected to one of the coil parts. Each driver is operable to drive a phase of the stepper motor, where first and second phases are opposites of each other and third and fourth phases are opposites of each other. The transmission control module houses the four transistors. A transmission is also disclosed that includes the disclosed stepper motor assembly. | 09-12-2013 |
20130324355 | CONTAINMENT CONTROL FOR A CONTINUOUSLY VARIABLE TRANSMISSION - A speed ratio containment process limits the speed ratio of a variator for a CVT for a motor vehicle when rolling backward by commanding a speed ratio that is higher than the actual speed ratio in an overdrive direction. Accordingly, the actual speed ratio moves to a lowest limit, which provides maximum torque when a driver of the motor vehicle steps on the accelerator pedal to resume forward motion of the motor vehicle. | 12-05-2013 |
20130333508 | HYDRAULIC CONTROL SYSTEM FOR A CONTINUOUSLY VARIABLE TRANSMISSION - A hydraulic control system for a continuously variable transmission includes a pressure regulator subsystem, a ratio control subsystem, a torque converter control (TCC) subsystem, a variable lubrication control subsystem, a variator clamping subsystem, and a clutch control subsystem. The variable lubrication control subsystem allows for increased and decreased oil flow to components of the variable transmission based on demand. The pressure regulator subsystem provides binary line pressure control to the lubrication subsystem. | 12-19-2013 |
20160053889 | CONTAINMENT CONTROL FOR A CONTINUOUSLY VARIABLE TRANSMISSION - A speed ratio containment process limits the speed ratio of a variator for a CVT for a motor vehicle when rolling backward by commanding a speed ratio that is higher than the actual speed ratio in an overdrive direction. Accordingly, the actual speed ratio moves to a lowest limit, which provides maximum torque when a driver of the motor vehicle steps on the accelerator pedal to resume forward motion of the motor vehicle. | 02-25-2016 |
Patent application number | Description | Published |
20110245167 | NaK-ATPase-Derived Peptide SRC Inhibitors and Ouabain Antagonists and Uses Thereof - A novel Src inhibitor that targets the Na/K-ATPase/Src receptor complex and antagonizes ouabain-induced protein kinase cascades and uses thereof are disclosed. | 10-06-2011 |
20110306570 | Na/K-Atpase Expression as an Indicator for the Treatment of Cancer - Methods for regulating the expression of Na/K-ATPase and uses thereof, including uses in the diagnosis/prognosis and treatment of cancer, are disclosed. | 12-15-2011 |
20120289479 | Materials and Methods Related to Sodium/Potassium Adenosine Triphosphate and Cholesterol - This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream. | 11-15-2012 |
20120302630 | Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof - Na/K-ATPase/Src ligands, assays and uses thereof are disclosed. | 11-29-2012 |
20130011335 | Materials and Methods Related to Sodium/Potassium Adenosine Triphosphate and SRC - This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream. | 01-10-2013 |
20130150294 | Na+/K+-ATPase-Specific Peptide Inhibitors/Activators of Src and Src Family Kinases - A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. | 06-13-2013 |
20140031419 | Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof - The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative. | 01-30-2014 |
20140128356 | Na/K-ATPase Ligand - Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described. | 05-08-2014 |
20140179608 | Materials and Methods Related to Sodium/Potassium Adenosine Triphosphatase and SRC - Described herein are methods to bind a compound to the SH2 domain of Src in a Src-expressing cell which includes contacting a compound comprising an amino acid compound to a Src-expressing cell; and binding a compound to the SH2 domain of Src. | 06-26-2014 |
20140187484 | NA/K-ATPASE-DERIVED PEPTIDE SRC INHIBITORS AND OUABAIN ANTAGONISTS AND USES THEREOF - A novel Src inhibitor that targets the Na/K-ATPase/Src receptor complex and antagonizes ouabain-induced protein kinase cascades and uses thereof are disclosed. | 07-03-2014 |
20150133389 | Na+/K+-ATPase-Specific Peptide Inhibitors/Activators of Src and Src Family Kinases - A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. | 05-14-2015 |
20150272923 | Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof - The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative. | 10-01-2015 |
20150342966 | Na/K-ATPase Ligand and Uses Thereof in Wound Healing - Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described. | 12-03-2015 |