29th week of 2013 patent applcation highlights part 45 |
Patent application number | Title | Published |
20130184425 | LOW MOLECULAR WEIGHT POLYSTYRENE RESIN AND METHODS OF MAKING AND USING THE SAME - A low z-average molecular weight, high softening point polystyrene resin having a narrow molecular weight distribution, as well as methods of making and using the same, are provided. The use of an inert solvent and/or the order of addition of reactants during polymerization may contribute to the unique properties of the final homopolymeric resin. The polystyrene resin can be partially or fully hydrogenated and may have particular use as a tackifying agent in a variety of hot melt adhesive and rubber compositions. | 2013-07-18 |
20130184426 | MIXTURE COMPRISING SULFONATE GROUP-CONTAINING COMPOUND AND METHOD OF MANUFACTURING THE SAME, SOLUTION COMPOSITION, POLYURETHANE RESIN AND METHOD OF MANUFACTURING THE SAME, AND MAGNETIC RECORDING MEDIUM - An aspect of the present invention relates to a mixture of a sulfonate group-containing compound denoted by general formula (1) with a protonic acid: | 2013-07-18 |
20130184427 | POLYMERIC MATERIALS - A method of making a polymeric material is described, the method comprising contacting, for example polycondensing, a compound of formula | 2013-07-18 |
20130184428 | SULPHUR-CONTAINING TRIAZINE MONOMER THAT CAN BE USED FOR THE SYNTHESIS OF A POLYMER MEMBRANE FOR A FUEL CELL - A sulphur-containing triazine monomer is provided that can be used in the synthesis of a polymer membrane for a PEM-type fuel cell. The sulphur-containing triazine monomer has a structure corresponding to a formula (I): | 2013-07-18 |
20130184429 | FUNCTIONAL BIODEGRADABLE POLYMERS - Biodegradable polyesters are made by synthesizing copolymers derived from biodegradable hydroxyacid monomers as well as from hydroxyacid monomers containing a functional group such as an azide group, a halogen group, a thioacetate group, and the like. Preferably, the functionalized biodegradable polyester copolymers are derived from a functionalized hydroxyacid such as a homolog of lactic acid and/or glycolic acid with the copolyester thus containing functional groups on the backbone thereof. These biodegradable polyesters can be utilized wherever biodegradable polyesters are currently used, and also serve as a polymer to which various medical and drug delivery systems can be attached. | 2013-07-18 |
20130184430 | ANTI-ELECTROSTATIC POLYESTER COMPOSITION - A polyester composition includes 150 to 250 parts by weight of terephthalic acid and 100 parts by weight of a diol component. The diol component includes ethylene glycol present in an amount ranging from 99.5 wt % to 95 wt % based on the weight of the diol component and a C3-C5 diol present in an amount ranging from 0.05 wt % to 5.0 wt % based on the weight of the diol component. | 2013-07-18 |
20130184431 | POLYAMIDE RESINS AND PROCESSES FOR MOLDING THEM - Provided is a polyamide resin having high heat resistance, excellent moldability and excellent mechanical properties. The polyamide resin comprises a diamine unit containing 70 mol % or more of a xylylenediamine unit and a dicarboxylic acid unit containing 70 mol % or more of a straight chain aliphatic dicarboxylic acid unit, wherein the xylylenediamine unit is composed of 50 to 95 mol % of p-xylylenediamine and 50 to 5 mol % of m-xylylenediamine; the straight chain aliphatic dicarboxylic acid unit is composed of 50 to 100 mol % of adipic acid and 0 to less than 50 mol % of sebacic acid or other straight chain aliphatic dicarboxylic acids; the molar ratio of reacted diamine units to reacted dicarboxylic acid units (the number of moles of reacted diamine units/the number of moles of reacted dicarboxylic acid units) is less than 0.994; and the polyamide resin has a number average molecular weight of 10,000 to 25,000 and a melting point of 285° C. or more. | 2013-07-18 |
20130184432 | PROCESS FOR THE PREPARATION OF POLYETHER CARBONATE POLYOLS - The present invention relates to a process for the preparation of polyether carbonate polyols from one or more alkylene oxides, carbon dioxide and optionally from one or more H-functional starter substances in the presence of at least one double metal cyanide catalyst, wherein the double metal cyanide catalyst comprises an unsaturated alcohol as a complexing ligand. | 2013-07-18 |
20130184433 | METHOD FOR ISOLATING A CYCLOHEXAPEPTIDE - The present invention relates to a method for isolating acyclohexapeptide and to a novel crystalline form of caspofungin diacetate thus obtained. | 2013-07-18 |
20130184434 | Peptide Toxin Formulation - Procedures are described which use solvents to increase the topical insecticidal activity of toxic insect peptides. These procedures comprise drying the peptides, if needed, followed by the addition of either: 1) a polar organic solvent, with or without water, to a dried peptide, or 2) the addition of polar aprotic solvent or other adjuvant to the dried peptide, followed by the addition of either: 1) a polar organic solvent, with or without water, (where a polar aprotic solvent is added first) or 2) a polar aprotic solvent or other adjuvant to the peptide polar organic solvent (where the polar organic solvent is added first), to the peptide formulation. | 2013-07-18 |
20130184435 | MULTI-DRUG LIGAND CONJUGATES - Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations in a patient. The compounds described herein include conjugates of a plurality of cytotoxic drugs and vitamin receptor binding ligands. The plurality of drugs may be the same or different. Similarly, the vitamin receptor binding ligands may be the same or different. The conjugates also include a linker that is formed from one or more spacer linkers, heteroatom linkers, and releasable linkers. | 2013-07-18 |
20130184436 | APPARATUS AND METHOD FOR SEMI-AUTOMATED PARALLEL SYNTHESIS OF PEPTIDES - An apparatus is provided for the semi-automated parallel synthesis of multiple peptides. The apparatus includes an array of nozzles, each positioned above or adjacent a separate reaction container, two or more liquid reservoirs, each reservoir coupled to the liquid dispenser(s), and base chamber(s) connected to the reaction containers for removing liquid there from. The addition and removal of liquids may be controlled by programmable electromagnetic valves. The apparatus may also be used for other parallel solid phase reactions. A method is also provided for synthesizing multiple polypeptides or other macromolecules, for example by using the above apparatus, wherein multiple common steps are performed automatically while reactants are added manually. | 2013-07-18 |
20130184437 | DESIGN AND USE OF NEW RECOMBINANT INTERFERONS WITH ALTERED SPATIAL CONFIGURATION AND THREE-DIMENSIONAL STRUCTURE - This invention provides a crystalline recombinant interferon (rSIFN-co) having (i) the same amino acid sequence as that of human consensus interferon, and (ii) altered three-dimensional structure as compared to IFN-α2 | 2013-07-18 |
20130184438 | MUTANT PROTEIN - The present invention relates to an immunoglobulin-binding protein, wherein at least one asparagine residue has been mutated to an amino acid other than glutamine or aspartic acid, which mutation confers an increased chemical stability at pH-values of up to about 13-14 compared to the parental molecule. The protein can for example be derived from a protein capable of binding to other regions of the immunoglobulin molecule than the complementarity determining regions (CDR), such as protein A, and preferably the B-domain of Staphylococcal protein A. The invention also relates to a matrix for affinity separation, which comprises an immunoglobulin-binding protein as ligand coupled to a solid support, in which protein ligand at least one asparagine residue has been mutated to an amino acid other than glutamine. | 2013-07-18 |
20130184439 | PROTEIN PURIFICATION - The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step. | 2013-07-18 |
20130184440 | SUPER-HUMANIZED ANTIBODIES - A method of preparing a germinalized hypervariable antibody region directed against a target, as well as the antibodies, antibody fragments, vectors and compositions including the germinalized hypervariable region. | 2013-07-18 |
20130184441 | Detection of Neurodegenerative Disease - Provided are methods of assessing the absence or presence of a neurodegenerative disease in a subject comprising characterizing TDP-43 in a tissue sample of the subject. Also disclosed are methods for diagnosing a neurodegenerative disease in a subject, and methods for determining the efficacy of a drug against a neurodegenerative disease. Novel antibodies that bind to TDP-43 are also provided. | 2013-07-18 |
20130184442 | METHOD FOR LABELING OF COMPOUNDS - The present invention relates to site-specific labeling of antibodies or fragments thereof with one or more reporter group(s) in a way that does not affect antigen binding. The method for labeling antibodies and/or fragments thereof, comprises the following steps a) providing an IgG binding protein, which comprises α-helix structures, with a photoactivatable group and at least one label; b) forming a mixture of said IgG binding protein and the antibodies and/or fragments to be labeled; and c) UV illuminating said mixture for site-specific labeling of said antibodies and/or fragments thereof. The IgG binding protein is preferably the Z domain of Protein A. | 2013-07-18 |
20130184443 | Methods for Preparing Conjugates - The present invention provides pharmaceutical compositions comprising a pharmaceutically acceptable excipient and a conjugate having a degradable linkage. The conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods for delivering such compositions are also provided. | 2013-07-18 |
20130184444 | COMPACT NANOPARTICLES FOR BIOLOGICAL APPLICATIONS - A water soluble nanoparticle can include a ligand of formula (I). The ligand can provide zwitterionic character and can provide water solubility, small hydrodynamic diameter, chemical stability, and the capability to modify the nanoparticle with additional functional moieties such as a small molecule, nucleic acid, or protein. | 2013-07-18 |
20130184445 | METHOD FOR OBSERVING PROTEIN CRYSTAL - Provided are a method for observing protein crystal, wherein the growth process of the protein crystals is nondestructively and three-dimensionally monitored on a real-time basis and the growth of the crystals is controlled at a high accuracy to thereby enable the formation of single crystals having good qualities, which comprises observing the protein crystals, said protein crystals having been produced by a crystallization method using a gel, by an OCT measurement using light emitted from an ultrawideband light source; | 2013-07-18 |
20130184446 | MICROORGANISM NUCLEIC ACID PURIFICATION FROM HOST SAMPLES - The present disclosure provides systems, devices, and methods for purifying microorganism nucleic acid from a host sample, such as a whole blood sample from a human. In certain embodiments, devices and systems with multiple filters are employed and provide for the selective removal of blood cells and host nucleic acids from a sample in order to enrich for microorganism nucleic acid. | 2013-07-18 |
20130184447 | METAL COORDINATED COMPOSITIONS - A metal coordination complex of a biologically active moiety and a metal is disclosed. The complex confers to the biologically active moiety an improved performance which can include potency, stability, absorbability, targeted delivery, and combinations thereof. | 2013-07-18 |
20130184448 | MODIFIED ETHYLENEDIAMINE-N, N'-DISUCCINATE: ETHYLENEDIAMINE LYASE - The present invention provides a modified ethylenediamine-N,N′-disuccinate:ethylenediamine lyase. The present invention also provides a protein that comprises the amino acid sequence represented by SEQ ID NO: 1; or a protein that comprises an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 by deletion, substitution, or addition of one or more amino acid residues, and has an ethylenediamine-N,N′-disuccinate:ethylenediamine lyase activity. | 2013-07-18 |
20130184449 | DNA Encoding a Plant Lipase, Transgenic Plants and a Method for Controlling Senescence in Plants - Regulation of expression of senescence in plants is achieved by integration of a gene or gene fragment encoding senescence-induced lipase into the plant genome in antisense orientation. The carnation and | 2013-07-18 |
20130184450 | METHOD FOR PREPARING RIBONUCLEOSIDE PHOSPHOROTHIOATE - A method for preparing a phosphorothioate RNA based on the oxazaphospholidine method, wherein cyanoethoxymethyl group is used instead of tert-butyldimethylsilyl group as a protective group of 2′-hydroxyl group of RNA. | 2013-07-18 |
20130184451 | NOVEL SYNTHESIS OF 5-DEOXY-5'-FLUOROCYTIDINE COMPOUNDS - This invention relates to a process of synthesizing a β-nucleoside compound of formula (I): | 2013-07-18 |
20130184452 | WATERLESS DEGUMMING SYSTEM - A method and system for cleaning lignin and other gums from lignocellulosic fiber is disclosed. Lignocellulosic fiber is rapidly depressurized to a pressure lower than atmospheric pressure. The fiber is exposed to ionized air during the rapid depressurization. The fiber is then repressurized to a pressure equal to or greater than atmospheric pressure. | 2013-07-18 |
20130184453 | LINEAR CYCLODEXTRIN COPOLYMERS - Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents. | 2013-07-18 |
20130184454 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION - The present invention relates to hydroxyalkyl starch conjugates, a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent and the cytotoxic agent comprising at least one tertiary hydroxyl group, wherein the hydroxyalkyl starch is linked via said tertiary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS′(-L-M) | 2013-07-18 |
20130184455 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION - The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M) | 2013-07-18 |
20130184456 | HETEROCYCLIC MACROCYCLE TEMPLATED METAL-ORGANIC MATERIALS - A process for the preparation of a heterocyclic macrocycle-templated supramolecular metal organic material, the process comprising preparing a reaction mixture containing a metal, a heterocyclic macrocycle, and organic ligands and forming, in the reaction mixture, a heterocyclic macrocycle-templated metal organic material comprising the metal, the heterocyclic macrocycle and the ligands by template-directed synthesis with the heterocyclic macrocycle serving as the template and being encapsulated within a cage of the template metal organic material. | 2013-07-18 |
20130184457 | METHOD FOR THE PREPARATION OF RIVORAXABAN - The present invention relates to the use of a compound having the formula (II) for the preparation of a compound having the formula (V). Methods of preparing the compound having the formula (V) using the compound having the formula (II) are also described. Individual reaction steps as well as intermediates are additionally claimed. | 2013-07-18 |
20130184458 | NITROGENATED AROMATIC COMPOUND, ORGANIC SEMICONDUCTOR MATERIAL, AND ORGANIC ELECTRONIC DEVICE - Provided are a novel nitrogen-containing aromatic heterocyclic compound and an organic electronic device using the compound. This nitrogen-containing aromatic compound is represented by the general formula (1). Further, the present invention relates to organic electronic devices such as a light-emitting device, a thin-film transistor, and a photovoltaic device each using the nitrogen-containing aromatic compound. | 2013-07-18 |
20130184459 | P2X4 RECEPTOR ANTAGONIST - A compound having the following formula (II) or a pharmacologically acceptable salt thereof is used as a P2X | 2013-07-18 |
20130184460 | GLYCINE TRANSPORTER INHIBITING SUBSTANCES - The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, pain, and sleep disorder: | 2013-07-18 |
20130184461 | Mechanosynthesis Trajectories - Mechanosynthesis trajectories are described which are approximately coaxial, and are shown to be useful in a wide range of mechanosynthesis reactions regardless of the nature of the tip or the feedstock being transferred. | 2013-07-18 |
20130184462 | METHOD FOR PREDICTING AND MODELING ANTI-PSYCHOTIC ACTIVITY USING VIRTUAL SCREENING MODEL - The present invention relates to the development of a virtual screening model for predicting antipsychotic activity using quantitative structure activity relationship (QSAR), molecular docking, oral bioavailability, ADME and Toxicity studies. The present invention also relates to the development of QSAR model using forward stepwise method of multiple linear regression with leave-one-out validation approach. QSAR model showed activity-descriptors relationship correlating measure (r | 2013-07-18 |
20130184463 | COMPOUNDS ACTING AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE - The present invention provides a compound, that is a 1-({halo-2-[(2-hydrocarbyl or substituted hydrocarbyl)oxy]phenyl}methyl)-(fused bicyclic nitrogen heteroaryl) carboxylic acid or an ester or sulfonamide thereof. The compound may be represented by the following formula | 2013-07-18 |
20130184464 | NOVEL MONTELUKAST 4-HALOBENZYLAMINE SALT AND METHOD FOR PREPARING MONTELUKAST SODIUM SALT BY USING THE SAME - Disclosed are a novel montelukast 4-halobenzylamine salt, and a method for preparing a montelukast sodium salt by using the same. In the disclosed method, a montelukast 4-halobenzylamine salt represented by Formula 2 or a montelukast sodium salt represented by Formula 1 is prepared by obtaining a compound represented by Formula 3 from a compound represented by Formula 5, in the same reactor, without an additional obtaining process. | 2013-07-18 |
20130184465 | Process for the synthesis of thio-triazolo-group containing compounds - The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation. | 2013-07-18 |
20130184466 | PROCESS FOR PREPARING THE CRYSTALLINE FORM II OF FEBUXOSTAT - The present invention relates to a novel process for preparing the crystalline form II of febuxostat by crystallization of a solvent selected from ethyl acetate, methyl acetate or ethyl formiate. | 2013-07-18 |
20130184467 | PROCESS AND COMPOSITION OF MAKING POLYMERIZABLE RESINS CONTAINING OXAZOLIDONE - Disclosed herein are a process and composition to make polymerizable resins containing oxazolidone, in which organic acid-catalyzed and/or thermal annealing process got involved and consequently promoted a unique intramolecular transformation from a linear urethane linkage to a cyclic urethane linkage for those specifically constructed urethane resins containing α-substituted β-ketone moieties. | 2013-07-18 |
20130184468 | PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES - The invention relates to a process for the preparation of a compound of formula (I) | 2013-07-18 |
20130184469 | PROCESS FOR PREPARATION OF RUFINAMIDE - The invention relates to a novel, industrially viable, cost effective process for the preparation of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide commonly known as Rufinamide and intermediates thereof. | 2013-07-18 |
20130184470 | Process for preparing 5-[1-(4-chlorophenyl)-methylene]-1-hydroxymethyl-2,2-dimethyl-cyclopentan- ol - Process for preparing 5-[1-(4-chlorophenyl)-methylene]-1-hydroxymethyl-2,2-dimethyl-cyclopentanol | 2013-07-18 |
20130184471 | Process for the preparation of bendamustine hydrochloride and related compounds - The present invention relates to a process for preparing bendamustine hydrochloride, derivatives and related compounds thereof. | 2013-07-18 |
20130184472 | Process for the Preparation of 1-ARYL-PYRAZOL-3-ONE Intermediates Useful in the Synthesis of SIGMA Receptors Inhibitors - The invention relates to a process for preparing 1-aryl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors. | 2013-07-18 |
20130184473 | Composition for Lowering Blood Lipid and Elevating High-density Lipoprotein and Method for Manufacturing the Same - The present invention discloses a composition for lowering blood lipid and elevating high-density lipoprotein and a method for manufacturing the same; the composition comprises monascin or ankaflavin, or a combination thereof; the manufacturing method comprises the steps of: treating a | 2013-07-18 |
20130184474 | METHOD FOR PREPARING AN AMINO ACID FROM 2 AMINOBUTYROLACTONE - The invention relates to a method for preparing an amino acid, or its salts, from 2-aminobutyrolactone (2ABL), said amino acid fitting the formula I, XCH | 2013-07-18 |
20130184475 | NOVEL DAIDZEIN ANALOGS AS TREATMENT FOR CANCER - Provided are compositions for treatment of cancers, including breast cancer, comprising at least one novel daidzein analog, as well as methods of using the same for preventing or treating cancer or tumor growth. | 2013-07-18 |
20130184476 | PREPARATION OF LUBIPROSTONE - Aspects of the present application relate to process for the preparation of lubiprostone. | 2013-07-18 |
20130184477 | Derivative of epichlorohydrin of natural origin - Derivative of epichlorohydrin of natural origin, selected from the group consisting of glycidyl ethers presenting an epoxide equivalent weight higher than or equal to 50 g/equivalent and lower than or equal to 15000 g/equivalent, of glycidyl esters, of glycidyl amides, of glycidyl imides, of glycidyl amines, and of any mixture thereof, and of which the | 2013-07-18 |
20130184478 | CRYSTALLINE SOLVATE AND NON-SOLVATED FORMS OF 6,6'-[[3,3',5,5'-TETRAKIS(1,1-DIMETHYLETHYL)-[1,1'-BIPHENYL]-2,2'-DIYL]BI- S(OXY)]BIS-DIBENZO [D,F] [1,3,2]-DIOXAPHOSPHEPINE - The present invention relates to a crystalline non-solvated form of 6,6′-[[3,3′,5,5′-tetrakis(1,1-dimethylethyl)-[1,1′-biphenyl]-2,2′-diyl]bis(oxy)]bis-dibenzo[d,f][1,3,2]-dioxaphosphepine (compound I) and toluene-solvates and acetone-solvates thereof. | 2013-07-18 |
20130184479 | BIARYL DIPHOSPHINE LIGANDS, INTERMEDIATES OF THE SAME AND THEIR USE IN ASYMMETRIC CATALYSIS - The present disclosure relates to biaryl diphosphine ligands of the formula (B), processes for the production of the ligands and the use of the ligands in metal catalysts for asymmetric synthesis. The disclosure also relates to intermediates used for the production of the biaryl diphosphine ligand. (Formula (B)) | 2013-07-18 |
20130184480 | ORGANOMETALLIC COMPOUND PURIFICATION AND APPARATUS - A method of purifying crude organometallic compounds using a stripping column and a gas stream is provided. This method removes relatively more volatile impurities as compared to the organometallic compound. | 2013-07-18 |
20130184481 | ORGANOMETALLIC COMPOUND PURIFICATION - A method of purifying crude organometallic compounds using a plurality of distillation columns is provided. This method effectively removes both relatively more volatile impurities and relatively less volatile impurities as compared to the organometallic compound. | 2013-07-18 |
20130184482 | Process For Preparing An Acryloyloxysilane - A process for preparing an acryloyloxysilane, the process comprising reacting a metal salt of a carboxylic acid having the formula [CR | 2013-07-18 |
20130184483 | METHOD OF PRODUCING ALKOXYSILANES AND PRECIPITATED SILICAS FROM BIOGENIC SILICAS - A method of producing alkoxysilanes and precipitated silicas from biogenic silicas is provided. In a first step, biogenically concentrated silica is mixed with a liquid polyol to obtain a mixture, and then the mixture is heated. In a second step, a base is added to obtain a reaction mixture. In a third step, the reaction mixture is filtered to remove the carbon enriched RHA or other undissolved biogenic silica and recover the solution of alkoxysilane and alcoholate. In a fourth step, alkoxysilane is purified by filtering, distilling, precipitating or extracting from the original reaction solution to precipitate various forms of silica. In a final step, residual base present in alkoxysilane is neutralized to eliminate the residual alkali metal base. | 2013-07-18 |
20130184484 | PROCESS FOR PREPARING BORONIC ACIDS AND ESTERS IN THE PRESENCE OF MAGNESIUM METAL - The present invention relates to the process for preparing a boronic acid or ester chemically, in which an aromatic compound is reacted with a boronating agent, in the presence of magnesium metal (Mg | 2013-07-18 |
20130184485 | Method for Allylating and Vinylating Aryl, Heteroaryl, Alkyl, and Alkene Halogenides Using Transition Metal Catalysis - What is described is a process for preparing organic compounds of the general formula (I) | 2013-07-18 |
20130184486 | NOVEL CARBOXYLATE COMPOUND AND METHOD OF PRODUCING THE SAME AND PERFUME COMPOSITION THEREOF - There are provided a novel carboxylate compound useful as a blending perfume raw material and having a brisk pine-like odor and a method of producing the same and a perfume composition containing such a carboxylate compound. | 2013-07-18 |
20130184487 | Method to produce a stable dry ionic-bonded creatine alpha ketoglutarate of high oral absorbability - The invention provides a method to produce a stable, ionic-bonded, dry creatine-α-ketoglutarate product at a molar ratio of about 2:1. The product is stable at room temperature when kept dry for periods of up to one year. The product can be supplemented with additional biologically active, natural amino acid, preferably l-arginine, l-taurine and l-citrulline. The serving dosage is typically between about 1 and 2 g. | 2013-07-18 |
20130184488 | Separation Method and Method for Producing Isocyanate - Disclosed is a method for separating, with a multi-stage distillation column, a mixture containing an active hydrogen-containing compound (A) and a compound (B) that reversibly reacts with the active hydrogen containing compound (A), the method comprising distillation-separating the active hydrogen-containing compound (A) and the compound (B) with the multi-stage distillation column in the presence of an intermediate-boiling-point inactive compound (C) that has a normal boiling point between a normal boiling point of the active hydrogen-containing compound (A) and a normal boiling point of the compound (B) and is chemically inactive for both of the (A) and the compound (B). | 2013-07-18 |
20130184489 | Method for Separation of Racemic Compound-Forming Chiral Substances by a Cyclic-Crystallization Process and a Crystallization Device - The invention concerns a method for separating a racemic compound-forming chiral substance by a cyclic crystallization process which is conducted in at least one first crystallization unit ( | 2013-07-18 |
20130184490 | PROCESS TO PREPARE S-2-HYDROXY-3-METHOXY-3,3-DIPHENYL PROPIONIC ACID - Disclosed is a process for the preparation of S-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid (I) the key intermediate for the preparation of Ambrisentan [(+)-2(S)-(4,6-Dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionic acid]. Ambrisentan of the formula (IA) is approved under the trademark “Letairis ®” by the US Food and Drug Administration for the treatment of Pulmonary artery hypertension (PAH). | 2013-07-18 |
20130184491 | Production of Acetic Acid with Enhanced Catalyst Stability - Processes for the production of acetic acid by carbonylation of methanol and reactive derivatives thereof in a liquid phase reaction medium, wherein the reaction medium comprises a finite amount of water, a homogeneous catalyst, an alkyl halide promoter, and a catalyst stabilizer/co-promoter comprising a dissymmetric phosphonium cation. | 2013-07-18 |
20130184492 | PROCESSES FOR PRODUCING HOOC-R-COOH COMPOUND ACIDS FROM FERMENTATION BROTHS CONTAINING NH4+ -OOC-R-COO-NH4+ COMPOUNDS - A process for making HOOC—R—COOH compound acid from a clarified NH | 2013-07-18 |
20130184493 | PROCESS FOR PREPARATION OF 4-FLUORO-alpha-[2METHYL-L-OXOPROPYL]-gamma-OXO-N-beta-DIPHENYLBENZENE BUTANE AMIDE - A process for preparation of 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N-β-diphenylbenzene butane amide also known as a diketone intermediate of atorvastatin, completely devoid of impurities 3,4-difluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-n-β-diphenylbenzene butane amide; methyl, 2{-2[-(4-fluorophenyl)-2-oxo-1-phenylethyl)]}-4-methyl-3-oxo pentanoate; 1,4-bis(4-fluorophenyl)-2,3-diphenylbutane-1,4-dione, 1-(4-fluorophenyl)-2-phenyl ethanone; 1-(4-fluorophenyl)-2-phenyl ethanone and containing about 0.05% or less of 2-methyl-1-oxopropyl]-γ-oxo-N-β-diphenylbenzene butane amide. In that process the said diketone intermediate of formula 1 is obtained by maintaining temperature −25° C. to 50° C. during Friedel-Crafts acylation, in situ halogenation of formula II in presence of a solvent and nucleophilic substitution from a compound of formula III with formula IV in presence of a base. | 2013-07-18 |
20130184494 | Oxidation Catalyst for Hydrocarbon Compound, and Method and Apparatus for Producing Oxide of Hydrocarbon Compound Using Same - According to the first embodiment of the present invention, an oxide of a hydrocarbon compound can be produced with high yield and high productivity by oxidizing the hydrocarbon compound with molecular oxygen in the co-presence of an N-hydroxy compound, such as methyl ethyl ketone or N-hydroxysuccinimide, and a phosphate ester, such as dibutyl phosphate. According to another embodiment of the present invention, an oxide of a hydrocarbon compound can be produced with high yield by using an oxidation catalyst that comprises an oxime compound, such as methyl ethyl ketone. According to another embodiment of the present invention, an alcohol and/or a ketone can be produced with high yield by oxidizing the hydrocarbon compound at a temperature of 160° C. or less, and by decomposing the resulting hydroperoxide, for example, in a unit having an inner surface formed by a material from which no transition metal ion is generated. | 2013-07-18 |
20130184495 | PROCESS FOR PRODUCTION OF HEXAMETHYLENEDIAMINE FROM CARBOHYDRATE-CONTAINING MATERIALS AND INTERMEDIATES THEREFOR - Processes are disclosed for the conversion of a carbohydrate source to hexamethylenediamine (HMDA) and to intermediates useful for the production of hexamethylenediamine and other industrial chemicals. HMDA is produced by direct reduction of a furfural substrate to 1,6-hexanediol in the presence of hydrogen and a heterogeneous reduction catalyst comprising Pt or by indirect reduction of a furfural substrate to 1,6-hexanediol wherein 1,2,6-hexanetriol is produced by reduction of the furfural substrate in the presence of hydrogen and a catalyst comprising Pt and 1,2,6-hexanediol is then converted by hydrogenation in the presence of a catalyst comprising Pt to 1,6 hexanediol, each process then proceeding to the production of HMDA by known routes, such as amination of the 1,6 hexanediol. Catalysts useful for the direct and indirect production of 1,6-hexanediol are also disclosed. | 2013-07-18 |
20130184496 | PROCESS FOR TRANSFORMATION OF LIGNOCELLULOSIC BIOMASS OR CELLULOSE BY TUNGSTEN-OXIDE-BASED SOLID LEWIS ACID CATALYSTS AND A METAL THAT IS SELECTED FROM GROUPS 8 TO 11 - The invention relates to a process for transformation of lignoceliulosic biomass or cellulose that uses tungsten-oxide-based heterogeneous catalysts that are dispersed on an oxide-based substrate, preferably with a base of oxide(s) of aluminum and/or zirconium and/or titanium and/or niobium and containing an element in the particular metallic state. The use of these catalysts makes it possible to obtain directly upgradable products containing three carbon atoms, in particular hydroxyacetone and propylene glycol with high selectivity. | 2013-07-18 |
20130184497 | METHOD FOR PRODUCING DITRIMETHYLOLPROPANE - The present invention provides a method for producing ditrimethylolpropane which is characterized by the following (1) and (2): (1) a distillation still residue separated from purified trimethylolpropane is subjected to re-distillation under specific conditions to obtain a ditrimethylolpropane-containing solution having given contents of bis-TMP and tri-TMP; and (2) when subjecting the ditrimethylolpropane-containing solution to crystallization with an organic solvent, the crystallization is initiated under pressure at a temperature exceeding a boiling point of the organic solvent as measured under normal pressures, and the resulting crystallization product solution is cooled at a temperature drop rate of 2° C./min or less. According to the above method, it is possible to produce a high-purity ditrimethylolpropane from a distillation still residue obtained upon production of trimethylolpropane in a simple, industrially useful manner. | 2013-07-18 |
20130184498 | PROCESS FOR THE PRODUCTION OF DIMETHYL ETHER - A process for the production of dimethyl ether from a methanol reactor effluent is disclosed. The process may include: contacting an aqueous extractant comprising water and an effluent from a methanol synthesis reactor comprising methanol and one or more of methane, water, carbon monoxide, carbon dioxide, hydrogen, and nitrogen. At least a portion of the methanol partitions into the aqueous extractant; recovering an extract fraction comprising the aqueous extractant and methanol. The extract fraction is fed to a catalytic distillation reactor system for concurrently: contacting the methanol with catalyst in a reaction zone thereby catalytically reacting at least a portion of the methanol to form dimethyl ether and water; and fractionating the resulting dimethyl ether and the water to recover a first overheads fraction comprising dimethyl ether and a first bottoms fraction comprising water. | 2013-07-18 |
20130184499 | PREPARATION OF CATALYST FOR SELECTIVE HYDROGENATION OF HYDROGENATABLE PRECURSORS - A reduced metallic catalyst or pre-activated catalyst is formed by contacting a precursor catalyst or a reduced metallic catalyst with a modifier solution in the presence of a source of hydrogen and heat treating the precursor catalyst or the reduced metallic catalyst at super-atmospheric pressure to obtain the reduced metallic catalyst from the precursor catalyst or the pre-activated catalyst from the reduced metallic catalyst. A method of hydrogenating a hydrogenatable precursor includes providing a reduced metallic catalyst or the pre-activated catalyst prepared with modifier buffer and contacting the reduced metallic catalyst or pre-activated catalyst with the hydrogenatable precursor in the presence of hydrogen and, optionally, in the presence of a modifier solution. | 2013-07-18 |
20130184500 | Process for Acetal Removal In the Purification of a Crude Ethanol Product - Recovery of ethanol from a crude ethanol product obtained from the hydrogenation of acetic acid. Separation and purification processes of the crude ethanol products are employed to allow recovery of ethanol and hydrolyze acetal impurities by the addition of an acid stream. | 2013-07-18 |
20130184501 | HYDROGENATION CATALYSTS WITH ACIDIC SITES - The present invention relates to catalysts and to chemical processes employing such catalysts. The catalysts are preferably used for converting acetic acid to ethanol. The catalyst comprises acidic sites and two or more metals. The catalyst has acidic sites on the surface and the balance favors Lewis acid sites. | 2013-07-18 |
20130184502 | REDUCED WATER CONTENT PREPARATION PROCESS FOR HYDROGENATION CATALYSTS - The present invention relates to processes for making catalysts, to catalyst prepared by a specific process, and to chemical processes employing such catalysts. The catalysts are preferably used for converting acetic acid to ethanol. The catalyst comprises less than 20% solvent prior to calcining. | 2013-07-18 |
20130184503 | MEMBRANE HAVING A PORE-FREE SEPARATING LAYER AND USE AND METHOD OF MANUFACTURING A MEMBRANE - The invention relates to a membrane having a pore-free separating laye | 2013-07-18 |
20130184504 | METHOD FOR PREPARING 2,3-DIMETHYL-2,3-DINITROBUTANE - The present invention relates to a method for preparing 2,3-dimethyl-2,3-dinitrobutane (DMNB), which includes the following steps: (1) making titanium-silicate molecular sieve catalyst, acetone, hydrogen peroxide and ammonia contact and react at 65-80° C. to obtain a modified titanium-silicate molecular sieve catalyst; and (2-1) making acetone oxime and hydrogen peroxide contact and react in the presence of the modified titanium-silicate molecular sieve catalyst and water under the conditions of temperature of 60-90° C. and pH of 8-10, and separating DMNB from the reaction products thereof; or (2-2) making acetone, ammonia and hydrogen peroxide contact and react in the presence of the modified titanium-silicate molecular sieve catalyst and water under the conditions of temperature of 60-90° C. and pH of 8-10, and separating DMNB from the reaction products thereof. By the method provided by the present invention, DMNB can be prepared without having to use dangerous chemicals, such as 2-nitropropane, NaH and the like. | 2013-07-18 |
20130184505 | Methods for Producing Hydrocarbon Products from Bio-Oils and/or Coal-Oils - The present invention relates to a method for producing a hydrocarbon product from coal and/or biomass comprising the following steps: converting the coal to a coal-oil and/or converting the biomass to bio-oil, optionally processing the coal-oil and/or bio-oil in a hydroprocessing reaction to remove one or more of oxygen, nitrogen or sulfur from hydrocarbon compounds in the coal-oil and/or bio-oil; and using at least a portion of the coal-oil and/or bio-oil as a feedstock in a cracking reaction to convert hydrocarbon compounds in the feedstock into a mixture of smaller hydrocarbon compounds comprising the hydrocarbon product. | 2013-07-18 |
20130184506 | METHOD FOR PRODUCING AROMATIC HYDROCARBONS - Disclosed is a method for producing aromatic hydrocarbons including a cracking reforming reaction step of bringing a feedstock having a 10 vol % distillation temperature of 140° C. or higher and a 90 vol % distillation temperature of 380° C. or lower, into contact with a catalyst for monocyclic aromatic hydrocarbon production containing a crystalline aluminosilicate to cause the feedstock to react with the catalyst, and thereby obtaining a product including monocyclic aromatic hydrocarbons having 6 to 8 carbon numbers and a heavy oil fraction having 9 or more carbon numbers; a step of separating the monocyclic aromatic hydrocarbons and the heavy oil fraction from the product obtained from the cracking reforming reaction step; a step of purifying the monocyclic aromatic hydrocarbons separated in the separating step, and collecting the hydrocarbons; and a step of separating naphthalene compounds from the heavy oil fraction separated in the separating step, and collecting the naphthalene compounds. | 2013-07-18 |
20130184507 | Hydrogenation Process Using Catalyst Comprising Ordered Intermetallic Compound - The present invention relates to a process for the hydrogenation, in particular the selective hydrogenation of unsaturated hydrocarbon compounds using a hydrogenation catalyst comprising an ordered intermetallic compound. The ordered intermetallic compound comprises at least one metal of type A capable of activating hydrogen, and at least one metal of type B not capable of activating hydrogen, and the structure of the ordered intermetallic compound is such that at least one king of type A metals is mainly surrounded by atoms of the metal of type B. According to another aspect, the present invention is concerned with a catalyst comprising a support and the above ordered intermetallic compound supported on the support. According to still another aspect, the invention pertains to the use of a binary Pd—Ga ordered intermetallic compound as a catalyst. The hydrogenation process and catalysts of the present invention achieve a selectivity to the target compounds, e.g. in the selective hydrogenation of acetylene to ethylene, which is superior to the prior art. | 2013-07-18 |
20130184508 | Dilute Liquid Phase Alkylation - Methods of forming ethylbenzene are described herein. In one embodiment, the method includes contacting dilute ethylene with benzene in the presence of an alkylation catalyst to form ethylbenzene, wherein such contact occurs in a liquid phase reaction zone and recovering ethylbenzene from the reaction zone. | 2013-07-18 |
20130184509 | Methods of Making Xylene Isomers - Disclosed herein are methods of making xylene isomers. The methods generally include contacting an aromatics-comprising feed with a non-sulfided catalyst under conditions suitable for converting the feed to a product comprising xylene isomers. The catalyst includes a support impregnated with a hydrogenation component. The support includes a macroporous binder and a sieve selected from the group consisting of a medium pore sieve, a large pore sieve, and mixtures thereof. The selection of the sieve will depend upon the size of the molecules in the feed, intermediate, and product that can be expected from the catalytic reactions. When the molecules are expected to be large, a large pore sieve should be used. In contrast, when the molecules are expected to be smaller, either a large pore sieve, a medium pore sieve, or a mixture thereof may be used. The macropores within the support have been found to be especially beneficial because they help to overcome diffusional limitations observed when utilizing highly-active catalysts lacking such macropores. | 2013-07-18 |
20130184510 | METHOD FOR REDUCING COKE DEPOSITION - A method for reducing coke deposits includes heating an alcohol-fuel mixture to decompose alcohol and form water to produce a fuel-water mixture and delivering the fuel-water mixture to a carbon-steam gasification catalyst. The fuel-water mixture reacts with the carbon-steam gasification catalyst such that coke deposits are prevented from remaining in a space near the carbon-steam gasification catalyst. | 2013-07-18 |
20130184511 | Radiosurgical Neuromodulation Devices, Systems, and Methods for Treatment of Behavioral Disorders by External Application of Ionizing Radiation - Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased. | 2013-07-18 |
20130184512 | CHARGED PARTICLE BEAM IRRADIATION DEVICE - A charged particle beam irradiation device includes a particle accelerator that accelerates charged particles and ejects a charged particle beam, a cylindrical outer shell part that is capable of rotating around a rotating axis, an irradiation unit that is capable of irradiating an irradiation target with the charged particle beam, the irradiation direction of which changes in accordance with the rotation of the outer shell part, and a beam transport line that transports the charged particle beam ejected from the particle accelerator to the irradiation unit. The particle accelerator and the beam transport line may be at least partially housed within the outer shell part. | 2013-07-18 |
20130184513 | SKIN CARE METHOD AND SKIN CARE DEVICE - A skin care method using a closed-bottomed casing | 2013-07-18 |
20130184514 | PRESSURE ACTUATED SINGLE-LUMEN BLOOD PUMPING DEVICE - A pressure actuated single-lumen blood pumping device has a housing ( | 2013-07-18 |
20130184515 | DOUBLE BALLOON PUMP CARDIAC ASSIST DEVICE AND RELATED METHOD OF USE - A system and method for cardiac assist of a heart in a beating stage comprising a double balloon catheter having a proximal end and a distal end, the catheter having at least one lumen; an inflatable intra-ventricular balloon mounted on the catheter near the distal end of the catheter, the balloon having a lumen in fluid communication with the lumen of the catheter and being configured for inflation in a ventricle; and an intra-aortic balloon mounted on the catheter proximally to the intra-ventricular balloon; a control unit comprising a bidirectional pump; a fluid reservoir; and a processor configured to activate the pump; wherein the proximal end of the catheter is configured for attachment to the control unit to form a fluid conduction system in which fluid is configured to be pumped by the pump between the fluid reservoir and the intra-ventricular balloon and the intra-aortic balloon; and systolic augmentation comprising a new pressure wave which is generated when said balloon is inflated at the end of the slow ejection phase of the beating heart, such that any residual volume of blood left in said ventricle is displaced. | 2013-07-18 |
20130184516 | RELAXATION INDUCING SLEEP MASK - A relaxation inducing sleep mask includes a comfortable eye mask and a sleep module carried by the eye mask providing audible and/or visible patterns each intended to promote relaxation and to induce sleep. | 2013-07-18 |
20130184517 | System and Method for Measuring and Controlling Stress - A computer program product for processing heart rate information signals, which, when run on a computer controls the computer to estimate stress levels of a user in real time and provide generative feedback and alerts to the user when appropriate. | 2013-07-18 |
20130184518 | MECHANICAL BIOMARKERS FOR OOCYTE AND EMBRYO VIABILITY - Provided are methods for the determination of the viability of a mammalian embryo or a potential embryo generated from a mammalian oocyte, comprising applying a mechanical stimulus to the embryo or oocyte, detecting a temporal response of the embryo or oocyte to the mechanical stimulus, and deriving measurements for one or more parameters from the temporal response, the measurements being indicative of viability. Also provided are methods for selecting an embryo for transfer and methods for enhancing the viability of an embryo or oocyte. | 2013-07-18 |
20130184519 | CARDIAC SUPPORT DEVICE WITH DIFFERENTIAL COMPLIANCE - A cardiac support device comprising a jacket of flexible and biocompatible material having a first axis for alignment generally parallel to a longitudinal axis of a patient's heart and a second axis that is transverse to the first axis. The material exhibits an amount of expansion in response to a force applied to the material along the first axis that is different than an amount of expansion in response to the force applied to the material along the second axis. | 2013-07-18 |
20130184520 | HEART STABILIZER - Disclosed is a heart stabilizer used when a coronary artery of a heart is operated. The heart stabilizer allows an intake tube connected to a suction unit for holding the heart to perform a suctioning operation while preventing clogging in any circumstances, allows the direction of the suction unit to be converted to forward, rearward, leftward, and rightward directions, allows the angle of the suction unit to be minutely adjusted even after the suction unit is primarily fixed, and is cleaned while the suction unit maintains the adjusting function of the adjustor for adjusting and fixing the angle. | 2013-07-18 |
20130184522 | PUMP UNIT AND ENDOSCOPE APPARATUS USING THE SAME - A pump unit which can be made to be small-sized, and which enables to achieve a sufficient flow and an endoscope apparatus using such pump are provided. The pump unit which transports a fluid in a channel upon generating a progressive wave which is propagated in a longitudinal direction of the channel, in a first flexible thin film which constitutes at least a part of a channel-wall surface, includes a vibration exciter unit. | 2013-07-18 |
20130184523 | INSTRUMENT TIP HAVING WIRE RETENTION SLOT - An instrument tip includes a wire retention chamber extending in a width direction of the tip and open at the sides of a tip, the wire retention chamber configured to removably retain a wire therein, and a wire retention slot extending from the outermost side of the tip to the wire retention chamber and in an oblique direction with respect to a longitudinal axis of the tip, the wire retention slot in open communication with the wire retention chamber, wherein the wire retention chamber has a diameter greater than a diameter of the wire retention slot. | 2013-07-18 |
20130184524 | Scanning Endoscope Device - A scanning endoscope device including two core portions that are provided parallel to each other and that radiate illuminating beams having optical characteristics different from each other toward a subject; a driving unit that two-dimensionally scans the two illuminating beams radiated from the core portions by causing vibration of distal-end portions of the core portions; a light receiving unit that receives return beams, returned from the subject, of the two illuminating beams; a light splitting unit that splits the return beams received by the light receiving unit according to the optical characteristics; two light detecting units that photoelectrically convert the two return beams split by the light splitting unit to output captured image signals; and an image generating unit that generates two images for two viewpoint based on the each captured image signal. | 2013-07-18 |
20130184525 | IMAGE PICKUP APPARATUS, ENDOSCOPE DISTAL END PORTION INCLUDING THE IMAGE PICKUP APPARATUS, AND ENDOSCOPE DISTAL END UNIT - A distal end rigid member, a prism provided inside the distal end rigid member and positioned at the rear in an optical axis direction of a lens for observing a site to be examined, an image pickup device fixed to a light exit surface of the prism inside the distal end rigid member, and a substrate including a surface fixed to the image pickup device and another surface fixed to an inner circumferential face of the distal end rigid member are included, and the other surface of the substrate is formed in a shape that reduces or eliminates a space between the inner circumferential face of the distal end rigid member and the other surface of the substrate. | 2013-07-18 |