Patent application number | Description | Published |
20090018425 | ANALYTE MONITORING: STABILIZER FOR SUBCUTANEOUS GLUCOSE SENSOR WITH INCORPORATED ANTIGLYCOLYTIC AGENT - An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring. | 01-15-2009 |
20090095642 | TRANSITION METAL COMPLEXES WITH PYRIDYL-IMIDAZOLE LIGANDS - Enzyme-based electrochemical sensors comprising transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators and include substituted or unsubstituted pyridyl-imidazole ligands. Transition metal complexes attached to polymeric backbones are also described. | 04-16-2009 |
20090099434 | OXYGEN-EFFECT FREE ANALYTE SENSOR - The present invention provides an electrochemical sensor having a sensing chemistry that operates substantially free of any “oxygen effect”. The electrochemical sensors are useful in determining the level of an analyte in a biological sample from a subject. The present invention also provides sensor assemblies including the electrochemical sensors as well as methods of using the same. | 04-16-2009 |
20090292188 | Analyte Sensors and Methods of Use - An analyte sensor system including a substrate, a first electrode disposed on a first surface of the substrate, a second electrode disposed on a second surface of the substrate, a third electrode provided in electrical contact with at least one of the first or second electrodes, where at least a portion of the first electrode and the second electrode are subcutaneously positioned in a patient, and where the third electrode is substantially entirely positioned external to the patient, and corresponding methods are provided. | 11-26-2009 |
20090294301 | Reference Electrodes Having An Extended Lifetime for Use in Long Term Amperometric Sensors - The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions. | 12-03-2009 |
20090294306 | REFERENCE ELECTRODES HAVING AN EXTENDED LIFETIME FOR USE IN LONG TERM AMPEROMETRIC SENSORS - The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions. | 12-03-2009 |
20090294307 | REDOX POLYMER BASED REFERENCE ELECTRODES HAVING AN EXTENDED LIFETIME FOR USE IN LONG TERM AMPEROMETRIC SENSORS - The present application provides redox polymer based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions. | 12-03-2009 |
20090298104 | REFERENCE ELECTRODES HAVING AN EXTENDED LIFETIME FOR USE IN LONG TERM AMPEROMETRIC SENSORS - The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions. | 12-03-2009 |
20100065441 | CATIONIC POLYMER BASED WIRED ENZYME FORMULATIONS FOR USE IN ANALYTE SENSORS - Embodiments of the invention include analyte-responsive compositions and electrochemical analyte sensors having a sensing layer that includes an analyte-responsive enzyme and a cationic polymer. Also provided are systems and methods of making the sensors and using the electrochemical analyte sensors in analyte monitoring. | 03-18-2010 |
20100213057 | Self-Powered Analyte Sensor - Generally, embodiments of the invention relate to self-powered analyte determining devices (e.g., electrochemical analyte monitoring systems) that include a working electrode, a counter electrode, and an optional resistance value, where the working electrode includes analyte sensing components and the self-powered analyte determining device spontaneously passes a current directly proportional to analyte concentration in the absence of an external power source. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring. | 08-26-2010 |
20100213082 | Self-Powered Analyte Sensor - Generally, embodiments of the invention relate to self-powered analyte determining devices (e.g., electrochemical analyte monitoring systems) that include a working electrode, a counter electrode, and an optional resistance value, where the working electrode includes analyte sensing components and the self-powered analyte determining device spontaneously passes a current directly proportional to analyte concentration in the absence of an external power source. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring. | 08-26-2010 |
20100270180 | SERVICE-DETECTABLE ANALYTE SENSORS AND METHODS OF USING AND MAKING SAME - Generally, embodiments of the invention relate to analyte determining devices (e.g., electrochemical analyte monitoring systems) that include an indicator element that provides information relating to service history of the analyte determining devices, including, for example, previous use of the analyte determining devices. Also provided are systems and methods of using the, for example electrochemical, analyte determining devices in analyte monitoring. | 10-28-2010 |
20110046465 | Analyte Sensors and Methods of Use - An analyte sensor system including a substrate, a first electrode disposed on a first surface of the substrate, a second electrode disposed on a second surface of the substrate, a third electrode provided in electrical contact with at least one of the first or second electrodes, where at least a portion of the first electrode and the second electrode are subcutaneously positioned in a patient, and where the third electrode is substantially entirely positioned external to the patient, and corresponding methods are provided. | 02-24-2011 |
20110046466 | Analyte Sensors Including Nanomaterials and Methods of Using Same - Generally, embodiments of the invention relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of one or more components, improved stability, and improved response time of the sensor by inclusion of a nanomaterial, such as inert inorganic nanomaterials, where the components are disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring. | 02-24-2011 |
20110257495 | Analyte Monitoring Device and Methods - Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts , on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes , on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided. | 10-20-2011 |
20120078070 | Redox Polymer Based Reference Electrodes Having An Extended Lifetime For Use In Long Term Amperometric Sensors - The present application provides redox polymer based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions. | 03-29-2012 |
20120088995 | Analyte Monitoring Devices and Methods - Methods and devices for providing application specific integrated circuit architecture for a two electrode analyte sensor or a three electrode analyte sensor are provided. Systems and kits employing the same are also provided. | 04-12-2012 |
20120132525 | REDOX POLYMERS FOR USE IN ANALYTE MONITORING - Polymers for use as redox mediators in electrochemical biosensors are described. The transition metal complexes attached to polymeric backbones can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. | 05-31-2012 |
20120165636 | Systems and Methods for Improved In Vivo Analyte Sensor Function - Embodiments of the present disclosure relate to systems for improving the performance of one or more components of a sensor, such as an in vivo analyte sensor, including, for example, continuous and/or automatic in vivo analyte sensors, by detecting inflammation at an insertion site and adjusting the signal of the sensor, adjusting the display of the signal (e.g., inactivation of display), or indicating administration of an anti-inflammatory agent, such as an interleukin 1 receptor antagonist. Embodiments of the present disclosure also relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved signal response and stability by inclusion of one or more of a clot activator and/or an immunosuppressant proximate to a working electrode of an in vivo analyte sensor. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring. | 06-28-2012 |
20120296186 | Analyte Sensors Having a Membrane with Low Temperature Sensitivity - Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane with low temperature sensitivity. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring. | 11-22-2012 |
20120330120 | Analyte Monitoring: Stabilizer for Subcutaneous Glucose Sensor with Incorporated Antiglycolytic Agent - An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring. | 12-27-2012 |
20130006079 | Analyte Sensor, and Associated System and Method Employing a Catalytic Agent - An analyte sensor for use in connection with a biofluid is described. The analyte sensor may comprise any suitable interface between the biofluid and a derivative of the biofluid and any suitable transducer of information concerning an analyte. At least one catalytic agent is provided in a locale or vicinity of the interface. The catalytic agent, such as a proteinaceous agent or a non-proteinaceous, organic-metal agent, is sufficient to catalyze the degradation of reactive oxygen and/or nitrogen species that may be present in the vicinity of the interface. An analyte-sensing kit and a method of sensing an analyte are also described. | 01-03-2013 |
20130053667 | Reference Electrodes Having an Extended Lifetime for use in Long Term Amperometric Sensors - The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions. | 02-28-2013 |
20130184546 | Service-Detectable Analyte Sensors and Methods of Using and Making Same - Generally, embodiments of the invention relate to analyte determining devices (e.g., electrochemical analyte monitoring systems) that include an indicator element that provides information relating to service history of the analyte determining devices, including, for example, previous use of the analyte determining devices. Also provided are systems and methods of using the, for example electrochemical, analyte determining devices in analyte monitoring. | 07-18-2013 |
20140026646 | Analyte Sensors and Methods of Using Same - Provided are sensors for determining the concentration of an analyte in a sample fluid. In certain embodiments, the sensors include conductive particles and exhibit improved uniformity of distribution of one or more sensing chemistry components, increased effective working electrode surface area, and/or reduced entry of interfering components into a sample chamber of the sensor. Methods of using and manufacturing the sensors are also provided. | 01-30-2014 |
20140054171 | Analyte Sensor Utilizing Oxygen as Oxidant - An analyte sensor configured to utilize oxygen as an oxidant and method for manufacturing and using the same are provided. The analyte sensor includes a catalyst to facilitate use of oxygen as oxidant. The catalyst may be provided on an electrode of the analyte sensor. | 02-27-2014 |
20140085600 | FACILITATION OF TEMPERATURE COMPENSATION FOR CONTACT LENS SENSORS AND TEMPERATURE SENSING - Apparatus, systems and methods employing contact lens sensors are provided. In some aspects, a contact lens includes a substrate and a circuit. The circuit can include: one or more sensors disposed on or within the substrate, that sense a feature associated with a wearer of the contact lens; and a compensation circuit disposed on or within the substrate, coupled to the sensor(s) and that outputs information to adjust an output of the sensor(s). The compensation circuit can include: a temperature component that senses the temperature of the sensor(s); and a communication component that outputs information indicative of the temperature of the sensor(s), and receives information associated with adjusting the output of the sensor(s). In other aspects, a contact lens includes a circuit that senses the body temperature, or ambient temperature outside of the body, of the contact lens wearer. Sensor fusion and/or calibration can be performed based on the information. | 03-27-2014 |
20140087452 | IN-VITRO CONTACT LENS TESTING - Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated. | 03-27-2014 |
20140088381 | FACILITATION OF TEAR SAMPLE COLLECTION AND TESTING USING A CONTACT LENS - Apparatus, systems and methods are provided that employ contact lenses that facilitate testing for an analyte present within tear fluid. In an aspect, a contact lens includes a substrate that forms at least part of a body of the contact lens and one or more cavities disposed within the substrate configured to collect and store tear fluid over time when the contact lens is worn over an eye. In another aspect, a contact lens includes a substrate that forms at least part of a body of the contact lens and one or more receptors disposed on or within the substrate, the one or more receptors are configured to bind to a known ligand. | 03-27-2014 |
20140107444 | Microelectrodes In An Ophthalmic Electrochemical Sensor - An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have at least one dimension less than 25 micrometers. The reference electrode can have an area at least five times greater than an area of the working electrode. A portion of the polymeric material can surround the working electrode and the reference electrode such that an electrical current conveyed between the working electrode and the reference electrode is passed through the at least partially surrounding portion of the transparent polymeric material. | 04-17-2014 |
20140107445 | Microelectrodes In An Ophthalmic Electrochemical Sensor - An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have at least one dimension less than 25 micrometers. The reference electrode can have an area at least five times greater than an area of the working electrode. A portion of the polymeric material can surround the working electrode and the reference electrode such that an electrical current conveyed between the working electrode and the reference electrode is passed through the at least partially surrounding portion of the transparent polymeric material. | 04-17-2014 |
20140107447 | In-vitro Calibration Of An Ophthalmic Analyte Sensor - An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. A calibration-solution measurement is obtained while the eye-mountable device is exposed to a calibration solution. A calibration value is determined based on at least the calibration-solution measurement and an analyte concentration of the calibration solution. A tear-film measurement is obtained while the eye-mountable device is mounted to an eye so as to be exposed to tear film. The analyte concentration of the tear film is determined based on at least the tear-film measurement and the calibration value. | 04-17-2014 |
20140107448 | In-vitro Calibration Of An Ophthalmic Analyte Sensor - An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. A calibration-solution measurement is obtained while the eye-mountable device is exposed to a calibration solution. A calibration value is determined based on at least the calibration-solution measurement and an analyte concentration of the calibration solution. A tear-film measurement is obtained while the eye-mountable device is mounted to an eye so as to be exposed to tear film. The analyte concentration of the tear film is determined based on at least the tear-film measurement and the calibration value. | 04-17-2014 |
20140141487 | Cationic Polymer Based Wired Enzyme Formulations for Use in Analyte Sensors - Embodiments of the invention include analyte-responsive compositions and electrochemical analyte sensors having a sensing layer that includes an analyte-responsive enzyme and a cationic polymer. Also provided are systems and methods of making the sensors and using the electrochemical analyte sensors in analyte monitoring. | 05-22-2014 |
20140190839 | CONTACT LENSES HAVING TWO-ELECTRODE ELECTROCHEMICAL SENSORS - Apparatus, systems and methods employing contact lenses with two-electrode electrochemical sensors are provided. In some aspects, the contact lens includes: a substrate that forms at least part of a body of the contact lens; and a circuit, disposed on or within the substrate, and including a two-electrode electrochemical sensor. The two-electrode electrochemical sensor can include: a working electrode; and a combination reference-counter electrode. The electrochemical sensor can be an amperometric sensor that senses a biological feature of a wearer of the contact lens. The working electrode can generate a signal indicative of the sensed analyte, and the combination reference-counter electrode can pass the signal generated from the working electrode. The signal can be employed to determine the analyte concentration of a solution in contact with the contact lens. | 07-10-2014 |
20140192315 | IN-SITU TEAR SAMPLE COLLECTION AND TESTING USING A CONTACT LENS - Apparatus, systems and methods employing contact lenses having one or more sensor that sense an analyte in tear fluid and one or more recesses that collect the tear fluid. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a recess formed within the substrate configured to collect tear fluid when the contact lens is worn. The contact lens further includes at least one sensor disposed within the substrate configured to sense presence of an analyte in the collected tear fluid. | 07-10-2014 |
20140194706 | IN-SITU TEAR SAMPLE COLLECTION AND TESTING USING A CONTACT LENS - Apparatus, systems and methods employing contact lenses having one or more sensor that sense an analyte in tear fluid and one or more recesses that collect the tear fluid. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a recess formed within the substrate configured to collect tear fluid when the contact lens is worn. The contact lens further includes at least one sensor disposed within the substrate configured to sense presence of an analyte in the collected tear fluid. | 07-10-2014 |
20140194713 | CONTACT LENSES HAVING TWO-ELECTRODE ELECTROCHEMICAL SENSORS - Apparatus, systems and methods employing contact lenses with two-electrode electrochemical sensors are provided. In some aspects, the contact lens includes: a substrate that forms at least part of a body of the contact lens; and a circuit, disposed on or within the substrate, and including a two-electrode electrochemical sensor. The two-electrode electrochemical sensor can include: a working electrode; and a combination reference-counter electrode. The electrochemical sensor can be an amperometric sensor that senses a biological feature of a wearer of the contact lens. The working electrode can generate a signal indicative of the sensed analyte, and the combination reference-counter electrode can pass the signal generated from the working electrode. The signal can be employed to determine the analyte concentration of a solution in contact with the contact lens. | 07-10-2014 |
20140206966 | SENSOR - Apparatus, systems and methods employing contact lenses having an electrochemical sensor to detect ethanol concentration of a wearer of the contact lens are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and an electrochemical sensor, disposed on or within the substrate, that detects information related to concentration of alcohol present in blood of a wearer of the contact lens. | 07-24-2014 |
20140329303 | In-vitro contact lens testing - Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated. | 11-06-2014 |
20140336486 | Analyte Monitoring: Stabilizer for Subcutaneous Glucose Sensor with Incorporated Antiglycolytic Agent - An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring. | 11-13-2014 |
20140371558 | Symmetrically Arranged Sensor Electrodes in an Ophthalmic Electrochemical Sensor - An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have a first side edge and a second side edge. The reference electrode can be situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode. | 12-18-2014 |