Patent application number | Description | Published |
20110136163 | Method of Toxicological Assessment - A method of assessing toxicity of a candidate agent to a sample of cells comprises the steps of providing a sample of cells, exposing the cells to the candidate agent for a suitable period of time, assaying the cells to measure data for at least one parameter of cellular function; and correlating the measured data of the at least one parameter of cellular function with toxicity, wherein the step of exposing the cells to the candidate agent is carried out in the presence of a reagent capable of facilitating transport of the candidate agent into the cell. The transport reagent may be an endocytosis, pinocytosis inducing agent, a peptide, or a liposome. The at least one parameter of cellular function may be selected from the group consisting of: cell viability; proliferation rate; membrane integrity; and a metabolic parameter. Also described is a method of generating a toxicity signature for a candidate agent comprising the step of carrying out the method of the invention for a plurality of cellular function parameters, and compiling the measured data for each of the cellular function parameters to provide a toxicity signature. | 06-09-2011 |
20130280751 | METHOD AND PROBE FOR MONITORING OXYGEN STATUS IN LIVE MAMMALIAN CELLS - The invention is based on the use of photoluminescent probes for intracellular sensing of oxygen, especially assaying intracellular oxygen concentration. The photoluminescent probe comprises a suspension of polymeric particles having an average diameter in the 20 nm to 100 nm range, formed from an amphiphilic cationic co-polymer which is oriented in the formed particle to provide a hydrophobic core and a hydrophilic shell. The probe includes a hydrophobic oxygen-sensitive photoluminescent dye such as Pt-tetrakis(pentafluorophenyl)porphine, PtPFPP embedded in the hydrophobic core of the particle, and the co-polymer includes quaternary ammonium groups which provide hydrophilic and cationic character to the particle shell. The photoluminescent probe, which in use is provided in the form of an aqueous suspension of probe, is incubated with live mammalian cells in a suitable growth medium for a period of time to allow the probe particles passively load into the cells. Oxygen can then be sensed by detecting a photoluminescent signal of the photoluminescent probe, which can be correlated with oxygen status, for example oxygen concentration or changes in oxygen concentration/levels, using existing techniques. | 10-24-2013 |
Patent application number | Description | Published |
20090069987 | Automatic Blade Control System with Integrated Global Navigation Satellite System and Inertial Sensors - Disclosed are method and apparatus for controlling the blade elevation and blade slope angle of a dozer blade. Elevation and slope angle measurements are calculated from measurements received from a global navigation satellite system (GNSS) antenna and an inertial measurement unit mounted on the dozer blade. The inertial measurement unit includes three orthogonally placed accelerometers and three orthogonally placed rate gyros. The measurements are processed by algorithms to calculate estimates of the blade elevation, blade vertical velocity, blade slope angle, and blade slope angular velocity. These estimates are then provided as inputs to a control algorithm which provides control signals to control a dozer hydraulic system which controls the blade elevation and blade slope angle. | 03-12-2009 |
20120130602 | Automatic Blade Control System with Integrated Global Navigation Satellite System and Inertial Sensors - Disclosed are method and apparatus for controlling the blade elevation and blade slope angle of a dozer blade. Elevation and slope angle measurements are calculated from measurements received from a global navigation satellite system (GNSS) antenna and an inertial measurement unit mounted on the dozer blade. The inertial measurement unit includes three orthogonally placed accelerometers and three orthogonally placed rate gyros. The measurements are processed by algorithms to calculate estimates of the blade elevation, blade vertical velocity, blade slope angle, and blade slope angular velocity. These estimates are then provided as inputs to a control algorithm which provides control signals to control a dozer hydraulic system which controls the blade elevation and blade slope angle. | 05-24-2012 |
20130261902 | Automatic Control of a Joystick for Dozer Blade Control - Dozers outfitted with manual or electric valves can be retrofitted with a control system for automatically controlling the elevation and orientation of the blade. No modification of the existing hydraulic drive system or existing hydraulic control system is needed. An arm is operably coupled to the existing joystick, whose translation controls the elevation and orientation of the blade. The arm is driven by an electrical motor assembly. Measurement units mounted on the dozer body or blade provide measurements corresponding to the elevation or orientation of the blade. A computational system receives the measurements, compares them to target reference values, and generates control signals. Drivers convert the control signals to electrical drive signals. In response to the electrical drive signals, the electrical motor assembly translates the arm, which, in turn, translates the joystick. If necessary, an operator can override the automatic control system by manually operating the joystick. | 10-03-2013 |
20140207331 | ESTIMATION OF THE RELATIVE ATTITUDE AND POSITION BETWEEN A VEHICLE BODY AND AN IMPLEMENT OPERABLY COUPLED TO THE VEHICLE BODY - An implement having an implement acceleration is operably coupled to a vehicle body having a body acceleration. An attitude of the implement is estimated by receiving acceleration measurements from an accelerometer mounted on the vehicle body and an accelerometer mounted on the implement. A state vector estimate is calculated based at least in part on the body acceleration measurement and the implement acceleration measurement. The state vector estimate includes a representation of the attitude of the implement relative to the vehicle body. In addition to the accelerometer measurements, angular velocity measurements can be received from a gyro mounted on the vehicle body and a gyro mounted on the implement. The state vector estimate is then calculated based at least in part on the body acceleration measurement, the implement acceleration measurement, the body angular velocity measurement, and the implement angular velocity measurement. | 07-24-2014 |
20150308074 | Semi-Automatic Control of a Joystick for Dozer Blade Control - On a dozer, a semi-automatic system automatically translates a joystick to control blade elevation and provides an indicator display to guide manual control of blade slope angle. A mechanical linkage operably couples the joystick to an electrical motor. A computational system receives measurements from measurement units mounted on the dozer; calculates estimated values of elevation and slope angle; compares the estimated values to reference values; and calculates error and control signals. Drivers generate a motor drive signal and a display drive signal. In response to the motor drive signal, the electrical motor translates the joystick to control elevation. In response to the display drive signal, the indicator display generates a graphical representation of the status of slope angle. When the operator needs to take manual control, a proximity sensor detects the presence of at least a portion of the operator's hand, wrist, or forearm and disengages automatic control of elevation. | 10-29-2015 |
Patent application number | Description | Published |
20090119040 | SECURITY SCREENING AND INSPECTION BASED ON BROADBAND ELECTROMAGNETIC HOLOGRAPHIC IMAGING - A method of security screening and inspection of people in airlines, ships, or secured buildings, involves placing an array of transmitters and receivers in operational association with the medium. The transmitters generate a broad band harmonic (frequency domain) or pulse (time domain) primary electromagnetic field (EM) field, including the lower frequency portions of the EM spectrum, whose propagation is typically characterized by the diffusion phenomena, or by the combination of the diffusion and wave phenomena. The primary field propagates through and interacts with the examined person and any objects carried by the person to produce a scattered field, which is recorded by the receivers. The scattered EM field components measured by the receivers are applied as an artificial EM field to generate a backscattering EM field. Cross power spectra of the primary and backscattering fields (in the frequency domain) or cross correlation between these fields (in the time domain) produce a numerical reconstruction of an EM hologram. The desired properties of the person, including the properties of any objects carried by the person, such as conductivity or dielectric permittivity, are then derived from this hologram. | 05-07-2009 |
20100179762 | Method of Correcting Imaging Data For Standoff and Borehole Rugosity - An apparatus having transmitter and receiver antennas is provided for measuring conductivity of an earth formation surrounding a borehole. The apparatus utilizes an initial model to invert induction measurements of the earth formation to provide a conductivity model that includes a plurality of coaxial cylinders. | 07-15-2010 |
20110175603 | Method and Apparatus for Measuring Magnetic Fields - A new ultra-sensitive magnetometer is disclosed and described. The ultra-sensitive magnetometer relies on non-tunneling magneto-transport (MT) and control of MT in organic solid state devices. These organic devices can have different active components as magnetic and non-magnetic polymers and self-assembled monolayers (SAMs). Magnetic field sensors can include a pair of electrodes spaced apart from one another. An organic layer can be oriented between the pair of electrodes to form an organic solid state device, wherein at least one of the organic layer and electrodes is magnetic and when the organic layer is not magnetic the organic layer comprises a self assembled monolayer and the magnetic field sensor operates under non-tunneling magnetic spin transport. | 07-21-2011 |
Patent application number | Description | Published |
20100194394 | SYSTEMS AND METHODS FOR REMOTE ELECTROMAGNETIC EXPLORATION FOR MINERAL AND ENERGY RESOURCES - A method for measuring the resistivity of geologic formations is described. An electromagnetic field may be generated using at least one stationary long-range transmitter. The frequency of the electromagnetic field may be between and/or including the ULF/ELF range. At least one component of the electromagnetic field may be measured by land, marine, and/or airborne receiver. A conductivity distribution may be determined based on the at least one measured component. The determined conductivity distribution may be correlated with geological formations and/or hydrocarbon deposits. | 08-05-2010 |
20110144472 | METHODS OF GRAVITY AND/OR MAGNETIC HOLOGRAPHIC IMAGING USING VECTOR AND/OR TENSOR DATA - A method for holographic imaging an object having density and/or magnetization is described, the object being located in an examined medium using potential field data including but not limited to gravity and/or magnetic total field and/or vector and/or tensor data. The potential field sensors may measure the gravity and/or magnetic total field and/or vector and/or tensor data at least one receiving position with respect to the examined medium. At least one component of the measured potential field in at least one receiver location (potential field data) may be used as at least one artificial source of the potential field data. Artificial sources may produce a back-propagating (migration) field. An integrated sensitivity of the potential field data to density and/or magnetization perturbation may be calculated. A spatial weighting of at least one of the back-scattering (migration) fields may form a potential field holographic image. At least one desired property of the medium, such as density and/or magnetization, may be derived from this holographic image. | 06-16-2011 |
20120026314 | METHODS OF ELECTROMAGNETIC MIGRATION IMAGING OF GEOLOGIC FORMATION - Methods and systems for imaging-while-drilling and look-ahead imaging of a geological formation using a borehole devices measuring multi-component vector and/or tensor logging data. An electromagnetic field transmitter generates an electromagnetic field. Electromagnetic receivers measure the response from the geological formation around the borehole and ahead of the device at various receiving positions. A central processing unit may compute a migration field by simulating the replacement of the receivers with conceptual transmitters, calculate an integrated sensitivity of the recorded electromagnetic field data, compute a reference field, and calculate a cross power spectra of the reference and the migration fields or cross correlation functions between the reference and the migration fields. A spatial weighting of the cross power spectra or cross correlation functions produces a numerical reconstruction of directional images and look-ahead images of the conductivity distribution around the borehole and/or ahead of the device located within the borehole. | 02-02-2012 |
20130018585 | METHOD OF REAL TIME SUBSURFACE IMAGING USING ELECTROMAGNETIC DATA ACQUIRED FROM MOVING PLATFORMS - A method for the real time volume imaging of geological structures and/or man-made objects having electrical conductivity is described, using electromagnetic (EM) sources and/or EM sensors mounted from at least one moving platform. The EM sources may include natural EM sources and/or man-made inductive sources and/or man-made galvanic sources. The EM sensors may measure at least one component of the EM field at the at least one sensor position. The EM fields measured for each combination of EM source and EM sensor may be volume imaged in real time using a moving sensitivity domain that captures the finite spatial sensitivity of each combination of EM sources and EM sensors. At least one desired property, such as conductivity, dielectric permittivity and/or induced polarization parameters, may be derived from the volume image, providing a reconstruction or classification of the physical properties of the geological structures and/or man-made objects. | 01-17-2013 |
20130018588 | METHOD OF REAL TIME SUBSURFACE IMAGING USING GRAVITY AND/OR MAGNETIC DATA MEASURED FROM A MOVING PLATFORM - A method for rapid real time imaging of geological formations and/or man-made objects having density and/or magnetization is described, using gravity and/or magnetic scalar and/or vector and/or tensor data measured by a moving platform. The gravity and/or magnetic field sensors may measure gravity and/or magnetic data at the at least one receiver along the survey lines by the moving platform. The recorded data may be applied as an artificial source of the potential field to generate an evolving migration (backpropagating) field, and may be applied iteratively. An integrated sensitivity of the potential field to density and/or magnetization perturbation may be calculated. A spatial weighting of at least one of the evolving migration fields may form an evolving real time holographic image. At least one desired property of the medium may be derived providing real time reconstruction of the volume physical properties of the geological formations and/or man-made objects. | 01-17-2013 |
20130253874 | METHODS OF CONSTRUCTING DATA ACQUISITION SYSTEMS WITH FOCUSING CONTROLLED SENSITIVITY - A method for constructing data acquisition systems with focusing controlled sensitivity, capable of resolving physical parameters of the targeted area of a medium under investigation. The sensors of a data acquisition system may measure different physical fields and signals, generated by natural or artificial sources, including seismic, electromagnetic, gravity and/or magnetic fields, and/or optical, radio, low and high frequency radiation signals. A sensitivity of the data acquisition system to the parameters of the examined medium may be calculated. A priori integrated sensitivity, having maximum values within desirable parts of the examined medium, may be selected. The parameters of the optimal transformation of the original data acquisition system into a new one with integrated sensitivity closely duplicating the preselected sensitivity may be determined. This optimal transformation may be applied to the sensors of the original data acquisition system to construct a new data acquisition system with focusing controlled sensitivity. | 09-26-2013 |
20130338923 | SYSTEMS AND METHODS FOR REMOTE ELECTROMAGNETIC EXPLORATION FOR MINERAL AND ENERGY RESOURCES USING STATIONARY LONG-RANGE TRANSMITTERS - A method for measuring the resistivity of geologic formations is described. An electromagnetic field may be generated using at least one stationary long-range transmitter. The frequency of the electromagnetic field may be between and/or including the ULF/ELF range. At least one component of the electromagnetic field may be measured by land, marine, submarine, and/or airborne receiver. A conductivity distribution may be determined based on the at least one measured component. The determined conductivity distribution may be correlated with geological formations and/or hydrocarbon deposits. | 12-19-2013 |
20140056481 | METHODS OF MULTINARY INVERSION FOR IMAGING OBJECTS WITH DISCRETE PHYSICAL PROPERTIES - A method of multinary inversion for imaging objects with discrete physical properties of the examined medium is described. The model parameters of the target area are parameterized in terms of a multinary function of the physical properties that accepts a finite number of discrete values from the continuum of at least one physical property. The multinary function is chosen such that the derivative of the multinary function with respect to the physical property is a continuous and known function. The imaging is based on solving the optimization problem for parametric functional of the multinary functions describing the target model parameters. The method can be applied for multi-modal imaging, such that at least one physical property representing the physical properties of the examined medium, may be derived to provide a reconstruction or classification of the physical properties of the examined medium. | 02-27-2014 |
20140129194 | METHODS OF THREE-DIMENSIONAL POTENTIAL FIELD MODELING AND INVERSION FOR LAYERED EARTH MODELS - A method for 3D modeling and inversion of potential field geophysical survey data measured above a geological formation having density and/or magnetization and/or susceptibility is described, using potential field data including but not limited to gravity and/or magnetic scalar and/or vector and/or tensor data. The 3D earth model is parameterized in terms of spatially variable contrast surfaces between different geological formations which are characterized by physical properties such as density and/or magnetization and/or susceptibility values and/or functions. The properties of the 3D earth model may be constrained from a priori information. The potential field responses and/or Frechet derivatives (sensitivities) of the spatially variable contrast surfaces between different geological formations and/or physical properties are analytically evaluated using Cauchy-type integral representations of the potential fields for each of the contrast surfaces. | 05-08-2014 |