29th week of 2013 patent applcation highlights part 37 |
Patent application number | Title | Published |
20130183623 | EXPOSURE APPARATUS AND EXPOSURE METHOD, AND DEVICE MANUFACTURING METHOD - An exposure apparatus is equipped with a table which holds a wafer and is movable along an XY plane and has a grating provided on its rear surface, an encoder which irradiates a first measurement beam on the grating from below, receives a return light, and measures a first position information of the table when the table moves in a predetermined range, and another encoder which has a head section provided in a frame and irradiates a second measurement beam on a different grating on the table from the head section, receives a return light, and can measure a second position information of the table, concurrently with measurement of the first position information by the encoder when the table moves in predetermined range. A controller drives the table, based on position information having a higher reliability of the first and the second position information. | 2013-07-18 |
20130183624 | RADIATION-SENSITIVE RESIN COMPOSITION - A radiation-sensitive resin composition includes a compound represented by a formula (1), and a polymer that serves as a base resin. R | 2013-07-18 |
20130183625 | PATTERNED GRAPHENE FABRICATION METHOD - A method for fabricating patterned graphene structures, which adopts a photolithographic etching process to fabricate patterned graphene structures, comprises steps: providing a substrate; forming a catalytic layer on the substrate; forming a carbon layer on the catalytic layer; heating the carbon layer to a synthesis temperature to form a graphene layer. A photolithographic etching process is performed on the catalytic layer before formation of the carbon layer. Alternatively, a photolithographic etching process is performed on the carbon layer before heating. Alternatively, a photolithographic etching process is performed on the graphene layer after heating. Compared with the laser etching process, the photolithographic etching process is suitable to fabricate large-area patterned graphene structures and has advantages of high productivity and low cost. | 2013-07-18 |
20130183626 | METHOD FOR FORMING FINE PATTERN, AND COATING AGENT FOR PATTERN FINING - A method for forming a fine pattern, including forming a resist film by applying, on a substrate, a resist composition containing a base material having a solubility, in a developer liquid including an organic solvent, that decreases according to an action of an acid, a compound which generates an acid upon irradiation, and an organic solvent; exposing the resist film; forming a resist pattern using the developer liquid; applying, on the resist pattern, a coating agent for pattern fining including a resin and an organic solvent; and heating the resist pattern on which a coating film is formed. | 2013-07-18 |
20130183627 | EXPOSURE METHOD AND EXPOSURE APPARATUS, AND DEVICE MANUFACTURING METHOD - Exposure apparatus is equipped with an illumination optical device which illuminates a mask with an exposure beam, a mask table which holds a periphery of a pattern area of the mask from above so that a pattern surface of the mask becomes substantially parallel to an XY plane and makes a force at least parallel to an XY plane and on the mask, and a wafer stage which moves along the XY plane, holding a wafer substantially parallel to the XY plane. Therefore, an overlay with high precision of a pattern of a mask and an underlying pattern on the substrate can be realized, even though the exposure apparatus employs a proximity method, that is, the exposure apparatus does not use a projection optical system. | 2013-07-18 |
20130183628 | ADDITIVE FUEL COMPOSITION, AND METHOD OF USE THEREOF - An additive composition for a fuel comprises: | 2013-07-18 |
20130183629 | EVERSIBLE CANDLE HOLDER - An eversible candle holder comprises a flexible generally cylindrical body capable of being manipulated between rest and everted configurations, the body having sidewalls extending upwardly from a base. In the rest configuration the central portion of a heat sink is seated on a central pedestal of the base and a horizontal lip extending from a skirt wall depending from the pedestal's central portion is disposed in an inwardly-facing recess in a recessed perimeter portion of the base and is locked in the recess by an overlapping inwardly-extending retaining flange. In an everted configuration, the locking flange is rotated outwardly about an annular hinge section away from the central pedestal opening the recess a sufficient width to release the lip, enabling removal of the heat sink from the base, and facilitating disposal of candle wax accumulated in the bottom of the holder. | 2013-07-18 |
20130183630 | THERMOPLASTIC-BASED POLYMER ADHESIVE COMPOSITIONS AND METHODS AND APPARATUSES FOR THEIR USE IN DENTAL APPLICATIONS - A thermoplastic-based polymer adhesive for use in dentistry includes a thermoplastic polymer and an additional polymer or additive including at least one moiety, monomer, or prepolymer capable of changing at least one property of the thermoplastic-based polymer adhesive when exposed to an activation energy. The activation energy may be heat energy and/or sonic or ultrasonic energy. Bonding a dental component to a tooth includes placing the thermoplastic-based polymer adhesive between the dental component and the surface of the tooth and compressing the dental component against the adhesive, and, while compressing, applying an activation energy to cause crosslinking of the additional polymer or additive with the thermoplastic polymer. | 2013-07-18 |
20130183631 | Orthodontic Pliers for Four Quadrant V-Bends - A single pair of pliers for bending orthodontic arch wires in all quadrants of a patient's mouth. Includes first and second actuating members, each including a handle portion for grasping in the hand, and a head portion that projects at an angle. The actuating members are pivotally joined so that the head portions can be moved toward and away from each other into respective closed and open positions. A first occlusal jaw on head portion of the first actuating member has an internally angled channel profile and a second occlusal jaw on the head portion of the second actuating member also has an internally angled channel profile facing the other internal channel. A gingival jaw member having upper and lower externally angled corners is adapted to mate with the internally angled profiles of the upper and lower occlusal jaws, respectively, when the head portions are in the closed position. | 2013-07-18 |
20130183632 | UNIVERSAL LINGUAL BRACKET SYSTEM - The present invention discloses a universal lingual bracket system, comprising No. 1-7 universal lingual brackets connected in series by an arch wire. The universal lingual bracket includes a base plate and a bracket body portion that are integrated as a whole. A mesh bottom is arranged on the base plate and the mesh bottom is integrally molded with the base plate. The mesh bottom, the base plate and the bracket body portion are integrally molded. In addition, the mesh bottom is in the structure of an interlaced woven wire mesh, so that the universal lingual brackets have strong capability to be against the teeth surfaces and they are unlikely to come off. Even if they come off, they will not damage the mesh bottom. The mesh bottom can be used again once it is treated by sandblasting. The universal lingual bracket system provided by the invention has the advantages that it can be securely and easily installed and has high durability; therefore it is applicable to various universal lingual appliances. | 2013-07-18 |
20130183633 | SYSTEM AND METHOD FOR THREE-DIMENSIONAL INTRA-ORAL IMAGING - A portable three-dimensional intra-oral imaging system is comprised of a processor, a housing encasing the processor, an imaging sensor extensibly coupled to the housing for capturing images, and a touchscreen display to display the images acquired by the imaging sensor. An arm is coupled to the housing and supports the touchscreen display, wherein the arm is configurable to be retracted and protracted to allow placement of the touchscreen display within a range of heights. A handle of the housing is provided for portability. | 2013-07-18 |
20130183634 | EXPANSION DEVICE FOR TREATMENT OF BLACK TRIANGLE DISEASE AND METHOD - An expansion device includes an inflatable balloon moveable from an unexpanded configuration to an expanded configuration configured to pass through soft tissue between two adjacent teeth of a patient when in the unexpanded configuration. The an expansion device also includes an inflation tube having one end connected to the inflatable balloon and another end serving as an entry port for an inflation fluid. The inflatable balloon has a triangular shape when in the expanded configuration. | 2013-07-18 |
20130183635 | Dental Wound Dressing - A dental dressing to promote healing and relieve pain and swelling associated with exposed dental alveoli. The dressing includes a three-dimensional dressing matrix to absorb leaked fluid associated with one or more exposed alveoli, and a therapeutic member to provide substantially localized cold therapy to one or more exposed alveoli, the therapeutic member embedded substantially within the dressing matrix and shaped to substantially engage one or more exposed alveoli while fitting substantially between contiguous teeth. At least part of the dressing matrix substantially conforms to one or more exposed alveoli, thereby engaging the therapeutic member with one or more exposed alveoli. | 2013-07-18 |
20130183636 | ROTARY DENTAL TOOL AND METHOD OF MANUFACTURE - A rotary dental tool. The tool comprises a blank having a shaft portion and a head portion. A single layer of grit comprising diamond crystals extends from the blank at substantially uniform height, said grit covering a predetermined proportion of the surface area of the head portion. A bonding material substantially surrounds the diamond crystals, forming micro-channels between the diamond crystals. The diamond crystal size is substantially less than other rapid cutting tools yet outperforms other tools in cutting speed, durability and smoothness of finish. The micro-channels are believed to both cool the dental tool and facilitate debris removal during use. | 2013-07-18 |
20130183637 | COUPLING FOR A MULTI-PART DENTAL IMPLANT SYSTEM - The invention relates to an abutment for use in a dental implant system, wherein the abutment is provided with a guiding and lock means for associating the abutment to a dental implant, the guiding and lock means including: a first conically tapered section; a second substantially non-tapered section arranged apically adjacent to the first section, the second section being provided with an anti-rotational means; and a third substantially circular cylindrical section arranged apically adjacent to the second section, such that to provide axial guiding to the abutment upon the insertion thereof into a dental implant. Further, the invention relates to a dental implant formed in a similar manner. | 2013-07-18 |
20130183638 | METHODS, INSERTS, AND SYSTEMS USEFUL FOR ENDODONTIC TREATMENT - Described are devices, methods, inserts, and systems useful in endodontic treatments, involving, for example, a shaped regenerative endodontic insert comprising platelet-fibrin matrix. | 2013-07-18 |
20130183639 | Adapter for Communicating Between an Anti-Personnel Training Device and a User Worn Monitoring Device - An adapter device for use in a combat training system communicates between an anti-personnel training device and a user monitoring device in a training exercise. The anti-personnel training device may be a simulated improvised explosive device including a trigger and an output arranged to output a simulated attack, for example light and sound representative of an explosion, in response to activation of the trigger. The user monitoring device, for example existing training products, such as the Stressvest™ system, the IR Tactical system™, or the MILES™ system, is worn by a user and includes an input which receives a hit signal indicative of the user being hit and an indicator output arranged to indicate the user has been hit. The adapter device has an input sensor to sense the simulated attack of the anti-personnel training device and a signal output to output a hit signal detectable by the user monitoring device. | 2013-07-18 |
20130183640 | Centrifuge-Based-Flight Simulator - Some implementations include a method for operating a centrifuge-based-flight simulator in at least one of several different modes: a heightened G-force mode, a normal G-force mode; and transition modes (i.e., ramp-up or ramp-down modes) between the heightened G-force and normal G-force modes. During the normal-G-force mode the simulator ceases planetary motion altogether or substantially decreases rotations to replicate a plurality of flight conditions that physically imparts, on the trainee during operation of the simulator, a G-force that is not greater than approximately one (1) G. The reduction of planetary motion while maintaining realistic motion and force sensations that are appropriate for the virtual-flight conditions being experienced allows realistic flight simulation experience for the trainee and reduces the negative effects of constant planetary motion. | 2013-07-18 |
20130183641 | BRAILLE READING-WRITING DEVICE - A braille reading-writing device includes a body and a plurality of braille buttons. The body has a first surface and a second surface. The braille buttons are disposed through the body. Each of the braille buttons includes a pressing portion located at the same side with the first surface and a touching portion located at the same side with the second surface. The touching portion protrudes from the second surface when the pressing portion is pressed. The braille reading-writing device allows the blind people to write braille on the first surface and to touch to read the written braille on the second surface, thereby integrating the functions of writing and reading braille. | 2013-07-18 |
20130183642 | SYSTEM AND METHOD FOR DISPLAYING RECIPES VISUALLY - A recipe system for simulating an operational environment of a food establishment for guiding a user, such as an employee, to prepare recipes in the actual operational environment. The user may be guided through each step of preparation of a product from a recipe. The recipe system may also be used for training a user to learn a layout of ingredients, and memorize recipes for meals and drinks prepared using the ingredients. The recipe system may allow the user to interact with the recipe system to provide user input to simulate preparation of a meal. The recipe system may track time required by the user to prepare a product and adjust a training process based on user's performance. The recipe system can further be used to simulate different layouts of the operational environment and assess efficiency of each layout by receiving user input simulating preparation of recipes using the layout. | 2013-07-18 |
20130183643 | AUDIBLE DICTIONARY DEVICE - The present invention is an audible dictionary device that includes an attached pointer, an on and off switch, a volume control switch, a keyboard that includes a shift button and a delete button that is utilized to delete a previous usage history of one or more words researched or looked-up. The device also includes an audio speaker that emits any sounds that would include one or more words or other suitable verbiage and one or more meanings that are requested by the user, a submit button that is used to submit or enter any word or suitable combination of words that the audible dictionary device would give one or more meanings or definitions to, a language switch button that controls a language that the words entered and their the meanings would be emitted and pronounced and a screen display that displays the words and their the definitions. | 2013-07-18 |
20130183644 | POLYGONAL DEVICE FOR KINESTHETIC LEARNERS - A polygonal device for teaching students who prefer kinesthetic learning methods is presented in which the polygonal device can represent two-dimensional polygons of varying shapes and sizes. One or more of the sides, or legs, of the polygonal device are extendable, and the angles of the polygonal device may be manipulated to a desired angle. The devices presented include, but are not limited to, triangles, quadrilaterals, parallelograms, rectangles, squares, trapezoids, and kites. In each of these devices, the legs of the device are non-detachable, i.e. the device does not come apart during normal manipulation and operation. | 2013-07-18 |
20130183645 | ANALYZING EXTERNAL DATA USING A VIRTUAL REALITY WELDING SYSTEM - A real-time virtual reality welding system including a programmable processor-based subsystem, a spatial tracker operatively connected to the programmable processor-based subsystem, at least one mock welding tool capable of being spatially tracked by the spatial tracker, and at least one display device operatively connected to the programmable processor-based subsystem. The system is capable of simulating, in virtual reality space, a weld puddle having real-time molten metal fluidity and heat dissipation characteristics. The system is further capable of importing data into the virtual reality welding system and analyzing the data to characterize a student welder's progress and to provide training. | 2013-07-18 |
20130183646 | BIOMETRIC SENSING AND PROCESSING APPARATUS FOR MOBILE GAMING, EDUCATION, AND WELLNESS APPLICATIONS - An apparatus for interoperably utilizing multiple biosensor data obtained from a finger of the user. A biometric sensor board is retained in a housing adapted for retaining a finger of the user and maintaining multiple sensors in contact with the skin thereof. Implementations are described for fingertip and ring mounted sensor boards. In one implementation, these sensors can be sensors electrodermal response (EDR), or photoplethysmograph (PPG) signals, or temperature, or acceleration in three axes, and combinations thereof. The biometric sensor board registers and processes the signals from the sensors and communicates them to a mobile device which interoperably utilizes multiple sensor information to determine aspects of user emotional state within an application to generate results which are displayed on the mobile device. | 2013-07-18 |
20130183647 | System and Method for Managing Information About Playground Installations - An information and management system configured to obtain and provide information about a playground installation may include a readable tag located on or near a playground installation. In response to reading the tag, a user interface of a mobile device may display information such as an identifying description that is specific to the playground installation, a check-in feature enabling a user to notify others of his or her location at the playground installation, instructions for how to use at least one aspect of the playground installation, and a parts list of at least some of the components of the playground installation. The system may further provide a claiming function configured to allow a user to identify a sales order associated with the readable tag with a second user interface, the second user interface configured to further manage the playground installation. | 2013-07-18 |
20130183648 | CHEST COMPRESSION MANIKIN - Chest compression training arrangement comprising an upper plate ( | 2013-07-18 |
20130183649 | METHOD FOR GENERATING VISUAL MAPPING OF KNOWLEDGE INFORMATION FROM PARSING OF TEXT INPUTS FOR SUBJECTS AND PREDICATES - A method for performing relational analysis of parsed input is employed to create a visual map of knowledge information. A title, header or subject line for an input item of information is parsed into syntactical components of at least a subject component and any predicate component(s) relationally linked as topic and subtopics. A search of topics and subtopics is carried out for each parsed component. If a match is found, then the parsed component is taken as a chosen topic/subtopic label. If no match is found, then the parsed component is formatted as a new entry in the knowledge map. A translation function for translating topics and subtopics from an original language into one or more target languages is enabled by user request or indicated user preference for display on a generated visual map of knowledge information. | 2013-07-18 |
20130183650 | Answer Text Knolwdge Network - A messaging system using text-messaging protocol (limited to 160 characters) for automated delivery, at user-defined intervals, of multiple-choice questions (“Challenges”) to targeted electronic devices. The individual to whom the Challenges are directed, or adult in the case of a minor, must self-select their profile and opt-in to the service; no unsolicited Challenges are allowed to be delivered. The outcome of the interaction with the system is an award that is measured in objective, alpha-numeric values (“Achievements”). | 2013-07-18 |
20130183651 | SERVER, LEARNING TERMINAL APPARATUS, AND LEARNING CONTENT MANAGING METHOD - There is provided a server including a teaching material storage unit configured to store teaching material data, notebook templates, and link information indicating associations between the teaching material data and the notebook templates, and a transmission unit configured to transmit the teaching material data and the notebook templates associated with the teaching material data to a learning terminal apparatus according to a request from the learning terminal apparatus. The link information indicates association of a notebook template selected by a teacher for a designated page of the teaching material data. The notebook template is superimposed on another layer and displayed in the learning terminal apparatus. | 2013-07-18 |
20130183652 | METHOD AND SYSTEM FOR PROVIDING SETS OF USER COMMENTS AS ANSWERS TO A QUESTION - A computer-implemented method of providing sets of user comments as answers to a question includes receiving a question from a user. The question includes information posted by the user on a website. The computer-implemented method also includes constructing a query from the question. Further, the computer-implemented method includes analyzing the query. Furthermore, the computer-implemented method includes extracting the sets of user comments related to the question from a database. Moreover, the computer-implemented method includes rendering the sets of user comments as answers to the question. | 2013-07-18 |
20130183653 | LEARNING ASSISTANT DEVICE AND METHOD - The various embodiments herein provide a method and device for assisting a learner for learning a subject matter. The device comprises an inner rotating cylinder provided with two co-axial and concentric cylinders of same altitude but with different diameters. An outer rotating cylinder having several port holes is adapted to embrace the inner rotating cylinder. Several vanes are provided between the two co-axial and concentric cylinders for creating several cells. The number of cells is equal to a number of days in a learning plan. The review papers containing several subject matters are placed in the cells. The number of portholes is equal to a number of review stages in the learning plan. The device enables the learner to review the subject matters by opening the portholes until the end of the learning plan is achieved. | 2013-07-18 |
20130183654 | Compositions and methods for modulating ischemic injury - The invention is directed to methods of modulating ischemic injury in tissues and organs. The invention is further directed to methods of increasing time to ischemic injury in tissues and organs. Such methods utilize compositions comprising cells capable of modulating inflammatory responses, referred to herein as Inflammatory Response Modulating Cells (IRMCs). The IRMCs any be used directly or cell membranes derived from them may be used in practicing the methods of the invention. In addition, the IRMCs and IRMC membranes may be used alone or in combination with each other and/or in combination with various suitable active agents. | 2013-07-18 |
20130183655 | COAGULATION CONTROLLING AGENTS AND DEVICES COMPRISING THE SAME - A device and kit and method for controlling coagulation in a blood sample. The coagulation controlling agent is at least one of citrate, a protamine salt, its homologs and derivatives, benzamidine, or para-aminobenzamidine. Additives such as water soluble polymers and sugars are also contemplated. The device and kit comprise a container that contains an effective amount of thrombin and a coagulation controlling agent. The method combines thrombin and a coagulation controlling agent to stabilize thrombin or accelerate its activity in a blood sample. | 2013-07-18 |
20130183657 | MATERIALS AND METHOD FOR DETECTING CYTOMEGALOVIRUS (CMV) - Methods and kits for amplifying cytomegalovirus (CMV) nucleic acid sequences in a sample comprising pairs of primers for amplification of UL34 and UL80.5 nucleic acid sequences or one or more reagents. | 2013-07-18 |
20130183658 | Methods and Devices for Rapid Detection of Live Microorganisms by Aptamers and/or Antibodies Immobilized on Permeable Membranes - The present invention provides methods, devices and test kits for rapid detection and identification of one or more live target microorganisms in a liquid sample or grown on plates containing solid nutrient media. The invention includes mixing the one or more target microorganisms with one or more aptamers and/or one or more antibodies, each conjugated to a reporter compound and specific for a first site on the one or more target microorganisms to form a mixture. The mixture is placed on a permeable membrane having immobilized thereon one or more aptamers linked to an amine compound, and/or one or more antibodies, each specific for a second site on the one or more target microorganisms or a site on the aptamer conjugate and/or antibody conjugate. A detection solution is added to the membrane, and detection and identification of the one or more target microorganisms is achieved in less than one hour. | 2013-07-18 |
20130183659 | MICROFLUIDIC DEVICES - The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids. | 2013-07-18 |
20130183660 | Apparatus for Disease Detection - Among others, the present invention provides apparatus for detecting a disease, comprising a system delivery biological subject and a probing and detecting device, wherein the probing and detecting device includes a first micro-device and a first substrate supporting the first micro-device, the first micro-device contacts a biologic material to be detected and is capable of measuring at the microscopic level an electric, magnetic, electromagnetic, thermal, optical, acoustical, biological, chemical, physical, or mechanical property of the biologic material. | 2013-07-18 |
20130183661 | STABILIZED LEUKOCYTES AND THEIR USE IN HIV-DIAGNOSIS AND THERAPY - A method of producing extremely stable leukocytes from human blood samples which are stable for long period of time under extraordinary temperature conditions. The method also relates to producing and stabilizing the leukocytes with formaldehyde release agents. The method is directed at the use of the stabilized leukocytes as a control in assays for determining CD4+ and HIV diagnosis and therapy. | 2013-07-18 |
20130183662 | MEANS AND METHODS FOR IDENTIFYING AN INCREASED RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) PATIENTS FOR DEVELOPING RENAL MANIFESTATIONS - The present invention relates to means and methods for identifying an increased risk of systemic lupus erythematosus (SLE) patients for developing renal manifestations. The present invention further relates to polypeptides binding to one or more components of neutrophil extracellular traps (NET(s)) and to kits comprising components suitable to carry out the methods provided herein. | 2013-07-18 |
20130183663 | LABELED REACTANTS AND THEIR USES - Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions, that include structural components that maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated. | 2013-07-18 |
20130183664 | SYSTEMS AND METHODS FOR CONSTRUCTING FREQUENCY LOOKUP TABLES FOR EXPRESSION SYSTEMS - Methods for determining a property that affects expression of polynucleotides are provided. A plurality of polynucleotides each encoding a polypeptide sequence is constructed. A frequency that a sequence element is used in a first polynucleotide is different than in a second polynucleotide. Each polynucleotide is expressed in an expression system to obtain an expression property value thereby constructing a dataset that contains, for each respective polynucleotide, sequence element occurrence in the respective polynucleotide and the measured expression property value of the respective polynucleotide. A model is computed that describes variation in the measured expression property values as a function of a plurality of variables and weights. From the model, a property that affects expression of polynucleotides in the expression system is determined, where the property is an effect that the frequency of occurrence of one or more sequence elements has on the expression property of polynucleotides in the expression system. | 2013-07-18 |
20130183665 | SYNTHESIS OF FLUORESCENT NOBLE METAL NANOPARTICLES - A process for the production of fluorescent nanoparticles selected from noble metal, silica or polymer nanoparticles which comprises: 1. A process for the production of fluorescent nanoparticles selected from noble metal or silica nanoparticles which comprises: (1) providing a platform of nanoparticles; (2) covering the surfaces of the nanoparticles to saturation with thiol-terminated polymers by one of the following methods: 1. mixing the nanoparticles with methoxy-(polyethylene glycol)-thiol and biotin-(polyethylene glycol)-thiol; 2. mixing the nanoparticles with fluorescently-labeled methoxy-(polyethylene glycol)-thiol and/or biotin-(polyethylene glycol)-thiol 3. coordinating thiol and biotin thiol to the surfaces of the nanoparticles by a non-covalent bond; and 4. directly conjugating methoxy-thiol and biotin-thiol to the surfaces of the nanoparticles, so that the polymers bind to the surfaces of the nanoparticles as a brush layer via thiol particle coordination of the thiol ends so that the biotin or methoxy ends are free; and (3) homogeneously mixing the resulting biotin nanoparticles with fluorescent avidin or a derivative thereof in proportions such that the final concentration is 1 biotin molecule for every 10 to 1000 avidin molecules in the fluorescent multi-coloured nanoparticle-avidin complexes, each being capable of having a different targeting molecule, and which may be mixed with biotin related targets, and the fluorescent labeled avidin or a derivative thereof being spaced away from the particle surface, thus reducing or removing the potential quenching of the dye. | 2013-07-18 |
20130183666 | PARTIAL GENOTYPING BY DIFFERENTIAL HYBRIDIZATION - In a method of detecting the number of repeat units in a selected short tandem repeat (STR) in a genomic sample, the genomic sample is amplified by PCR and a single stranded target DNA is selected and separated for use in differential hybridization experiments. Subsequent partial genotyping comprises the steps of admixing to the target DNA at least one fluorescent labeled STR probe oligonucleotide and one different fluorescent labeled reference probe oligonucleotide allowing hybridization to the single stranded target DNA in a hybridization experiment. Measurement of the fluorescence intensities of the probes that are bound to the repeat units of the selected STR and normalizing the fluorescence intensity of the STR probes on the base of the reference probe intensity reveals a relative fluorescence signal representing the result of the differential hybridization experiment. Also disclosed are kits for carrying out partial genotyping by differential hybridization. | 2013-07-18 |
20130183667 | METHODS FOR CANCER SCREENING IN LATIN AMERICAN/HISPANIC POPULATIONS - Provided herein are novel methods for diagnosing ovarian and breast cancer risk in a Latin American/Hispanic population based on the presence of specific BRCA1 and/or BRCA2 mutations. | 2013-07-18 |
20130183668 | METHODS RELATING TO IDENTIFICATION OF SUSCEPTIBILITY TO LIVER INJURY - The present invention relates to methods for identifying susceptibility of impaired hepatic wound healing in a patient, most particularly by identifying modifications of the of PPAR-γ and TGFβ1 genes. It further relates to stratifying populations of patients to determine susceptibility to impaired hepatic wound healing and direct appropriate healthcare resources. More specifically methods can be used to stratify liver disease patient populations to identify those most likely to progress to cirrhosis, or to identify the likelihood that a patient with liver disease will progress to having cirrhosis. | 2013-07-18 |
20130183669 | COMPOSITIONS AND METHODS FOR DIAGNOSING AUTISM - Mutations located within the gene encoding the homeobox transcription factor, ENGRAILED 2 (EN2), have now been identified as molecular markers associated with susceptibility for autism and related disorders. Thus, the present invention relates to compositions in the form of diagnostic kits, primers and target sequences, for use in methods for determining the predisposition, the onset or the presence of autism spectrum disorder in a mammal. Moreover, therapeutic methods for treating a person inflicted with, or predisposed to, an autism spectrum disorder based upon modulating the level or activity of EN2 are also provided. | 2013-07-18 |
20130183670 | METHOD FOR PRODUCING NUCLEIC ACID PROBES - The present disclosure provides nucleic acid probes, as well as kits that include such probes. Methods for producing and using (for example in chromosomal in situ hybridization) the probes are also provided. Such probes in some examples are used to detect chromosomal abnormalities or the presence of a pathogen. | 2013-07-18 |
20130183671 | ALLELIC DISORDERS CAUSED BY MUTATIONS IN TRPV4 - The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C). | 2013-07-18 |
20130183672 | 3-D GENOMIC REGION OF INTEREST SEQUENCING STRATEGIES - The invention relates to methods for determining the sequence of a genomic region of interest comprising a target nucleotide sequence comprising, fragmenting a crosslinked DNA, ligating the fragmented cross linked DNA, reversing the crosslinking and determining at least part of the sequences of ligated DNA fragments which comprise a target nucleotide sequence. | 2013-07-18 |
20130183673 | NEW MARKERS FOR THE EPITHELIAL AND PROLIFERATIVE OR MESENCHYMAL INVASIVE PHENOTYPE OF HUMAN NEOPLASIAS - The present invention relates to a new Ena/VASP protein isoform, uses thereof, diagnostic methods and kits comprising the same. | 2013-07-18 |
20130183674 | METHOD OF NOCICEPTOR DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS AND USES THEREOF - The present invention relates to the field of stem cell biology, in particular the linage specific differentiation of pluripotent or multipotent stem cells, which can include, but is not limited to, human embryonic stem cells (hESC), human induced pluripotent stem cells (hiPSC), somatic stem cells, cancer stem cells, or any other cell capable of lineage specific differentiation. Specifically described are methods to direct the lineage specific differentiation of hESC and/or hiPSC to nociceptors (i.e. nociceptor cells) using novel culture conditions. The nociceptors made using the methods of the present invention are further contemplated for various uses including, but limited to, use in in vitro drug discovery assays, pain research, and as a therapeutic to reverse disease of, or damage to, the peripheral nervous system (PNS). Further, compositions and methods are provided for producing melanocytes from human pluripotent stem cells for use in disease modeling. | 2013-07-18 |
20130183675 | BIOMARKERS FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA - Provided herein are biomarkers for hepatocellular carcinoma and uses thereof. | 2013-07-18 |
20130183676 | FILTERLESS TIME-DOMAIN DETECTION OF ONE OR MORE FLUOROPHORES - A device and method are described in which the lifetime of a fluorescent species or fluorophores is detected in the absence of any optical filter. Based on the measured fluorescent lifetimes, molecules or compounds attached to a fluorophores such as small organic molecules, polymers, peptides, saccharides and nucleic acids can be identified or assayed. | 2013-07-18 |
20130183677 | METHOD FOR PREDICTING DIFFERENTIATION-INDUCING PROPERTIES TO REGULATORY T-CELLS, BIOMARKER USED FOR THE METHOD, AND USE THEREOF - A method for predicting differentiation-inducing properties of naive T-cells to regulatory T-cells comprising: measuring an amount of ZAK in naive T-cells contained in the body fluid collected from the living body; and predicting differentiation-inducing properties of the naive T-cells to regulatory T-cells based on the measurement results is disclosed. A method for determining the risk of development of Graft versus Host Disease and a biomarker for predicting differentiation-inducing properties of naive T-cells to regulatory T-cells are also disclosed. | 2013-07-18 |
20130183678 | LOW RESOURCE PROCESSOR USING SURFACE TENSION VALVES FOR EXTRACTING, CONCENTRATING AND DETECTING MOLECULAR SPECIES - Systems and methods are described for isolation, separation and detection of a molecular species using a low resource device for processing of samples. Methods include isolation, separation and detection of a molecular species for protein-protein, DNA-DNA and other chemical interactions. | 2013-07-18 |
20130183679 | METHOD FOR DETECTING THE PRESENCE OF BACTERIAL STRAINS RESISTANT TO ANTIBIOTICS IN A BIOLOGICAL SAMPLE - The invention relates to the field of molecular diagnostic, in particular for the detection of the presence of gram-negative bacterial strains resistant to antibiotic in a biological sample. The invention more specifically relates to an in vitro method for detecting the presence of gram-negative bacterial strains resistant to antibiotics in a biological sample, said method comprising the steps of: a) providing a biological sample; b) preparing said biological sample for nucleic acid amplification; c) performing nucleic acid amplification using (i) nucleic acid from said biological sample as a template, (ii) at least one or more set of primers specific of bacterial genes encoding integrase of integrons of class 1, 2 and 3, and, (iii) at least one or more set of primers specific of bacterial genes encoding CTX-M type β-lactamases; and, d) determining the presence or absence of amplicons; wherein the presence of at least one amplicon is indicative of a high likelihood that said biological sample contains bacterial strains resistant to antibiotics. The method may be carried out directly on clinical samples, e.g. from septic patients. | 2013-07-18 |
20130183680 | ASSAYS AND METHODS FOR THE DIAGNOSIS OF POST-STREPTOCOCCAL DISORDERS - Provided are methods for diagnosing a disease in a subject with a previous streptococcal infection by determining the presence or absence of one or more autoantibodies in a biological sample from the subject, wherein the one or more autoantibodies recognize an antigen from a protein selected from the group consisting of ELAVL2, ELAVL3, ELAVL4, Nova-1, Nova-2, Cdr1, Cdr2; and Cdr3. The presence of such autoantibodies is indicative of a positive diagnosis for a post-streptococcal disease such as PANDAS, post-GABHS glomerulonephritis, rheumatic fever, autism and Syndenham's chorea. | 2013-07-18 |
20130183681 | DEVICE AND METHOD OF MONITORING A PATIENT - A device for remote management of patients suffering or likely to suffer from heart failure that can measure the amplitude and frequency changes of one or more biomarkers. The device aids in predicting the need for medical intervention in such patients. The device may further aid in monitoring the efficacy and safety of treatment in such patients. | 2013-07-18 |
20130183682 | Detection and Measurement of Blood-Feeding Activity - This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive against antigens or markers as they appear in the excrement or other ectoparasitic materials. Such markers or antigens may be produced by the ectoparasite itself or may have been introduced into the ectoparasite because of its blood feeding activity. The method of the present invention comprises collecting from the enclosure or area, a sample comprising environmental dust or materials and subjecting the sample to tests for detecting the presence of hematophagous ectoparasitic markers, host markers or both. | 2013-07-18 |
20130183683 | METHODS OF DIAGNOSING ACUTE CARDIAC DISORDERS USING BNP-SP - The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring BNP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection. | 2013-07-18 |
20130183684 | PROTEIN BIOMARKERS FOR OBSTRUCTIVE AIRWAYS DISEASES - Provided herein are methods for the diagnosis of obstructive airways diseases such as asthma and chronic obstructive pulmonary disease, and the discrimination between such diseases based on the expression profiles of biomarker proteins and combinations of biomarker proteins. In particular embodiments the biomarker proteins are selected from ceruloplasmin, haptoglobin, hemopexin, - | 2013-07-18 |
20130183685 | METHOD OF RECOMBINANT MACROMOLECULAR PRODUCTION - A method for recombinantly expressing a macromolecule in a host cell is disclosed which involves culturing a host cell which contains two nucleic acid sequences, i.e., a first nucleic acid sequence encoding a membrane-permeabilizing agent and a second nucleic acid sequence encoding a desired macromolecule under the operative control of an inducible promoter, to a selected cell density that permits accumulation of the agent. Thereafter the host cell is exposed to an environmental condition that induces the agent to disrupt the integrity of the cell membrane without complete lysis of the cell membrane. The host cell thereby allows transport through the membrane of small molecular weight compounds. These resulting host cells are cultured in the presence of a nutrient cocktail that contains components that can transport through the disrupted cell membrane, e.g., an inducing agent that induces the tightly regulated promoter and metabolic requirements that permit expression of the macromolecule. | 2013-07-18 |
20130183686 | METHOD OF EVALUATING IMMUNOSUPPRESSION - Provided is a method for determining immunosuppression in an individual. The method entails testing blood cells for nuclear NFkB and/or nuclear NFAT. The blood cells can be from a sample of blood from an individual. The cells can be contacted with an activating agent to obtain activated cells, and the amount of nuclear NFkB and/or NFAT can be compared to a control. An amount of nuclear NFkB and/or NFAT that is higher than the control is considered to be indicative of insufficient immunosuppression in the individual. An amount of nuclear NFkB and/or NFAT that is lower than the control is considered to be indicative of excessive immunosuppression in the individual. An amount of nuclear NFkB and/or NFAT that is the same as the control is considered to be indicative of an appropriate amount of immunosuppression in the individual. | 2013-07-18 |
20130183687 | METHODS OF DIAGNOSING NON-ALCOHOLIC STEATOHEPATITIS (NASH) - Non-invasive methods for detecting non-alcoholic fatty liver disease (NAFLD) and identifying the presence or absence of non-alcoholic steatohepatitis (NASH) in a subject utilize one or more biomarkers. The methods can differentiate between subjects with NASH and those with simple steatosis. Kits containing one or more agents for measuring the level of the biomarkers can be utilized to perform the described methods. | 2013-07-18 |
20130183688 | TIM-3 LIGANDS AND METHODS THEREOF - The invention relates to isolated polypeptides and nucleic acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses. | 2013-07-18 |
20130183689 | METHOD FOR DETECTING AND REMOVING ENDOTOXIN - The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca | 2013-07-18 |
20130183690 | HIGH AFFINITY BINDING SITE OF HGFR AND METHODS FOR IDENTIFICATION OF ANTAGONISTS THEREOF - Use of a polynucleotide encoding or a polypeptide comprising at least the extra-cellular IPT-3 and IPT-4 domains of hepatocyte growth factor receptor for the screening and/or development of pharmacologically active agents useful in the treatment of cancer, preferably a cancer with dysregulation of hepatocyte growth factor receptor. | 2013-07-18 |
20130183691 | POLYPEPTIDE MARKER FOR DIAGNOSIS OF ARTERIOSCLEROSIS, METHOD FOR DETECTION OF ARTERIOSCLEROSIS BY USING THE MAKER OR THE LIKE, AND KIT FOR DIAGNOSIS OF ARTERIOSCLEROSIS - Disclosed are: a polypeptide marker for diagnosing arteriosclerosis; a gene marker for diagnosing arteriosclerosis; an antibody; a probe for detecting an arteriosclerosis marker gene; a DNA microarray or a DNA chip for detecting an arteriosclerosis marker gene; a method for detecting arteriosclerosis; and a kit for diagnosing arteriosclerosis; with which an arteriosclerotic lesion can be detected with much improved accuracy. Specifically disclosed are: a polypeptide marker for diagnosing arteriosclerosis, which comprises a polypeptide having an amino acid sequence set forth in any one of SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, and 35 of the Sequence Listing, or a partial amino acid sequence thereof; a gene which encodes the amino acid sequence; a probe for detecting the gene; a DNA microarray or a DNA chip comprising the probe; an antibody bindable to the polypeptide as an antigen; a kit comprising any one of the above-mentioned items; and a method for detecting arteriosclerosis by using any one of the above-mentioned items. | 2013-07-18 |
20130183692 | INTOLERANCE TESTING FOR INGREDIENTS IN NUTRIENTS, FLAVORINGS AND THERAPEUTICS - Diagnosing an ingredient sensitivity or intolerance in companion animals comprises collecting a sample; screening the sample to detect the presence of an antibody to a particular ingredient. The sample can be saliva or other bodily fluid to detect the presence of an IgA, or IgM antibody to a particular ingredient or composition. Firstly a saliva or blood spot or other non-serum bodily fluid sample is collected. Secondly a blood sample is collected and serum from the sample is screened to detect the semi-quantitative or quantitative presence of at least one of an IgA, or IgM antibody to a particular food ingredient or composition. Thirdly, a biologically active nutrient in relation to the animal is determined. | 2013-07-18 |
20130183693 | METHOD AND KIT FOR DETECTING THE EARLY ONSET OF RENAL TUBULAR CELL INJURY - A method and kit for detecting the early onset of renal tubular cell injury, utilizing NGAL as an early urinary biomarker. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine following renal tubule cell injury. NGAL protein expression is detected predominantly in proximal tubule cells, in a punctate cytoplasmic distribution reminiscent of a secreted protein. The appearance of NGAL in the urine is related to the dose and duration of renal ischemia and nephrotoxemia, and is diagnostic of renal tubule cell injury and renal failure. NGAL detection is also a useful marker for monitoring the nephrotoxic side effects of drugs or other therapeutic agents. | 2013-07-18 |
20130183694 | Method For Analyzing A Sample - The invention relates to a method of analysing a sample, comprising the analysis of clinical-chemical parameters and the analysis of immunodiagnostic parameters in a fully automatic analysis apparatus, wherein the analysis apparatus comprises a pipetting apparatus, at least one holder for a reagent cartridge containing the components necessary for carrying out the analysis, a holding apparatus for a measurement cell, at least one measurement cell, with each reagent cartridge being associated with a measurement cell, a holding apparatus for a sample container containing sample, and a photometric or spectrometric measurement device. On the basis of a sample it is possible here for a plurality of different clinical-chemical and/or immunodiagnostic parameters to be determined, to which end a dedicated reagent cartridge is inserted into a holding apparatus of the analysis apparatus for each clinical-chemical or immunodiagnostic parameter to be determined. | 2013-07-18 |
20130183695 | BIOMECHANICAL-BASED METHODS OF DIAGNOSING SCOLIOSIS - Methods for diagnosing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and/or a predisposition to developing a scoliosis based on the determination of the variation of osteopontin (OPN) levels induced by mechanical forces/stimuli are described. | 2013-07-18 |
20130183696 | METHODS OF USE AND KIT FOR MEASUREMENT OF LIPOPOLYSACCHARIDE WITH A TIME RESOLVED FLUORESCENCE BASED ASSAY - The present invention relates to the methods of use for measurement of lipopolysaccharide (LPS) and methods of use for diagnosis of sepsis and LPS-related conditions. Specifically the present invention relates to a time resolved fluorescence (TRF) based assay for the measurement of LPS and methods of use for the measurement of LPS to diagnose sepsis, Gram-negative bacterial infections, and LPS-related conditions. | 2013-07-18 |
20130183697 | Methods And Compositions For Detecting Fungi And Mycotoxins - The invention relates to a method of identifying a specific fungal species in patient tissue or body fluid. The method comprises the steps of extracting and recovering DNA of the fungal species from the patient tissue or body fluid, amplifying the DNA, hybridizing a probe to the DNA to specifically identify the fungal species, and specifically identifying the fungal species. The invention also relates to a method of identifying a mycotoxin in patient tissue or body fluid. The method comprises the steps of extracting and recovering the mycotoxin from the patient tissue or body fluid, contacting the mycotoxin with an antibody directed against the mycotoxin, and identifying the myocotoxin. Both of these methods can be used to determine if a patient is at risk for or has developed a disease state related to a fungal infection, and to develop an effective treatment regimen for the patient. | 2013-07-18 |
20130183698 | IMMUNOCHROMATOGRAPHY DEVICES, METHODS AND KITS - A membrane-based assay device, methods and kits for determining the presence or quantity of an analyte in a test sample are provided. The immunochromatographic device comprises a membrane having a capture antibody bound thereto at a test zone, wherein the capture antibody is capable of binding with an analyte, in particular a Z-AAT protein present in a sample from a PiZ gene carrier. | 2013-07-18 |
20130183699 | METHOD OF DIFFERENTIATING BETWEEN BLOOD AND CONTROL SOLUTIONS CONTAINING A COMMON ANALYTE - Glucose measured in blood samples is distinguished from glucose measured in the control solutions used to test the optical instruments which make such measurements. The control solutions contain a labeling substance recognized by the optical instrument to distinguish glucose measurements made of control solutions from those made of blood samples. | 2013-07-18 |
20130183700 | SULFONATED COUMARINS, SYNTHESIS THEREOF, FLUOROGENIC SUBSTRATES RESULTING FROM GRAFTING SAID COUMARINS ONTO SUGARS, METHOD FOR PREPARING SAID SUBSTRATES, AND USES THEREOF - Substituted sulfonated coumarins are expressed in the general formula (I), where: R | 2013-07-18 |
20130183701 | Fluorogenic Sensors for Phospholipase C Isozymes - The present invention provides fluorogenic substrates and methods of use in detecting and analyzing phospholipase C isozyme (PLC) activity. | 2013-07-18 |
20130183702 | PROTEASE SELECTIVE SUPRAMOLECULAR ASSEMBLIES - Supramolecular assemblies for delivering active agents to cancerous or precancerous tissues in a subject are provided. These supramolecular assemblies are also useful in assays for detecting and imaging of cancerous and precancerous cells. The assemblies are protease-sensitive and comprise a peptide linkage containing a protease consensus sequence. The assemblies can be selectively targeted to cancerous tissue where the protease enzymes degrade the peptide linkage thereby releasing the active agents which were physically or mechanically contained in or retained by the supramolecular assembly. | 2013-07-18 |
20130183703 | ANALYTICAL METHOD FOR FAB AND FAB' MOLECULES - A method of measuring acidic species generated by degradation of a Fab or Fab′ component of a Fab-PEG or a Fab′-PEG comprising the steps of: a) cleaving the PEG and linker from the Fab-PEG or Fab′-PEG with an enzyme; b) optionally separating the PEG and linker generated in step a) from the Fab or Fab′, to provide a Fab or Fab′; and c) quantitatively analyzing acidic species associated with the cleaved Fab or Fab′ and/or the cleaved PEG. | 2013-07-18 |
20130183704 | Labeling Agent and Methods for Simultaneous Sequencing and Quantification of Multiple Peptides and Proteins Using the Same - The present invention provides a compound that can utilize hydrogen isotope and, at the same time, can quantify multiplexed samples at one time, as well as decreasing the cost for synthesis of the labeling agent. In addition, the present invention provides a novel method for quantitatively analyzing protein and peptide analytes having different quantities form each other using the labeling agent, wherein y-type fragment ions having a high mass which comprises the analyte remained after coupling the labeling agent with the analyte and then removing a part of the labeling agent through tandem mass spectrometry are utilized to conduct the quantitative analysis. | 2013-07-18 |
20130183705 | CONVERSION OF ALGAE TO LIQUID METHANE, AND ASSOCIATED SYSTEMS AND METHODS - Systems and methods for converting algae to liquid methane are disclosed. The system in accordance with a particular embodiment includes an algae cultivator, an anaerobic digester operatively coupled to the algae cultivator to receive algae and produce biogas, and a biogas converter coupled to the anaerobic digester to receive the biogas and produce liquefied methane and thermal energy, at least a portion of the thermal energy resulting from a methane liquefaction process. The system can further include a thermal path between the biogas converter and at least one of the algae cultivator and the anaerobic digester. The system can still further include a controller coupled to the biogas converter and at least one of the algae cultivator and the anaerobic digester. The controller can be programmed with instructions that, when executed (e.g., based on measured variables of the system), direct the portion of thermal energy between the biogas converter and the algae cultivator and/or anaerobic digester. | 2013-07-18 |
20130183706 | Method for Culturing Adipocytes - The present invention relates to a method for culturing adipocytes, in which a homogeneous population of mature adipocytes isolated from adipose tissue is cultured on a three-dimensional culture substrate. | 2013-07-18 |
20130183707 | STEM CELL BIOINFORMATICS - Ex vivo cell culture, especially the culture of stem cells, is a valuable and widely used technique. The appearance of unlabeled cultured cells contains significant information about the cell's identity, including its differentiation status and lineage. However, mere visual inspection of cells is a subjective process subject to inconsistencies between microscopists. This disclosure provides methods of quantifying cells' appearance, validating identity with known biomarkers, allowing automated classification of cells as well as automated segmentation and delineation of the borders of a cell colony. Also provided are systems and methods for comparing and standardizing cells cultured by different scientists using different cell culture methods. | 2013-07-18 |
20130183708 | APPARATUS FOR EXECUTION OF TREATMENT OPERATIONS IN CONNECTION WITH COLOURING OF TISSUE SPECIMENS ON OBJECT GLASSES - An apparatus for automatic execution of different treatment operations in connection with staining of tissue specimens on microscope slides, wherein the apparatus ( | 2013-07-18 |
20130183709 | MATERIAL FOR SCREENING FOR COMPOUND ACTING ON ION CHANNEL AND USE THEREOF - An object of the present invention is to provide a screening system that targets ion channels and has superior efficiency. The present invention provides a material for screening for compounds that act on a target ion channel, comprising cells which retain at least one first DNA encoding a voltage-dependent Na ion channel that has been inhibited from being inactivated, and in which a K ion channel has been activated so that a resting membrane potential becomes deeper in a negative direction. | 2013-07-18 |
20130183710 | Reference sample for quality control in molecular diagnosis - The present invention relates to a reference sample for quality control purposes in molecular diagnosis of biological samples, which reference sample comprises a mixture of cells from at least one reference cell line which exhibits a particular gene expression profile, and at least one type of lymphocytes. Furthermore, the invention relates to productions methods for such references samples as well as to methods of their use. | 2013-07-18 |
20130183711 | LIQUID CRYSTALS WITH SWITCHABLE WETTABILITY FOR CELL SORTING - Disclosed are methods and apparatuses for identifying and sorting cells based on the cells' response to an external stimulus. Cellular adherence to liquid crystals with tunable wettability is measured before and after an induced change in the liquid crystal wettability. The cell-based liquid crystal reorientation can be measured and used for monitoring and sorting of cells in a label-free manner, and thus provides a positive method for selecting cells, such as stem cells, for use in tissue engineering applications. | 2013-07-18 |
20130183712 | METHOD AND COMPOSITIONS FOR THE DETECTION OF PROTEIN GLYCOSYLATION - The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with posttranslational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits the ability of an engine˜red mutant of β-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of biotin, thereby enabling detection of the modified protein. The approach permits the rapid visualization of proteins that are at the limits of detection using traditional methods. Further, the preferred embodiments can be used for detection of certain disease states, such as cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes. | 2013-07-18 |
20130183713 | Polypeptides Having Beta-Glucosidase Activity, Beta-Xylosidase Activity, or Beta-Glucosidase Activity and Beta-Xylosidase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2013-07-18 |
20130183714 | MYELOMA CELL CULTURE IN TRANSFERRIN-FREE LOW IRON MEDIUM - The present invention relates to a method for culturing mammalian cells in a culture medium which is transferrin free and which contains no lipophilic or synthetic nitrogen-containing chelators. Also provided is the use of the medium and a process for providing a mammalian product by culturing cells capable of producing the product in the medium. | 2013-07-18 |
20130183715 | Method and Apparatus for Producing Engineered Fuel from High Cellulose Feedstock - An apparatus and method for producing methane gas, synthetic hydrocarbon gas, and fertilizer is provided. The apparatus includes a mix tank for mixing cellulosic material with a solvent into a slurry and a generator having an exhaust. The apparatus further includes a stir tank reactor for converting the slurry to a solution containing lignin-like carbon and liquid, and a separator for separating the lignin-like carbon and liquid. An anaerobic digester decomposes the received liquid received from the stir tank into methane and liquid components. A carbon dioxide scrubber scrubs the methane component of carbon dioxide. | 2013-07-18 |
20130183716 | NOVEL GLUCOSE DEHYDROGENASE - The invention relates to a glucose dehydrogenase showing an NADP/NAD activity ratio, namely the value obtained by dividing the enzyme activity value obtained by using NADP as a coenzyme by the enzyme activity value obtained by using NAD as a coenzyme, of not lower than 300, to a gene coding therefor, and to a transformant harboring that gene. The enzyme of the invention is very high in NADP specificity and can be suitably used, for example, for NADPH production, for coenzyme regeneration in enzymatic reduction reactions, and in biosensors for glucose concentration measurements. | 2013-07-18 |
20130183717 | CHANNELS WITH CROSS-SECTIONAL THERMAL GRADIENTS - Provided herein are systems, devices, and methods for generating thermal gradients in channels and uses thereof. In particular, provided herein are system, methods, and devices employing first and second thermal layers positioned around a channel in order to create a thermal gradient across a cross-section of the channel having, for example, a nucleic acid denaturation zone, a nucleic acid annealing zone, and a nucleic acid polymerization zone. Such devices find use in, for example, nucleic acid amplification procedures, including digital polymerase chain reaction (dPCR) to temperature cycle droplets for amplification of nucleic acid templates within the droplets. | 2013-07-18 |
20130183718 | Method for Synthesizing RNA using DNA Template - The present invention relates to a method of RNA synthesis by RNA-dependent RNA polymerases (RdRp) displaying an RNA polymerase activity on single-stranded DNA templates and to a kit for carrying out the method. The RdRp showing DNA-dependent RNA polymerase activity has a “right hand conformation” and the amino acid sequence of said RdRp comprises a conserved arrangement of the following sequence motifs: a. XXDYS, b. GXPSG, c. YGDD, d. XXYGL, e. XXXXFLXRXX (with the following meanings: D: aspartate, Y: tyrosine, S: serine, G: glycine, P: proline, L: leucine, F: phenylalanine, R: arginine, X: any amino acid). This class of RdRp is exemplified by the RdRp enzymes of viruses of the Caliciviridae family. The present invention also relates to a method for transferring at least one ribonucleotide (rC, rA, rU or rG) to the 3′-end of a single-stranded DNA by using the RdRp of the invention. | 2013-07-18 |
20130183719 | METHOD FOR PRODUCING VIRUS VECTOR - The present invention provides a method for producing a virus vector, which comprises a step wherein cells that are capable of producing a virus vector are cultured in a culture medium that contains, as active components, a retinoic acid and a histone deacetylase inhibiting substance; and a culture medium for the production of a virus vector, which is characterized by containing, as active components, a retinoic acid and a histone deacetylase inhibiting substance. | 2013-07-18 |
20130183720 | PROCESSING BIOMASS - Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce a product or intermediate, e.g., energy, a food, a fuel, or a material. | 2013-07-18 |
20130183721 | COOLING AND PROCESSING MATERIALS - Systems and methods for cooling and processing materials are disclosed. | 2013-07-18 |
20130183722 | Compositions Comprising A Polypeptide Having Cellulolytic Enhancing Activity And A Nitrogen-Contaning Compound And Uses Thereof - The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a nitrogen-containing compound. The present invention also relates to methods of using the compositions. | 2013-07-18 |
20130183723 | "Compositions Comprising A Polypeptide Having Cellulolytic Enhancing Activity And An Organic Compound And Uses Thereof" - The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and an organic compound. The present invention also relates to methods of using the compositions. | 2013-07-18 |