15th week of 2021 patent applcation highlights part 23 |
Patent application number | Title | Published |
20210108129 | ENERGIZED NATURAL GAS FOAM DELIVERY DEVICES AND METHODS - Foaming formulations and methods and systems for using foaming formulations are disclosed. Concentric tubing can be positioned in a wellbore in a subterranean formation to position an exit orifice of the concentric tubing at a target zone. A foaming formulation can be injected through a first flow path of the concentric tubing and a blowing gas can be injected through a second flow path of the concentric tubing to maintain separation until the foaming formulation and the blowing gas exit the concentric tubing. Mixing of the foaming formulation and the blowing gas at the target zone can generate foam. | 2021-04-15 |
20210108130 | Chemical Additives for Enhancing the Performance of Friction Reducer Solution and Its Applications Thereof - Chemical additives useful for hydraulic fracturing operation are comprising of lubricant/nonpolar solvents; hydro-dual-phobic domains as core encapsulated by emulsifiers as shell, suspended in water by hydrogel polymers as hydrophilic domains; soy protein isolate (SPI) and sweet rice flour were modified with crosslinking polymers of isocyanate as hydrophobic domains, which is incorporated into the frac fluid as a standard alone friction reducer solution or as an enhancer of frac fluid viscosity of the final frac fluid products in high salinity brines having a concentration as high as 25.0% at an ambient temperature at a downhole well temperature from 30 to 180° F. | 2021-04-15 |
20210108131 | Multifunctional Coatings and Chemical Additives - Multifunctional coatings and chemical additives, comprising of lubricant, micro/nano-textured particles, emulsifiers, hydrogel polymers, cross-linking agent to modify the hydrogel polymers, antimicrobial to preserve the bio-based materials, and water solvent, are useful in hydraulic fracturing operation either directly applied on the surface of proppants, or/and mixed with other friction reducer additives to totally or partially substitute the regular friction reducer chemicals, alternatively, as additive components blended or mixed into regular fracturing fluid for easily pumping proppants downhole and stabilizing the pumping pressure; beneficial to the well productivity, effectively suppress and mitigate the risk of respirable microcrystalline dust as the coated materials are transported and handled in the manufacturing plant, terminal, and oil application fields without a need for drying operation on the coating products. | 2021-04-15 |
20210108132 | WELL TREATMENT COMPOSITIONS AND METHODS COMPRISING CERTAIN MICROEMULSIONS AND CERTAIN CLAY CONTROL ADDITIVES EXHIBITING SYNERGISTIC EFFECT OF ENHANCING CLAY SWELLING PROTECTION AND PERSISTENCY - Compositions and methods comprising certain microemulsions and certain clay control additives for enhancing clay swelling protection and persistency in treating swelling clay of a subterranean formation of oil and/or gas wells are generally provided. The combination of certain microemulsions and certain clay control additives exhibit synergistic effects by enhancing clay swelling protection and persistency in treating swelling clay. The well treatment composition may use up to four times less concentration of clay control additive compared to using the same clay control additive alone, while still providing the same, similar, or higher degree of clay swelling protection and enhanced persistency. The microemulsion and the clay control additive may be added to a carrier fluid to form the well treatment composition, which is injected into the subterranean formation to provide enhanced clay swelling protection and persistency of continuing to provide clay swelling protection for a longer period of time during flowback. | 2021-04-15 |
20210108133 | COMPOUND, COLOR CONVERSION COMPOSITION AND COLOR CONVERSION FILM COMPRISING SAME, BACK LIGHT UNIT COMPRISING SAME, DISPLAY DEVICE COMPRISING SAME, AND METHOD FOR MANUFACTURING COLOR CONVERSION FILM - The present specification relates to a compound having structure openness for a boron atom of 0.5 or less, a color conversion composition and a color conversion film including the same, a backlight unit including the same, a display apparatus including the same, and a method for manufacturing a color conversion film. | 2021-04-15 |
20210108135 | QUANTUM DOT, CURABLE COMPOSITION COMPRISING THE SAME, CURED LAYER USING THE COMPOSITION AND COLOR FILTER INCLUDING THE CURED LAYER - Quantum dots surface-modified with a compound represented by Chemical Formula 1 or Chemical Formula 2, a curable composition including the quantum dots, a cured layer, and a color filter. | 2021-04-15 |
20210108136 | Coherent Poly Propagation Materials with 3-Dimensional Photonic Control Over Visible Light - Nano-silicates are the template for photonic control materials with research for a material allowing three-dimensional (3-d) photonic control ongoing for years. This author discovered a material that physically enables 3-d photonic control over the visible spectrum via the previously unidentified property of coherent poly propagation (CPP). CPP allows actualized 3-d photonic demultiplexing in several precious opal nano-silicate specimens. This is a working material that accurately demultiplexes, up/downconverts and propagates the shapes of several types of mono and polychromatic incident light sources. This material is a durable 3-d demultiplexing photonic waveguide that works without cables. The propagated shapes are able to be manually moved across the 3-d specimen surfaces. Other, previously unknown, properties displayed by this material: spectrophotometric and polariscopic play-of-color, plus photonic rotational symmetry. This material is environmentally friendly, in that it emits no beta or alpha particles, performs at ambient temperatures/pressures and is made of commonly available silica. | 2021-04-15 |
20210108137 | METHOD FOR PREPARING CsPbX3 PEROVSKITE QUANTUM DOT FILM BY ONE-STEP CRYSTALLIZATION - The present disclosure provides a method for preparing a perovskite quantum dot film by one-step crystallization, and belongs to the field of perovskite quantum dot material technology. The present disclosure uses adamantanemethylamine and hydrohalic acid as ligands, first mixes a cesium halide, a lead halide, and the ligands with a solvent to obtain a precursor solution, then deposits the precursor solution on a substrate, and then heats the substrate to obtain the CsPbX | 2021-04-15 |
20210108138 | MATERIALS COMPRISING MATRIX MATERIAL DOPED WITH METAL AND METHODS FOR FABRICATION - A material comprising a first layer of matrix material doped with a dopant metal is disclosed. The matrix material comprises a rare-earth metal, oxygen, and one or both of sulfur and selenium. In the first layer of matrix material doped with the dopant metal, the rare-earth metal has an oxidation state of +3 and the dopant metal has an oxidation state of +2. Further is disclosed a method for fabricating the material and a device comprising the material. | 2021-04-15 |
20210108139 | PHOSPHOR AND SEMICONDUCTOR LIGHT EMITTING DEVICE USING THE SAME - A phosphor is represented by a chemical formula of Lu | 2021-04-15 |
20210108140 | WET ETCHING COMPOSITION AND METHOD - The invention provides a composition and method for improving the selectivity of nitride etching versus oxide etching and can be used with conventional phosphoric acid wet etch compositions. The invention describes additives that serve to inhibit silicon, oxides, and related compounds regrowth (i.e., redeposition) on the silicon oxide surface. In certain embodiments, the invention provides certain amino-substituted aryl compounds which are bound to a tri-alkoxy silane. | 2021-04-15 |
20210108141 | QUINONE METHIDE AND AMMONIUM SALT ANTIPOLYMERANT COMPOSITION AND METHOD - Described are compositions and methods for inhibiting polymerization of a monomer (e.g., styrene) composition a quinone methide polymerization retarder and an ammonium salt. In a mixture, the ammonium salt improves the efficacy of the quinone methide polymerization retarder and provides greater antipolymerant activity. In turn, the mixture reduces or prevents apparatus fouling and improves the purity of monomer streams. | 2021-04-15 |
20210108142 | POLARIZED LUMINESCENT FILM - To provide a polarized luminescent film obtained by applying, to a substrate material, a polymerizable composition including a rod-like luminescent nanocrystal and a polymerizable liquid crystal compound, and radiating an active energy ray, and to provide a film having good polarization characteristics. The present invention provides a polarized luminescent film and a polarized luminescent multilayered body formed from a polymerizable composition containing a rod-like luminescent nanocrystal and a polymerizable liquid crystal compound. The present invention also provides a backlight and a display device including a polarized luminescent multilayered body according to the present invention. | 2021-04-15 |
20210108143 | LIQUID CRYSTAL DISPLAY DEVICE, METHOD FOR MANUFACTURING LIQUID CRYSTAL DISPLAY DEVICE, AND ELECTRONIC APPARATUS - A liquid crystal display device includes an element substrate, a counter substrate, a liquid crystal layer sandwiched between the element substrate and the counter substrate, reflective electrodes placed on a surface of the element substrate that is located on the liquid crystal layer side, and a pair of alignment films each of which is placed on a corresponding one of a surface of the element substrate that is located on the liquid crystal layer side and a surface of the counter substrate that is located on the liquid crystal layer side. A liquid crystal composition contained in the liquid crystal layer contains a compound containing an alkoxy group. The alignment films contain a polymer including polyimide. The polyimide is derived from a polyamic acid and contains a side chain represented by Formula (1). | 2021-04-15 |
20210108144 | FIREPROOF BUFFERING STRUCTURE, SUPPORTING CUSHION APPARATUS AND CHILD SAFETY CAR SEAT THEREWITH - A fireproof buffering structure includes a buffering plate and a fireproof plate attached thereto. A combustion rate of the fireproof plate is lower than that of the buffering plate. In contrast to conventional buffering structures, the fireproof buffering structure adopts the combined buffering plate and fireproof plate. The buffering plate has good impact absorbing capacity for providing a soft and comfortable seating environment and buffering and protection effects during a crash accident, and the fireproof plate can reduce the combustion rate of the integral structure when catching fire. Therefore, the fireproof buffering structure achieves the purposes of safety and comfort. The present application further discloses a supporting cushion apparatus which includes a covering member and the aforementioned fireproof buffering structure accommodated therein. The present application further discloses a child safety car seat which includes the aforementioned fireproof buffering structure and the supporting cushion apparatus. | 2021-04-15 |
20210108145 | TREATMENT FOR UPGRADING HEAVY CRUDE OIL - The subject invention provides microbe-based products, as well as their use to improve oil well production and increase the value of heavy crude oil. Specifically, the subject invention provides cultivated yeast products, which can be applied to oil and/or oil and gas production equipment to improve production and increase the economic value of heavy crude oil by, for example, upgrading heavy oils and/or converting heavy hydrocarbon substances, such as asphalts, asphaltenes, tars, bitumens and/or petcokes into lighter hydrocarbon substances. | 2021-04-15 |
20210108146 | ADDITIVE MANAGEMENT SYSTEM - A system including an additive management system configured to oversee hydrate formation in a hydrocarbon extraction system, the additive management system including a flow meter configured to measure a fluid flow rate, a first sensor configured to measure at least one of a fluid property and an environmental condition, and a chemical injection device configured to inject a hydrate inhibitor into a fluid flow. | 2021-04-15 |
20210108147 | LIGHT OIL REFLUX HEAVIES REMOVAL PROCESS - The invention relates to various nonlimiting embodiments that include methods, apparatuses or systems for processing natural gas comprising a heavies removal column processing natural gas and light oil reflux. The overhead stream goes to heavies treated natural gas storage. The heavies removal column reboiler bottoms stream product is input to a debutanizer column. The debutanizer column overhead lights are input to a flash drum where the bottoms is pumped through a heat exchanger as a light oil reflux input to the heavies removal column, while the debutanizer reboiler bottoms product is stored as stabilized condensate. Alternatively, debutanizer column overhead lights are sent to heavies treated gas storage and the bottoms stream product goes to a depentanizer column, the overhead lights are pumped through a heat exchanger as a light oil reflux input to the heavies removal column, while the depentanizer reboiler bottoms product is stabilized condensate. | 2021-04-15 |
20210108148 | LUBRICANTS WITH IMPROVED SEAL COMPATIBILITY - The present invention relates to lubricating compositions and particularly gear oil compositions that include a specific class of substituted triazoles, where the substituted triazole includes at least one hydrocarbyl group linked to one of the nitrogen atoms in the triazole ring. Such compositions provide surprisingly good seal compatibility compared to compositions with other triazoles and/or alternative additives. | 2021-04-15 |
20210108149 | Conjugated Linoleic Acid Composition and Method for Producing Same - The present invention provides a conjugated linoleic acid containing c9,t11-conjugated linoleic acid, wherein the mass ratio of total t10,c12-conjugated linoleic acid to total c9,t11-conjugated linoleic acid is less than 0.25. | 2021-04-15 |
20210108150 | PROCESS FOR PRODUCING OILS AND DEFATTED MEAL BY MEANS OF SOLID/LIQUID EXTRACTION - The present invention relates to a process for producing an oil and a defatted cake by solid/liquid extraction. The process comprises a step of solid/liquid extraction using a solvent comprising 2-methyloxolane and water. | 2021-04-15 |
20210108151 | CONTINUOUS BIOMASS EXTRACTION SYSTEM AND PROCESS - A method for producing valuable organic liquid from a biomass wherein a gas is heated to a predetermined temperature to produce a heated gas. The heated gas is mixed with a biomass to produce an enriched organic vapor and a biomass waste product. The biomass waste product is separated from the enriched organic vapor. The enriched organic vapor is cooled to produce a liquid organic oil and the liquid organic oil is collected. A system for producing the liquid organic oil wherein the system includes a heat source for heating a gas to produce a heated gas and a first separation unit to separate an enriched organic vapor and a biomass waste product. The enriched organic vapor and the biomass waste product are generated from mixing the heated gas and a biomass. The system also includes a wet scrubber for cooling the enriched organic vapor to remove certain compounds from the enriched organic vapor to generate an enriched organic smoke. The organic smoke can be transformed to the liquid organic oil in an electrostatic precipitator | 2021-04-15 |
20210108152 | A METHOD AND AN APPARATUS FOR PREPARING A HIGH-POLYPHENOLS OLIVE OIL - A process for making olive oil having a high polyphenol content and, in particular a high hydroxytyrosol content, comprises the conventional steps of transforming (II) olives ( | 2021-04-15 |
20210108153 | VETIVER ODORANT - Compounds of formula (I) in the form of any one of its stereoisomers or a mixture thereof are provided, wherein the dotted lines represent a carbon-carbon single bond or a carbon-carbon double bond; and one R | 2021-04-15 |
20210108154 | METHODS FOR PRODUCING ALKYLBENZENES, PARAFFINS, OLEFINS AND OXO ALCOHOLS FROM WASTE PLASTIC FEEDSTOCKS - The present invention relates generally to methods for producing detergent compounds from waste plastic feedstocks. More specifically, the invention relates to methods for producing detergent intermediates, including alkylbenzenes, paraffins, olefins, oxo alcohols, and surfactant derivatives thereof from waste plastic feedstock. | 2021-04-15 |
20210108155 | CLEANING COMPOSITIONS EMPLOYING EXTENDED CHAIN ANIONIC SURFACTANTS - The invention discloses synergistic combinations of surfactant blends and cleaning compositions employing the same. In certain embodiments a surfactant system is disclosed which includes an extended anionic surfactant with novel linker surfactants including one or more of an alkyl glycerol ether, an ethoxylated alkyl glycerol ether, an alcohol ethoxylate and/or a Gemini surfactant. This system forms emulsions with, and can remove greasy and oily stains, even those comprised of non-trans fats. The compositions may be used alone, as a pre-spotter or other pre-treatment or as a part of a soft surface or hard surface cleaning composition. | 2021-04-15 |
20210108156 | METHOD OF LAUNDERING FABRIC - A method of laundering fabrics includes: a) contacting a laundry detergent to water to form a wash liquor, wherein the laundry detergent includes detersive surfactant, wherein the wash liquor includes detersive surfactant at a concentration in the range of from 100 ppm to 2500 ppm; b) contacting fabric to the wash liquor, and washing the fabric in the wash liquor; c) after a period of time of at least 6 minutes from contacting the fabric to the wash liquor, introducing calcium cations into the wash liquor to form a calcium enriched wash liquor, wherein the calcium enriched wash liquor includes calcium cations at a concentration in the range of from 20 ppm to 400 ppm; d) washing the fabric in the calcium-enriched wash liquor for a period of time of at least 2 minutes; and e) removing the excess calcium-enriched wash liquor from the fabric, and rinsing the fabric in water. | 2021-04-15 |
20210108157 | SOLVENT APPLICATION IN BOTTLE WASH USING AMIDINE BASED FORMULAS - According to the invention, the compositions and methods provide for the complete removal of labels, synthetic glues and/or adhesives from a plurality of surfaces through the use of an aqueous or non-aqueous basic organic solvent and/or an amidine, optionally in combination with surfactants, chelants, acidulants and/or additional bottle wash additives. Beneficially, the compositions and methods are suitable for use at lower temperatures and pH conditions, along with under caustic-free and/or reduced caustic conditions to effectively remove such labels, synthetic glues and/or adhesives from a surface within less than about 30 minutes. | 2021-04-15 |
20210108158 | LIQUID HAND DISHWASHING DETERGENT COMPOSITION - The need for a liquid hand-dishwashing composition which provides further improved sudsing volume and longevity when washing dishware, especially at elevated temperatures, using diluted liquid hand dishwashing compositions, and especially in the presence of greasy soil and particulate soil, while avoiding unsightly residues on dishware, is met by combining a sudsing surfactant system with an EO-PO-EO triblock copolymer and a highly ethoxylated nonionic surfactant. | 2021-04-15 |
20210108159 | DETERGENT COMPOSITIONS - An aqueous liquid detergent composition is disclosed. The aqueous liquid detergent composition having suds compatibility and improved cleaning. The composition has from about 1% to about 60%, by weight of the composition, from about 0.001% to about 4.0%, by weight of the composition, of an anti-foam selected from organomodified silicone polymers with aryl or alkylaryl substituents combined with silicone resin and a primary filler, which is modified silica, and from about 0.01% to about 2.5%, by weight of the composition, of a structurant, wherein the structurant is selected from: crystalline, hydroxyl-containing stabilizers, polymer gums, and mixtures thereof. The surfactant system includes linear alkylbenzene sulfonate and between 1% and 30% by weight of alkyl ethoxylated sulfate surfactant. The ratio of linear alkylbenzene sulfonate to alkyl ethoxylated sulfate surfactant is between 1.1:1 to 10:1. | 2021-04-15 |
20210108160 | Materials and Methods for Maintaining Industrial, Mechanical and Restaurant Equipment - The subject invention provides yeast-based products, as well as their use to improve industrial production and performance by, for example, efficiently cleaning contaminating and/or fouling substances such as FOG, biofilm, paraffin, and/or asphaltenes from industrial equipment. | 2021-04-15 |
20210108161 | SANITISING COMPOSITION - The invention relates to methods and liquid compositions suitable for high level disinfection (“HLD”) of medical instruments at close to ambient temperatures. The methods and compositions are also effective for digesting biological contaminants, and, surprisingly, can be used to clean and disinfect concurrently. Both cleaning and disinfection efficacy meet the criteria for cleaning and disinfection of medical devices. Use of compositions according to the invention enable reprocessing of instruments more quickly with greater energy efficacy, and greater convenience than prior art reprocessing methods. Compositions according to the invention are also useful for simultaneous cleaning and disinfecting other surfaces, for example in hospitals, food preparation areas and the like, or fabrics and the like such as are treated in hospital laundries. | 2021-04-15 |
20210108162 | PRECURSOR POLYELECTROLYTE COMPLEXES COMPOSITIONS - The invention relates to compositions and methods of treatment employing compositions comprising polyelectrolyte complexes. The compositions include a water-soluble first polyelectrolyte bearing a net cationic charge or capable of developing a net cationic charge and a water-soluble second polyelectrolyte bearing a net anionic charge or capable of developing a net anionic charge. The total polyelectrolyte concentration of the first solution is at least 110 millimolar. The composition is free of coacervates, precipitates, latex particles, synthetic block copolymers, silicone copolymers, cross-linked poly(acrylic) and cross-linked water-soluble polyelectrolyte. The composition may be a concentrate, to be diluted prior to use to treat a surface. | 2021-04-15 |
20210108163 | METHOD OF STILLAGE CLARIFICATION USING TRANSGLUTAMINASE - Methods, compositions, and systems for fermentation, particularly large scale operations for production of ethanol and dried distiller's grain are provided. Addition of a transglutaminase source to a process stream aids in removing protein from the system in order to provide a high protein feed product and/or provide clarified backset for fermentation. Transglutaminase can be in reagent form or can be produced by microorganisms added to the process stream. | 2021-04-15 |
20210108164 | PUNCH DOWN APPARATUS - The present invention relates to a punch down apparatus and rotating sprayer that is axially movable along its shaft through the supporting vat, also provided with an element for breaking the solid upper cover referred to as “cap” in the art. | 2021-04-15 |
20210108165 | Organics Removal For Algae Biofuel Systems - A system for growing algae for biofuel production includes a bioreactor configured to contain an algae slurry, an algae-water separator fluidly coupled to the bioreactor to receive and separate the algae slurry into algae and separated water, and an organics treatment system that receives a portion of the separated water and is configured to reduce a concentration of organics in the portion of the separated water. A recycle line conveys the portion of the separated water back to the bioreactor following processing in the organics treatment system, wherein the portion of the separated water is recycled and forms part of the algae slurry reducing the raw water demand of the bioreactor. | 2021-04-15 |
20210108166 | SUSTAINABLE CURTAIN WALL - A microalgae curtain wall includes photobioreactors, an interior glass panel, an exterior glass panel, and transoms. The photobioreactors are adapted to receive sunlight and carbon dioxide to grow microalgae received therein. The exterior glass panel is offset from the interior glass panel forming a gap therebetween. The transoms hold the interior glass panel and the exterior glass panel therebetween. The transoms suspend the photobioreactors in the gap and between the interior glass panel and the exterior glass panel. | 2021-04-15 |
20210108167 | RESERVOIR FOR FOOD WASTE RECYCLING APPLIANCE - The disclosure relates to a liquid reservoir for a food waste recycling appliance. The liquid reservoir includes a reservoir body with a hollow interior and having an exterior surface bounding an interstitial space. A food waste through opening can pass through the interstitial space. The reservoir body can also include a channel on the exterior surface. | 2021-04-15 |
20210108168 | MICROBIOTA TRAPPING DEVICE, MICROBIOTA TRAPPING APPARATUS, AND MICROBIOTA TRAPPING METHOD - Provided is a technique for easily trapping microbiota in a sample. A microbiota trapping device of the present disclosure includes a first solution tank having a first filter adapted to trap residue in a sample, and a second solution tank having a second filter adapted to trap bacteria in the sample. The second solution tank has a vent above the second filter. | 2021-04-15 |
20210108169 | SENSOR DEVICE FOR TRACKING POSITION AND PROCESS PARAMETERS IN A CONTAINER - Provided is a novel sensor device for tracking position and process parameters in a container (e.g. a bioreactor) that comprises a position determination unit comprising an accelerometer and a pressure sensor, a microcontroller comprising the software algorithm to determine the position of the sensor, a power management unit, a process parameter sensor and a communication unit. | 2021-04-15 |
20210108170 | PHENOTYPIC READOUT FOR EDITED SEQUENCES IN LIVE CELLS IN AUTOMATED INSTRUMENTATION - The present disclosure provides instruments, modules and methods for phenotypic readout for edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited and display a desired phenotype. | 2021-04-15 |
20210108171 | INSTRUMENTS, MODULES, AND METHODS FOR IMPROVED DETECTION OF EDITED SEQUENCES IN LIVE CELLS - The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited. | 2021-04-15 |
20210108172 | THREE DIMENSIONAL HYDROGEL FOR CULTURING OF CELLS - Fully dissolved, aqueous solutions of polycationic macromolecules and polyanionic macromolecules with a cell suspension are mixed to form a three dimensional hydrogel, useful for clinical, diagnostic, and therapeutic applications. | 2021-04-15 |
20210108173 | METHOD FOR PRODUCING OTIC PROGENITORS - This invention relates to an improved method for generating otic progenitor cells. The invention also relates to uses of such otic progenitor cells, for example as a medicament (e.g. in the treatment of hearing loss, deafness or other auditory disorder associated with loss of inner ear function) and/or in drug screening methods. | 2021-04-15 |
20210108174 | MATERIALS AND METHODS FOR ENGINEERING CELLS AND USES THEREOF IN IMMUNO-ONCOLOGY - Materials and methods for producing genome-edited cells engineered to express a chimeric antigen receptor (CAR) construct on the cell surface, and materials and methods for genome editing to modulate the expression, function, or activity of one or more immuno-oncology related genes in a cell, and materials and methods for treating a patient using the genome-edited engineered cells. | 2021-04-15 |
20210108175 | UNIVERSAL CAR-T CELL AND PREPARATION METHOD AND USE THEREOF - Disclosed are a universal CAR-T cell knocking out one or more of CD3 delta, CD3 gamma, CD3 epsilon and CD3 zeta, and simultaneously introducing the HSV-TK gene. Also disclosed are a method for preparing the above-mentioned CAR-T cell, a preparation comprising the CAR-T cell, and the use of the CAR-T cell. | 2021-04-15 |
20210108176 | TRANSDUCTION AND EXPANSION OF CELLS - Provided is a method of transducing and expanding a population of cells, the method comprising, in order: a cell selection step; a pre-transduction activation step; a cell transduction step; and a cell expansion phase. At least the cell transduction step and the expansion phase comprise incubation of the cells with IL-15. The methods of the invention are well suited to the transduction and expansion of populations of cells expressing chimeric antigen receptors (CARs), and in particular for the transduction and expansion of populations of invariant natural killer T (iNKT) cells expressing CARs. Also provided are populations of cells produced by the methods of the invention, and pharmaceutical compositions comprising populations of cells, as well medical uses of the pharmaceutical compositions and populations of cells. The cells and pharmaceutical composition are suitable for application in medical use and methods of treatment, including immunotherapy. | 2021-04-15 |
20210108177 | HUMAN INNATE LYMPHOID CELL PRECURSORS: IDENTIFICATION, CHARACTERIZATION, APPLICATIONS - Innate lymphoid cells (ILCs) represent innate versions of T helper and cytotoxic T cells that differentiate from committed ILC precursors (ILCP). Still, how ILCP relate to mature tissue-resident ILCs remains unclear. ILCP that are present in the blood and all tested lymphoid and non-lymphoid human tissues were identified. Human ILCP fail to express the signature transcription factors (TF) and cytokine outputs of mature NK cells and ILCs but are epigenetically poised to do so. Human ILCP robustly generate all ILC subsets in vitro and in vivo. While human ILCP express RAR related orphan receptor C (RORC), circulating ILCP can be found in RORC-deficient patients that retain potential for EOMES | 2021-04-15 |
20210108178 | SYSTEMS AND METHODS FOR MULTILANE VASCULATURE - Systems and methods for multilane vasculature and multiorgan vascular-vessel fluidic interfaces in in vitro models. The method includes embedding at least one tissue into a 3D structure, forming a vascular interface for nutrient perfusion into the tissue or tissues, tuning the vascular interface or interfaces together or separately to possess a property of a native biological target tissue or target environment by modifying a vessel attribute; and lining a fluidic interface channel, for providing a growth fluid in a physiologically recapitulating manner. The 3D structure includes a vasculogenic element for angiogenesis or vasculogenesis. | 2021-04-15 |
20210108179 | GENERATION OF HUMAN iPS CELLS BY A SYNTHETIC SELF-REPLICATIVE RNA - The disclosure provides methods and compositions useful for obtaining induced stem cells, methods of making and use thereof. | 2021-04-15 |
20210108180 | ELECTROCONDUCTIVE DECELLULARIZED EXTRACELLULAR MATRIX COMPOSITIONS FOR PREPARATION OF ENGINEERED TISSUES AND RELATED METHODS - Hybrid hydrogels comprised of decellularized extracellular matrix (dECM) and biocompatible conductive nanomaterials are disclosed. The hybrid hydrogels provide a more instructive microenvironment for proper cell and tissue development. The mechanical and electrical properties of the hydrogels can be tuned. The hydrogels can be used in bioinks for printing tissues in a high-throughput manner, and engineered tissues generated using the hybrid hydrogels can be utilized to assess biological activity of drug candidates. | 2021-04-15 |
20210108181 | RIFT VALLEY FEVER VACCINE - Certain embodiments are directed to an improved RVF vaccine for human use, and method for producing the same. | 2021-04-15 |
20210108182 | Method for Producing Long-chain Glycosylated Genistein - The disclosure discloses a method for producing long-chain glycosylated genistein and belongs to the technical fields of enzyme engineering and fermentation engineering. The disclosure provides a method for producing long-chain glycosylated genistein. By using this method to produce long-chain glycosylated genistein, the content of long-chain glycosylated genistein in a reaction solution and the ratio of the content of long-chain glycosylated genistein in the reaction solution to the content of total glycosylated genistein in the reaction solution can be increased. The content of long-chain glycosylated genistein in the reaction solution can be increased to 10.3 g/L, and the ratio of the content of long-chain glycosylated genistein in the reaction solution to the content of total glycosylated genistein in the reaction solution can be increased to 70%. | 2021-04-15 |
20210108183 | DP04 POLYMERASE VARIANTS - Recombinant DP04-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DP04 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes. | 2021-04-15 |
20210108184 | Methods of Reducing Odor - The present invention related to lipase variants having lipase activity and having between 60% to less than 100% sequence identity to a parent lipase or a fragment thereof, wherein the variant comprises one or more substitutions selected from H198A/D/E/F/G/I/L/N/Q/S/T/V/Y, F7H/K/R, F51A/I/L/V/Y, T143A/G/S/V, A150G/V, N200H/K/Q/R, I202G/LN, S224C/F/H/I/L/P/Y, L227D/E/K/R, V228P, P229H/K/R, V230H/K/L/R, I255A/G/N/P/S/T/V/Y, P256A/K/N/Q/R/S/T/W, A257F/H/I/L/V/Y, L259F/Y, and W260D/E/F/H/I/L/N/Q/S/T/Y using SEQ ID NO:10 for position numbering or selected from H198A/D/E/F/G/I/L/N/Q/S/T/V/Y, F7H/K/R, F51A/I/L/V/Y, T143A/G/S/V, A150G/V, N200H/K/Q/R, I202G/L/V, S224C/F/H/I/L/P/Y, L227D/E/K/R, V228P, P229H/K/R, V230H/K/L/R, I255A/G/N/P/S/T/V/Y, T256A/K/N/Q/R/S/P/W, A257F/H/I/L/V/Y, L259F/Y, and W260D/E/F/H/I/L/N/Q/S/T/Y using SEQ ID NO:2 for position numbering. Further the invention relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; to compositions comprising the variants as well as methods of producing and using the variants. | 2021-04-15 |
20210108185 | ENGINEERED GRAM-NEGATIVE ENDOLYSINS - The present invention relates in general to the field of antimicrobial enzymes. In particular, the present invention relates to a polypeptide comprising the amino acid sequence of a globular Gram-negative endolysin and the amino acid sequence of a cell wall binding domain of i) a modular Gram-negative endolysin or ii) a bacteriophage tail/baseplate protein. The present invention relates also to corresponding nucleic acids, vectors, bacteriophages, host cells, and compositions. The present inventions also relates to the use of said polypeptides, nucleic acids, vectors, bacteriophages, host cells, and compositions in methods for treatment of the human or animal body by surgery or therapy or in diagnostic methods practiced on the human or animal body. The polypeptides, nucleic acids, vectors, bacteriophages, host cells, and compositions according to the invention may also be used as an antimicrobial in, e.g., food or feed, in cosmetics, or as disinfecting agent. | 2021-04-15 |
20210108186 | GENE THERAPY FOR ALZHEIMER`S DISEASE - The present disclosure provides, among other things, methods for using presenilin based gene therapy to treat neurodegenerative dementia including, but not limited to Alzheimers disease, frontotemporal dementia, frontotemporal lobar degeneration, Picks disease, Lewy body dementia, memory loss, and cognitive impairment including mild cognitive impairment (MCI). | 2021-04-15 |
20210108187 | BOTULINUM NEUROTOXINS PRODUCTION METHODS - Disclosed herein are systems and methods for manufacturing botulinum neurotoxin serotype E (BoNT/E) with improved yield and purity of BoNT/E. Disclosed herein are systems and methods for manufacturing BoNT/E drug substance. | 2021-04-15 |
20210108188 | NON-COVALENT SYSTEMS AND METHODS FOR DNA EDITING - This document relates to materials and methods for DNA base editing with reduced off-target mutations. In particular, this document relates to materials and methods that include using fusion proteins containing a Cas9 molecule and an APOBEC-interacting molecule to achieve specific DNA edits with reduced levels of off-target edits. | 2021-04-15 |
20210108189 | PROCESSES FOR PREPARING SILICA-CARBON ALLOTROPE COMPOSITE MATERIALS AND USING SAME - The present document describes a carbon allotrope-silica composite material comprising a silica microcapsule comprising a silica shell having a thickness of from about 50 nm to about 500 μm, and a plurality of pores, said shell forming a capsule having a diameter from about 0.2 μm to about 1500 μm, and having a density of about 0.001 g/cm3 to about 1.0 g/cm3, wherein said shell comprises from about 0% to about 70% Q3 configuration, and from about 30% to about 100% Q4 configuration, or wherein said shell comprises from about 0% to about 60% T2 configuration and from about 40% to about 100% T3 configuration, or wherein said shell comprises a combination of T and Q configurations thereof, and wherein an exterior surface of said capsule is covered by a functional group; a carbon allotrope attached to said silica microcapsule. Also described is a carbon allotrope-silica composite material comprising a carbon allotrope attached to a silica moiety comprising a silica nanoparticle having a diameter from about 5 nm to about 1000 nm, wherein an exterior surface of said silica nanoparticle is covered by a functional group. | 2021-04-15 |
20210108190 | METHODS AND COMPOSITIONS FOR PRODUCING DOUBLE ALLELE KNOCK OUTS - The present invention provides a method and compositions utilizing the CRISPR system to disrupt a target gene in eukaryotic cells to produce double allele knock outs. The method finds use in producing afucosylated antibodies with enhanced ADCC activity. | 2021-04-15 |
20210108191 | Methods of Production of Biologically Active Lasso Peptides - Recombinant and in vitro reconstitution methods for producing lasso peptides are provided. Methods of screening lasso peptides are also provided. | 2021-04-15 |
20210108192 | Water-Soluble Prolamin, Preparation Thereof, and Uses Thereof for Food-Grade Application Including Prolamin Compositions Combining Prolamin and DNA Taggants - A water-soluble prolamin composition, such as a zein composition, and methods for producing the same. A method for tagging items comprising applying a plurality of non-coding DNA tags in a prolamin composition, such as a zein composition, wherein the selection of the particular taggants corresponds with a binary or nonbinary code sequence containing information about the tagged items. | 2021-04-15 |
20210108193 | METHODS FOR SCREENING GENETIC PERTURBATIONS - Understanding the complex effects of genetic perturbations on cellular state and fitness in human pluripotent stem cells (hPSCs) has been challenging using traditional pooled screening techniques which typically rely on unidimensional phenotypic readouts. Here, Applicants use barcoded open reading frame (ORF) overexpression libraries with a coupled single-cell RNA sequencing (scRNA-seq) and fitness screening approach, a technique we call SEUSS (ScalablE fUnctional Screening by Sequencing), to establish a comprehensive assaying platform. Using this system, Applicants perturbed hPSCs with a library of developmentally critical transcription factors (TFs), and assayed the impact of TF overexpression on fitness and transcriptomic cell state across multiple media conditions. Applicants further leveraged the versatility of the ORF library approach to systematically assay mutant gene libraries and also whole gene families. From the transcriptomic responses, Applicants built genetic co-perturbation networks to identify key altered gene modules. Strikingly, we found that KLF4 and SNAI2 have opposing effects on the pluripotency gene module, highlighting the power of this method to characterize the effects of genetic perturbations. From the fitness responses, Applicants identified ETV2 as a driver of reprogramming towards an endothelial-like state. | 2021-04-15 |
20210108194 | NUCLEIC ACID SECURITY AND AUTHENTICATION - Methods and systems for security, authentication, tagging, and tracking using nucleic acid (e.g., deoxyribonucleic acid) molecules encoding information. Unique nucleic acid molecules are efficiently produced from pre-fabricated fragments to quickly produce libraries of nucleic acid molecules encoding encrypted or randomized information. Physical objects or artifacts can be tagged with libraries to authenticate the objects, grant access to secured assets or locations, or track the objects or entities. Chemical methods can be applied to verify authenticity, decrypt, or decode information stored in the libraries. | 2021-04-15 |
20210108195 | AUTOMATED CELL PROCESSING METHODS, MODULES, INSTRUMENTS, AND SYSTEMS - In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells. | 2021-04-15 |
20210108196 | FUNCTIONAL GENOMICS USING CRISPR-CAS SYSTEMS, COMPOSITIONS, METHODS, SCREENS AND APPLICATIONS THEREOF - The present invention generally relates to libraries, compositions, methods, applications, kits and screens used in functional genomics that focus on gene function in a cell and that may use vector systems and other aspects related to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas systems and components thereof. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. | 2021-04-15 |
20210108197 | SHRNA EXPRESSION CASSETTE, POLYNUCLEOTIDE SEQUENCE CARRYING SAME, AND APPLICATION THEREOF - An shRNA expression cassette, a polynucleotide sequence carrying the same, and an use thereof. In an order of 5′ to 3′, the shRNA expression cassette sequentially includes a DNA sequence for expressing the shRNA and a stuffer sequence, and a sequence length of the shRNA expression cassette sequence is proximate to a length of a wild-type AAV genome. | 2021-04-15 |
20210108198 | APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT AND RELATED PRODUCTS THEREOF - The present application relates to extracting a plurality of compounds from a traditional Chinese medicine, or synthesizing a compound capable of promoting nucleic acid delivery, and utilizing the extracted compound, or a plurality of combinations to promote absorption and entry of a nucleic acid such as sRNA into a target cell, and to facilitate the entry of a nucleic acid into a target site in a subject in need thereof. | 2021-04-15 |
20210108199 | Treatment for aggressive cancers by targeting C9ORF72 - Knock down or other inhibition of C9ORF72 expression provides a method of treating cancer, in particular cancers susceptible to PARP inhibition such as glioblastoma. Thus, agents that target C9orf72, such as inhibitory oligonucleotides or antibodies can be used to treat cancers. A specific embodiment includes methods for treating cancers by administrating such agents, such as an inhibitory oligonucleotide that targets C9orf72. Also disclosed are methods that involve the co-administration of a PARP inhibitor and an agent that targets C9ORF72. | 2021-04-15 |
20210108200 | BRANCHED LIPID CONJUGATES OF siRNA FOR SPECIFIC TISSUE DELIVERY - This disclosure relates to an siRNA-lipid conjugate of formula Y-L-(H) | 2021-04-15 |
20210108201 | FN3 Domain-siRNA Conjugates and Uses Thereof - The present disclosure relates to compositions, such as siRNA molecules and FN3 domains conjugated to the same, as well as methods of making and using the molecules. | 2021-04-15 |
20210108202 | COMPOSITIONS COMPRISING EICOSAPENTAENOIC ACID AND MIPOMERSEN AND METHODS OF USE THEREOF - The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases. | 2021-04-15 |
20210108203 | APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF - The present invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the apolipoprotein C3 (APOC3) gene, and methods of using such RNAi agents to inhibit expression of APOC3 and methods of treating subjects having an APOC3 associated disorder, e.g., hypertriglyceridemia. | 2021-04-15 |
20210108204 | RNA Modulating Oligonucleotides with Improved Characteristics for the Treatment of Duchenne and Becker Muscular Dystrophy - The current invention provides an improved oligonucleotide and its use for treating, ameliorating, preventing and/or delaying DMD or BMD. | 2021-04-15 |
20210108205 | MicroRNA Compounds and Methods for Modulating MIR-122 - Described herein are compositions and methods for the inhibition of miR-122 activity. The compositions have certain nucleoside modifications that yield potent inhibitors of miR-122 activity. The compounds may comprise conjugates to facilitate delivery to the liver. The compositions may be administered to subjects infected with hepatitis C virus, as a treatment for hepatitis C virus and related conditions. | 2021-04-15 |
20210108206 | RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS - RNA interference is provided for inhibition of HIF1A mRNA expression for treating patients with ocular angiogenesis, particularly for treating retinal edema, diabetic retinopathy, sequela associated with retinal ischemia, posterior segment neovascularization (PSNV), and neovascular glaucoma, and for treating patients at risk of developing such conditions. | 2021-04-15 |
20210108207 | OLIGONUCLEOTIDE DERIVATIVE OR SALT THEREOF - The present invention provides, for example, an oligonucleotide derivative or a salt thereof comprising a circular oligonucleotide and a linear oligonucleotide, wherein the circular oligonucleotide and the linear oligonucleotide have base sequences complementary to each other, and form a complex via a hydrogen bond between the complementary base sequences, and a method for producing the same. | 2021-04-15 |
20210108208 | TARGETED AUGMENTATION OF NUCLEAR GENE OUTPUT - Provided herein are methods and compositions for increasing production of a target protein or functional RNA by a cell. | 2021-04-15 |
20210108209 | Products and Methods for Treatment of Familial Amyotrophic Lateral Sclerosis - The present invention relates to RNA-based methods for inhibiting the expression of the superoxide dismutase 1 (SOD-1) gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding RNAs that knock down the expression of SOD-1. The methods have application in the treatment of amyotrophic lateral sclerosis. | 2021-04-15 |
20210108210 | MUCOSAL HEALING PROMOTER - From experiments using colitis model mice, the present inventors discovered that siRNAs that suppress the CHST15 gene expression have a therapeutic effect against Crohn's disease or ulcerative colitis. Specifically, the present inventors discovered that the siRNAs which suppress the CHST15 gene expression can serve as an agent for promoting mucosal healing, in particular, an agent for treating Crohn's disease or ulcerative colitis, and thereby completed the present invention. | 2021-04-15 |
20210108211 | MODULATORS OF GROWTH HORMONE RECEPTOR - The present embodiments provide methods, compounds, and compositions for treating, preventing, or ameliorating a disease associated with excess growth hormone using antisense compounds or oligonucleotides targeted to growth hormone receptor (GHR). | 2021-04-15 |
20210108212 | RNAi Constructs for Inhibiting ASGR1 Expression and Methods of Use Thereof - The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described. | 2021-04-15 |
20210108213 | A METHOD FOR OPTIMIZING ANTIBODY EXPRESSION - Disclosed herein are methods, compositions and components for optimizing or increasing expression of a protein, polypeptide or fragment therefrom. | 2021-04-15 |
20210108214 | RECOMBINANT VECTOR CARRYING DISULFIDE BOND ISOMERASE SIGNAL PEPTIDE AND USE THEREOF - The present invention relates to a recombinant vector carrying a disulfide bond isomerase signal peptide and a use thereof. More particularly, the use of the recombinant vector of the present invention is advantageous in that a protein whose amino acid sequence does not start with methionine can be produced through an | 2021-04-15 |
20210108215 | Genus Hydrogenophilus Bacterium Transformant - A transformant obtained by introducing a DNA of (a1), (a2), or (a3) below, and (b) an alcohol dehydrogenase gene, into a bacterium of the genus | 2021-04-15 |
20210108216 | NOVEL PROMOTER DERIVED FROM ORGANIC ACID-RESISTANT YEAST AND METHOD FOR EXPRESSION OF TARGET GENE BY USING SAME - The present invention relates to a novel promoter for regulating ADH gene expression in an organic acid-resistant yeast, and a method of producing an organic acid by expressing an organic acid production-related gene using the same. When an organic acid production-related target gene is expressed in the organic acid-resistant yeast using the novel promoter according to the present invention, there is an advantage in that the yeast can produce the organic acid with high efficiency while having resistance to the organic acid without inhibiting the growth ability of the yeast. | 2021-04-15 |
20210108217 | UNIQUE MODULAR VECTOR DESIGN - The current invention provides a modular vector system that enables the insertion of gene expression cassettes in a recursive directional stacking fashion by rare restriction sites which requires only one type of vector. The invention also provides DNA molecules, compositions, and transgenic organisms, plants, plant tissues, plant seeds, and cells comprising recombined restriction sites for rare restriction enzymes. | 2021-04-15 |
20210108218 | PROTEIN EXPRESSION SYSTEM IN PLANT CELL AND USE THEREOF - An expression system is provided, including a first nucleic acid fragment containing a long intergenic region (LIR) derived from geminivirus, a small intergenic region (SIR) derived from geminivirus, and an expression cassette of a target protein linked between the LIR and the SIR and a second nucleic acid fragment containing an expression cassette of a Rep/RepA protein derived from geminivirus, in which the expression cassette of the target protein includes a promoter, a nucleic acid fragment encoding the target protein, and two or more linked terminators in this order. | 2021-04-15 |
20210108219 | PALE YELLOW LOCUS AND ITS APPLICATIONS IN TOBACCO - The present disclosure relates to tobacco plants, tobacco seeds, compositions, and methods related to the identification and introgression of the Pale Yellow locus in tobacco. It also relates to generating novel mutations within the PY locus in tobacco. | 2021-04-15 |
20210108220 | SIMULTANEOUS GENE SILENCING AND SUPPRESSING GENE SILENCING IN THE SAME CELL - The present invention relates to genetically modified cells that are capable of optimal transgene expression by co-expressing a silencing suppressor whilst at the same time are also capable of silencing a gene, such as a naturally occurring gene of the cell. The present invention also relates to methods of producing the modified cells, as well as relates to processes for obtaining a genetically modified cell with a desired property. | 2021-04-15 |
20210108221 | ENDOSTATIN FRAGMENTS AND VARIANTS FOR USE IN TREATING FIBROSIS - Materials and methods for using polypeptides containing fragments and variants of endostatin to treat fibrosis are described herein. | 2021-04-15 |
20210108222 | PLANTS HAVING INCREASED RESISTANCE TO L. MACULANS AND METHODS OF USE - Provided herein is a transgenic plant having increased expression of a coding region encoding a resistance protein, where the transgenic plant has increased resistance to infection by | 2021-04-15 |
20210108223 | INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE - Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity. | 2021-04-15 |
20210108224 | PESTICIDAL GENES AND METHODS OF USE - Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptide sequences having pesticidal activity, recombinant and synthetic nucleic acid molecules encoding the pesticidal polypeptides, DNA constructs comprising the nucleic acid molecules, vectors comprising the nucleic acid molecules, host cells comprising the vectors, and antibodies to the pesticidal polypeptides. Nucleotide sequences encoding the polypeptides provided herein can be used in DNA constructs or expression cassettes for transformation and expression in organisms of interest. The compositions and methods provided herein are useful for the production of organisms with enhanced pest resistance or tolerance. Transgenic plants and seeds comprising a nucleotide sequence that encodes a pesticidal protein of the invention are also provided. Methods are provided for producing the polypeptides disclosed herein, and for using those polypeptides for controlling a pest. Methods and kits for detecting polypeptides of the invention in a sample are also included. | 2021-04-15 |
20210108225 | NEUROPEPTIDE-EXPRESSING VECTORS AND METHODS FOR THE TREATMENT OF EPILEPSY - The present invention provides delivery vectors for transferring a nucleic acid sequence to a cell in vitro, ex vivo or in vivo. The present invention provides methods of delivering a nucleic acid sequence to a cell and methods of treating focal epilepsies. | 2021-04-15 |
20210108226 | METHODS OF PACKAGING MULTIPLE ADENO-ASSOCIATED VIRUS VECTORS - Provided herein are methods related to co-packaging of multiple rAAV particles, e.g., by introducing multiple nucleic acid vectors encoding proteins or polypeptides or RNAs of interest into a single cell preparation. | 2021-04-15 |
20210108227 | Parvovirus Vector Production - Provided is a cell containing a nucleic acid sequence having a parvovirus terminal repeat sequence, wherein the cell overexpresses single strand binding protein compared to a cell of a wild-type (WT) strain of the same species. Also provided is a nucleic acid vector containing a nucleic acid sequence having a parvovirus terminal repeat sequence and a nucleic acid sequence encoding a single strand binding protein. Methods of using said nucleic acid vector to propagate and purify nucleic acid vectors involved in the production of parvovirus vector particle production are also described. | 2021-04-15 |
20210108228 | TARGETED LIPID PARTICLES FOR SYSTEMIC DELIVERY OF NUCLEIC ACID MOLECULES TO LEUKOCYTES - Disclosed are targeted lipid based particles for delivery of nucleic acid molecules (such as siRNA) to leukocytes (such as T-Cells and B-cells). Further disclosed are uses of the targeted lipid based particles for treating Leukocytes-associated diseases, such as, cancer. | 2021-04-15 |
20210108229 | SYSTEMS, METHODS, AND COMPOSITIONS FOR CORRECTION OF FRAMESHIFT MUTATIONS - The disclosure provides systems, methods, and compositions for a target specific nuclease and a blunting enzyme to correct frameshift mutations for genome editing and treatment of diseases. In some embodiments, the target specific nuclease and the blunting enzyme are combined with a guide RNA and/or a microhomology-mediated end joining (MMEJ) inhibitor. | 2021-04-15 |